naproxen has been researched along with ketoprofen in 242 studies
| Studies (naproxen) | Trials (naproxen) | Recent Studies (post-2010) (naproxen) | Studies (ketoprofen) | Trials (ketoprofen) | Recent Studies (post-2010) (ketoprofen) |
|---|---|---|---|---|---|
| 4,551 | 1,057 | 1,429 | 3,089 | 677 | 1,008 |
| 4,551 | 1,057 | 1,429 | 6 | 0 | 2 |
| Protein | Taxonomy | naproxen (IC50) | ketoprofen (IC50) |
|---|---|---|---|
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | 0.5 | |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | 1.1942 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 0.008 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 1.168 | |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | 0.18 | |
| Solute carrier family 22 member 6 | Homo sapiens (human) | 1.35 | |
| Interleukin-8 | Homo sapiens (human) | 0.02 | |
| C-X-C chemokine receptor type 1 | Homo sapiens (human) | 0.034 | |
| C-X-C chemokine receptor type 2 | Homo sapiens (human) | 0.034 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (16.12) | 18.7374 |
| 1990's | 32 (13.22) | 18.2507 |
| 2000's | 70 (28.93) | 29.6817 |
| 2010's | 87 (35.95) | 24.3611 |
| 2020's | 14 (5.79) | 2.80 |
| Authors | Studies |
|---|---|
| Bundgaard, H; Nielsen, NM | 1 |
| Apiwattanakul, N; Chairoungdua, A; Endou, H; Kanai, Y; Nakajima, N; Sekine, T; Sophasan, S | 1 |
| Strassburg, CP; Tukey, RH | 1 |
| Danelian, E; Hämäläinen, MD; Hansson, A; Karlén, A; Karlsson, R; Lennernäs, H; Löfâs, S; Winiwarter, S | 1 |
| Duffy, EM; Jorgensen, WL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Cihlar, T; Ho, ES; Mulato, AS | 1 |
| Faller, B; Wohnsland, F | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Abe, T; Itoh, T; Kato, Y; Kusuhara, H; Meier, PJ; Shitara, Y; Sugiyama, D; Sugiyama, Y | 1 |
| Charitos, C; Doulgkeris, C; Galanakis, D; Gavalas, A; Kourounakis, AP; Kourounakis, PN; Kravaritou, C; Rekka, EA; Tsiakitzis, KC | 1 |
| Beroza, P; Cai, D; Damodaran, K; Gomez, RF; Hsu, N; Keck, JG; Laborde, E; Lum, RT; Macke, TJ; Martin, G; Schow, SR; Simon, RJ; Villar, HO; Wick, MM | 1 |
| Chang, TK; Ensom, MH; Kiang, TK | 1 |
| Caron, G; Ermondi, G | 1 |
| Allegretti, M; Berdini, V; Bertini, R; Bizzarri, C; Cesta, MC; Colotta, F; Di Bello, N; Di Bitondo, R; Di Cioccio, V; Fantucci, P; Florio, S; Galliera, E; Locati, M; Nano, G; Nicolini, L; Russo, V; Topai, A; Zampella, G | 1 |
| Brozic, P; Gobec, S; Rizner, TL | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Carrupt, PA; Martel, S; Ottaviani, G | 2 |
| Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Anderluh, M; Brunskole, M; Gobec, S; Lanisnik Rizner, T; Stefane, B; Stojan, J; Zorko, K | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Avdeef, A; Tam, KY | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Buttar, D; Colclough, N; Gerhardt, S; MacFaul, PA; Maskos, K; Phillips, SD; Plowright, A; Steinbacher, S; Steuber, H; Tam, K; Whittamore, P | 1 |
| Akamatsu, M | 1 |
| Fujiwara, R; Koga, T; Nakajima, M; Yokoi, T | 1 |
| Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Horie, T; Horiguchi, A; Kitamura, S; Kotake, Y; Ohshita, H; Ohta, S; Sanoh, S; Sugihara, K; Tateno, C; Tayama, Y | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Kumar, M; Sinha, VR; Thareja, S | 1 |
| Ambrosi, G; Bauer, J; Elkady, M; Laufer, SA; Luderer, S; Nieß, R; Schaible, AM; Werz, O | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Capim, SL; Dos Santos, GC; Gonçalves, GM; Marinho, BG; Vasconcellos, ML | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Brewster, C; Deering-Rice, CE; Reilly, CA; Rose, TM | 1 |
| Alcaraz, B; Bratoeff, E; Cabeza, M; Camacho-Arroyo, I; Garrido, M; González-Arenas, A | 1 |
| Kourounakis, PN; Kourti, M; Rekka, EA; Theodosis-Nobelos, P; Tziona, P | 1 |
| Gavalas, A; Kourti, M; Rekka, EA; Theodosis-Nobelos, P | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Jones, TA; Nakagawa, A; Smith, CE; Soti, S; Xue, D; Yin, H | 1 |
| Akgul, O; Alfawaz Altamimi, AS; Angeli, A; Bartolucci, G; Carta, F; Di Cesare Mannelli, L; Ghelardini, C; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Boixareu, N; Campanera, JM; Navarro, L; Pors, K; Pouplana, R; Pujol, MD; Rosell, G; Sánchez, S | 1 |
| Altman, RA; Borel, T; Davis, I; de Azambuja, F; Johnson, D; Liu, A; Sorrentino, JP; Udokwu, C; Yang, Y | 1 |
| Boyle, E; Freeman, PC; Goudie, AC; Mangan, FR; Thomson, M | 1 |
| Mann, NS; Sachdev, AJ | 1 |
| Huskisson, EC | 1 |
| Hart, FD | 1 |
| Miehlke, K | 1 |
| Arvidsson, B; Magnusson, B; Sölvell, L | 1 |
| Reinicke, C | 1 |
| Lindroth, Y; Sjöblom, KG; Wollheim, FA | 1 |
| Burdeĭnyĭ, AP | 1 |
| Pemberton, RE; Strand, LJ | 1 |
| Spisani, S; Traniello, S; Vanzini, G | 1 |
| Mörsdorf, K; Wolf, G | 1 |
| Irwin, WJ; Slack, JA | 1 |
| Balme, HW; Franklin, S; Huskisson, EC; Scott, J; Woolf, DL | 1 |
| Kitchen, EA; Meacock, SC | 1 |
| Klein, G; Wottawa, A | 2 |
| Guyonnet, JC; Julou, L | 1 |
| Knights, KM; Roberts, BJ | 1 |
| de Pouvourville, G | 1 |
| Cerretani, D; Fiaschi, AI; Giorgi, G; Micheli, L | 2 |
| Jones, ME; Knights, KM | 1 |
| Ambrus, JL; Chesky, L; Engler, RJ; Haneiwich, S; McFarland, P | 1 |
| Casady, RL; Itoh, T; Magavi, R; Nishihata, T; Rytting, JH | 1 |
| Fritz, ME; Green, MD; Mayambala, CS; Odle, BM; Offenbacher, S; Sena, FJ; Smith, MA; van Dyke, TE; Yeh, KC | 1 |
| Artuso, T; Bernadou, J; Meunier, B; Paillous, N | 1 |
| Waterworth, RF; Waterworth, SM | 1 |
| Battellino, LJ; Dorronsoro de Cattoni, ST; Ragagnin, C | 1 |
| Akerlund, M; Strömberg, P | 2 |
| Besner, JG; Caillé, G; du Souich, P; Gervais, P; Vézina, M | 1 |
| Paulus, HE; Schlegel, SI | 1 |
| Atkinson, LK; Goodship, TH; Ward, MK | 1 |
| Sallmann, AR | 2 |
| Rizzi, F; Rossi, S; Tadini, R | 1 |
| Boudinot, FD; Satterwhite, JH | 1 |
| Duffill, MB; Taylor, BJ | 1 |
| Bassi, GP; Borghi, C; Camarri, E; Cocco, F; Francucci, BM; Giannini, R; Giordano, N; Marcolongo, R; Mordini, M; Neri, D | 1 |
| Machtey, I | 1 |
| Ward, JR | 1 |
| Court, H; Volans, GN | 1 |
| Isomäki, H; Kaarela, K; Kajander, A; Koota, K; Lehtinen, K; Luukkainen, R; Martio, J; Martio, T; Nissilä, M; Nuotio, P | 1 |
| Whittle, BJ | 1 |
| Bailey, RR; Lynn, KL; Munn, E | 1 |
| Keinänen-Kiukaanniemi, S; Kouvalainen, K; Similä, S | 1 |
| Buskin, JN; Guentert, TW; Riegelman, S; Upton, RA; Williams, RL | 1 |
| Buskin, JN; Holford, NH; Riegelman, S; Upton, RA; Williams, RL | 1 |
| Dickinson, RG; Worrall, S | 1 |
| Lange, R; Lentz, R | 1 |
| Aleotti, A; Alvisi, V; Caselli, M; DeCarlo, L; LaCorte, R; Ruina, M; Trevisani, L; Trotta, F | 1 |
| Dainaka, J; Hashii, H; Inoue, K; Kimura, K; Motonaga, A; Nishimura, T; Ueda, F; Yamate, K | 1 |
| Condorelli, G; Costanzo, LL; De Guidi, G; Giuffrida, S; Pappalardo, G; Sortino, S | 1 |
| Gran, JT | 1 |
| Dobson, A; Henry, D; Turner, C | 1 |
| Hartenbach, EM; Hunter, VJ; Sammarco, MJ | 1 |
| Hirrlinger, B; Knackmuss, HJ; Stolz, A | 1 |
| Becker, L; Eberlein-König, B; Przybilla, B | 1 |
| Fox, SM; Johnston, SA | 1 |
| Agut, J; Conejo, L; Márquez, M; Ortiz, JA; Palop, D; Sacristán, A | 1 |
| Borgå, B; Borgå, O | 1 |
| Giri, AK; Khan, KA; Philipose, B; Singh, R | 1 |
| Landt, M; Smith, CH; Way, BA; Wilhite, TR | 1 |
| Chouini-Lalanne, N; Defais, M; Paillous, N | 1 |
| Dajani, EZ | 1 |
| el-Bary, AA; el-Nabarawi, MA; Mohamed, MI | 1 |
| Gynther, J; Jarvinen, T; Nevalainen, T; Rautio, J; Taipale, H; Vepsalainen, J | 1 |
| Pedersen-Bjergaard, S; Rasmussen, KE | 1 |
| Hercegová, A; Polonský, J; Sádecká, J | 1 |
| Bae, SJ; Cho, U; Kang, K; Kim, WM; Kuettner, KE; Lee, DH; Lee, MH; Lee, MS; Nam, S; Schwartz, DE | 1 |
| Alberghina, L; Botta, M; Cernia, E; Corelli, F; D'Acquarica, I; Lotti, M; Manetti, F; Mileto, D; Palocci, C; Soro, S | 1 |
| Bertucci, C | 1 |
| Bujak-Gizycka, B; Kłys, M; Latacz, B; Skupień, E | 1 |
| Barbuzzi, T; Bonina, FP; de Caprariis, P; Palagiano, F; Puglia, C; Rimoli, MG; Saija, A | 1 |
| Foppoli, A; Gazzaniga, A; Giordano, F; Maroni, A; Sangalli, ME; Zema, L | 1 |
| Mason, JC; Patonay, G; Sowell, J; Strekowski, L | 1 |
| Lozano, JJ; Pouplana, R; Ruiz, J | 1 |
| Hansen, SH; Mortensen, RW; Sidelmann, UG; Tjørnelund, J | 1 |
| Chiang, HN; Wang, LF; Wu, PC | 1 |
| Bonina, F; Puglia, C; Saija, A; Santagati, NA; Tita, B; Tomaino, A | 1 |
| Cassely, A; Hoffmann, J; Mechref, Y; Novotny, MV | 1 |
