Page last updated: 2024-09-04

naproxen and methotrexate

naproxen has been researched along with methotrexate in 63 studies

Compound Research Comparison

Studies (naproxen)	Trials (naproxen)	Recent Studies (post-2010) (naproxen)	Studies (methotrexate)	Trials (methotrexate)	Recent Studies (post-2010) (methotrexate)
4,551	1,057	1,429	41,593	5,666	11,969

Protein Interaction Comparison

Protein	Taxonomy	methotrexate (IC50)
Thymidylate synthase	Escherichia coli	1.8
nuclear receptor coactivator 3 isoform a	Homo sapiens (human)	0.211
Toll-like receptor 4	Homo sapiens (human)	1.04
Fatty-acid amide hydrolase 1	Mus musculus (house mouse)	0.08
Dihydrofolate reductase	Homo sapiens (human)	0.0522
Dihydrofolate reductase	Mus musculus (house mouse)	0.0331
Dihydrofolate reductase	Bos taurus (cattle)	0.0348
Dihydrofolate reductase	Gallus gallus (chicken)	0.0545
Dihydrofolate reductase	Enterococcus faecium	0.0014
Dihydrofolate reductase	Lacticaseibacillus casei	0.0138
Thymidylate synthase	Homo sapiens (human)	0.343
5-hydroxytryptamine receptor 2C	Rattus norvegicus (Norway rat)	0.0147
Thymidylate synthase	Escherichia coli K-12	0.0181
Dihydrofolate reductase	Escherichia coli K-12	0.1529
Bifunctional dihydrofolate reductase-thymidylate synthase	Plasmodium falciparum K1	0.084
Folate receptor beta	Homo sapiens (human)	0.1585
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	0.0011
Cytochrome P450 11B1, mitochondrial	Bos taurus (cattle)	0.0012
Folate receptor alpha	Homo sapiens (human)	0.2263
Dihydrofolate reductase	Pneumocystis carinii	0.0717
Histidine decarboxylase	Rattus norvegicus (Norway rat)	0.0014
Trifunctional purine biosynthetic protein adenosine-3	Homo sapiens (human)	0.01
Bifunctional purine biosynthesis protein ATIC	Homo sapiens (human)	0.01
Delta-type opioid receptor	Rattus norvegicus (Norway rat)	0.003
Mu-type opioid receptor	Rattus norvegicus (Norway rat)	0.003
Kappa-type opioid receptor	Rattus norvegicus (Norway rat)	0.003
Reduced folate transporter	Homo sapiens (human)	0.012
Dihydrofolate reductase	Mycobacterium tuberculosis H37Rv	0.0174
Folylpolyglutamate synthase, mitochondrial	Homo sapiens (human)	3.2
Bifunctional dihydrofolate reductase-thymidylate synthase	Toxoplasma gondii	0.0547
Bifunctional dihydrofolate reductase-thymidylate synthase	Trypanosoma cruzi	0.11
Dihydrofolate reductase	Bacillus anthracis	0.0136
Dihydrofolate reductase	Rattus norvegicus (Norway rat)	0.0047
Proton-coupled folate transporter	Homo sapiens (human)	0.1207

