Page last updated: 2024-09-28

Bazin Disease

A type of panniculitis characterized histologically by the presence of granulomas, vasculitis, and necrosis. It is traditionally considered to be the tuberculous counterpart of nodular vasculitis, but is now known to occur without tuberculous precedent. It is seen most commonly in adolescent and menopausal women, is initiated or exacerbated by cold weather, and typically presents as one or more recurrent erythrocyanotic nodules or plaques on the calves. The nodules may progress to form indurations, ulcerations, and scars.

Synonyms(4)

Synonym
Bazin Disease
Erythema Induratum
Bazin's Disease
Tuberculosis Cutis Indurativa

Research Excerpts

Research

Studies (51)

TimeframeStudies, This Condition (%)All Conditions %
pre-199017 (33.33)23.3326
1990's10 (19.61)12.5806
2000's11 (21.57)18.1394
2010's10 (19.61)28.8240
2020's3 (5.88)9.53
DrugIndicatedRelationship StrengthStudiesTrials
formaldehyde0low10
niacin0low10
pyrazinamide0low20
aspirin0low10
cefixime0low10
clofazimine0low10
hydroxyurea0low10
isoniazid0low110
mesalamine0low10
aminosalicylic acid0low40
procarbazine0low10
prednisolone0low30
prednisone0low40
estrone0low10
kanamycin a0low10
colchicine0low10
acridines0low10
ethambutol0low30
streptomycin0low40
phenyl acetate0low10
etoposide0low10
amikacin0low10
zileuton0low10
naproxen0low10
montelukast0low10
caseins0low10
rifampin0low60