| Aguilar, C; Borrull, F; Calull, M; Macià, A | 1 |
| Heydel, JM; Humbert, AC; Li, X; Little, JM; Magdalou, J; Radominska-Pandya, A; Sabolovic, N | 1 |
| Faassen, F; Vromans, H | 1 |
| Foster, GD; Thomas, PM | 1 |
| Gwak, HS; Han, HK; Oh, JH | 1 |
| Azarmi, Y; Barzegar-Jalali, M; Tajerzadeh, H; Valizadeh, H; Zakeri-Milani, P | 1 |
| Kronberg, L; Lindqvist, N; Tuhkanen, T | 1 |
| Quintana, JB; Reemtsma, T; Weiss, S | 1 |
| Choi, JS; Han, HK; Jin, MJ | 1 |
| Lin, AY; Reinhard, M | 1 |
| Joguet, L; Matijević, E; Sondi, I | 1 |
| Han, HK; Oh, YH | 1 |
| Corrigan, OI; Lane, ME; Levis, K; McDonald, GS | 1 |
| Chen, JS; Huang, SJ; Lin, SC; Lin, YJ; Peng, YS; Wang, LF; Wang, YM | 1 |
| Dawood, MY | 1 |
| Chiap, P; François, Y; Gareil, P; Juillerat, E; Servais, AC; Varenne, A | 1 |
| Balchen, M; Gjelstad, A; Pedersen-Bjergaard, S; Rasmussen, KE | 1 |
| Berger, MY; Damen, L; Koes, BW; Merlijn, V; Passchier, J; Verhagen, AP | 1 |
| Lukosek, M; Nachajski, MJ; Zgoda, MM | 2 |
| Baumann, K; Lindberg, W; Persson, AM; Pettersson, C; Sokolowski, A; Sundelöf, LO | 1 |
| Babazadeh, M | 1 |
| Blasi, P; Bonina, F; Puglia, C; Ricci, M; Rizza, L; Rossi, C; Schoubben, A | 1 |
| Archibold, EF; Duan, P; Habicht, SC; Kenttämaa, HI; Vinueza, NR | 1 |
| Kołodziejczyk, MK; Lukosek, M; Nachajski, MJ; Woskowicz, MH; Zgoda, MM | 1 |
| Molnár-Perl, I; Palkó, G; Sebok, A; Vasanits-Zsigrai, A; Záray, G | 1 |
| Cárdenas, S; Cruz-Vera, M; Lucena, R; Valcárcel, M | 1 |
| Asami, M; Fujiwara, J; Kunikane, S; Manabe, S; Matsuda, M; Simazaki, D | 1 |
| Ivanov, IT; Tsokeva, Z | 1 |
| Fanali, S; Rocco, A | 1 |
| Es'haghi, Z | 1 |
| Cheong, WJ; Zaidi, SA | 1 |
| Angeletti, M; Censi, R; Di Martino, P; Gashi, Z; Gobetto, R; Malaj, L; Masic, A; Mozzicafreddo, M | 1 |
| Benhamou, M; Dougados, M; Gossec, L | 1 |
| Cuerda-Correa, EM; de Heredia, JB; Domínguez-Vargas, JR; Olivares-Marín, FJ | 1 |
| Barcelo, D; Budzinski, H; Castiglioni, S; de Alencastro, LF; Farre, M; Gans, O; Heath, E; Kosjek, T; Langford, K; Loos, R; Petrovic, M; Quintana, JB; Radjenović, J; Rocca, LM; Tsipi, D | 1 |
| Helenkár, A; Molnár-Perl, I; Sebok, A; Vasanits-Zsigrai, A; Záray, G | 1 |
| Higashi, K; Ideura, S; Moribe, K; Waraya, H; Yamamoto, K | 1 |
| Aguilar, C; Borrull, F; Botello, I; Calull, M | 1 |
| Chasovskikh, E; Imran ul-haq, M; Signorell, R | 1 |
| Ezoddin, M; Hidalgo, M; Jönsson, JA; Larsson, E; Sagristà, E; Salvadó, V | 1 |
| Gunsch, CK; Wang, S | 1 |
| Elsinghorst, PW; Holzgrabe, U; Kinzig, M; Rodamer, M; Sörgel, F | 1 |
| Hashim, NH; Khan, SJ | 1 |
| Huang, YP; Li, R; Liu, ZS; Wei, ZH; Wu, X; Zhang, B | 1 |
| Hashim, NH; Khan, SJ; Nghiem, LD; Stuetz, RM | 1 |
| Unlü, B; van Leeuwen, JS; Vermeulen, NP; Vos, JC | 1 |
| Dobor, J; Varga, M; Záray, G | 1 |
| Chouini-Lalanne, N; Fabre, PL; Hajj, V; Latapie, L; Michaud, S; Noirot, A; Sartor, V | 1 |
| Alcudia-León, MC; Cárdenas, S; Lucena, R; Riaño, S; Valcárcel, M | 1 |
| Chen, L; Duan, YP; Meng, XZ; Wen, ZH | 2 |
| Dickenson, ER; Drewes, JE; Hoppe-Jones, C | 1 |
| Chen, L; Duan, YP; Ke, RH; Meng, XZ; Wen, ZH | 1 |
| Bouchet, LM; de la Guardia, M; Delgado-Pérez, T; Galian, RE; Pérez-Prieto, J | 1 |
| Larsson, DG; Ramaswamy, BR; Sampath, S; Selvaraj, KK; Shanmugam, G | 1 |
| Baldelli, F; Cipriani, S; D'Amore, C; Distrutti, E; Fiorucci, S; Francisci, D; Mencarelli, A; Renga, B; Santucci, L | 1 |
| Dong, YB; Kuang, X; Ma, Y; Su, H; Tang, B; Zhang, J | 1 |
| Kuentz, M; Niederquell, A | 1 |
| Jia, Y; Tan, J; Tang, J; Wang, Y; Xie, Q; Xu, C | 1 |
| Bursová, M; Cabala, R; Hložek, T | 1 |
| Mahugo-Santana, C; Montesdeoca-Esponda, S; Santana-Rodríguez, JJ; Sosa-Ferrera, Z | 1 |
| Gaš, B; Riesová, M; Svobodová, J; Tošner, Z; Ušelová, K; Zusková, I | 1 |
| Ademollo, N; Capri, S; Patrolecco, L | 1 |
| Boyer, TH; Huang, CH; Landry, KA; Sun, P | 1 |
| Alidina, M; Drewes, JE; Shewchuk, J | 1 |
| Caballo, C; Rubio, S; Sicilia, MD | 1 |
| Akdeniz, A; Anzenbacher, P; Minami, T; Mosca, L | 1 |
| Chen, J; Huang, C; Li, Y; Wang, J; Wang, L; Yang, J | 1 |
| Bendtsen, L; Derry, S; Moore, RA; Wiffen, PJ | 1 |
| Aguilar, C; Borrull, F; Calull, M; García-Vázquez, A | 1 |
| Lee, HK; Li, SF; Naing, NN | 1 |
| Olender, D; Pawełczyk, A; Sowa-Kasprzak, K; Zaprutko, L | 1 |
| Ahkola, HS; Herve, SH; Knuutinen, JS; Koistinen, J; Lahti, K; Lindholm-Lehto, PC; Vahtera, H | 1 |
| Chen, B; He, M; Hu, B; Mao, X | 1 |
| Kramulová, B; Marsik, P; Rezek, J; Tauchen, J; Vaněk, T; Židková, M | 1 |
| Burton, D; Jamieson, R; Khosravi, K; Price, GW; Zhang, Y | 1 |
| Higashi, K; Liu, N; Moribe, K; Ueda, K | 1 |
| Araujo, L; Dugas, V; Espina-Benitez, M; Navalón, A; Prieto, A; Valera, P; Vílchez, JL; Zambrano, A | 1 |
| Hachuła, B | 1 |
| Canotilho, J; Castro, RAE; Eusébio, MES; Machado, SMT; Maria, TMR | 1 |
| Chen, J; Huang, C; Jin, J; Li, Y; Peng, J; Wang, J; Yang, J | 1 |
| Hai, FI; Khan, SJ; McDonald, JA; Nghiem, LD; Nguyen, LN; Price, WE | 1 |
| Chen, J; Huang, C; Jin, J; Li, Y; Ma, H; Peng, J; Yang, J | 1 |
| Iwaki, M; Kawase, A; Kobayashi, Y; Ogiso, T; Shimada, H; Tanahashi, S | 1 |
| Cristina, RH; María Jesús, MV; Miguel Ángel, BL; Rut, FT | 1 |
| Abagyan, R; Cohen, IV; Lee, KC; Makunts, T | 1 |
| Apriceno, A; Astolfi, ML; Girelli, AM; Scuto, FR | 1 |
| Bahashi, J; Bi, E; Yu, C | 1 |
| Bello-López, MÁ; López-Pérez, G; Martín-Valero, MJ; Román-Hidalgo, C | 1 |
| Coppola, M; Gabano, E; Osella, D; Perin, E; Rangone, B; Ravera, M; Zanellato, I | 1 |
| Chen, J; Han, X; Li, Z; Qiu, H | 1 |
| Aydin, ME; Aydin, S; Ulvi, A | 1 |
| Chen, Y; Hao, C; Nie, W; Wang, L; Xu, P; Yin, Y | 1 |
| Barceló, D; López-Doval, JC; Rodríguez-Mozaz, S; Sabater, S; Serra-Compte, A | 1 |
| Ito, S; Iwamoto, K; Kamimura, H; Mizunaga, M; Nakayama, K; Negoro, T; Nishiwaki, M; Nomura, Y; Suemizu, H; Yamazaki, H; Yoneda, N | 1 |
| De Aramburu Mera, T; Ochando Díez-Canseco, M; Prados Castaño, M; Reguero Capilla, M | 1 |
| Xia, Y; Yang, C; Yang, Y; Zheng, R | 1 |
| Bączek, T; Chung, DS; Jeong, S; Kwon, JY; Kwon, W; Miękus, N; Valdez, JE | 1 |
| Kulig, K; Maciążek-Jurczyk, M; Owczarzy, A; Pożycka, J; Rogóż, W; Szkudlarek, A | 1 |
| Gorenflo, M; Saur, P; van den Anker, JN; van Dyk, M; Welzel, T; Ziesenitz, VC | 1 |
| Baratta, M; Cirillo, G; Curcio, M; De Filpo, G; Mashin, AI; Nezhdanov, AV; Nicoletta, FP; Tursi, A | 1 |
| Li, J; Li, Q; Wang, F; Wang, M; Wang, T; Xu, J | 1 |
| Dorazilová, J; Dvořák, M; Kubáň, P; Ryšavá, L; Sedláček, P; Vojtová, L | 1 |
| Jamieson, R; Lake, C; Price, GW; Shu, W | 1 |
| Goto, S; Kurosawa, Y; Tsurushima, M | 1 |
16 review(s) available for naproxen and ketoprofen
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
UDP-glucuronosyltransferases and clinical drug-drug interactions.
Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Antiinflammatory drugs.
Topics: Adult; Anti-Inflammatory Agents; Apazone; Arthritis, Rheumatoid; Aspirin; Benzylidene Compounds; Child; Drug Evaluation; Female; Humans; Ibuprofen; Indenes; Indomethacin; Ketoprofen; Mefenamic Acid; Naproxen; Phenylacetates; Phenylbutazone; Pregnancy; Pregnancy Complications; Propionates; Tolmetin | 1977 |
[Nonsteroid antirheumatic agents].
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Fenoprofen; Flufenamic Acid; Humans; Indomethacin; Ketoprofen; Mefenamic Acid; Naproxen; Phenylbutazone; Propionates; Salicylates | 1977 |
[Drug therapy of ankylosing spondyloarthritis (Bechterew's disease)].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Apazone; Butadienes; Cyclophosphamide; Diclofenac; Drug Combinations; Drug Evaluation; Glycolates; Gold; Humans; Ibuprofen; Indomethacin; Ketoprofen; Levamisole; Naproxen; Oxyphenbutazone; Phenylbutazone; Salicylates; Spondylitis, Ankylosing; Sulindac | 1978 |
Non-steroidal and analgesic therapy in the elderly.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents; Apazone; Aspirin; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Diclofenac; Drug Hypersensitivity; Gastrointestinal Diseases; Hematologic Diseases; Humans; Ibuprofen; Indomethacin; Ketoprofen; Kidney Diseases; Kinetics; Naproxen; Phenylbutazone; Piroxicam; Salicylates; Thiazines | 1986 |
[Naproxen sodium compared with ketoprofen lysine and lysine acetylsalicylate in the management of postoperative pain in gynecologic surgery].
