naproxen has been researched along with ml-3000 in 9 studies
| Studies (naproxen) | Trials (naproxen) | Recent Studies (post-2010) (naproxen) | Studies (ml-3000) | Trials (ml-3000) | Recent Studies (post-2010) (ml-3000) |
|---|---|---|---|---|---|
| 4,551 | 1,057 | 1,429 | 130 | 9 | 56 |
| Protein | Taxonomy | naproxen (IC50) | ml-3000 (IC50) |
|---|---|---|---|
| Prostaglandin E synthase | Homo sapiens (human) | 6.14 | |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | 0.1925 | |
| Prostaglandin G/H synthase 2 | Bos taurus (cattle) | 0.21 | |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | 0.185 | |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | 0.3017 | |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | 3.6 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 2.7425 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 0.422 | |
| 5-lipoxygenase | Bos taurus (cattle) | 0.47 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Celotti, F; Durand, T | 1 |
| Bias, P; Buchner, A; Klesser, B; Laufer, S | 1 |
| Guévremont, M; Laufer, S; Marcouiller, P; Martel-Pelletier, J; Pelletier, JP; Ranger, P; Reboul, P | 1 |
| Abram, F; Beaulieu, AD; Bias, P; Choquette, D; Dorais, M; Haraoui, B; Laufer, S; Martel-Pelletier, J; Pelletier, JP; Raynauld, JP; Vignon, E | 1 |
| Abram, F; Bias, P; Choquette, D; Dorais, M; Emmert, KH; Haraoui, B; Laufer, S; Martel-Pelletier, J; Pelletier, JP; Raynauld, JP | 1 |
| Abram, F; Caron, J; Choquette, D; Dorais, M; Haraoui, B; Martel-Pelletier, J; Mineau, F; Pelletier, JP; Raynauld, JP | 1 |
| Abram, F; Dorais, M; Martel-Pelletier, J; Pelletier, JP; Raynauld, JP; Wildi, LM | 1 |
| Abram, F; Choquette, D; Dorais, M; Haraoui, B; Martel-Pelletier, J; Pelletier, JP; Raynauld, JP; Wildi, LM | 1 |
| Liu, M; Martel-Pelletier, J; Pelletier, JP; Rahman, P; Randell, EW; Zhai, G | 1 |
1 review(s) available for naproxen and ml-3000
| Article | Year |
|---|---|
The metabolic effects of inhibitors of 5-lipoxygenase and of cyclooxygenase 1 and 2 are an advancement in the efficacy and safety of anti-inflammatory therapy.
Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Cardiovascular System; Clinical Trials, Phase III as Topic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Intestinal Mucosa; Isoenzymes; Leukotrienes; Lipoxygenase Inhibitors; Membrane Proteins; Naproxen; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrroles | 2003 |
7 trial(s) available for naproxen and ml-3000
| Article | Year |
|---|---|
The gastrointestinal tolerability of the LOX/COX inhibitor, licofelone, is similar to placebo and superior to naproxen therapy in healthy volunteers: results from a randomized, controlled trial.
Topics: Acetates; Adult; Cyclooxygenase Inhibitors; Duodenoscopy; Duodenum; Female; Gastric Mucosa; Gastroscopy; Humans; Incidence; Intestinal Mucosa; Lipoxygenase Inhibitors; Male; Naproxen; Peptic Ulcer; Pyrroles | 2004 |
Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI.
Topics: Aged; Antirheumatic Agents; Cartilage, Articular; Chi-Square Distribution; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Image Processing, Computer-Assisted; Knee Joint; Lipoxygenase Inhibitors; Magnetic Resonance Imaging; Male; Middle Aged; Naproxen; Osteoarthritis, Knee; Pain Measurement; Pyrroles; Radiography; Treatment Outcome | 2009 |
Analysis of the precision and sensitivity to change of different approaches to assess cartilage loss by quantitative MRI in a longitudinal multicentre clinical trial in patients with knee osteoarthritis.
Topics: Cartilage, Articular; Double-Blind Method; Female; Follow-Up Studies; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Naproxen; Osteoarthritis, Knee; Pyrroles; Sensitivity and Specificity | 2008 |
Decrease in serum level of matrix metalloproteinases is predictive of the disease-modifying effect of osteoarthritis drugs assessed by quantitative MRI in patients with knee osteoarthritis.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; C-Reactive Protein; Cartilage, Articular; Drug Monitoring; Female; Humans; Magnetic Resonance Imaging; Male; Matrix Metalloproteinases; Middle Aged; Naproxen; Osteoarthritis, Knee; Pyrroles; Severity of Illness Index; Treatment Outcome | 2010 |
Relationship between bone marrow lesions, cartilage loss and pain in knee osteoarthritis: results from a randomised controlled clinical trial using MRI.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Diseases; Cartilage, Articular; Cyclooxygenase Inhibitors; Epidemiologic Methods; Female; Humans; Knee Joint; Magnetic Resonance Imaging; Male; Middle Aged; Naproxen; Osteoarthritis, Knee; Pain; Pain Measurement; Pyrroles | 2010 |
Risk factors predictive of joint replacement in a 2-year multicentre clinical trial in knee osteoarthritis using MRI: results from over 6 years of observation.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Knee; C-Reactive Protein; Disease Progression; Epidemiologic Methods; Female; Humans; Knee Joint; Magnetic Resonance Imaging; Male; Menisci, Tibial; Middle Aged; Naproxen; Osteoarthritis, Knee; Prognosis; Pyrroles; Tibial Meniscus Injuries | 2011 |
Serum lysophosphatidylcholines to phosphatidylcholines ratio is associated with symptomatic responders to symptomatic drugs in knee osteoarthritis patients.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cyclooxygenase Inhibitors; Female; Humans; Lysophosphatidylcholines; Male; Middle Aged; Naproxen; Osteoarthritis, Knee; Phosphatidylcholines; Pyrroles; Treatment Outcome | 2019 |
1 other study(ies) available for naproxen and ml-3000
| Article | Year |
|---|---|
Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis.
Topics: Acetates; Aged; Arachidonic Acid; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; In Vitro Techniques; Leukotriene B4; Lipopolysaccharides; Male; Masoprocol; Naproxen; Osteoarthritis, Knee; Pyrroles; Signal Transduction; Synovial Membrane | 2005 |