Compounds > naproxen
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naproxen and Acute Liver Injury, Drug-Induced

naproxen has been researched along with Acute Liver Injury, Drug-Induced in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19906 (20.00)18.7374
1990's6 (20.00)18.2507
2000's3 (10.00)29.6817
2010's15 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Ding, D; Fang, H; Kelly, R; Liu, Z; Shi, Q; Tong, W1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bahde, R; Gupta, S; Kapoor, S1
Kruhlak, NL; Zhu, X1
Ash, MM; Jolly, PS1
Funakami, Y; Kato, Y; Nagai, N; Tanino, T1
Andrade, RJ; Carrascosa, MF; Caviedes, JR; Lavín, AC; Lucena, MI; Mones, JC; Rivero, AP; Serrano, VB1
Ali, S; Ma, C; Pimentel, JD1
Adamek, R; Krupiński, B; Wilczek, L1
Amir, M; Javed, SA; Kumar, H1
Hardt, F; Krogsgaard, K; Malchow-Møller, A1
Castañeda-Hernández, G; Favari, L; Hoyo-Vadillo, C2
Carson, JL; Manoukian, AV1
Duque-Oliart, A; García-Rodríguez, LA; Pérez-Gutthann, S; Varas-Lorenzo, C1
Achong, MR1
Dean, AD; Derby, LE; García Rodríguez, LA; Jick, H; Jick, SS1
Bell, H; Raknerud, N1
Paulus, HE; Schlegel, SI1
Andrejak, M; Capron, JP; Davion, T; Gineston, JL1
Catalano, MA1
Delendi, M; Falconieri, G; Giarelli, L1

Reviews

5 review(s) available for naproxen and Acute Liver Injury, Drug-Induced

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Cholestatic hepatic injury associated with vismodegib, aspirin, and naproxen use: a case study and review of vismodegib safety.
    International journal of dermatology, 2015, Volume: 54, Issue:3

    Topics: Aged; Anilides; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Carcinoma, Basal Cell; Chemical and Drug Induced Liver Injury; Cholestasis; Drug Interactions; Dysgeusia; Humans; Male; Myalgia; Naproxen; Pyridines; Skin Neoplasms

2015
Naproxen-induced liver injury.
    Hepatobiliary & pancreatic diseases international : HBPD INT, 2011, Volume: 10, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Jaundice; Liver; Naproxen; Pruritus; Time Factors

2011
Nonsteroidal anti-inflammatory drug-induced hepatic disorders. Incidence and prevention.
    Drug safety, 1996, Volume: 15, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Chemical and Drug Induced Liver Injury; Cohort Studies; Diclofenac; Humans; Incidence; Indomethacin; Liver; Liver Diseases; Naproxen; Oxaprozin; Phenylbutazone; Propionates; Risk Factors; Sulindac

1996
Non-steroidal and analgesic therapy in the elderly.
    Clinics in rheumatic diseases, 1986, Volume: 12, Issue:1

    Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents; Apazone; Aspirin; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Diclofenac; Drug Hypersensitivity; Gastrointestinal Diseases; Hematologic Diseases; Humans; Ibuprofen; Indomethacin; Ketoprofen; Kidney Diseases; Kinetics; Naproxen; Phenylbutazone; Piroxicam; Salicylates; Thiazines

1986

Trials

1 trial(s) available for naproxen and Acute Liver Injury, Drug-Induced

ArticleYear
Worldwide safety experience with diclofenac.
    The American journal of medicine, 1986, Apr-28, Volume: 80, Issue:4B

    Topics: Adult; Aged; Aspirin; Chemical and Drug Induced Liver Injury; Child; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Female; Gastrointestinal Diseases; Gastroscopy; Humans; Ibuprofen; Kidney Diseases; Middle Aged; Naproxen; Occult Blood; Piroxicam; Thiazines

1986

Other Studies

24 other study(ies) available for naproxen and Acute Liver Injury, Drug-Induced

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Models, Biological; Predictive Value of Tests

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Nonselective inhibition of prostaglandin-endoperoxide synthases by naproxen ameliorates acute or chronic liver injury in animals.
    Experimental and molecular pathology, 2014, Volume: 96, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cyclooxygenase 1; Cyclooxygenase 2; End Stage Liver Disease; Hepatocytes; Inflammation; Male; Membrane Proteins; Naproxen; Necrosis; Rats; Rats, Inbred F344

2014
Construction and analysis of a human hepatotoxicity database suitable for QSAR modeling using post-market safety data.
    Toxicology, 2014, Jul-03, Volume: 321