Topics: Clinical Trials as Topic; Drug Evaluation; Female; Genital Diseases, Female; Humans; Ketoprofen; Lysine; Naproxen; Pain, Postoperative; Phenylpropionates | 1988 |
Update on ibuprofen for rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Tolerance; Fenoprofen; Humans; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Piroxicam; Sulindac; Thiazines; Tolmetin | 1984 |
Use of carprofen for the treatment of pain and inflammation in dogs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carbazoles; Clonixin; Cyclooxygenase Inhibitors; Dog Diseases; Dogs; Ibuprofen; Indomethacin; Ketoprofen; Meclofenamic Acid; Meloxicam; Naproxen; Osteoarthritis; Pain; Phenylbutazone; Piroxicam; Thiazines; Thiazoles | 1997 |
Biowaivers for oral immediate-release products: implications of linear pharmacokinetics.
Topics: Administration, Oral; Animals; Bile; Biological Availability; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Estrenes; Furans; Humans; Ketoprofen; Naproxen; Norethindrone; Solubility; Therapeutic Equivalency | 2004 |
Primary dysmenorrhea: advances in pathogenesis and management.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Contraceptives, Oral, Combined; Decision Trees; Dysmenorrhea; Female; Humans; Ibuprofen; Ketoprofen; Naproxen | 2006 |
Is any one analgesic superior for episodic tension-type headache?
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Diclofenac; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Ibuprofen; Ketoprofen; Naproxen; Nonprescription Drugs; Secondary Prevention; Tension-Type Headache; Treatment Outcome | 2006 |
Ibuprofen for acute treatment of episodic tension-type headache in adults.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Cyclooxygenase Inhibitors; Diclofenac; Humans; Ibuprofen; Ketoprofen; Naproxen; Numbers Needed To Treat; Pain Measurement; Piroxicam; Randomized Controlled Trials as Topic; Tension-Type Headache; Time Factors | 2015 |
Efficacy and safety of over-the-counter analgesics for primary dysmenorrhea: A network meta-analysis.
Topics: Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Dysmenorrhea; Female; Humans; Ibuprofen; Ketoprofen; Middle Aged; Naproxen; Network Meta-Analysis; Nonprescription Drugs; Treatment Outcome; Young Adult | 2020 |
Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years.
Topics: Adolescent; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Child; Chronic Disease; Diclofenac; Flurbiprofen; Humans; Ibuprofen; Infant; Ketoprofen; Ketorolac; Meloxicam; Naproxen; Niflumic Acid; Pain | 2022 |
15 trial(s) available for naproxen and ketoprofen
| Article | Year |
|---|---|
A comparative study of gastrointestinal bleeding during administration of ketoprofen and naproxen.
Topics: Administration, Oral; Adult; Benzophenones; Capsules; Clinical Trials as Topic; Gastrointestinal Hemorrhage; Humans; Ketoprofen; Male; Naphthaleneacetic Acids; Naproxen; Placebos; Tablets | 1977 |
A comparison of ketoprofen and naproxen in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Joints; Ketoprofen; Male; Middle Aged; Naproxen; Phenylpropionates | 1978 |
A review of upper-gastrointestinal effects of the newer nonsteroidal antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Evaluation; Fenoprofen; Gastric Mucosa; Gastritis; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Ibuprofen; Ketoprofen; Naproxen; Phenylbutazone; Registries; Sulindac; Tolmetin | 1979 |
Four new anti-inflammatory drugs: responses and variations.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Fenoprofen; Gastrointestinal Diseases; Humans; Ibuprofen; Ketoprofen; Naproxen; Pain | 1976 |
[Pain relief in dysmenorrhea can be achieved more rapidly with ketoprofen than with naproxen].
Topics: Drug Evaluation; Dysmenorrhea; Female; Humans; Ketoprofen; Naproxen; Randomized Controlled Trials as Topic; Sweden; Time Factors | 1990 |
Comparison of ketoprofen and naproxen in the treatment of dysmenorrhoea, with special regard to the time of onset of pain relief.
Topics: Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Humans; Ketoprofen; Middle Aged; Naproxen; Palliative Care; Time Factors | 1989 |
Effects of food and sucralfate on the pharmacokinetics of naproxen and ketoprofen in humans.
Topics: Adolescent; Adult; Food; Humans; Ketoprofen; Male; Naproxen; Phenylpropionates; Sucralfate | 1989 |
[Naproxen sodium compared with ketoprofen lysine and lysine acetylsalicylate in the management of postoperative pain in gynecologic surgery].
Topics: Clinical Trials as Topic; Drug Evaluation; Female; Genital Diseases, Female; Humans; Ketoprofen; Lysine; Naproxen; Pain, Postoperative; Phenylpropionates | 1988 |
Double-blind preference and compliance multicentre study in osteoarthritis: once-a-day treatment.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Administration Schedule; Humans; Indomethacin; Indoprofen; Ketoprofen; Middle Aged; Naproxen; Osteoarthritis; Pain; Patient Compliance; Piroxicam; Thiazines | 1985 |
Naproxen (Naprosyn) and ketoprofen (Orudis).
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Benzophenones; Clinical Trials as Topic; Edema; Humans; Ketoprofen; Naphthaleneacetic Acids; Naproxen | 1974 |
Update on ibuprofen for rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Tolerance; Fenoprofen; Humans; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Piroxicam; Sulindac; Thiazines; Tolmetin | 1984 |
Comparison of the analgesic effect of ten nonsteroidal anti-inflammatory drugs.
Topics: Adult; Aged; Analgesics; Anti-Inflammatory Agents; Apazone; Arthritis, Rheumatoid; Aspirin; Carbazoles; Diclofenac; Female; Humans; Ibuprofen; Indomethacin; Ketoprofen; Male; Middle Aged; Naproxen; ortho-Aminobenzoates; Quinazolines | 1984 |
Comparison ketoprofen, ibuprofen and naproxen sodium in the treatment of tension-type headache.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Ibuprofen; Ketoprofen; Male; Middle Aged; Naproxen; Pain Measurement; Prospective Studies; Tension-Type Headache | 1995 |
Local anesthesia for cryosurgery on the cervix.
Topics: Anesthesia, Local; Cervix Uteri; Colposcopy; Cryosurgery; Female; Humans; Injections, Subcutaneous; Ketoprofen; Lidocaine; Naproxen; Preanesthetic Medication; Prospective Studies; Uterine Cervical Dysplasia | 1993 |
Clinical relevance of C-reactive protein in ankylosing spondylitis and evaluation of the NSAIDs/coxibs' treatment effect on C-reactive protein.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; C-Reactive Protein; Celecoxib; Cyclooxygenase 2 Inhibitors; Epidemiologic Methods; Female; Humans; Ketoprofen; Male; Middle Aged; Naproxen; Pyrazoles; Spondylitis, Ankylosing; Sulfonamides; Treatment Outcome | 2010 |
213 other study(ies) available for naproxen and ketoprofen
| Article | Year |
|---|---|
Esters of N,N-disubstituted 2-hydroxyacetamides as a novel highly biolabile prodrug type for carboxylic acid agents.
Topics: Acetamides; Biotransformation; Carboxylic Acids; Half-Life; Humans; Indicators and Reagents; Kinetics; Structure-Activity Relationship | 1987 |
Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes.
Topics: Animals; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Carrier Proteins; Oocytes; Xenopus laevis | 1999 |
SPR biosensor studies of the direct interaction between 27 drugs and a liposome surface: correlation with fraction absorbed in humans.
Topics: Humans; Intestinal Absorption; Liposomes; Pharmaceutical Preparations; Pharmacokinetics; Predictive Value of Tests; Surface Plasmon Resonance | 2000 |
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1.
Topics: Adenine; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Biological Transport; Carrier Proteins; Humans; Kidney; Organophosphonates; Structure-Activity Relationship | 2000 |
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport.
Topics: Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibiotics, Antitubercular; Antimalarials; Biological Transport, Active; Digoxin; Enzyme Inhibitors; Estradiol; Ibuprofen; LLC-PK1 Cells; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Quinidine; Quinine; Rats; Rifampin; Swine | 2002 |
Synthesis and pharmacological evaluation of amide conjugates of NSAIDs with L-cysteine ethyl ester, combining potent antiinflammatory and antioxidant properties with significantly reduced gastrointestinal toxicity.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cholesterol; Cysteine; Drug Evaluation; Gastrointestinal Diseases; Lipoproteins, LDL; Mice; Rats; Triglycerides | 2004 |
Novel cyclooxygenase-1 inhibitors discovered using affinity fingerprints.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Combinatorial Chemistry Techniques; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Design; Drug Evaluation, Preclinical; Ibuprofen; Inhibitory Concentration 50; Isoenzymes; Models, Molecular; Models, Theoretical; Molecular Structure; Prospective Studies; Prostaglandin-Endoperoxide Synthases; Quantitative Structure-Activity Relationship | 2004 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors.
Topics: Animals; Binding Sites; Cell Line, Tumor; Cell Movement; Chemokines, CXC; Chemotaxis, Leukocyte; Female; Humans; Ketoprofen; Ligands; Lymphoma; Macrophages, Peritoneal; Mice; Models, Molecular; Mutagenesis, Site-Directed; Propionates; Receptors, Interleukin-8A; Recombinant Proteins; Structure-Activity Relationship | 2005 |
Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of anticancer agents.
Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Drug Design; Enzyme Inhibitors; Humans; Hydroxyprostaglandin Dehydrogenases; Molecular Structure; Tumor Cells, Cultured | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability.
Topics: 1-Octanol; Diffusion; Dimethylpolysiloxanes; Humans; In Vitro Techniques; Membranes, Artificial; Myristates; Permeability; Skin; Skin Absorption; Water | 2006 |
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water | 2007 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Towards the first inhibitors of trihydroxynaphthalene reductase from Curvularia lunata: synthesis of artificial substrate, homology modelling and initial screening.
Topics: Amino Acid Sequence; Ascomycota; Benzopyrans; Enzyme Inhibitors; Fungal Proteins; Melanins; Models, Molecular; Molecular Sequence Data; Oxidoreductases Acting on CH-CH Group Donors; Recombinant Proteins; Structural Homology, Protein; Substrate Specificity | 2008 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.
Topics: Binding Sites; Crystallography, X-Ray; Drug Interactions; Humans; Pharmaceutical Preparations; Protein Binding; Protein Structure, Tertiary; Serum Albumin; Spectrometry, Fluorescence | 2010 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Comet Assay; DNA Damage; Glucuronides; Glucuronosyltransferase; HEK293 Cells; Hepatocytes; Humans; Kidney | 2011 |
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Prediction of in vivo hepatic clearance and half-life of drug candidates in human using chimeric mice with humanized liver.
Topics: Animals; Cells, Cultured; Child, Preschool; Chimera; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Drugs, Investigational; Female; Half-Life; Hepatocytes; Humans; Immunomagnetic Separation; Liver; Male; Metabolic Clearance Rate; Mice; Mice, SCID; Recombinant Proteins; Species Specificity; Urokinase-Type Plasminogen Activator | 2012 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Self-organizing molecular field analysis of NSAIDs: assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Computational Biology; Least-Squares Analysis; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship | 2012 |
Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Cell Line; Humans; Indomethacin; Intramolecular Oxidoreductases; Lipoxygenase Inhibitors; Microsomes; Prostaglandin-E Synthases; Pyrazoles; Structure-Activity Relationship; Sulfonamides | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
High analgesic and anti-inflammatory in vivo activities of six new hybrids NSAIAs tetrahydropyran derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Mice; Molecular Structure; Motor Activity; Pyrans | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates.