Protein Targets (486)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Ferritin light chain2002
thioredoxin reductase6006
TDP1 protein9009
Microtubule-associated protein tau3003
Smad33003
aldehyde dehydrogenase 1 family, member A19009
alpha-galactosidase1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 14004
flap endonuclease 13003
DNA polymerase iota isoform a (long)4004
DNA topoisomerase 2-alpha0118
Acetylcholinesterase0101
estrogen nuclear receptor alpha180018
peripheral myelin protein 224004
histone acetyltransferase KAT2A isoform 13003
lamin isoform A-delta108008
ATP-binding cassette sub-family C member 3014014
Multidrug resistance-associated protein 4014014
Bile salt export pump017017
Canalicular multispecific organic anion transporter 1015016
Aminoglycoside 3'-phosphotransferase 0001
ATP-dependent phosphofructokinase3003
Chain A, 2-oxoglutarate Oxygenase5005
thioredoxin glutathione reductase3003
euchromatic histone-lysine N-methyltransferase 2120012
microphthalmia-associated transcription factor isoform 90202
Carbonic anhydrase 10505
Carbonic anhydrase 20607
Tyrosine-protein phosphatase non-receptor type 10011
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE7007
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein5005
Chain B, HADH2 protein5005
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 83003
GLS protein5005
AR protein130013
thyroid stimulating hormone receptor6006
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 47007
EWS/FLI fusion protein4004
glucocorticoid receptor [Homo sapiens]110011
retinoic acid nuclear receptor alpha variant 1100010
estrogen-related nuclear receptor alpha9009
cytochrome P450 2D62002
glucocerebrosidase2002
peroxisome proliferator-activated receptor delta6006
Rac1 protein0011
IDH12002
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
Bloom syndrome protein isoform 13003
DNA polymerase kappa isoform 12002
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)3003
Prostaglandin-H2 D-isomerase0101
Solute carrier family 22 member 60202
Prostaglandin G/H synthase 1 0203
Prostaglandin G/H synthase 2 0102
Epidermal growth factor receptor0202
Fatty acid-binding protein, liver0202
Integrin beta-30101
Myeloperoxidase0202
Prostaglandin G/H synthase 10404
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb0101
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10404
Adenosine receptor A10202
Adenosine receptor A2a0202
Substance-P receptor0101
Prostaglandin G/H synthase 20606
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma3003
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-16107
Prostaglandin G/H synthase 20202
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Sigma non-opioid intracellular receptor 10112
Sigma non-opioid intracellular receptor 10011
PPM1D protein2002
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
Spike glycoprotein0112
Replicase polyprotein 1ab0112
glucose-6-phosphate 1-dehydrogenase isoform b0101
Transmembrane protease serine 20112
Dihydrofolate reductase 0101
DNA ligase0101
Interferon beta6006
Riboflavin-binding protein0011
Major prion protein0011
Amyloid-beta precursor protein0202
Histidine-rich protein PFHRP-II0102
Procathepsin L0112
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M40101
Cytochrome P450 3A40404
Muscarinic acetylcholine receptor M50101
Alpha-2A adrenergic receptor0303
Replicase polyprotein 1a0112
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0112
Spike glycoprotein0112
Replicase polyprotein 1ab0112
Muscarinic acetylcholine receptor M10303
Ribosyldihydronicotinamide dehydrogenase [quinone]0101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0303
DNA ligase 10101
Muscarinic acetylcholine receptor M30303
Serine/threonine-protein kinase mTOR0101
Nuclear receptor subfamily 4 group A member 20011
Beta-secretase 10101
Spike glycoprotein4116
Calcium-dependent protein kinase 10011
MO15-related protein kinase Pfmrk 0101
DNA ligase A0101
Potassium voltage-gated channel subfamily H member 20202
Sigma intracellular receptor 20101
Phosphoethanolamine N-methyltransferase0101
Ataxin-25005
Angiotensin-converting enzyme 2 0112
Cysteine proteinase falcipain 2a 0101
Cysteine proteinase falcipain 2a 0101
Chain A, JmjC domain-containing histone demethylation protein 3A2002
phosphopantetheinyl transferase3003
USP1 protein, partial5005
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
G3003
67.9K protein5005
cytochrome P450 2D6 isoform 13003
vitamin D3 receptor isoform VDRA5005
chromobox protein homolog 15005
potassium voltage-gated channel subfamily H member 2 isoform d3003
transcriptional regulator ERG isoform 31001
thyroid hormone receptor beta isoform 26006
importin subunit beta-1 isoform 11001
mitogen-activated protein kinase 11001
mitogen-activated protein kinase kinase kinase kinase 2 isoform 10011
eyes absent homolog 2 isoform a1001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
geminin5005
streptokinase A precursor0011
mitogen-activated protein kinase kinase kinase 3 isoform 10011
HLA class I histocompatibility antigen, B alpha chain 3003
Estrogen receptor0011
ATP-dependent translocase ABCB10406
5-hydroxytryptamine receptor 1A0011
Cruzipain0101
C-terminal-binding protein 11001
Estrogen receptor beta0011
Inositol hexakisphosphate kinase 13003
Broad substrate specificity ATP-binding cassette transporter ABCG20303
cytochrome P450 2C9, partial3003
Chain A, Beta-lactamase1001
Luciferase3003