Research

Studies (63)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (11.11)	18.7374
1990's	7 (11.11)	18.2507
2000's	20 (31.75)	29.6817
2010's	26 (41.27)	24.3611
2020's	3 (4.76)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Topliss, JG; Yoshida, F	1
Faller, B; Wohnsland, F	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Caron, G; Ermondi, G; Lorenti, M	1
Jolivette, LJ; Ward, KW	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Alonso-Castro, AJ; Campos-Xolalpa, N; Hernández-Munive, A; Pérez-González, C; Pérez-Gutiérrez, S; Zapata-Morales, JR	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Moen, F	1
Kitchen, EA; Meacock, SC	1
Bradley, JD; Brater, DC; Hall, SD; Jones, DR; Krohn, K; Tracy, TS	1
Calin, A; Elswood, J	1
Arkin, CR; Evans, WE; Fleming, RA; Stewart, CF	1
Guleria, JS; Malaviya, AN; Pandey, JN; Singh, RR	1
Graham, RM; Macfarlane, AW; Ng, HW; Verbov, JL	1
Aarbakke, J; Jaeger, R; Sager, G; Slørdal, L	1
Lee, KT; Lee, WM; Reiner, JM	1
Bracht, A; Ishii-Iwamoto, EL; Nascimento, EA; Yamamoto, NS	1
Balsa, A; Gamallo, C; Gijón-Baños, J; Martín-Mola, E	1
Sherry, DD; Smith, AL; Wallace, CA	1
Andersen, A; Ekstrøm, PO; Giercksky, KE; Slørdal, L	1
Altan, L; Aydiner, S; Bingöl, U; Karakoç, Y; Yurtkuran, M	1
Beri, A; Gupta, A; Khullar, M; Singh, S	1
Chen, J; Liu, C	1
Lovell, DJ; Sullivan, K; Zaoutis, TE	1
Amer, F; Andhivarothai, N; Kukulka, MJ; Vakily, M	1
Kandefer-Szerszeń, M; Majdan, M; Parada-Turska, J; Rzeski, W; Turski, WA	1
Abukawa, D; Ichinohazama, R; Imaizumi, M; Nakano, K; Sato, A; Takeyama, J	1
Chen, J; Lin, J; Liu, C	1
Hashkes, PJ; Laxer, RM	1
Kozic, H; Mendoza, V; Vahid, B; Weibel, S	1
Gupta, R; Kabra, SK; Lodha, R; Verma, S	1
Bazso, A; Consolaro, A; Filocamo, G; Magni-Manzoni, S; Malattia, C; Martini, A; Pistorio, A; Ravelli, A; Ruperto, N; Viola, S	1
Berbegal, J; Femenia, M; Martínez, P; Moreno, D	1
Guo, L; He, D; Jiang, B; Li, Y; Ma, L; Ouyang, L	1
Eliasaf, S; Livneh, A; Naimushin, A	1
Fathalla, BM; Safi, KH	1
Chen, J; Lin, J; Liu, C; Veras, MM	1
Bachmann, F; Blume-Peytavi, U; Garcia Bartels, N; Minden, K; Philipp, S; Stieler, K	1
Disney, B; Perkins, P; Szeto, MC; Wood, G	1
Bouwer, LR; Hutting, KH; Keukens, FM	1
Banerjee, D; Das, A; Gayen, G; Mondal, R	1
Gittler, J; Kahn, P; Meehan, S; Oza, VS; Stringer, T	1
Bordy, R; Demougeot, C; Prati, C; Totoson, P; Verhoeven, F; Wendling, D	1
Dhir, V; Dhooria, A; Jha, S; Kumar, RR; Mittal, S; Rawat, A	1
Ji, H; Sun, Q; Tang, Z	1
Eshaghi, H; Safavi, M; Vasei, M	1
Caron, MMJ; Castermans, TMR; Haartmans, MJJ; van Rhijn, LW; van Rietbergen, B; Welting, TJM; Witlox, AMA	1
Ferraccioli, G; Gremese, E; Zanardi, R	1