Topics: Amidohydrolases; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Flurbiprofen; Humans; Serotonin; TRPV Cation Channels | 2014 |
Effect of new hybrids based on 5,16-pregnadiene scaffold linked to an anti-inflammatory drug on the growth of a human astrocytoma cell line (U373).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Humans; Molecular Structure; Pregnadienes; Sulindac; Time Factors | 2015 |
Esters of some non-steroidal anti-inflammatory drugs with cinnamyl alcohol are potent lipoxygenase inhibitors with enhanced anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cinnamates; Edema; Esters; Glycine max; Hyperlipidemias; Indoleacetic Acids; Lipoxygenase Inhibitors; Polyethylene Glycols; Propanols; Propionates; Rats; Thioctic Acid | 2015 |
Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory activity.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholesterol; Cholesterol, LDL; Edema; Hyperlipidemias; Hypolipidemic Agents; Morpholines; Rats; Triglycerides | 2016 |
Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Caspase Inhibitors; Caspases; Caspases, Initiator; Cell Line; Cell Survival; High-Throughput Screening Assays; Humans; Ibuprofen; Inhibitory Concentration 50; Ketorolac; Naproxen; Small Molecule Libraries; Substrate Specificity | 2017 |
Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Management of Rheumatoid Arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Carbonic Anhydrase Inhibitors; Humans; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfonamides | 2018 |
Synthesis and biological properties of aryl methyl sulfones.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Edema; Humans; Male; Mice; Models, Molecular; Molecular Structure; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Structure-Activity Relationship; Sulfones; Thermodynamics | 2018 |
Diflunisal Derivatives as Modulators of ACMS Decarboxylase Targeting the Tryptophan-Kynurenine Pathway.
Topics: Bacterial Proteins; Binding Sites; Biosynthetic Pathways; Carboxy-Lyases; Catalytic Domain; Crystallography, X-Ray; Diflunisal; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kynurenine; Molecular Docking Simulation; NAD; Pseudomonas fluorescens; Structure-Activity Relationship; Tryptophan | 2021 |
The role of copper in preventing gastrointestinal damage by acidic anti-inflammatory drugs.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chelating Agents; Copper; Edema; Female; In Vitro Techniques; Indomethacin; Ketoprofen; Male; Naproxen; Niflumic Acid; Peptic Ulcer; Prostaglandins E; Pyrroles; Rats | 1976 |
Acute erosive gastritis induced by aspirin, ketoprofen, ibuprofen, and naproxen: its prevention by metiamide and cimetidine.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Gastritis; Guanidines; Histamine H2 Antagonists; Ibuprofen; Imidazoles; Ketoprofen; Male; Metiamide; Naproxen; Rats; Thiourea | 1977 |
The new antirheumatic drugs.
Topics: Anti-Inflammatory Agents; Fenoprofen; Flufenamic Acid; Humans; Ibuprofen; Ketoprofen; Mefenamic Acid; Naproxen; Penicillamine; Phenylacetates; Rheumatic Diseases; Salicylates | 1975 |
Old and new pharmaceutical non-steroidal compounds prescribed for the management of patients with rheumatic diseases.
Topics: Anti-Inflammatory Agents; Fenoprofen; Humans; Ibuprofen; Ketoprofen; Naproxen; Rheumatic Diseases; Sulindac; Tolmetin | 1979 |
Inhibition of human leucocytes locomotion by anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents; Aspirin; Cell Movement; Chemotaxis, Leukocyte; Depression, Chemical; Humans; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Neutrophils; Salicylates | 1979 |
[On the efficiency of new antiinflammatory agents. A comparative study (author's transl)].
Topics: Animals; Anti-Inflammatory Agents; Benzylidene Compounds; Carrageenan; Diclofenac; Edema; Fenoprofen; In Vitro Techniques; Indenes; Indomethacin; Ketoprofen; Naproxen; Phenylbutazone; Protease Inhibitors; Rats | 1977 |
The identification of ibuprofen and analogues in urine by pyrolysis gas chromatography mass spectrometry.
Topics: Anti-Inflammatory Agents; Chromatography, Gas; Fenoprofen; Humans; Ibuprofen; Ketoprofen; Mass Spectrometry; Naproxen; Propionates | 1978 |
Some effects of non-steroidal anti-inflammatory drugs on leucocyte migration.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Cell Movement; Edema; Fenoprofen; Ibuprofen; Indomethacin; Ketoprofen; Leukocytes; Male; Methotrexate; Naproxen; Phenylbutazone; Pleurisy; Rats | 1976 |
[Effect of antirheumatic agents on DNA synthesis and DNA repair in various cell systems (proceedings)].
Topics: Animals; Anti-Inflammatory Agents; Apazone; DNA; DNA Repair; Flufenamic Acid; Humans; Ketoprofen; Mice; Mutagens; Naproxen; Oxyphenbutazone; Phenothiazines; Rats; Tolmetin | 1976 |
Relationship between the inhibitory activity on 'RCS' and prostaglandins synthesis and the anti-inflammatory activity of ketoprofen and several other non-steroidal anti-inflammatory agents.
Topics: Abscess; Animals; Anti-Inflammatory Agents; Aorta; Arachidonic Acids; Aspirin; Benzophenones; Colon; Guinea Pigs; Hydroxy Acids; Ibuprofen; In Vitro Techniques; Indomethacin; Ketoprofen; Lung; Muscle Contraction; Naproxen; Phenylbutazone; Prostaglandin Antagonists; Prostaglandins; Pyrans | 1976 |
[Effect of antirheumatic agents on DNA-systems and DNA repair of various cell systems].
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; DNA; DNA Repair; Flufenamic Acid; Humans; In Vitro Techniques; Ketoprofen; Naproxen; Oxyphenbutazone; Phenothiazines; Tolmetin | 1976 |
Inhibition of rat peroxisomal palmitoyl-CoA ligase by xenobiotic carboxylic acids.
Topics: Animals; Carboxylic Acids; Coenzyme A Ligases; Fenoprofen; Ketoprofen; Kinetics; Liver; Male; Microbodies; Naproxen; Rats; Repressor Proteins; Saccharomyces cerevisiae Proteins; Xenobiotics | 1992 |
The economic consequences of NSAID-induced gastropathy: the French context.
Topics: Ambulatory Care; Anti-Inflammatory Agents, Non-Steroidal; Cost of Illness; Diclofenac; Duodenal Ulcer; Economics, Hospital; Etodolac; France; Gastrointestinal Diseases; Humans; Ketoprofen; Naproxen; National Health Programs; Piroxicam; Rheumatic Diseases; Sulindac | 1992 |
Effect of non-steroidal anti-inflammatory drugs on glutathione levels in various organs of rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cell Death; Eye; Gastric Mucosa; Glutathione; Heart; Ketoprofen; Liver; Male; Muscles; Naproxen; Piroxicam; Rats; Rats, Wistar; Stomach | 1992 |
Inhibition kinetics of hepatic microsomal long chain fatty acid-CoA ligase by 2-arylpropionic acid non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Coenzyme A Ligases; Fenoprofen; Ibuprofen; Ketoprofen; Kinetics; Male; Microsomes, Liver; Naproxen; Palmitoyl Coenzyme A; Rats; Rats, Inbred Strains; Repressor Proteins; Saccharomyces cerevisiae Proteins; Stereoisomerism; Substrate Specificity; Triglycerides | 1992 |
Improved in vitro antigen-specific antibody synthesis in two patients with common variable immunodeficiency taking an oral cyclooxygenase and lipoxygenase inhibitor (ketoprofen).
Topics: Administration, Oral; Adolescent; Adult; Antibody Formation; B-Lymphocytes; Cell Differentiation; Child; Cyclooxygenase Inhibitors; Female; Humans; Ibuprofen; Immunologic Deficiency Syndromes; Ketoprofen; Lipoxygenase Inhibitors; Lymphocyte Activation; Male; Middle Aged; Mitogens; Naproxen | 1991 |
A method to predict the percutaneous permeability of various compounds: shed snake skin as a model membrane.
Topics: Animals; Cell Membrane Permeability; Hydrocortisone; Ibuprofen; Indomethacin; Ketoprofen; Models, Biological; Molecular Weight; Naproxen; Particle Size; Progesterone; Skin; Snakes | 1990 |
Inhibition of human periodontal prostaglandin E2 synthesis with selected agents.
Topics: Arachidonic Acid; Arachidonic Acids; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Dinoprostone; Eicosapentaenoic Acid; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Meclofenamic Acid; Naproxen; Periodontitis; Periodontium; Vitamin E | 1990 |
DNA strand breaks photosensitized by benoxaprofen and other non steroidal antiinflammatory agents.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bacteriophage phi X 174; Diflunisal; DNA Damage; DNA, Circular; DNA, Superhelical; DNA, Viral; Ketoprofen; Light; Molecular Structure; Naproxen; Propionates | 1990 |
Ketoprofen vs naproxen or diclofenac sodium in osteoarthritis.
Topics: Diclofenac; Humans; Ketoprofen; Multicenter Studies as Topic; Naproxen; Osteoarthritis | 1990 |
Impairment of human antipyrine metabolism by piroxicam.
Topics: Administration, Oral; Adolescent; Adult; Antipyrine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Ketoprofen; Male; Naproxen; Piroxicam; Saliva; Time Factors | 1990 |
Acute renal failure associated with acute pyelonephritis and consumption of non-steroidal anti-inflammatory drugs.
Topics: Acute Kidney Injury; Adult; Aged; Anti-Inflammatory Agents; Apazone; Female; Humans; Ibuprofen; Ketoprofen; Middle Aged; Naproxen; Pyelonephritis | 1986 |
The history of diclofenac.
Topics: Chemical Phenomena; Chemistry; Diclofenac; Humans; Hydrogen-Ion Concentration; Ibuprofen; Indenes; Indomethacin; Ketoprofen; Naproxen; Phenylbutazone; Piroxicam; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship; Thiazines | 1986 |
High-performance liquid chromatographic determination of ketoprofen and naproxen in rat plasma.
Topics: Animals; Chromatography, High Pressure Liquid; Injections, Intravenous; Ketoprofen; Naproxen; Phenylpropionates; Rats; Reference Standards; Spectrophotometry, Ultraviolet | 1988 |
Pseudoporphyria from nonsteroidal antiinflammatory drugs.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Diagnosis, Differential; Diflunisal; Humans; Ketoprofen; Middle Aged; Naproxen; Porphyrias; Skin Diseases; Time Factors | 1987 |
The history of diclofenac.
Topics: Diclofenac; History, 20th Century; Ibuprofen; Ketoprofen; Models, Molecular; Naproxen; Phenylbutazone; Piroxicam; Solubility; Structure-Activity Relationship; Thiazines | 1985 |
Diclofenac in the treatment of painful joints and traumatic tendinitis (including strains and sprains): a brief review.
Topics: Diclofenac; Flufenamic Acid; Humans; Ibuprofen; Indomethacin; Joint Diseases; Ketoprofen; Naproxen; Pain; Sprains and Strains; Tendinopathy | 1985 |
Poisoning after overdose with non-steroidal anti-inflammatory drugs.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Child; Child, Preschool; Diflunisal; Female; Fenoprofen; Feprazone; Humans; Ibuprofen; Indomethacin; Ketoprofen; London; Male; Mefenamic Acid; Naproxen; Oxyphenbutazone; Phenylbutazone; Piroxicam; Thiazines; Tolmetin | 1984 |
Arachidonic acid metabolites and the gastro-intestinal toxicity of anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Cyclooxygenase Inhibitors; Digestive System; Flurbiprofen; Gastric Mucosa; Indomethacin; Intestinal Mucosa; Ketoprofen; Naproxen; Prostaglandins; Rats | 1981 |
Renal papillary necrosis following regular consumption of non-steroidal anti-inflammatory drugs.
