Bernhardt-Roth Syndrome

Disease involving the femoral nerve. The femoral nerve may be injured by ISCHEMIA (e.g., in association with DIABETIC NEUROPATHIES), nerve compression, trauma, COLLAGEN DISEASES, and other disease processes. Clinical features include MUSCLE WEAKNESS or PARALYSIS of hip flexion and knee extension, ATROPHY of the QUADRICEPS MUSCLE, reduced or absent patellar reflex, and impaired sensation over the anterior and medial thigh.

Synonym
Bernhardt-Roth Syndrome
Mononeuropathy, Femoral
Femoral Neuritis
Femoral Neuropathy
Neuropathy, Femoral
Lateral Femoral Cutaneous Nerve Entrapment
Femoral Mononeuropathy
Meralgia Paresthetica
Femoral Nerve Diseases
Femoral Nerve Dysfunction

Excerpt	Reference
"Meralgia paresthetica is an entrapment neuropathy involving the lateral femoral cutaneous nerve of the thigh."	( Maalouf, G; Moucharafieh, R; Wehbe, J, 2008)
"Meralgia paresthetica is a mononeuropathy affecting the lateral femoral cutaneous nerve that is extremely rare in children."	( Fernández, PM; Fernández-Jaén, A; Fernández-Mayoralas, DM; Jareño, NM; Pérez, BC; Sola, AG, 2010)
"Meralgia paresthetica is a well-known sensory syndrome describing paresthesia and/or anesthesia in the anterolateral aspect of the thigh that is supplied by the lateral femoral cutaneous nerve."	( Dharmasaroja, P, 2010)
"Meralgia paresthetica is an entrapment mononeuropathy of lateral femoral cutaneous nerve, which results in localized area of paresthesia and numbness on the anterolateral aspect of the thigh."	( Chen, CK; Phui, VE; Saman, MA, 2012)
"Meralgia paresthetica is a mononeuropathy of the lateral femoral cutaneous nerve."	( Arends, S; Kloosterziel, ME; Tavy, DLJ; van Zwet, EW; Wirtz, PW; Zijdewind, JM, 2020)

Excerpt	Reference
"Treatment of meralgia paresthetica with ultrasound-guided perineural injections resulted in substantial symptom relief in most patients 2 months after injection."	( Lacelli, F; Martinoli, C; Perrone, N; Serafini, G; Tagliafico, A; Valsania, V, 2011)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	3 (6.67)	23.3326
1990's	0 (0.00)	12.5806
2000's	17 (37.78)	18.1394
2010's	22 (48.89)	28.8240
2020's	3 (6.67)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	1	0
salicylic acid	low	1	0
dalteparin	low	2	0
acetaminophen	low	1	0
albendazole	low	1	0
alprazolam	low	1	0
amitriptyline	low	1	0
bupivacaine	low	4	0
gabapentin	low	1	0
guaifenesin	low	1	0
lidocaine	medium	2	1
mepivacaine	low	2	0
prilocaine	medium	3	1
ticlopidine	low	2	0
prednisolone	low	1	0
methylprednisolone acetate	low	2	0
methylprednisolone	medium	3	1
betamethasone	medium	3	1
fluorobenzenes	low	1	0
chromium	low	1	0
trolamine salicylate	low	2	0
phenyl acetate	low	1	0
fomesafen	low	1	0
clopidogrel	low	1	0
betamethasone sodium phosphate	medium	2	1
cobalt	low	1	0
betamethasone-17,21-dipropionate	low	1	0
naproxen	low	1	0
ropivacaine	low	1	0
inositol 3-phosphate	low	1	0
tacrolimus	low	1	0
D-fructopyranose	low	1	0
topiramate	low	1	0
morphine	medium	1	1
warfarin	low	3	0
olanzapine	low	1	0