Reviews

7 review(s) available for naproxen and methotrexate

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Methotrexate for ankylosing spondylitis. The Cochrane database of systematic reviews, 2004, Issue:3 Topics: Antirheumatic Agents; Humans; Methotrexate; Naproxen; Randomized Controlled Trials as Topic; Spondylitis, Ankylosing	2004
Methotrexate for ankylosing spondylitis. The Cochrane database of systematic reviews, 2006, Oct-18, Issue:4 Topics: Antirheumatic Agents; Humans; Methotrexate; Naproxen; Randomized Controlled Trials as Topic; Spondylitis, Ankylosing	2006
Update on the medical treatment of juvenile idiopathic arthritis. Current rheumatology reports, 2006, Volume: 8, Issue:6 Topics: Antibodies, Blocking; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Juvenile; Child; Child, Preschool; Humans; Immunologic Factors; Infliximab; Isoxazoles; Leflunomide; Meloxicam; Methotrexate; Naproxen; Rheumatology; Thiazines; Thiazoles	2006
[Visceral leishmaniasis infection in a rheumatoid arthritis patient treated with adalimumab: a case description and literature review]. Enfermedades infecciosas y microbiologia clinica, 2010, Volume: 28, Issue:4 Topics: Adalimumab; Aged; Animals; Animals, Domestic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Bone Marrow; Cats; Disease Reservoirs; Dog Diseases; Dogs; Drug Therapy, Combination; Duodenum; Female; Humans; Immunocompromised Host; Immunosuppressive Agents; Latent Tuberculosis; Leishmaniasis, Visceral; Methotrexate; Naproxen; Prednisone	2010
Methotrexate for ankylosing spondylitis. The Cochrane database of systematic reviews, 2013, Feb-28, Issue:2 Topics: Antirheumatic Agents; Humans; Methotrexate; Naproxen; Randomized Controlled Trials as Topic; Spondylitis, Ankylosing	2013
Ascites and other incidental findings revealing undiagnosed systemic rheumatoid arthritis. BMJ case reports, 2015, Jun-08, Volume: 2015 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Ascites; Humans; Incidental Findings; Liver Function Tests; Male; Methotrexate; Naproxen; Pericardial Effusion; Pleural Effusion; Prednisolone; Referral and Consultation; Rheumatoid Factor; Rheumatoid Nodule; Treatment Outcome	2015

Trials

3 trial(s) available for naproxen and methotrexate

Article	Year
Clinical investigation of methotrexate in the treatment of ankylosing spondylitis. Scandinavian journal of rheumatology, 2001, Volume: 30, Issue:5 Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Naproxen; Severity of Illness Index; Spondylitis, Ankylosing; Treatment Outcome	2001
Coadministration of lansoprazole and naproxen does not affect the pharmacokinetic profile of methotrexate in adult patients with rheumatoid arthritis. Journal of clinical pharmacology, 2005, Volume: 45, Issue:10 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Dizziness; Dose-Response Relationship, Drug; Female; Headache; Humans; Lansoprazole; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Naproxen; Nausea; Omeprazole; Vomiting	2005
Observation of the clinical effect of the combined therapy of zushima tablet and western medicine in the treatment of rheumatoid arthritis and MRI test results. Pakistan journal of pharmaceutical sciences, 2019, Volume: 32, Issue:3 Special Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drugs, Chinese Herbal; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Naproxen; Prednisolone; Sulfasalazine; Tablets; Treatment Outcome; Western World	2019