Topics: Aged; Anti-Inflammatory Agents; Humans; Ibuprofen; Indomethacin; Ketoprofen; Kidney Papillary Necrosis; Male; Middle Aged; Naproxen; Osteoarthritis | 1982 |
Oral antipyretic therapy evaluation of the propionic acid derivatives ibuprofen, ketoprofen, fenoprofen and naproxen.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Fenoprofen; Fever; Ibuprofen; Ketoprofen; Naproxen | 1980 |
Convenient and sensitive high-performance liquid chromatography assay for ketoprofen, naproxen and other allied drugs in plasma or urine.
Topics: Chromatography, High Pressure Liquid; Humans; Ketoprofen; Naproxen; Phenylpropionates | 1980 |
Negligible excretion of unchanged ketoprofen, naproxen, and probenecid in urine.
Topics: Humans; Hydrolysis; Ketoprofen; Male; Naproxen; Phenylpropionates; Probenecid; Specimen Handling; Time Factors | 1980 |
Rat serum albumin modified by diflunisal acyl glucuronide is immunogenic in rats.
Topics: Animals; Antibody Formation; Cross Reactions; Diflunisal; Epitopes; Glucuronates; Immunoglobulin G; Ketoprofen; Male; Naproxen; Rats; Rats, Wistar; Serum Albumin | 1995 |
Histological findings in gastric mucosa in patients treated with non-steroidal anti-inflammatory drugs.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Diclofenac; Female; Gastric Mucosa; Gastritis; Helicobacter Infections; Helicobacter pylori; Humans; Ketoprofen; Male; Middle Aged; Naproxen; Osteoarthritis | 1995 |
Effect of etodolac on prostaglandin E2 biosynthesis, active oxygen generation and bradykinin formation.
Topics: Animals; Aspirin; Bradykinin; Bromelains; Cartilage, Articular; Cell Line; Concanavalin A; Depression, Chemical; Diclofenac; Dinoprostone; Dogs; Etodolac; Gastric Mucosa; Guinea Pigs; Indomethacin; Interleukin-1; Ketoprofen; Kidney; Naproxen; Oxygen; Pain; Piroxicam; Rabbits; Rats | 1994 |
Antioxidant effect of copper(II) on photosensitized lipid peroxidation.
Topics: Amino Acid Sequence; Antioxidants; Copper; Ketoprofen; Lipid Peroxidation; Liposomes; Molecular Sequence Data; Naproxen; Oligopeptides; Peroxides; Phosphatidylcholines; Photochemistry; Photosensitizing Agents; Thiobarbituric Acid Reactive Substances; Ultraviolet Rays | 1995 |
Non-steroidal anti-inflammatory drugs (NSAIDs) affect the glutathione (GSH) levels in the brain.
Topics: Animals; Brain Chemistry; Cerebellum; Cerebral Cortex; Glutathione; Ketoprofen; Male; Naproxen; Piroxicam; Rats; Rats, Wistar | 1993 |
[Sternocostoclavicular hyperostosis].
Topics: Adult; Diagnosis, Differential; Female; Humans; Hyperostosis, Sternocostoclavicular; Ketoprofen; Naproxen | 1993 |
Variability in the risk of major gastrointestinal complications from nonaspirin nonsteroidal anti-inflammatory drugs.
Topics: Administration, Oral; Administration, Rectal; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Alcohol Drinking; Aspirin; Case-Control Studies; Dose-Response Relationship, Drug; Female; Gastrointestinal Diseases; Humans; Incidence; Ketoprofen; Male; Middle Aged; Naproxen; Peptic Ulcer; Piroxicam; Prospective Studies; Risk Factors; Sex Factors; Time Factors | 1993 |
Purification and properties of an amidase from Rhodococcus erythropolis MP50 which enantioselectively hydrolyzes 2-arylpropionamides.
Topics: Amidohydrolases; Amino Acid Sequence; Hot Temperature; Hydrogen-Ion Concentration; Ketoprofen; Metals; Molecular Sequence Data; Molecular Weight; Naproxen; Rhodococcus; Sequence Alignment; Sequence Homology, Amino Acid; Stereoisomerism; Substrate Specificity | 1996 |
Phototoxicity of non-steroidal anti-inflammatory drugs: in vitro studies with visible light.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Dermatitis, Phototoxic; Diclofenac; Erythrocytes; Hemolysis; Humans; Ibuprofen; In Vitro Techniques; Ketoprofen; Light; Naproxen; Phenylbutazone; Photosensitizing Agents; Piroxicam; Propionates | 1996 |
Histamine H2-receptor antagonist action of ebrotidine. Effects on gastric acid secretion, gastrin levels and NSAID-induced gastrotoxicity in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzenesulfonates; Diclofenac; Dose-Response Relationship, Drug; Female; Gastric Acid; Gastrins; Guinea Pigs; Heart Atria; Heart Rate; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Indomethacin; Ketoprofen; Male; Naproxen; Pentagastrin; Ranitidine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thiazoles | 1997 |
Serum protein binding of nonsteroidal antiinflammatory drugs: a comparative study.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Chromatography, High Pressure Liquid; Diclofenac; Female; Fenoprofen; Flurbiprofen; Humans; Ketoprofen; Male; Middle Aged; Naproxen; Protein Binding; Tolmetin | 1997 |
Comparative mutagenic and genotoxic effects of three propionic acid derivatives ibuprofen, ketoprofen and naproxen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Cells; Ibuprofen; In Vitro Techniques; Ketoprofen; Male; Mice; Microsomes, Liver; Mutagenicity Tests; Mutagens; Naproxen; Rats; Salmonella typhimurium; Sister Chromatid Exchange | 1997 |
Measurement of plasma ibuprofen by gas chromatography-mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Cystic Fibrosis; Drug Monitoring; Fenoprofen; Gas Chromatography-Mass Spectrometry; Humans; Ibuprofen; Ketoprofen; Naproxen; Sensitivity and Specificity | 1997 |
Nonsteroidal antiinflammatory drug-photosensitized formation of pyrimidine dimer in DNA.
Topics: Anti-Inflammatory Agents, Non-Steroidal; DNA; DNA Damage; DNA, Single-Stranded; Energy Transfer; In Vitro Techniques; Indomethacin; Ketoprofen; Naproxen; Photochemistry; Photosensitizing Agents; Propionates; Pyrimidine Dimers | 1998 |
Gastrointestinal toxicity of over-the-counter analgesics.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Gastric Mucosa; Humans; Ibuprofen; Intestinal Mucosa; Intestines; Ketoprofen; Naproxen; Nonprescription Drugs; Peptic Ulcer; Stomach; Time Factors | 1998 |
Effect of chemical structure on the release of certain propionic acid derivatives from their dosage forms.
Topics: Capsules; Chemical Phenomena; Chemistry, Physical; Dosage Forms; Drug Compounding; Drug Stability; Drug Storage; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Molecular Structure; Naproxen; Propionates; Suppositories | 1998 |
In vitro evaluation of acyloxyalkyl esters as dermal prodrugs of ketoprofen and naproxen.
Topics: Acylation; Alkylation; Chromatography, High Pressure Liquid; Esters; Humans; In Vitro Techniques; Ketoprofen; Naproxen; Prodrugs; Skin Physiological Phenomena; Solubility; Spectrometry, Mass, Secondary Ion; Time Factors | 1998 |
Liquid-phase microextraction and capillary electrophoresis of acidic drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentration; Ibuprofen; Ketoprofen; Naproxen | 2000 |
Determination of some antirheumatics by capillary isotachophoresis.
Topics: Antirheumatic Agents; Electrophoresis, Capillary; Fenoprofen; Humans; Ibuprofen; Ketoprofen; Naproxen | 2000 |
Molecular characteristics of the inhibition of human neutrophil elastase by nonsteroidal antiinflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Affinity; Computer Simulation; Enzyme Inhibitors; Humans; Isoenzymes; Ketoprofen; Leukocyte Elastase; Models, Molecular; Naproxen; Phenylbutazone; Salicylates; Spectrum Analysis, Raman | 2000 |
Design and realization of a tailor-made enzyme to modify the molecular recognition of 2-arylpropionic esters by Candida rugosa lipase.
Topics: Base Sequence; Binding Sites; Candida; Esters; Ketoprofen; Lipase; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Naproxen; Propionates; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 2000 |
Enantioselective inhibition of the binding of rac-profens to human serum albumin induced by lithocholate.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Binding, Competitive; Chromatography; Circular Dichroism; Drug Interactions; Fenoprofen; Humans; Ketoprofen; Lithocholic Acid; Naproxen; Phenylpropionates; Serum Albumin; Stereoisomerism; Substrate Specificity; Suprofen | 2001 |
[Two complex suicidal poisonings with drugs and their medicolegal aspects].
Topics: Adult; Atenolol; Chromatography, High Pressure Liquid; Diclofenac; Estazolam; Fatal Outcome; Female; Humans; Ibuprofen; Illicit Drugs; Ketoprofen; Male; Metronidazole; Naproxen; Poland; Suicide, Attempted; Theophylline; Tolperisone | 2001 |
In vitro and in vivo evaluation of polyoxyethylene esters as dermal prodrugs of ketoprofen, naproxen and diclofenac.
Topics: Administration, Cutaneous; Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Diclofenac; Erythema; Female; Gels; Humans; Ketoprofen; Male; Middle Aged; Naproxen; Polyethylene Glycols; Prodrugs; Skin Absorption; Solubility; Solvents | 2001 |
Influence of betacyclodextrin on the release of poorly soluble drugs from inert and hydrophilic heterogeneous polymeric matrices.
Topics: beta-Cyclodextrins; Biocompatible Materials; Cyclodextrins; Drug Carriers; Ketoprofen; Kinetics; Naproxen; Time Factors | 2001 |
Binding constant determination of drugs toward subdomain IIIA of human serum albumin by near-infrared dye-displacement capillary electrophoresis.
Topics: Binding, Competitive; Clofibrate; Coloring Agents; Electrophoresis, Capillary; Humans; Ibuprofen; Imipramine; Indoles; Ketoprofen; Kinetics; Naproxen; Protein Binding; Protein Structure, Tertiary; Quinidine; Serum Albumin; Stereoisomerism; Sulfonic Acids | 2001 |
Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Computer Graphics; Computer Simulation; Crystallography, X-Ray; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Energy Transfer; Flurbiprofen; Humans; Indomethacin; Isoenzymes; Ketoprofen; Meclofenamic Acid; Mefenamic Acid; Membrane Proteins; Models, Molecular; Naproxen; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides | 2002 |
Stereospecific pH-dependent degradation kinetics of R- and S-naproxen-beta-l-O-acyl-glucuronide.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Stability; Female; Glucuronides; Hydrogen-Ion Concentration; In Vitro Techniques; Ketoprofen; Kinetics; Microsomes, Liver; Naproxen; Stereoisomerism; Swine | 2002 |
Kinetics and hydrolysis mechanism of polymeric prodrugs containing ibuprofen, ketoprofen, and naproxen as pendent agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Stability; Edema; Female; Hydrogen-Ion Concentration; Hydrolysis; Ibuprofen; Ketoprofen; Kinetics; Methacrylates; Naproxen; Polymers; Prodrugs; Rats; Rats, Wistar; Solubility; Treatment Outcome | 2002 |
Oligoethylene ester derivatives of ketoprofen, naproxen and diclofenac as oral prodrugs: a pharmacological evaluation.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Edema; Esters; Hydrolysis; Ketoprofen; Male; Mice; Naproxen; Pain Measurement; Pharmaceutical Vehicles; Polyethylene Glycols; Prodrugs; Rats; Rats, Sprague-Dawley; Stomach Ulcer | 2002 |
Complexation trends and binding constants between dextrin oligomers and small molecules as measured through affinity capillary electrophoresis.
