Page last updated: 2024-09-27

Intra-Articular Fractures

Fractures of the articular surface of a bone.

Synonyms(2)

Synonym
Intraarticular Fractures
Intra-Articular Fractures

Research Excerpts

Treatment

ExcerptReference
"The best treatment for intraarticular fractures is still debated."( Abate, A; Caizzi, G; Moretti, B; Vicenti, G; Vittore, D, 2014)

Research

Studies (75)

TimeframeStudies, This Condition (%)All Conditions %
pre-19904 (5.33)23.3326
1990's0 (0.00)12.5806
2000's2 (2.67)18.1394
2010's45 (60.00)28.8240
2020's24 (32.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
methane0medium11
lactic acid0low10
nickel0low20
bupivacaine0medium21
celecoxib0medium11
diclofenac0medium11
lidocaine0low10
urethane0medium11
limestone0medium11
durapatite0low20
vancomycin0medium11
titanium0medium71
tricalcium phosphate0low60
calcium sulfate0medium44
trolamine salicylate0medium221
clodronic acid0low10
triamcinolone0low10
cephalosporin c0low10
polytrimethylene carbonate0low10
naproxen0medium11
ropivacaine0medium32
fibrin0low10
tacrolimus0low10
methyl-thiohydantoin-tryptophan0low10
icariin0low10
vendex0low10
chitosan0low20
ap201870low10
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone0low10