Protein Targets (556)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
RAR-related orphan receptor gamma	8	0	0	8
ATAD5 protein, partial	4	0	0	4
GLS protein	5	0	0	5
Microtubule-associated protein tau	2	0	0	2
Smad3	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
thyroid stimulating hormone receptor	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	7	0	0	7
progesterone receptor	9	0	0	9
EWS/FLI fusion protein	7	0	0	7
retinoic acid nuclear receptor alpha variant 1	8	0	0	8
retinoid X nuclear receptor alpha	8	0	0	8
estrogen-related nuclear receptor alpha	11	0	0	11
estrogen nuclear receptor alpha	18	0	0	18
peroxisome proliferator activated receptor gamma	9	0	0	9
aryl hydrocarbon receptor	7	0	0	7
chromobox protein homolog 1	7	0	0	7
thyroid hormone receptor beta isoform 2	11	0	0	11
peripheral myelin protein 22	4	0	0	4
cytochrome P450 3A4 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	3	3	0	6
ATP-binding cassette sub-family C member 3	0	13	0	13
Multidrug resistance-associated protein 4	0	13	0	13
Solute carrier family 22 member 6	0	3	0	3
Carbonic anhydrase 12	0	3	0	5
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	3	0	3
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Bile salt export pump	0	21	0	21
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	5	0	7
Carbonic anhydrase 2	0	5	1	9
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	0	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 3	0	3	0	4
Cytochrome P450 3A4	0	5	1	6
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2C9	0	5	0	5
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	3	3	0	6
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	3	3	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	3	3	1	7
UDP-glucuronosyltransferase 1-6	0	0	0	1
Glutamate receptor 2	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-5	3	3	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	3	3	0	6
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	0	0	1
Carbonic anhydrase 4	0	3	0	5
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 6	0	3	0	5
Gamma-aminobutyric acid receptor subunit gamma-1	3	3	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	3	3	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	3	3	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	3	3	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	3	3	0	6
Carbonic anhydrase 5A, mitochondrial	0	3	1	6
Prostaglandin G/H synthase 2	0	4	0	5
Carbonic anhydrase 7	0	3	0	5
Nuclear receptor ROR-gamma	1	0	0	1
Cytochrome P450 2J2	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	3	3	1	7
Gamma-aminobutyric acid receptor subunit beta-3	3	3	0	6
Gamma-aminobutyric acid receptor subunit beta-2	3	3	1	7
Carbonic anhydrase 9	0	3	0	5
GABA theta subunit	3	3	0	6
Canalicular multispecific organic anion transporter 1	0	13	0	13
Carbonic anhydrase 15	0	3	0	4
Carbonic anhydrase 13	0	3	0	5
Gamma-aminobutyric acid receptor subunit epsilon	3	3	0	6
Carbonic anhydrase 14	0	3	0	5
Carbonic anhydrase 5B, mitochondrial	0	3	0	5
toxin B	0	0	0	1
Chain A, Beta-lactamase	5	0	0	5
Luciferase	3	0	0	3
glp-1 receptor, partial	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	5	0	0	5
Fumarate hydratase	2	0	0	2
TDP1 protein	10	0	0	10
GLI family zinc finger 3	9	0	0	9
AR protein	15	0	0	15
caspase 7, apoptosis-related cysteine protease	2	0	0	2
glucocorticoid receptor [Homo sapiens]	14	0	0	14
farnesoid X nuclear receptor	5	0	0	5
pregnane X nuclear receptor	11	0	0	11
polyprotein	2	0	0	2
67.9K protein	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	9	0	0	9
caspase-3	2	0	0	2
IDH1	7	0	0	7
euchromatic histone-lysine N-methyltransferase 2	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	11	0	0	11
v-jun sarcoma virus 17 oncogene homolog (avian)	6	0	0	6
nuclear receptor subfamily 1, group I, member 2	6	0	0	6
Histone H2A.x	4	0	0	4
cellular tumor antigen p53 isoform a	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	6
transcriptional regulator ERG isoform 3	2	0	0	2
histone deacetylase 9 isoform 3	1	0	0	1
heat shock protein beta-1	4	0	0	4
mitogen-activated protein kinase 1	3	0	0	3
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
geminin	12	0	0	12
Vif	0	0	0	1
survival motor neuron protein isoform d	3	0	0	3
muscleblind-like protein 1 isoform 1	2	0	0	2
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
lamin isoform A-delta10	9	0	0	9
neuropeptide S receptor isoform A	2	0	0	2
Interferon beta	7	0	0	7
Cellular tumor antigen p53	7	0	0	7
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Methionine aminopeptidase	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Inositol monophosphatase 1	2	0	0	2
ATPase family AAA domain-containing protein 5	7	0	0	7
Ataxin-2	8	0	0	8
nuclear receptor ROR-gamma isoform 1	2	0	0	2
Bromodomain-containing protein 4	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	2	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Cholecystokinin receptor type A	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	2	4
Gamma-aminobutyric acid receptor subunit beta-2	0	2	1	3
Cholecystokinin receptor type A	0	1	0	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
thioredoxin reductase	5	0	0	5
USP1 protein, partial	5	0	0	5
NFKB1 protein, partial	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
cytochrome P450 2D6	6	0	0	6
arylsulfatase A	3	0	0	3
cytochrome P450 2D6 isoform 1	2	0	0	2
D(1A) dopamine receptor	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	6	0	0	6
muscarinic acetylcholine receptor M1	3	0	0	3
Solute carrier family 22 member 1	0	2	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
5-hydroxytryptamine receptor 4	0	4	0	4
Albumin	0	0	2	2
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M4	0	4	0	4
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
5-hydroxytryptamine receptor 2C	0	3	0	3
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M5	0	4	0	4
Alpha-2A adrenergic receptor	0	6	1	7
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M1	0	3	1	4
Angiotensin-converting enzyme	0	3	0	3
D(2) dopamine receptor	0	4	0	4
5-hydroxytryptamine receptor 2A	0	3	0	3
Alpha-2B adrenergic receptor	0	6	0	6
Alpha-2C adrenergic receptor	0	6	0	6
5-hydroxytryptamine receptor 1A	0	3	0	3
Muscarinic acetylcholine receptor M3	0	4	0	4
D(1A) dopamine receptor	0	4	0	4
D(1B) dopamine receptor	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	3