Topics: Analgesics; Carbohydrate Sequence; Dextrins; Electrophoresis, Capillary; Fluorescent Dyes; Glucans; Ibuprofen; Ketoprofen; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Naproxen; Oligosaccharides; Protein Binding; Pyrenes; Staining and Labeling | 2003 |
Application of capillary electrophoresis with different sample stacking strategies for the determination of a group of nonsteroidal anti-inflammatory drugs in the low microg x L(-1) concentration range.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Electrophoresis, Capillary; Fenoprofen; Ibuprofen; Ketoprofen; Naproxen; Water | 2004 |
Carboxyl nonsteroidal anti-inflammatory drugs are efficiently glucuronidated by microsomes of the human gastrointestinal tract.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Etodolac; Gastrointestinal Tract; Gene Expression Regulation, Enzymologic; Glucuronides; Glucuronosyltransferase; Humans; Ketoprofen; Microsomes; Naproxen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2004 |
Tracking acidic pharmaceuticals, caffeine, and triclosan through the wastewater treatment process.
Topics: Caffeine; Diclofenac; Ibuprofen; Ketoprofen; Meclofenamic Acid; Models, Chemical; Naproxen; Pharmaceutical Preparations; Triclosan; Waste Disposal, Fluid; Water Pollutants, Chemical | 2005 |
Effects of non-steroidal anti-inflammatory drugs on the pharmacokinetics and elimination of aciclovir in rats.
Topics: Acyclovir; Animals; Anti-HIV Agents; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Drug Synergism; Half-Life; Injections, Intravenous; Ketoprofen; Male; Metabolic Clearance Rate; Naproxen; Organic Anion Transport Protein 1; Rats; Rats, Sprague-Dawley | 2005 |
Simultaneous determination of naproxen, ketoprofen and phenol red in samples from rat intestinal permeability studies: HPLC method development and validation.
Topics: Acetonitriles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calibration; Chemistry, Pharmaceutical; Chromatography; Chromatography, High Pressure Liquid; Drug Industry; Ethylamines; Hydrogen-Ion Concentration; Indicators and Reagents; Intestines; Ketoprofen; Naproxen; Perfusion; Permeability; Phenolsulfonphthalein; Phosphoric Acids; Rats; Reproducibility of Results; Time Factors; Ultraviolet Rays | 2005 |
Occurrence of acidic pharmaceuticals in raw and treated sewages and in receiving waters.
Topics: Bezafibrate; Diclofenac; Environmental Pollutants; Hydrogen-Ion Concentration; Ibuprofen; Ketoprofen; Molecular Structure; Naproxen; Sewage; Water | 2005 |
Pathways and metabolites of microbial degradation of selected acidic pharmaceutical and their occurrence in municipal wastewater treated by a membrane bioreactor.
Topics: Aerobiosis; Amides; Bezafibrate; Biodegradation, Environmental; Bioreactors; Cities; Diclofenac; Ibuprofen; Ketoprofen; Naproxen; Pharmaceutical Preparations; Sewage; Spectrometry, Mass, Electrospray Ionization; Time Factors; Waste Disposal, Fluid; Water Pollutants, Chemical | 2005 |
Role of monocarboxylic acid transporters in the cellular uptake of NSAIDs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzoic Acid; Caco-2 Cells; Carbon Radioisotopes; Diclofenac; Diflunisal; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Ketoprofen; Lactic Acid; Monocarboxylic Acid Transporters; Naproxen; Permeability | 2005 |
Photodegradation of common environmental pharmaceuticals and estrogens in river water.
Topics: Chromatography, High Pressure Liquid; Environmental Monitoring; Estrogens; Gemfibrozil; Half-Life; Ibuprofen; Ketoprofen; Naproxen; Oxygen; Pharmaceutical Preparations; Photolysis; Propranolol; Rivers; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Water Pollutants, Chemical | 2005 |
Preparation of nanosized drug particles by the coating of inorganic cores: naproxen and ketoprofen on alumina.
Topics: Aluminum Oxide; Ketoprofen; Nanoparticles; Naproxen | 2002 |
Altered pharmacokinetics of zalcitabine by concurrent use of NSAIDs in rats.
Topics: Animals; Anti-HIV Agents; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Drug Interactions; Ketoprofen; Male; Naproxen; Rats; Rats, Sprague-Dawley; Zalcitabine | 2006 |
Comparative assessment of two indices of drug induced permeability changes in the perfused rat intestine.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Glycine; Ibuprofen; In Vitro Techniques; Intestinal Mucosa; Intestines; Ketoprofen; Naproxen; Permeability; Phenylalanine; Polyethylene Glycols; Rats | 2006 |
Chondroitin sulfate-based anti-inflammatory macromolecular prodrugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Carrageenan; Chemical Phenomena; Chemistry, Physical; Chondroitin ABC Lyase; Chondroitin Sulfates; Edema; Excipients; Hydrolysis; Ibuprofen; Ketoprofen; Magnetic Resonance Spectroscopy; Male; Naproxen; Polyethylene Glycols; Prodrugs; Rats; Rats, Wistar; Solubility; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared | 2006 |
Nonaqueous capillary electrophoretic behavior of 2-aryl propionic acids in the presence of an achiral ionic liquid. A chemometric approach.
Topics: Carbazoles; Electrolytes; Electrophoresis, Capillary; Ionic Liquids; Ketoprofen; Models, Chemical; Molecular Structure; Multivariate Analysis; Naproxen; Phenylpropionates; Propionates; Stereoisomerism; Suprofen | 2007 |
Electrokinetic migration of acidic drugs across a supported liquid membrane.
Topics: Acids; Chromatography, Micellar Electrokinetic Capillary; Electrophoresis, Capillary; Flurbiprofen; Gemfibrozil; Heptanol; Hydrogen-Ion Concentration; Ketoprofen; Membranes, Artificial; Naproxen; Pharmaceutical Preparations; Probenecid; Reproducibility of Results; Warfarin | 2007 |
Micellar solubilization of selected non-steroidal therapeutic agents by new surface-active agents of the class of the products of oxyethylation of ursodeoxycholic acid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Ibuprofen; Ketoprofen; Micelles; Naproxen; Pharmaceutical Preparations; Solubility; Solutions; Surface-Active Agents; Ursodeoxycholic Acid; Viscosity | 2006 |
Equilibrium solubilization of lipophilic therapeutic agents by aqueous solutions of products of catalytic oxyethylation of Croda-type lanolin as model excipients of the class of non-ionic surface active agents.
Topics: Administration, Cutaneous; Algorithms; Catalysis; Chemistry, Pharmaceutical; Ethylenes; Excipients; Ibuprofen; Ketoprofen; Lanolin; Models, Chemical; Naproxen; Pharmaceutical Vehicles; Solubility; Solutions; Structure-Activity Relationship; Surface-Active Agents; Thermodynamics; Viscosity; Water | 2007 |
Design and characterization of a new miniaturized rotating disk equipment for in vitro dissolution rate studies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Equipment Design; Hydrogen-Ion Concentration; In Vitro Techniques; Ketoprofen; Kinetics; Miniaturization; Naproxen; Solubility | 2008 |
Design, synthesis and in vitro evaluation of vinyl ether type polymeric prodrugs of ibuprofen, ketoprofen and naproxen.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Delayed-Action Preparations; Hydrogen-Ion Concentration; Hydrolysis; Ibuprofen; Ketoprofen; Magnetic Resonance Spectroscopy; Naproxen; Polymers; Prodrugs; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Vinyl Compounds | 2008 |
Lipid nanoparticles for prolonged topical delivery: an in vitro and in vivo investigation.
Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Drug Delivery Systems; Female; Gels; Humans; In Vitro Techniques; Ketoprofen; Lipids; Male; Nanoparticles; Naproxen; Particle Size; Skin; Skin Absorption; Ultrasonics | 2008 |
Identification of the carboxylic acid functionality by using electrospray ionization and ion-molecule reactions in a modified linear quadrupole ion trap mass spectrometer.
Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Borates; Carboxylic Acids; Cations, Monovalent; Ibuprofen; Ketoprofen; Methanol; Naproxen; Sodium; Spectrometry, Mass, Electrospray Ionization | 2008 |
Solubilizing and lithogenolitic properties of water solutions of non-ionic surfactants of cholesterol oxyethylenation products.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Catalysis; Cholesterol; Ethylene Oxide; Ibuprofen; Ions; Ketoprofen; Lithiasis; Micelles; Models, Theoretical; Naproxen; Solubility; Solutions; Surface-Active Agents; Water | 2007 |
Identification and quantification of ibuprofen, naproxen, ketoprofen and diclofenac present in waste-waters, as their trimethylsilyl derivatives, by gas chromatography mass spectrometry.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Gas Chromatography-Mass Spectrometry; Hungary; Ibuprofen; Ketoprofen; Naproxen; Trimethylsilyl Compounds; Waste Disposal, Fluid; Water Pollutants, Chemical | 2008 |
Ionic liquid-based dynamic liquid-phase microextraction: application to the determination of anti-inflammatory drugs in urine samples.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Fractionation; Flurbiprofen; Humans; Hydrogen-Ion Concentration; Indomethacin; Ionic Liquids; Ketoprofen; Molecular Structure; Naproxen; Phenylbutyrates; Reproducibility of Results; Tolmetin | 2008 |
Removal of selected pharmaceuticals by chlorination, coagulation-sedimentation and powdered activated carbon treatment.
Topics: Antipyrine; Charcoal; Clofibric Acid; Diclofenac; Fenoprofen; Gemfibrozil; Halogenation; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Water Pollutants, Chemical; Water Purification; Water Supply | 2008 |
Effect of chirality on PVP/drug interaction within binary physical mixtures of ibuprofen, ketoprofen, and naproxen: a DSC study.
Topics: Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Hot Temperature; Ibuprofen; Ketoprofen; Molecular Structure; Naproxen; Povidone; Stereoisomerism | 2009 |
Enantiomeric separation of acidic compounds by nano-liquid chromatography with methylated-beta-cyclodextrin as a mobile phase additive.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzoxazoles; beta-Cyclodextrins; Carbazoles; Chromatography, Liquid; Flurbiprofen; Hydrogen-Ion Concentration; Indoprofen; Ketoprofen; Methylation; Molecular Structure; Nanotechnology; Naproxen; Propionates; Stereoisomerism; Suprofen; Time Factors | 2009 |
Determination of widely used non-steroidal anti-inflammatory drugs in water samples by in situ derivatization, continuous hollow fiber liquid-phase microextraction and gas chromatography-flame ionization detector.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Gas; Drug Residues; Flame Ionization; Ibuprofen; Ketoprofen; Naproxen; Reproducibility of Results; Water Pollutants, Chemical | 2009 |
Long open tubular molecule imprinted polymer capillary columns with excellent separation efficiencies in chiral and non-chiral separation by capillary electrochromatography.
Topics: Acetone; Capillary Electrochromatography; Ketoprofen; Molecular Imprinting; Naproxen; Phenylpropionates; Polymers; Porosity; Stereoisomerism | 2009 |
Differences in the interaction between aryl propionic acid derivatives and poly(vinylpyrrolidone) K30: A multi-methodological approach.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Carbon Isotopes; Crystallization; Drug Stability; Flurbiprofen; Hot Temperature; Humidity; Hydrogen Bonding; Ibuprofen; Ketoprofen; Magnetic Resonance Spectroscopy; Molecular Structure; Molecular Weight; Naproxen; Phase Transition; Phenylbutyrates; Polymers; Povidone; Static Electricity; X-Ray Diffraction | 2009 |
On the use of carbon blacks as potential low-cost adsorbents for the removal of non-steroidal anti-inflammatory drugs from river water.