endonuclease IV2002
PAX80001
pregnane X receptor2002
hypoxia-inducible factor 1 alpha subunit3003
RAR-related orphan receptor gamma8008
ATAD5 protein, partial3003
Fumarate hydratase2002
GLI family zinc finger 38008
Thrombopoietin1001
estrogen receptor 2 (ER beta)5005
nuclear receptor subfamily 1, group I, member 38008
retinoid X nuclear receptor alpha6006
farnesoid X nuclear receptor2002
pregnane X nuclear receptor110011
polyprotein2002
peroxisome proliferator activated receptor gamma6006
vitamin D (1,25- dihydroxyvitamin D3) receptor9009
aryl hydrocarbon receptor6006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
activating transcription factor 64004
v-jun sarcoma virus 17 oncogene homolog (avian)6006
nuclear receptor subfamily 1, group I, member 22002
nuclear receptor subfamily 0 group B member 10101
cellular tumor antigen p53 isoform a1001
cytochrome P450 2C19 precursor3003
cytochrome P450 2C9 precursor2002
thyroid hormone receptor beta isoform a3003
nuclear factor erythroid 2-related factor 2 isoform 25005
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A1001
steroidogenic factor 10101
nuclear factor erythroid 2-related factor 2 isoform 17007
cytochrome P450 3A4 isoform 16006
muscleblind-like protein 1 isoform 11001
caspase-1 isoform alpha precursor2002
neuropeptide S receptor isoform A1001
Gamma-aminobutyric acid receptor subunit pi6006
Solute carrier family 22 member 30101
Voltage-dependent calcium channel gamma-2 subunit4004
Tubulin alpha-1A chain0213
Tubulin beta chain0213
Plasma kallikrein0001
Tubulin beta-4A chain0225
Cellular tumor antigen p535005
ATP-dependent translocase ABCB10202
Tubulin beta chain0225
Tubulin alpha-3C chain0225
Serine/threonine-protein kinase pim-10101
Gamma-aminobutyric acid receptor subunit beta-16006
Gamma-aminobutyric acid receptor subunit delta6006
Gamma-aminobutyric acid receptor subunit gamma-26006
Glutamate receptor 24105
Gamma-aminobutyric acid receptor subunit alpha-56006
Gamma-aminobutyric acid receptor subunit alpha-36006
ATP-dependent translocase ABCB10202
Gamma-aminobutyric acid receptor subunit gamma-16006
Gamma-aminobutyric acid receptor subunit alpha-26006
Gamma-aminobutyric acid receptor subunit alpha-46006
Gamma-aminobutyric acid receptor subunit gamma-36006
Gamma-aminobutyric acid receptor subunit alpha-66006
Histamine H2 receptor3003
Gamma-aminobutyric acid receptor subunit beta-36006
Gamma-aminobutyric acid receptor subunit beta-26006
Tubulin alpha-1B chain0225
Tubulin alpha-4A chain0225
Tubulin beta-4B chain0225
Vesicular acetylcholine transporter0101
Tubulin beta-3 chain0225
Tubulin beta-2A chain0225
Tubulin polymerization-promoting protein0011
Tubulin beta-8 chain0225
Tubulin beta-2B chain0303
Tubulin alpha-3E chain0225
Tubulin alpha-1A chain0225
Similar to alpha-tubulin isoform 1 0202
Similar to alpha-tubulin isoform 1 0202
GABA theta subunit6006
CREB-binding protein1001
ATPase family AAA domain-containing protein 54004
Tubulin alpha-1C chain0225
Tubulin beta-6 chain0225
Tubulin beta-2B chain0225
Gamma-aminobutyric acid receptor subunit epsilon6006
Tubulin beta-1 chain0225
NFKB1 protein, partial2002
GALC protein2002
progesterone receptor5005
nonstructural protein 11001
arylsulfatase A2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a5005
hexokinase-4 isoform 11001
peripheral myelin protein 22 isoform 12002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
glucokinase regulatory protein1001
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
urokinase plasminogen activator surface receptor precursor4004
Rap guanine nucleotide exchange factor 31001
Estrogen receptor0416
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0202
Steryl-sulfatase0101
Aromatase0101
Polyunsaturated fatty acid lipoxygenase ALOX150303
17-beta-hydroxysteroid dehydrogenase type 10203
Androgen receptor0303
Sodium-dependent serotonin transporter0202
Mu-type opioid receptor0011
Alpha-synuclein1203
5-hydroxytryptamine receptor 2B0404
Solute carrier organic anion transporter family member 1A10202
Mu-type opioid receptor0011
Inositol monophosphatase 12002
TAR DNA-binding protein 432002
Cytochrome P450 1B10101
Estrogen receptor beta0315
Ghrelin O-acyltransferase0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0206
Pantothenate synthetase0202
glp-1 receptor, partial3003
SMAD family member 23003
SMAD family member 33003
caspase 7, apoptosis-related cysteine protease1001
caspase-31001
LMP1 [Human herpesvirus 4]0001
thyroid stimulating hormone receptor2002
Histone H2A.x4004
heat shock protein beta-11001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Prothrombin0001
Regulatory protein E20011
DNA topoisomerase 10102
Cytochrome P450 2C9 0415
DNA topoisomerase 20001
UDP-glucuronosyltransferase 1A1 0002
Serum paraoxonase/arylesterase 10101
Glutamate receptor ionotropic, NMDA 1 0001
Caspase-30202
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta0118
Glutamate receptor ionotropic, NMDA 2D0001
Integrase 0101
Glutamate receptor ionotropic, NMDA 3B0001
Solute carrier organic anion transporter family member 1B30406
Glutamate receptor ionotropic, NMDA 3A0001
acetylcholinesterase4004
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Stromelysin-10011
Gamma-aminobutyric acid receptor subunit alpha-10101
Urease subunit alpha0101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
Carbonic anhydrase 40202