Other Studies

53 other study(ies) available for naproxen and methotrexate

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes. Journal of medicinal chemistry, 2001, Mar-15, Volume: 44, Issue:6 Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Contribution of ionization and lipophilicity to drug binding to albumin: a preliminary step toward biodistribution prediction. Journal of medicinal chemistry, 2004, Jul-29, Volume: 47, Issue:16 Topics: Chromatography, Affinity; Hydrogen-Ion Concentration; Ions; Models, Molecular; Molecular Conformation; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Serum Albumin, Bovine; Ultracentrifugation	2004
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7 Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Synthesis, antinociceptive and anti-inflammatory effects of porphyrins. Bioorganic & medicinal chemistry, 2015, May-15, Volume: 23, Issue:10 Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Disease Models, Animal; Edema; Erythrocytes; Hemolysis; Indomethacin; Male; Mice; Naproxen; Nociception; Pain; Pain Measurement; Porphyrins; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate	2015
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
[Psoriatic arthropathy]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1977, Oct-30, Volume: 97, Issue:30 Topics: Arthritis; Humans; Indomethacin; Methotrexate; Naproxen; Phenylbutazone; Psoriasis	1977
Some effects of non-steroidal anti-inflammatory drugs on leucocyte migration. Agents and actions, 1976, Volume: 6, Issue:1-3 Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Cell Movement; Edema; Fenoprofen; Ibuprofen; Indomethacin; Ketoprofen; Leukocytes; Male; Methotrexate; Naproxen; Phenylbutazone; Pleurisy; Rats	1976
The effects of a salicylate, ibuprofen, and naproxen on the disposition of methotrexate in patients with rheumatoid arthritis. European journal of clinical pharmacology, 1992, Volume: 42, Issue:2 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blood Proteins; Choline; Female; Humans; Ibuprofen; Kidney; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Naproxen; Protein Binding; Salicylates	1992
A prospective nationwide cross-sectional study of NSAID usage in 1331 patients with ankylosing spondylitis. The Journal of rheumatology, 1990, Volume: 17, Issue:6 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Cross-Sectional Studies; Diclofenac; Female; Gold; Humans; Ibuprofen; Male; Methotrexate; Middle Aged; Naproxen; Penicillamine; Piroxicam; Prednisolone; Prospective Studies; Spondylitis, Ankylosing; Sulfasalazine; United Kingdom	1990
Coadministration of naproxen and low-dose methotrexate in patients with rheumatoid arthritis. Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:4 Topics: Absorption; Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Blood Proteins; Drug Therapy, Combination; Humans; Injections, Intravenous; Kidney; Metabolic Clearance Rate; Methotrexate; Middle Aged; Naproxen; Protein Binding	1990
Fatal interaction between methotrexate and naproxen. Lancet (London, England), 1986, Jun-14, Volume: 1, Issue:8494 Topics: Arthritis, Rheumatoid; Drug Interactions; Drug Therapy, Combination; Female; Humans; Methotrexate; Naproxen	1986
Near fatal drug interactions with methotrexate given for psoriasis. British medical journal (Clinical research ed.), 1987, Sep-26, Volume: 295, Issue:6601 Topics: Aged; Aged, 80 and over; Drug Interactions; Female; Humans; Methotrexate; Naproxen; Necrosis; Pancytopenia; Psoriasis; Skin; Skin Ulcer; Trimethoprim	1987
Interactions with the protein binding of 7-hydroxy-methotrexate in human serum in vitro. Biochemical pharmacology, 1988, Feb-15, Volume: 37, Issue:4 Topics: Adult; Humans; Indomethacin; Male; Methotrexate; Naproxen; Protein Binding; Serum Albumin	1988
Effects of naproxen and methotrexate on the extent of aortic lesions and cholesterol concentrations in cholesterol-fed rabbits. Experimental and molecular pathology, 1980, Volume: 33, Issue:3 Topics: Animals; Aorta; Arteriosclerosis; Body Weight; Cell Division; Cholesterol; Diet, Atherogenic; Male; Methotrexate; Naproxen; Rabbits	1980