Topics: Adsorption; Anti-Inflammatory Agents, Non-Steroidal; Costs and Cost Analysis; Ketoprofen; Naproxen; Osmolar Concentration; Rivers; Soot; Temperature; Water Pollutants, Chemical; Water Purification | 2010 |
Second interlaboratory exercise on non-steroidal anti-inflammatory drug analysis in environmental aqueous samples.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemistry Techniques, Analytical; Diclofenac; Environmental Monitoring; Filtration; Gas Chromatography-Mass Spectrometry; Ibuprofen; Ketoprofen; Naproxen; Reproducibility of Results; Water Pollutants, Chemical; Water Purification | 2010 |
The role of the acquisition methods in the analysis of the non-steroidal anti-inflammatory drugs in Danube River by gas chromatography-mass spectrometry.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Gas Chromatography-Mass Spectrometry; Ibuprofen; Ketoprofen; Limit of Detection; Naproxen; Rivers; Water Pollutants, Chemical | 2010 |
Structural evaluation of crystalline ternary γ-cyclodextrin complex.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Chemical Precipitation; Excipients; Flurbiprofen; gamma-Cyclodextrins; Ketoprofen; Magnetic Resonance Spectroscopy; Molecular Conformation; Naproxen; Pharmaceutic Aids; Powder Diffraction; Salicylic Acid; Spectroscopy, Fourier Transform Infrared; Water | 2011 |
Electrokinetic supercharging focusing in capillary zone electrophoresis of weakly ionizable analytes in environmental and biological samples.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Electrophoresis, Capillary; Fenoprofen; Humans; Hydrogen-Ion Concentration; Isoelectric Focusing; Ketoprofen; Methanol; Naproxen; Piroxicam; Reproducibility of Results; Rivers; Sensitivity and Specificity; Sodium Chloride; Time Factors; Water Pollutants, Chemical | 2010 |
Phase behavior of ketoprofen-poly(lactic acid) drug particles formed by rapid expansion of supercritical solutions.
Topics: Indomethacin; Ketoprofen; Kinetics; Lactic Acid; Microscopy, Electron, Scanning; Naproxen; Polyesters; Polymers; Solutions; Spectrophotometry, Infrared | 2010 |
Determination of non-steroidal anti-inflammatory drugs in sewage sludge by direct hollow fiber supported liquid membrane extraction and liquid chromatography-mass spectrometry.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Fractionation; Chromatography, Liquid; Diclofenac; Ibuprofen; Ketoprofen; Mass Spectrometry; Naproxen; Reproducibility of Results; Sewage | 2010 |
Effects of selected pharmaceutically active compounds on treatment performance in sequencing batch reactors mimicking wastewater treatment plants operations.
Topics: Bacteria; Biodiversity; Bioreactors; Carbamazepine; Drug-Related Side Effects and Adverse Reactions; Gemfibrozil; Ketoprofen; Microbial Consortia; Naproxen; Pharmaceutical Preparations; Waste Disposal, Fluid; Water Microbiology; Water Pollutants, Chemical | 2011 |
An LC-MS/MS procedure for the quantification of naproxen in human plasma: development, validation, comparison with other methods, and application to a pharmacokinetic study.
Topics: Chromatography, Liquid; Drug Stability; Humans; Ketoprofen; Linear Models; Naproxen; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2011 |
Enantioselective analysis of ibuprofen, ketoprofen and naproxen in wastewater and environmental water samples.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Gas Chromatography-Mass Spectrometry; Ibuprofen; Ketoprofen; Linear Models; Naproxen; Reproducibility of Results; Sewage; Solid Phase Extraction; Stereoisomerism; Tandem Mass Spectrometry; Waste Disposal, Fluid; Water Pollutants, Chemical | 2011 |
Coatings of one monomer molecularly imprinted polymers for open tubular capillary electrochromatography.
Topics: Amlodipine; Capillary Electrochromatography; Hydrogen-Ion Concentration; Ketoprofen; Microscopy, Electron, Scanning; Molecular Imprinting; Naproxen; Polymers; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism | 2011 |
Enantiospecific fate of ibuprofen, ketoprofen and naproxen in a laboratory-scale membrane bioreactor.
Topics: Bioreactors; Ibuprofen; Ketoprofen; Laboratories; Membranes, Artificial; Naproxen; Reference Standards; Stereoisomerism; Tandem Mass Spectrometry; Waste Disposal, Fluid | 2011 |
Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; ATP-Binding Cassette Transporters; Biological Transport, Active; Cytochrome P-450 Enzyme System; Diclofenac; Electron Transport; Genes, MDR; Ibuprofen; Indomethacin; Ketoprofen; Ketorolac; Mitochondria; Naproxen; Reactive Oxygen Species; Sulindac; Tolmetin; Yeasts | 2012 |
Biofilm controlled sorption of selected acidic drugs on river sediments characterized by different organic carbon content.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biofilms; Carbon; Diclofenac; Gas Chromatography-Mass Spectrometry; Geologic Sediments; Hydrogen-Ion Concentration; Ibuprofen; Ketoprofen; Naproxen; Rivers; Water Pollutants, Chemical | 2012 |
Correlations between electrochemical behaviors and DNA photooxidative properties of non-steroïdal anti-inflammatory drugs and their photoproducts.
Topics: Anti-Inflammatory Agents, Non-Steroidal; DNA; Ketoprofen; Naproxen; Photolysis; Photosensitizing Agents; Propionates | 2012 |
Determination of non-steroidal anti-inflammatory drugs in urine by the combination of stir membrane liquid-liquid-liquid microextraction and liquid chromatography.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Flurbiprofen; Humans; Indomethacin; Ketoprofen; Limit of Detection; Liquid Phase Microextraction; Naproxen | 2012 |
Acidic pharmaceuticals in domestic wastewater and receiving water from hyper-urbanization city of China (Shanghai): environmental release and ecological risk.
Topics: China; Cities; Diclofenac; Environmental Monitoring; Hydrogen-Ion Concentration; Ibuprofen; Ketoprofen; Naproxen; Pharmaceutical Preparations; Risk Assessment; Urbanization; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Water Pollution, Chemical | 2013 |
The role of microbial adaptation and biodegradable dissolved organic carbon on the attenuation of trace organic chemicals during groundwater recharge.
Topics: 2-Methyl-4-chlorophenoxyacetic Acid; 2,4-Dichlorophenoxyacetic Acid; Adaptation, Physiological; Biodegradation, Environmental; Carbon; Clofibric Acid; Gemfibrozil; Groundwater; Ibuprofen; Ketoprofen; Naproxen; Organic Chemicals; Soil Microbiology; Water Microbiology; Water Pollutants, Chemical; Water Purification | 2012 |
Multi-phase partitioning, ecological risk and fate of acidic pharmaceuticals in a wastewater receiving river: the role of colloids.
Topics: Aquatic Organisms; Clofibric Acid; Colloids; Diclofenac; Ecotoxicology; Geologic Sediments; Ibuprofen; Ketoprofen; Models, Theoretical; Naproxen; Pharmaceutical Preparations; Risk Assessment; Rivers; Wastewater; Water Pollutants, Chemical | 2013 |
[Occurrence and risk assessment of five selected PPCPs in municipal wastewater treatment plant and the receiving water].
Topics: China; Cities; Clofibric Acid; Diclofenac; Environmental Monitoring; Ibuprofen; Ketoprofen; Naproxen; Pharmaceutical Preparations; Risk Assessment; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical | 2013 |
Sensing chiral drugs by using CdSe/ZnS nanoparticles capped with N-acetyl-L-cysteine methyl ester.
Topics: Acetylcysteine; Cadmium Compounds; Circular Dichroism; Esters; Flurbiprofen; Ibuprofen; Ketoprofen; Naproxen; Pharmaceutical Preparations; Quantum Dots; Selenium Compounds; Spectrometry, Fluorescence; Stereoisomerism; Sulfides; Zinc Compounds | 2013 |
Non-steroidal anti-inflammatory drugs in Indian rivers.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Environmental Monitoring; Gas Chromatography-Mass Spectrometry; Humans; Ibuprofen; India; Ketoprofen; Naproxen; Rivers; Sewage; Solid Phase Extraction; Water Pollutants, Chemical | 2014 |
In vivo administration of ritonavir worsens intestinal damage caused by cyclooxygease inhibitors.
Topics: Alprostadil; Animals; Apoptosis; Aspirin; Chemokine CCL2; Cyclooxygenase Inhibitors; Dinoprostone; Drug Synergism; HIV Protease Inhibitors; HT29 Cells; Humans; Integrin alpha1beta1; Intestinal Mucosa; Intestine, Small; Ketoprofen; Mice; Mice, Inbred C57BL; Misoprostol; Naproxen; Nitric Oxide Synthase Type II; Ritonavir; RNA, Messenger; Tumor Necrosis Factor-alpha | 2014 |
High-performance liquid chromatographic enantioseparation of racemic drugs based on homochiral metal-organic framework.
Topics: Benzoin; Benzyl Alcohols; Chromatography, High Pressure Liquid; Coordination Complexes; Ethylenediamines; Ibuprofen; Ketoprofen; Naproxen; Porosity; Pyridines; Stereoisomerism; Zinc | 2014 |
Biorelevant dissolution of poorly soluble weak acids studied by UV imaging reveals ranges of fractal-like kinetics.
Topics: Celecoxib; Chemistry, Pharmaceutical; Hydrogen-Ion Concentration; Ketoprofen; Kinetics; Microscopy, Electron, Scanning; Naproxen; Powder Diffraction; Pyrazoles; Solubility; Spectrum Analysis, Raman; Sulfathiazole; Sulfathiazoles; Sulfonamides; X-Ray Diffraction | 2014 |
[Simultaneous determination of nine pharmaceuticals personal care products in waters by solid phase extraction-gas chromatography-mass spectrometry].
Topics: Acetaminophen; Agricultural Irrigation; Benzhydryl Compounds; Clofibric Acid; Diclofenac; Gas Chromatography-Mass Spectrometry; Ibuprofen; Ketoprofen; Naproxen; Phenols; Salicylic Acid; Solid Phase Extraction; Triclosan; Water; Water Pollutants, Chemical | 2014 |
Fast ibuprofen, ketoprofen and naproxen simultaneous determination in human serum for clinical toxicology by GC-FID.
Topics: Chromatography, Gas; Humans; Ibuprofen; Ketoprofen; Naproxen | 2014 |
A dispersive liquid-liquid micellar microextraction for the determination of pharmaceutical compounds in wastewaters using ultra-high-performace liquid chromatography with DAD detection.
Topics: Caffeine; Carbamazepine; Chloroform; Chromatography, High Pressure Liquid; Ketoprofen; Liquid Phase Microextraction; Micelles; Naproxen; Ornidazole; Osmolar Concentration; Pharmaceutical Preparations; Polidocanol; Polyethylene Glycols; Solvents; Spain; Temperature; Wastewater; Water Pollutants, Chemical | 2015 |
Determination of thermodynamic values of acidic dissociation constants and complexation constants of profens and their utilization for optimization of separation conditions by Simul 5 Complex.
Topics: Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextrins; Computer Simulation; Electrophoresis, Capillary; Flurbiprofen; Hydrogen-Ion Concentration; Ibuprofen; Ketoprofen; Magnetic Resonance Spectroscopy; Naproxen; Osmolar Concentration; Software; Thermodynamics; Viscosity | 2014 |
Occurrence of selected pharmaceuticals in the principal sewage treatment plants in Rome (Italy) and in the receiving surface waters.
Topics: Carbamazepine; Chromatography, Liquid; Diclofenac; Environmental Monitoring; Estrone; Gemfibrozil; Humans; Ibuprofen; Ketoprofen; Naproxen; Pharmaceutical Preparations; Risk Assessment; Rivers; Rome; Seasons; Solid Phase Extraction; Tandem Mass Spectrometry; Waste Disposal, Fluid; Water Pollutants, Chemical | 2015 |
Ion-exchange selectivity of diclofenac, ibuprofen, ketoprofen, and naproxen in ureolyzed human urine.
Topics: Acetaminophen; Anion Exchange Resins; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Diclofenac; Humans; Hydrogen Bonding; Ibuprofen; Ion Exchange; Ketoprofen; Kinetics; Molecular Structure; Naproxen; Static Electricity; Urea; Waste Disposal, Fluid; Water Pollutants, Chemical | 2015 |
Effect of temperature on removal of trace organic chemicals in managed aquifer recharge systems.
Topics: Benzophenones; Diclofenac; Gemfibrozil; Groundwater; Ketoprofen; Naproxen; Soil Microbiology; Temperature; Trimethoprim; Water Pollutants, Chemical | 2015 |
Enantioselective determination of representative profens in wastewater by a single-step sample treatment and chiral liquid chromatography-tandem mass spectrometry.