    Topics: Algorithms; Ampicillin; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Bile Duct Diseases; Calibration; Chemical and Drug Induced Liver Injury; Cholestasis; Data Mining; Databases, Factual; Drug Labeling; Endpoint Determination; Humans; Levofloxacin; Liver; Naproxen; Product Surveillance, Postmarketing; Quantitative Structure-Activity Relationship; Toxicity Tests; Vitamins

2014
Cyclosporin A-sensitive cytotoxicity of flurbiprofen non-stereoselectively mediated by cytochrome P450 metabolism in three-dimensional cultured rat hepatocytes.
    The Journal of pharmacy and pharmacology, 2015, Volume: 67, Issue:10

    Topics: Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Cytochrome P-450 Enzyme System; Flurbiprofen; Hepatocytes; Ibuprofen; L-Lactate Dehydrogenase; Male; Mitochondria; Naproxen; Phenylpropionates; Rats; Rats, Wistar; Stereoisomerism

2015
Fatal acute hepatitis after sequential treatment with levofloxacin, doxycycline, and naproxen in a patient presenting with acute Mycoplasma pneumoniae infection.
    Clinical therapeutics, 2009, Volume: 31, Issue:5

    Topics: Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Doxycycline; Fatal Outcome; Hepatitis; Humans; Levofloxacin; Liver Failure, Acute; Male; Middle Aged; Naproxen; Ofloxacin; Pericarditis; Pneumonia, Mycoplasma

2009
[Severe toxic liver failure after acute poisoning with paracetamol, ferrous sulphate and naproxen].
    Przeglad lekarski, 2004, Volume: 61, Issue:4

    Topics: Acetaminophen; Adult; Benzodiazepines; Chemical and Drug Induced Liver Injury; Female; Ferrous Compounds; Hepatic Encephalopathy; Humans; Liver Failure, Acute; Naproxen; Treatment Outcome

2004
Non-carboxylic analogues of naproxen: design, synthesis, and pharmacological evaluation of some 1,3,4-oxadiazole/thiadiazole and 1,2,4-triazole derivatives.
    Archiv der Pharmazie, 2007, Volume: 340, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Drug Design; Edema; Liver; Liver Function Tests; Male; Mice; Molecular Structure; Naproxen; Oxadiazoles; Pain; Rats; Stomach Ulcer; Thiadiazoles; Triazoles

2007
[Liver involvement after treatment with naproxen].
    Ugeskrift for laeger, 1980, Feb-11, Volume: 142, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Middle Aged; Naproxen

1980
Relationship between naproxen plasma concentration and its anti-inflammatory effect in experimental hepatitis.
    Arzneimittel-Forschung, 1995, Volume: 45, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemical and Drug Induced Liver Injury; Enzymes; Fever; Galactosamine; Half-Life; Liver Function Tests; Male; Naproxen; Rats; Rats, Wistar

1995
Pharmacokinetics and pharmacodynamics of naproxen in acute experimental hepatitis.
    Arzneimittel-Forschung, 1993, Volume: 43, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Proteins; Carrageenan; Chemical and Drug Induced Liver Injury; Galactosamine; Inflammation; Injections, Intravenous; Liver Function Tests; Liver Regeneration; Male; Naproxen; Protein Binding; Rats; Rats, Wistar

1993
Low-dose diclofenac, naproxen, and ibuprofen cohort study.
    Pharmacotherapy, 1999, Volume: 19, Issue:7

    Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cohort Studies; Diclofenac; Dose-Response Relationship, Drug; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Female; Gastrointestinal Hemorrhage; Hematologic Diseases; Humans; Ibuprofen; Male; Middle Aged; Naproxen

1999
When is a clinical event an adverse drug reaction?
    Canadian Medical Association journal, 1978, Dec-09, Volume: 119, Issue:11

    Topics: Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Female; Fever; Humans; Middle Aged; Naproxen; Time Factors

1978
Liver disease associated with diclofenac, naproxen, and piroxicam.
    Pharmacotherapy, 1992, Volume: 12, Issue:3

    Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Child; Diclofenac; Female; Follow-Up Studies; Humans; Male; Middle Aged; Naproxen; Piroxicam; Product Surveillance, Postmarketing; Risk Factors; United Kingdom

1992
[Fulminating hepatitis after treatment with naproxen and/or disulfiram?].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1991, Jan-30, Volume: 111, Issue:3

    Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Disulfiram; Drug Evaluation; Female; Hepatic Encephalopathy; Humans; Middle Aged; Naproxen

1991
Cross hepatotoxicity between non-steroidal anti-inflammatory drugs.
    British medical journal (Clinical research ed.), 1987, Jul-18, Volume: 295, Issue:6591

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Female; Fenoprofen; Humans; Naproxen; Propionates

1987
Fulminant hepatitis following naproxen administration.
    Human pathology, 1986, Volume: 17, Issue:10

    Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Naproxen

1986