Protein Targets (317)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Potassium channel subfamily K member 30303
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20112
Potassium channel subfamily K member 90101
Chain A, Carbonic anhydrase II0101
Chain A, Cruzipain1001
Carbonic anhydrase 0001
Carbonic anhydrase 0101
GTP-binding protein (rab7)0011
ras protein, partial0011
glp-1 receptor, partial2002
pregnane X receptor1001
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma5005
SMAD family member 23003
USP1 protein, partial2002
PPM1D protein1001
SMAD family member 33003
TDP1 protein3003
GLI family zinc finger 32002
AR protein7007
Smad32002
caspase 7, apoptosis-related cysteine protease1001
thyroid stimulating hormone receptor3003
estrogen receptor 2 (ER beta)2002
progesterone receptor2002
cytochrome P450 family 3 subfamily A polypeptide 42002
EWS/FLI fusion protein2002
glucocorticoid receptor [Homo sapiens]5005
retinoic acid nuclear receptor alpha variant 14004
retinoid X nuclear receptor alpha3003
estrogen-related nuclear receptor alpha3003
farnesoid X nuclear receptor1001
pregnane X nuclear receptor2002
estrogen nuclear receptor alpha7007
G1001
cytochrome P450 2D62002
Carbonic anhydrase 0101
Carbonic anhydrase 0101
67.9K protein1001
peroxisome proliferator-activated receptor delta1001
peroxisome proliferator activated receptor gamma2002
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
Carbonic anhydrase0101
Rac1 protein0011
caspase-31001
IDH12002
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
thyroid stimulating hormone receptor2002
activating transcription factor 61001
thyrotropin-releasing hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)2002
Histone H2A.x1001
Caspase-71001
interferon gamma precursor0001
prostaglandin E2 receptor EP2 subtype0001
thyroid hormone receptor beta isoform a2002
nuclear factor erythroid 2-related factor 2 isoform 22002
potassium voltage-gated channel subfamily H member 2 isoform d1001
caspase-31001
thyroid hormone receptor beta isoform 22002
heat shock protein beta-12002
nuclear factor erythroid 2-related factor 2 isoform 12002
geminin4004
peripheral myelin protein 222002
cytochrome P450 3A4 isoform 14004
lamin isoform A-delta104004
Gamma-aminobutyric acid receptor subunit pi4004
Prostaglandin E synthase0101
Histone deacetylase 30101
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
3-phosphoinositide-dependent protein kinase 10101
Carbonic anhydrase 120101
Prostaglandin G/H synthase 1 0303
Prostaglandin G/H synthase 2 0101
cGMP-specific 3',5'-cyclic phosphodiesterase0202
Cytochrome c oxidase subunit 10101
Cytochrome c oxidase subunit 20101
Catechol O-methyltransferase0101
Voltage-dependent calcium channel gamma-2 subunit1001
Bile salt export pump0707
Cytochrome c oxidase subunit 20202
Carbonic anhydrase 10303
Carbonic anhydrase 20303
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 1001
Cellular tumor antigen p533003
Prostaglandin G/H synthase 10303
Carbonic anhydrase 30101
Procathepsin L0101
Aldo-keto reductase family 1 member B10202
Seed linoleate 13S-lipoxygenase-10101
Neuronal acetylcholine receptor subunit alpha-40101
Polyunsaturated fatty acid 5-lipoxygenase0101
Quinolone resistance protein NorA0101
Adenosine receptor A30202
Cytochrome P450 2D60101
Cytochrome P450 2C9 0405
Neuronal acetylcholine receptor subunit beta-20101
Beta-3 adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit beta-14004
Alpha-1B adrenergic receptor0303
Calpain-2 catalytic subunit0101
Alpha-2B adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit delta4004
Gamma-aminobutyric acid receptor subunit gamma-24004
5-hydroxytryptamine receptor 1A0101
Glutamate receptor 21001
Gamma-aminobutyric acid receptor subunit alpha-54004
Gamma-aminobutyric acid receptor subunit alpha-34004
D(1A) dopamine receptor0202
Prostaglandin G/H synthase 10101
Carbonic anhydrase 40101
Prostaglandin G/H synthase 10304
Carbonic anhydrase 60101
Gamma-aminobutyric acid receptor subunit gamma-14004
Gamma-aminobutyric acid receptor subunit alpha-24004
Sodium-dependent noradrenaline transporter 0202
Adenosine receptor A10202
Cruzipain0101
Sodium/hydrogen exchanger 10101
Gamma-aminobutyric acid receptor subunit alpha-44004
Gamma-aminobutyric acid receptor subunit gamma-34004
Indoleamine 2,3-dioxygenase 10101
Gamma-aminobutyric acid receptor subunit alpha-64004
Sodium-dependent serotonin transporter0202
Sodium-dependent serotonin transporter0112
Delta-type opioid receptor0101
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Bifunctional epoxide hydrolase 20101
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 20416
Prostaglandin G/H synthase 2 0304
Carbonic anhydrase0101
Alpha-1A adrenergic receptor0303
Carbonic anhydrase 70101
Urotensin-2 receptor0101
Nuclear receptor ROR-gamma1001
Carbonic anhydrase0101
Histone deacetylase 40101
Ras-related protein Rab-2A0011
D(2) dopamine receptor0101
Gamma-aminobutyric acid receptor subunit alpha-14105
Gamma-aminobutyric acid receptor subunit beta-34004
Gamma-aminobutyric acid receptor subunit beta-24004
Prostaglandin G/H synthase 20404
Carbonic anhydrase 0101
Mu-type opioid receptor0202