Sodium-dependent noradrenaline transporter	0	3	0	3
Histamine H2 receptor	0	3	2	5
Alpha-1D adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	4	0	4
5-hydroxytryptamine receptor 1B	0	2	0	2
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	3	0	3
5-hydroxytryptamine receptor 6	0	1	0	1
Histamine H1 receptor	0	3	1	4
Sodium-dependent serotonin transporter	0	6	0	6
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Histamine H1 receptor	0	6	3	9
D(3) dopamine receptor	0	4	0	4
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	2
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 2B	0	4	0	4
Alpha-1A adrenergic receptor	0	2	0	2
Histamine H2 receptor	1	1	1	4
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	4	0	4
5-hydroxytryptamine receptor 7	0	2	0	2
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	7	0	7
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	1	3
5-hydroxytryptamine receptor 4	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	5	0	5
5-hydroxytryptamine receptor 3B	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	2	2	4
Sodium channel protein type 10 subunit alpha	0	1	0	1
pregnane X receptor	1	0	0	1
thyroid hormone receptor beta isoform a	3	0	0	3
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	6	1	12
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
ORF73	0	0	1	1
Potassium channel subfamily K member 3	0	4	0	4
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	1	2
Potassium channel subfamily K member 9	0	1	0	1
nonstructural protein 1	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Cytochrome P450 2C8	0	3	0	3
Cytochrome P450 2B6	0	3	0	3
Liver carboxylesterase 1	0	0	0	1
Cytochrome P450 2C19	0	4	0	4
Rap guanine nucleotide exchange factor 4	1	0	0	1
P2Y purinoceptor 12	0	1	0	1
estrogen receptor 2 (ER beta)	2	0	0	2
peroxisome proliferator-activated receptor delta	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Alpha-synuclein	1	0	0	1
Spike glycoprotein	5	0	0	5
thioredoxin glutathione reductase	1	0	0	1
regulator of G-protein signaling 4	4	0	0	4
Bloom syndrome protein isoform 1	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
ATP-dependent phosphofructokinase	2	0	0	2
Chain A, Ferritin light chain	4	0	0	4
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
histone acetyltransferase KAT2A isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Histone deacetylase 3	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Histone deacetylase 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
TAR DNA-binding protein 43	2	0	0	2
Histone deacetylase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Histone deacetylase 6	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Histone deacetylase 5	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
SMAD family member 2	3	0	0	3
SMAD family member 3	3	0	0	3
flap endonuclease 1	2	0	0	2
Rap guanine nucleotide exchange factor 3	1	0	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	6	0	0	6
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
phosphopantetheinyl transferase	1	0	0	1
GALC protein	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 3	0	1	0	2
Plasma kallikrein	0	0	0	1
Macrophage migration inhibitory factor	0	2	0	2
Adenosine receptor A1	0	2	0	3
5-hydroxytryptamine receptor 1D	0	0	0	1
Adenosine receptor A2a	0	1	0	2
Histamine H1 receptor	0	2	3	5
Metabotropic glutamate receptor 5	0	1	1	2
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	3
Histamine H3 receptor	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	2
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	1	0	3
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Solute carrier family 22 member 1	0	1	0	2
Carbonic anhydrase	0	1	0	3
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	1	0	2
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	2	0	3
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Solute carrier family 22 member 2	0	1	0	2
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
acetylcholinesterase	2	0	0	2
PPM1D protein	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
G	3	0	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Androgen receptor	0	3	0	3
Inositol hexakisphosphate kinase 1	3	0	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
cytochrome P450 2C9, partial	3	0	0	3
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	3
Translocator protein	0	0	1	1
Histidine decarboxylase	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	1	0	1
Delta-type opioid receptor	0	2	0	3
Delta-type opioid receptor	0	3	1	5
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	3	1	7
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	4
Delta-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	3	0	3
Beta-2 adrenergic receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	3
Hormone-sensitive lipase	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Caspase-1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Caspase-9	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	2
5-hydroxytryptamine receptor 3E	0	1	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	1	2
Alpha-1B adrenergic receptor	0	1	0	1
D	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
D(4) dopamine receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
D(4) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
D(2) dopamine receptor	0	3	0	3
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Transporter	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Transporter	0	1	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Albumin	0	1	1	2
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
PINK1	1	0	0	1
Parkin	1	0	0	1
photoreceptor-specific nuclear receptor	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Insulin receptor	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	2
DNA polymerase kappa isoform 1	2	0	0	2
UDP-glucuronosyltransferase 2B7	0	0	0	1
Cytochrome P450 3A5	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
thyroid stimulating hormone receptor	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(10)

Research Excerpts

Overview

Treatment

Research

Studies (45)

Protein Targets (556)

Bernhardt-Roth Syndrome

Synonyms(10)

Research Excerpts

Overview

Treatment

Research

Studies (45)

Drugs Studied (38)

Protein Targets (556)