Topics: Chromatography, Liquid; Ibuprofen; Ketoprofen; Limit of Detection; Naproxen; Stereoisomerism; Tandem Mass Spectrometry; Wastewater; Water Pollutants, Chemical | 2015 |
Sensing of enantiomeric excess in chiral carboxylic acids.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Carboxylic Acids; Crystallography, X-Ray; Fluorescence; Fluorescent Dyes; Ibuprofen; Ketoprofen; Models, Molecular; Molecular Structure; Naproxen; Stereoisomerism | 2015 |
Dendrimer-functionalized mesoporous silica as a reversed-phase/anion-exchange mixed-mode sorbent for solid phase extraction of acid drugs in human urine.
Topics: Adsorption; Chromatography, High Pressure Liquid; Dendrimers; Female; Humans; Ibuprofen; Ion Exchange; Ketoprofen; Naproxen; Pharmaceutical Preparations; Porosity; Silicon Dioxide; Solid Phase Extraction; Solvents; Spectroscopy, Fourier Transform Infrared | 2015 |
Single-drop microextraction combined in-line with capillary electrophoresis for the determination of nonsteroidal anti-inflammatory drugs in urine samples.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Electrophoresis, Capillary; Equipment Design; Humans; Ibuprofen; Ketoprofen; Limit of Detection; Liquid Phase Microextraction; Naproxen; Urinalysis | 2016 |
Graphene oxide-based dispersive solid-phase extraction combined with in situ derivatization and gas chromatography-mass spectrometry for the determination of acidic pharmaceuticals in water.
Topics: Diclofenac; Gas Chromatography-Mass Spectrometry; Graphite; Ibuprofen; Ketoprofen; Naproxen; Osmolar Concentration; Pharmaceutical Preparations; Solid Phase Extraction; Solvents; Water; Water Pollutants, Chemical | 2015 |
Hybrid Compounds Strategy in the Synthesis of Oleanolic Acid Skeleton-NSAID Derivatives.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Ibuprofen; Inflammation; Ketoprofen; Molecular Structure; Naproxen; Oleanolic Acid | 2016 |
Suitability of passive sampling for the monitoring of pharmaceuticals in Finnish surface waters.
Topics: Calibration; Carbamazepine; Chromatography, Liquid; Diclofenac; Environmental Monitoring; Finland; Ibuprofen; Ketoprofen; Lakes; Naproxen; Pharmaceutical Preparations; Rivers; Seasons; Tandem Mass Spectrometry; Wastewater; Water Pollutants, Chemical | 2016 |
Membrane protected C
Topics: Absorption, Physicochemical; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Filtration; Humic Substances; Hydrophobic and Hydrophilic Interactions; Ketoprofen; Lakes; Methanol; Naproxen; Polytetrafluoroethylene; Porosity; Sewage; Spectrophotometry, Ultraviolet; Water; Water Pollutants, Chemical | 2016 |
Non-steroidal anti-inflammatory drugs in the watercourses of Elbe basin in Czech Republic.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Czech Republic; Diclofenac; Environmental Monitoring; Gas Chromatography-Mass Spectrometry; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Rivers; Water Pollutants, Chemical | 2017 |
Sorption and desorption of selected non-steroidal anti-inflammatory drugs in an agricultural loam-textured soil.
Topics: Adsorption; Agriculture; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Ibuprofen; Ketoprofen; Naproxen; Soil; Soil Pollutants | 2017 |
Effect of guest drug character encapsulated in the cavity and intermolecular spaces of γ-cyclodextrins on the dissolution property of ternary γ-cyclodextrin complex.
Topics: Chemistry, Pharmaceutical; Drug Carriers; Flurbiprofen; gamma-Cyclodextrins; Ketoprofen; Naproxen; Salicylamides; Solubility | 2017 |
Development of a New Microextraction Fiber Combined to On-Line Sample Stacking Capillary Electrophoresis UV Detection for Acidic Drugs Determination in Real Water Samples.
Topics: Clofibric Acid; Electrophoresis, Capillary; Ketoprofen; Naproxen; Solid Phase Microextraction; Water Pollutants, Chemical | 2017 |
The nature of hydrogen-bonding interactions in nonsteroidal anti-inflammatory drugs revealed by polarized IR spectroscopy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Crystallography, X-Ray; Deuterium; Flurbiprofen; Hydrogen Bonding; Ketoprofen; Naproxen; Spectrophotometry, Infrared; Vibration | 2018 |
Levetiracetam+nonsteroidal anti-inflammatory drug binary systems: A contribution to the development of new solid dosage forms.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Drug Combinations; Drug Liberation; Flurbiprofen; Ibuprofen; Ketoprofen; Levetiracetam; Naproxen; Piracetam; Stereoisomerism | 2017 |
Preparation of a reversed-phase/anion-exchange mixed-mode spherical sorbent by Pickering emulsion polymerization for highly selective solid-phase extraction of acidic pharmaceuticals from wastewater.
Topics: Butylene Glycols; Emulsions; Environmental Monitoring; Ibuprofen; Ketoprofen; Limit of Detection; Naproxen; Pharmaceutical Preparations; Polymerization; Reproducibility of Results; Solid Phase Extraction; Wastewater; Water Pollutants, Chemical | 2017 |
Continuous transformation of chiral pharmaceuticals in enzymatic membrane bioreactors for advanced wastewater treatment.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bioreactors; Biotransformation; Ibuprofen; Ketoprofen; Membranes, Artificial; Naproxen; Wastewater; Water Pollutants, Chemical | 2017 |
Multifunctionalized mesoporous silica as an efficient reversed-phase/anion exchange mixed-mode sorbent for solid-phase extraction of four acidic nonsteroidal anti-inflammatory drugs in environmental water samples.
Topics: Adsorption; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Environmental Monitoring; Fresh Water; Ibuprofen; Ketoprofen; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Naproxen; Silanes; Silicon Dioxide; Solid Phase Extraction; Spectroscopy, Fourier Transform Infrared; Wastewater; Water Pollutants, Chemical | 2017 |
Correlation between glucuronidation and covalent adducts formation with proteins of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Flurbiprofen; Glucuronides; Ibuprofen; Ketoprofen; Male; Microsomes, Liver; Naproxen; Propionates; Protein Binding; Rats, Wistar | 2018 |
Use of Polymer Inclusion Membranes (PIMs) as support for electromembrane extraction of non-steroidal anti-inflammatory drugs and highly polar acidic drugs.
Topics: Amoxicillin; Anti-Inflammatory Agents, Non-Steroidal; Cellulose; Electrochemical Techniques; Hippurates; Ibuprofen; Ketoprofen; Membranes, Artificial; Naproxen; Niacin; ortho-Aminobenzoates; Quaternary Ammonium Compounds; Salicylic Acid | 2018 |
Population scale retrospective analysis reveals distinctive antidepressant and anxiolytic effects of diclofenac, ketoprofen and naproxen in patients with pain.
Topics: Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Anxiety; Cohort Studies; Depression; Diclofenac; Humans; Ketoprofen; Naproxen; Pain | 2018 |
A new laccase-mediator system facing the biodegradation challenge: Insight into the NSAIDs removal.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biodegradation, Environmental; Diclofenac; Hydroxylation; Ketoprofen; Laccase; Naproxen; Trametes | 2019 |
Mechanisms and quantification of adsorption of three anti-inflammatory pharmaceuticals onto goethite with/without surface-bound organic acids.
Topics: Acids; Adsorption; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Iron Compounds; Ketoprofen; Minerals; Naproxen; Osmolar Concentration | 2019 |
Chitosan tailor-made membranes as biopolymeric support for electromembrane extraction.
Topics: Amoxicillin; Biopolymers; Chitosan; Electrochemical Techniques; Hippurates; Humans; Ibuprofen; Ketoprofen; Naproxen; Niacin; ortho-Aminobenzoates; Salicylic Acid | 2019 |
Antiproliferative Activity of Pt(IV) Conjugates Containing the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Ketoprofen and Naproxen
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Ketoprofen; Molecular Structure; Naproxen; Organoplatinum Compounds; Prodrugs | 2019 |
Combustion fabrication of magnetic porous carbon as a novel magnetic solid-phase extraction adsorbent for the determination of non-steroidal anti-inflammatory drugs.
Topics: Adsorption; Anti-Inflammatory Agents, Non-Steroidal; Carbon; Diclofenac; Green Chemistry Technology; Ketoprofen; Limit of Detection; Magnetite Nanoparticles; Naproxen; Porosity; Rivers; Solid Phase Extraction; Water Pollutants, Chemical | 2019 |
Monitoring the release of anti-inflammatory and analgesic pharmaceuticals in the receiving environment.
Topics: Analgesics; Anti-Inflammatory Agents; Diclofenac; Environmental Monitoring; Hospitals; Humans; Ibuprofen; Ketoprofen; Naproxen; Pharmaceutical Preparations; Seasons; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical | 2019 |
Diet quality and NSAIDs promote changes in formation of prostaglandins by an aquatic invertebrate.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Diclofenac; Diet; Ibuprofen; Invertebrates; Ketoprofen; Lipid Metabolism; Naproxen; Prostaglandins | 2020 |
Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data.
Topics: Acetamides; Albuterol; Animals; Carbamates; Chromatography, Liquid; Diazepam; Diclofenac; Digitoxin; Humans; Itraconazole; Ketoprofen; Liver; Metabolic Clearance Rate; Mice; Mice, Transgenic; Naproxen; Pharmaceutical Preparations; Phenytoin; Piperidines; Pravastatin; Pyrimidines; Quinidine; Tandem Mass Spectrometry; Telmisartan; Terfenadine; Verapamil | 2020 |
Fixed Drug Eruption After Ingestion of Naproxen in a Patient Who Tolerated Ibuprofen and Dexketoprofen.
Topics: Administration, Oral; Adult; Allergens; Anti-Inflammatory Agents, Non-Steroidal; Drug Eruptions; Female; Humans; Ibuprofen; Immunization; Ketoprofen; Naproxen; Tromethamine | 2021 |
Core-shell MOF@COFs used as an adsorbent and matrix for the detection of nonsteroidal anti-inflammatory drugs by MALDI-TOF MS.
Topics: Adsorption; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drinking Water; Ketoprofen; Lakes; Limit of Detection; Metal-Organic Frameworks; Naproxen; Saliva; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Water Pollutants, Chemical | 2021 |
Facile and highly efficient three-phase single drop microextraction in-line coupled with capillary electrophoresis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Electrophoresis, Capillary; Humans; Ibuprofen; Ketoprofen; Naproxen | 2021 |
New look at the metabolism of nonsteroidal anti-inflammatory drugs: influence on human serum albumin antioxidant activity.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Binding Sites; Diclofenac; Humans; Ketoprofen; Naproxen; Serum Albumin; Serum Albumin, Human | 2023 |
Removal of Non-Steroidal Anti-Inflammatory Drugs from Drinking Water Sources by GO-SWCNT Buckypapers.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drinking Water; Environmental Pollutants; Ketoprofen; Naproxen | 2022 |
Synthesis of fluorescent artificial receptors with high specificity for simultaneous detection of non-steroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Coloring Agents; Fluorescein; Humans; Ketoprofen; Limit of Detection; Molecular Imprinting; Naproxen; Receptors, Artificial | 2023 |
Fully soluble polymeric foams for in-vial dried blood spot collection and analysis of acidic drugs by capillary electrophoresis.
Topics: Electrophoresis, Capillary; Ibuprofen; Ketoprofen; Naproxen; Solvents | 2023 |
Effect of biosolids amendment on the fate and mobility of non-steroidal anti-inflammatory drugs (NSAIDs) in a field-based lysimeter cell study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biosolids; Ibuprofen; Ketoprofen; Naproxen; Sand; Soil; Soil Pollutants | 2023 |
Propionic Acid Groups and Multiple Aromatic Rings Induce Binding of Ketoprofen and Naproxen to the Hydrophobic Core of Bovine Serum Albumin.
Topics: Binding Sites; Ketoprofen; Naproxen; Protein Binding; Serum Albumin, Bovine; Spectrometry, Fluorescence | 2023 |