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Sodium-dependent dopamine transporter 0202
Prostaglandin G/H synthase 20202
Histone deacetylase 10101
Mitogen-activated protein kinase 140101
Carbonic anhydrase 90303
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase0101
Carbonic anhydrase 0101
Sigma intracellular receptor 20101
Delta carbonic anhydrase0101
Prostaglandin G/H synthase 1 0304
Carbonic anhydrase 0101
Prostaglandin G/H synthase 10101
Carbonic anhydrase 130101
Cyclooxygenase-2 0101
Histone deacetylase 70101
Rap guanine nucleotide exchange factor 41001
GABA theta subunit4004
Inositol hexakisphosphate kinase 11001
Histone deacetylase 20101
Canalicular multispecific organic anion transporter 10404
Carbonic anhydrase 40303
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
ATPase family AAA domain-containing protein 53003
Ataxin-23003
Carbonic anhydrase 150101
Histone deacetylase 80101
P2Y purinoceptor 120202
Gamma-aminobutyric acid receptor subunit epsilon4004
Histone deacetylase 60101
Histone deacetylase 90101
Carbonic anhydrase 140101
Histone deacetylase 50101
Carbonic anhydrase 5B, mitochondrial0101
cytochrome P450 2C9, partial1001
Type IV secretion-like conjugative transfer relaxase protein TraI 0101
72 kDa type IV collagenase0101
Stromelysin-10101
Matrix metalloproteinase-90101
Macrophage metalloelastase0101
Aldo-keto reductase family 1 member B100101
UDP-glucuronosyltransferase 1A90102
Transient receptor potential cation channel subfamily A member 10011
Dihydrofolate reductase0202
Fatty acid-binding protein, liver0101
Transthyretin0013
Albumin0123
Cytochrome P450 3A40202
Interleukin-80101
Calcium/calmodulin-dependent protein kinase type II subunit alpha0101
Fatty acid-binding protein, intestinal0101
Aldo-keto reductase family 1 member B10101
UDP-glucuronosyltransferase 2B70103
UDP-glucuronosyltransferase 1-60202
UDP-glucuronosyltransferase 1A1 0202
UDP-glucuronosyltransferase 1A40102
Sodium- and chloride-dependent GABA transporter 10101
C-X-C chemokine receptor type 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
UDP-glucuronosyltransferase 1A30001
UDP-glucuronosyltransferase 2B10 0101
Sodium- and chloride-dependent betaine transporter0101
Cytochrome P450 2J20303
Solute carrier family 22 member 60202
Multidrug and toxin extrusion protein 10202
UDP-glucuronosyltransferase 1A70101
UDP-glucuronosyltransferase 1A100101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, Beta-lactamase2002
DNA polymerase beta1001
Lysine-specific histone demethylase 1A0101
interleukin 81001
aldehyde dehydrogenase 1 family, member A12002
aryl hydrocarbon receptor1001
cellular tumor antigen p53 isoform a3003
Integrin beta-33003
Integrin alpha-IIb3003
acetylcholinesterase1001
thioredoxin reductase2002
GLS protein1001
Microtubule-associated protein tau2002
euchromatic histone-lysine N-methyltransferase 22002
chromobox protein homolog 12002
mitogen-activated protein kinase 11001
flap endonuclease 11001
muscarinic acetylcholine receptor M11001
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Potassium voltage-gated channel subfamily A member 50101
Sodium channel protein type 4 subunit alpha0101
Potassium voltage-gated channel subfamily H member 20101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Sodium channel protein type 3 subunit alpha0101
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
phosphopantetheinyl transferase2002
alpha-galactosidase1001
nuclear receptor ROR-gamma isoform 12002
survival motor neuron protein isoform d1001
Indoleamine 2,3-dioxygenase 10202
Receptor-interacting serine/threonine-protein kinase 10112
Solute carrier family 22 member 60101
Polyunsaturated fatty acid 5-lipoxygenase0103
Hormone-sensitive lipase0101
Aldo-keto reductase family 1 member C40101
Caspase-10101
Adenosine receptor A2a0101
Aldo-keto reductase family 1 member C30101
Caspase-30101
Caspase-40101
Caspase-50101
Aldo-keto reductase family 1 member C2 0101
Caspase-90101
Aldo-keto reductase family 1 member C10101
Chain A, Ferritin light chain1001
DNA polymerase kappa isoform 12002
Nuclear receptor subfamily 1 group I member 20011
Cytochrome P450 3A50101
Serine/threonine-protein kinase mTOR0101
Spike glycoprotein1001
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Peptidyl-prolyl cis-trans isomerase FKBP50101
Splicing factor 3B subunit 30101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Solute carrier organic anion transporter family member 1B10101
ATAD5 protein, partial1001
NFKB1 protein, partial1001
thioredoxin glutathione reductase1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
arylsulfatase A1001
Bloom syndrome protein isoform 11001
peripheral myelin protein 22 isoform 11001
procathepsin L isoform 1 preproprotein0101
muscleblind-like protein 1 isoform 11001
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
15-lipoxygenase, partial1001
Alpha-2A adrenergic receptor0101
60 kDa heat shock protein, mitochondrial0101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0101
10 kDa heat shock protein, mitochondrial0101
D-alanyl-D-alanine dipeptidase0101
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Transporter0101
vitamin D3 receptor isoform VDRA1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]