Ribonucleoside-diphosphate reductase large subunit0101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Carbonic anhydrase 5A, mitochondrial0202
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Urease subunit beta0101
Gamma-aminobutyric acid receptor subunit epsilon0101
Gamma-aminobutyric acid receptor subunit alpha-60101
Carbonic anhydrase 90203
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit theta0101
bromodomain adjacent to zinc finger domain 2B2002
3-oxoacyl-[acyl-carrier-protein] synthase 3 0101
nuclear receptor ROR-gamma isoform 12002
N-glycosylase/DNA lyase0101
Polyphenol oxidase 20202
Bile salt export pump0505
Cytochrome P450 1A20202
Formamidopyrimidine-DNA glycosylase0101
DNA gyrase subunit A0101
DNA gyrase subunit B0101
Cytochrome P450 2C80202
Cytochrome P450 2A60101
Macrophage migration inhibitory factor0101
Cytochrome P450 2C190101
Endonuclease III-like protein 10101
DNA gyrase subunit B0202
DNA gyrase subunit A0202
Isocitrate lyase0101
Putative FAD-containing monooxygenase MymA0101
Dihydrofolate reductase0101
Endonuclease 8-like 10101
3-oxoacyl-[acyl-carrier-protein] synthase 30101
Gap junction alpha-1 protein0101
Gap junction beta-2 protein0101
Acyl-protein thioesterase 10101
Chain A, Breast cancer type 1 susceptibility protein1001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
15-lipoxygenase, partial3003
Solute carrier organic anion transporter family member 2B1 0203
Tumor necrosis factor0101
Neuraminidase0101
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0202
Platelet-activating factor receptor1001
Cystathionine gamma-lyase0101
Caspase-71001
10 kDa heat shock protein, mitochondrial0202
Thiosulfate sulfurtransferase0202
60 kDa chaperonin 0202
10 kDa chaperonin 0202
Protein-arginine deiminase type-40303
Cystine/glutamate transporter0101
Hydroxyacid oxidase 10101
Solute carrier organic anion transporter family member 1B10204
large T antigen0101
Tyrosine-protein kinase Fyn0101
Beta-2 adrenergic receptor0202
Aldo-keto reductase family 1 member B10202
Adenosine receptor A30202
Beta-3 adrenergic receptor0202
Alpha-1B adrenergic receptor0202
Substance-K receptor0202
Sodium-dependent noradrenaline transporter 0202
Thromboxane-A synthase 0101
D(3) dopamine receptor0202
Delta-type opioid receptor0202
Alpha-1A adrenergic receptor0202
Sodium-dependent dopamine transporter 0202
Uracil nucleotide/cysteinyl leukotriene receptor0101
Mitogen-activated protein kinase 140101
Leukotriene C4 synthase0101
Cysteinyl leukotriene receptor 10101
Cysteinyl leukotriene receptor 20202
Cysteinyl leukotriene receptor 10314
Chain A, Inosine-5'-Monophosphate Dehydrogenase 20101
survival motor neuron protein isoform d1001
UDP-glucuronosyltransferase 1A90001
Inosine-5'-monophosphate dehydrogenase 20202
Glutamate receptor 10101
Glutamate receptor 30101
Glutamate receptor 40101
Inosine-5'-monophosphate dehydrogenase 1 0202
Sodium-dependent serotonin transporter0101
Peroxisome proliferator-activated receptor gamma0011
Inosine-5'-monophosphate dehydrogenase0102
UDP-glucuronosyltransferase 1A70001
UDP-glucuronosyltransferase 1A100001
UDP-glucuronosyltransferase 1A80001
Dihydrofolate reductase0101
Polyunsaturated fatty acid 5-lipoxygenase0206
Hormone-sensitive lipase0101
Aldo-keto reductase family 1 member C40101
Caspase-10202
Prostaglandin G/H synthase 2 0103
Aldo-keto reductase family 1 member C30101
Caspase-40101
Cytochrome P450 2J20202
Caspase-50101
Aldo-keto reductase family 1 member C2 0101
Caspase-90101
Aldo-keto reductase family 1 member C10101
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0103
thyrotropin-releasing hormone receptor1001
lysosomal alpha-glucosidase preproprotein2002
Neuronal acetylcholine receptor subunit alpha-41001
Cholesteryl ester transfer protein0101
Neuronal acetylcholine receptor subunit beta-21001
D-amino-acid oxidase0101
Xanthine dehydrogenase/oxidase0101
Hydroxycarboxylic acid receptor 30011
Nicotinamidase0101
Hydroxycarboxylic acid receptor 20011
Hydroxycarboxylic acid receptor 20213
Multidrug and toxin extrusion protein 10101
D-aspartate oxidase0101
Hydroxycarboxylic acid receptor 20112
luciferase0001
Glucocorticoid receptor04211
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10404
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Histamine H1 receptor0011
Nociceptin receptor0011
dopamine D1 receptor1001
NAD-dependent protein deacetylase sirtuin-60101
Chain A, Cruzipain1001
DNA-directed RNA polymerase subunit beta0101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Solute carrier organic anion transporter family member 1A40101
Nuclear receptor subfamily 1 group I member 20011
Albumin0011
NH(3)-dependent NAD(+) synthetase0101
Cytochrome P450 2B60011
Arylacetamide deacetylase0102
Solute carrier organic anion transporter family member 1A20101
Glutathione S-transferase omega-10101
DNA-directed RNA polymerase subunit beta0101
Lanosterol 14-alpha demethylase0101
Prostaglandin E synthase0101
Tumor necrosis factor ligand superfamily member 110101
Polyunsaturated fatty acid 5-lipoxygenase0112
Leukotriene A-4 hydrolase0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Polyunsaturated fatty acid lipoxygenase ALOX120101
Arachidonate 5-lipoxygenase-activating protein0101
Bifunctional epoxide hydrolase 20101
Polyunsaturated fatty acid 5-lipoxygenase0101
Thromboxane-A synthase0101
Leukotriene B4 receptor 10112
Acyl-CoA:cholesterol acyltransferase 0101
Leukotriene B4 receptor 20011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]