Naproxen inhibits hepatic glycogenolysis induced by Ca(2+)-dependent agents. General pharmacology, 1995, Volume: 26, Issue:1 Topics: Animals; Calcium; Glucagon; Liver; Liver Glycogen; Male; Methotrexate; Naproxen; Phenylephrine; Rats; Rats, Wistar	1995
Histologic changes in rheumatoid synovitis induced by naproxen and methotrexate. The Journal of rheumatology, 1993, Volume: 20, Issue:9 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Arthritis, Rheumatoid; Female; HLA-DR Antigens; Humans; Male; Methotrexate; Middle Aged; Naproxen; Synovitis	1993
Pilot investigation of naproxen/methotrexate interaction in patients with juvenile rheumatoid arthritis. The Journal of rheumatology, 1993, Volume: 20, Issue:10 Topics: Adolescent; Adult; Arthritis, Juvenile; Biological Availability; Child; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Naproxen; Pilot Projects	1993
Alterations in methotrexate pharmacokinetics by naproxen in the rat as measured by microdialysis. Life sciences, 1997, Volume: 60, Issue:24 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Folic Acid Antagonists; Hydroxylation; Kidney; Liver; Male; Methotrexate; Microdialysis; Naproxen; Rats; Rats, Wistar	1997
Comparison of serum nitric oxide levels in active juvenile rheumatoid arthritis with those of patients in remission. Rheumatology international, 2004, Volume: 24, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Alkylating; Arthritis, Juvenile; Biomarkers; Blood Sedimentation; Child; Chlorambucil; Citrulline; Female; Health Status; Humans; Male; Methotrexate; Naproxen; Nitric Oxide; Predictive Value of Tests; Reactive Nitrogen Species; Reference Values; Remission Induction; Steroids; Surveys and Questionnaires; Up-Regulation	2004
Immunosuppressants, infection, and inflammation. Clinical immunology (Orlando, Fla.), 2004, Volume: 113, Issue:2 Topics: Arthralgia; Arthritis, Juvenile; Child, Preschool; Fever; Humans; Immunosuppressive Agents; Infections; Inflammation; Male; Methotrexate; Naproxen	2004
Effect of glutamate receptor antagonists and antirheumatic drugs on proliferation of synoviocytes in vitro. European journal of pharmacology, 2006, Mar-27, Volume: 535, Issue:1-3 Topics: Animals; Antirheumatic Agents; Benzodiazepines; Benzodiazepinones; Celecoxib; Cell Line; Cell Proliferation; Cell Survival; Diclofenac; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Inhibitory Concentration 50; Methotrexate; Naproxen; Pyrazoles; Quinoxalines; Sulfasalazine; Sulfonamides; Synovial Membrane	2006
Epstein-Barr virus associated Hodgkin lymphoma in a 9-year-old girl receiving long-term methotrexate therapy for juvenile idiopathic arthritis. Journal of pediatric hematology/oncology, 2006, Volume: 28, Issue:9 Topics: Arthritis, Juvenile; Child; Drug Therapy, Combination; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Hodgkin Disease; Humans; Immunosuppressive Agents; Methotrexate; Naproxen; Prednisone; Time Factors; Tumor Virus Infections	2006
Clinical and pathologic manifestations of necrobiosis lipoidica-like skin involvement in sarcoidosis. Joint bone spine, 2007, Volume: 74, Issue:6 Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Methotrexate; Middle Aged; Minocycline; Naproxen; Necrobiosis Lipoidica; Prednisone; Sarcoidosis; Treatment Outcome	2007
Feasibility and efficacy of intraarticular steroids (IAS) in juvenile idiopathic arthritis (JIA). Indian pediatrics, 2009, Volume: 46, Issue:3 Topics: Administration, Oral; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Juvenile; Child; Child, Preschool; Feasibility Studies; Female; Glucocorticoids; Humans; Hypnotics and Sedatives; Injections, Intra-Articular; Ketamine; Male; Methotrexate; Midazolam; Naproxen; Triamcinolone Acetonide	2009
Development and validation of a composite disease activity score for juvenile idiopathic arthritis. Arthritis and rheumatism, 2009, May-15, Volume: 61, Issue:5 Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Juvenile; Blood Sedimentation; Child; Child, Preschool; Cross-Sectional Studies; Disability Evaluation; Humans; Joints; Meloxicam; Methotrexate; Naproxen; Outcome Assessment, Health Care; Prognosis; Severity of Illness Index; Thiazines; Thiazoles; Treatment Outcome	2009
