naproxen has been researched along with digitoxin in 12 studies
| Studies (naproxen) | Trials (naproxen) | Recent Studies (post-2010) (naproxen) | Studies (digitoxin) | Trials (digitoxin) | Recent Studies (post-2010) (digitoxin) |
|---|---|---|---|---|---|
| 4,551 | 1,057 | 1,429 | 5,259 | 90 | 219 |
| Protein | Taxonomy | naproxen (IC50) | digitoxin (IC50) |
|---|---|---|---|
| STAT3, partial | Homo sapiens (human) | 0.7 | |
| Bile salt export pump | Homo sapiens (human) | 10 | |
| Sodium/potassium-transporting ATPase subunit alpha-1 | Homo sapiens (human) | 0.008 | |
| Sodium/potassium-transporting ATPase subunit beta-1 | Homo sapiens (human) | 0.008 | |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | 0.23 | |
| Sodium/potassium-transporting ATPase subunit alpha-3 | Homo sapiens (human) | 0.008 | |
| Sodium/potassium-transporting ATPase subunit beta-2 | Homo sapiens (human) | 0.008 | |
| Sodium/potassium-transporting ATPase subunit alpha-2 | Homo sapiens (human) | 0.008 | |
| Sodium/potassium-transporting ATPase subunit alpha-1 | Canis lupus familiaris (dog) | 0.008 | |
| Sodium/potassium-transporting ATPase subunit beta-3 | Homo sapiens (human) | 0.008 | |
| Sodium/potassium-transporting ATPase subunit gamma | Homo sapiens (human) | 0.008 | |
| Sodium/potassium-transporting ATPase subunit alpha-4 | Homo sapiens (human) | 0.008 | |
| Solute carrier organic anion transporter family member 4C1 | Homo sapiens (human) | 0.12 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Andersson, K; Borg, P; Frostell-Karlsson, A; Hämäläinen, M; Karlsson, R; Remaeus, A; Roos, H | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Romankiewicz, JA | 1 |
| Andersen, A; Børmer, OP; Kongsgaard, UE; Nordbø, A; Olsen, H | 1 |
| Benkestock, K; Edlund, PO; Roeraade, J | 1 |
| Andersen, A; Kongsgaard, UE; Olsen, H; Reine, PA; Thøgersen, AK | 1 |
| Ito, S; Iwamoto, K; Kamimura, H; Mizunaga, M; Nakayama, K; Negoro, T; Nishiwaki, M; Nomura, Y; Suemizu, H; Yamazaki, H; Yoneda, N | 1 |
1 trial(s) available for naproxen and digitoxin
| Article | Year |
|---|---|
Infusion of albumin attenuates changes in serum protein binding of drugs in surgical patients compared with volume replacement with HAES.
Topics: Adult; Aged; Albumins; Digitoxin; Female; Humans; Hydroxyethyl Starch Derivatives; Infusions, Parenteral; Male; Middle Aged; Naproxen; Pharmaceutical Preparations; Plasma Substitutes; Protein Binding; Surgical Procedures, Operative; Warfarin | 2008 |
11 other study(ies) available for naproxen and digitoxin
| Article | Year |
|---|---|
Biosensor analysis of the interaction between immobilized human serum albumin and drug compounds for prediction of human serum albumin binding levels.
Topics: Binding Sites; Biosensing Techniques; Digitoxin; Drug Stability; Humans; Molecular Weight; Naproxen; Orosomucoid; Pharmaceutical Preparations; Protein Binding; Quinine; Rifampin; Ritonavir; Serum Albumin; Solvents; Warfarin | 2000 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Effects of antacids on gastrointestinal absorption of drugs.
Topics: Animals; Antacids; Aspirin; Chlordiazepoxide; Chlorpromazine; Dicumarol; Digitoxin; Digoxin; Ephedrine; Guinea Pigs; Humans; Intestinal Absorption; Iron; Isoniazid; Levodopa; Naproxen; Pentobarbital; Pharmaceutical Preparations; Quinidine; Quinine; Rats; Sulfadiazine; Tetracyclines; Warfarin | 1976 |
Pharmaceutical-grade albumin: impaired drug-binding capacity in vitro.
Topics: Albumins; Digitoxin; Drug Industry; Humans; Naproxen; Pharmaceutical Preparations; Protein Binding; Serum Albumin; Warfarin | 2004 |
Electrospray ionization mass spectrometry as a tool for determination of drug binding sites to human serum albumin by noncovalent interaction.
Topics: Binding Sites; Digitoxin; Glyburide; Humans; Iopanoic Acid; Naproxen; Pharmaceutical Preparations; Protein Binding; Serum Albumin; Spectrometry, Mass, Electrospray Ionization; Warfarin | 2005 |
Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data.
Topics: Acetamides; Albuterol; Animals; Carbamates; Chromatography, Liquid; Diazepam; Diclofenac; Digitoxin; Humans; Itraconazole; Ketoprofen; Liver; Metabolic Clearance Rate; Mice; Mice, Transgenic; Naproxen; Pharmaceutical Preparations; Phenytoin; Piperidines; Pravastatin; Pyrimidines; Quinidine; Tandem Mass Spectrometry; Telmisartan; Terfenadine; Verapamil | 2020 |