Synthesis of novel dendrimers having aspartate grafts and their ability to enhance the aqueous solubility of model drugs. European journal of medicinal chemistry, 2010, Volume: 45, Issue:6 Topics: Aspartic Acid; Dendrimers; Drug Carriers; Histidine; Hydrogen-Ion Concentration; Methotrexate; Naproxen; Peptides; Pharmaceutical Preparations; Solubility; Surface Properties; Temperature; Water	2010
[Clostridium difficile-associated diarrhea: causes and relationship to reactive arthritis]. Harefuah, 2011, Volume: 150, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Clostridioides difficile; Enterocolitis, Pseudomembranous; Female; Humans; Methotrexate; Middle Aged; Naproxen; Risk Factors	2011
Inflammatory and noninflammatory arthropathy in patients with 18q deletion syndrome. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2012, Volume: 18, Issue:1 Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis; Child; Chromosome Deletion; Chromosome Disorders; Chromosomes, Human, Pair 18; Drug Therapy, Combination; Female; Humans; Magnetic Resonance Imaging; Methotrexate; Naproxen; Prednisone; Synovitis	2012
Skin manifestations associated with chronic recurrent multifocal osteomyelitis in a 9-year-old girl. Journal of the American Academy of Dermatology, 2014, Volume: 71, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthralgia; Child; Female; Humans; Magnetic Resonance Imaging; Methotrexate; Muscular Atrophy; Naproxen; Osteomyelitis; Paronychia; Psoriasis	2014
[A man with a painful index finger]. Nederlands tijdschrift voor geneeskunde, 2016, Volume: 160 Topics: Acrodermatitis; Anti-Inflammatory Agents, Non-Steroidal; Diagnosis, Differential; Fingers; Humans; Male; Methotrexate; Middle Aged; Nails; Naproxen	2016
Familial Juvenile Idiopathic Arthritis. Indian journal of pediatrics, 2017, Volume: 84, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Child; Child, Preschool; Female; Humans; Male; Methotrexate; Naproxen; Siblings	2017
Neutrophilic urticarial dermatosis as a presenting feature of systemic juvenile idiopathic arthritis. Pediatric dermatology, 2018, Volume: 35, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Child, Preschool; Colchicine; Glucocorticoids; Humans; Immunosuppressive Agents; Male; Methotrexate; Naproxen; Prednisolone; Skin; Sweet Syndrome; Tubulin Modulators	2018
Structural efficacy of NSAIDs, COX-2 inhibitor and glucocorticoid compared with TNFα blocker: a study in adjuvant-induced arthritis rats. Rheumatology (Oxford, England), 2019, 06-01, Volume: 58, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Experimental; Celecoxib; Cyclooxygenase 2 Inhibitors; Etanercept; Glucocorticoids; Hindlimb; Methotrexate; Naproxen; Prednisone; Rats; Treatment Outcome; Tumor Necrosis Factor-alpha	2019
An unusual cause of deforming erosive arthritis in an adult. Rheumatology (Oxford, England), 2020, Mar-01, Volume: 59, Issue:3 Topics: Adrenal Cortex Hormones; Adult; Antirheumatic Agents; Arthritis; DNA Mutational Analysis; Humans; Male; Methotrexate; Mutation; Naproxen; Nod2 Signaling Adaptor Protein; Sarcoidosis; Synovitis; Uveitis; Wrist Joint	2020
Chronic non-bacterial osteomyelitis of clavicle. Postgraduate medical journal, 2019, Volume: 95, Issue:1130 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Biopsy; Child; Chronic Disease; Clavicle; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; Methotrexate; Naproxen; Osteomyelitis; Radiography, Thoracic; Sarcoma, Ewing; Treatment Outcome	2019
Evaluation of impaired growth plate development of long bones in skeletally immature mice by antirheumatic agents. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2021, Volume: 39, Issue:3 Topics: Animals; Antirheumatic Agents; Arthritis, Juvenile; Cell Differentiation; Cell Line; Chondrogenesis; Cyclooxygenase Inhibitors; Female; Growth Plate; Methotrexate; Mice, Inbred C57BL; Naproxen; Osteogenesis	2021
Case report: crowned dens syndrome in a patient with seronegative rheumatoid arthritis. RMD open, 2023, Volume: 9, Issue:2 Topics: Aged; Arthritis, Rheumatoid; Chondrocalcinosis; Colchicine; Humans; Methotrexate; Naproxen; Neck Pain; Syndrome	2023