naproxen has been researched along with morphine in 38 studies
| Studies (naproxen) | Trials (naproxen) | Recent Studies (post-2010) (naproxen) | Studies (morphine) | Trials (morphine) | Recent Studies (post-2010) (morphine) |
|---|---|---|---|---|---|
| 4,551 | 1,057 | 1,429 | 44,270 | 5,200 | 8,695 |
| Protein | Taxonomy | naproxen (IC50) | morphine (IC50) |
|---|---|---|---|
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.2939 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.2278 | |
| Kappa-type opioid receptor | Mus musculus (house mouse) | 0.0828 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0385 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0545 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.122 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1199 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.9308 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.655 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.3305 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.202 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.25 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.26) | 18.7374 |
| 1990's | 6 (15.79) | 18.2507 |
| 2000's | 17 (44.74) | 29.6817 |
| 2010's | 12 (31.58) | 24.3611 |
| 2020's | 1 (2.63) | 2.80 |
| Authors | Studies |
|---|---|
| Strassburg, CP; Tukey, RH | 1 |
| Duffy, EM; Jorgensen, WL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Chang, TK; Ensom, MH; Kiang, TK | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Boezio, A; Butler, JR; Foti, RS; Kornecook, T; Ligutti, J; Milgram, BC; Moyer, BD; Rescourio, G; Shimanovich, R; Taborn, K; Weiss, M; Youngblood, BD; Yu, V | 1 |
| Ikeda, M; Itagaki, S; Ozawa, H; Shoji, T; Toyoguchi, Y | 1 |
| Back, DJ; Eagling, VA; Macleod, R; Sim, SM | 1 |
| Brown, CR; Bynum, LJ; Clarke, PJ; Dickie, G; Evans, SA; Moodie, JE; Smith, BA; Wild, VM | 1 |
| Abate, C; Amantea, B; Belfiore, F; Brando, G; Celano, S; Celentano, L; Cuocolo, R; Orlando, C; Santangelo, E; Savoia, G | 1 |
| Dellemijn, PL; Roos, PJ; van Vliet, JJ; Vecht, CJ; Verbiest, HB | 1 |
| Boer, C; de Lange, JJ; Treebus, AN; Zuurmond, WW | 1 |
| Jamison, RN; Katz, NP; Nedeljkovic, SS; Raymond, SA; Slawsby, EA | 1 |
| Archer, D; Breen, TW; Fick, G; Yang, T | 1 |
| Akyürek, C; Celik, C; Celik, JB; Reisli, R; Sarkilar, G; Tuncer, S | 1 |
| Boulet, J; Gottshall, S; Harrison, J; Mark, L; Pearson, M; Walker, K; Whiteside, GT | 1 |
| Roach, JT; Sufka, KJ | 1 |
| Barutçuoğlu, O; Erentuğ, V; Güzelmeriç, F; Kayacan, T; Koçak, T; Oğuş, H; Yaltirik, R | 1 |
| Jain, NK; Kulkarni, SK; Sharma, S | 1 |
| Chan, VW; Clark, AJ; Davis, JC; Jayawardene, S; Kellstein, D; Wolf, RS | 1 |
| Backman, SB; Christou, N; El Shobary, H; Gvocdic, B; Schricker, T | 1 |
| Laping, NJ; Leon, LA; Riedel, ES; Su, X | 1 |
| Atlas, S; Deshpande, A; Furlan, A; Mailis-Gagnon, A; Turk, D | 1 |
| Elmes, SJ; McIntosh, F; Perkins, MN; Rashid, MH; Theberge, Y | 1 |
| Abitbol, J; Cohen, E; Cohn, R; Gotlieb, WH; Hunter, S; Kessous, R; Large, N; Lau, S; Reiss, A; Rombaldi, M; Salvador, S | 1 |
| Antoniazzi, CTD; Dalenogare, DP; de Almeida, AS; De Prá, SD; Milioli, AM; Moresco, RN; Oliveira, SM; Pereira, GC; Peres, DS; Rigo, FK; Ritter, CDS; Stein, C; Trevisan, G | 1 |
| Alano, MA; Konduri, GG; Ngougmna, E; Ostrea, EM | 1 |
4 review(s) available for naproxen and morphine
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
UDP-glucuronosyltransferases and clinical drug-drug interactions.
Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Opioids for chronic low-back pain.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Humans; Low Back Pain; Morphine; Naproxen; Randomized Controlled Trials as Topic; Tramadol | 2007 |
7 trial(s) available for naproxen and morphine
| Article | Year |
|---|---|
Analgesic efficacy and safety of single-dose oral and intramuscular ketorolac tromethamine for postoperative pain.
Topics: Administration, Oral; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; Humans; Injections, Intramuscular; Ketorolac Tromethamine; Morphine; Naproxen; Pain Measurement; Pain, Postoperative; Tolmetin; Tromethamine | 1990 |
Medical therapy of malignant nerve pain. A randomised double-blind explanatory trial with naproxen versus slow-release morphine.
Topics: Adult; Aged; Aged, 80 and over; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle Aged; Morphine; Naproxen; Neoplasms; Neuralgia; Pain Measurement; Time Factors | 1994 |
Opioid therapy for chronic noncancer back pain. A randomized prospective study.
Topics: Activities of Daily Living; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Mood Disorders; Morphine; Naproxen; Oxycodone; Pain Measurement; Prospective Studies; Sleep; Surveys and Questionnaires; Treatment Outcome | 1998 |
Comparison of 0.25 mg and 0.1 mg intrathecal morphine for analgesia after Cesarean section.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cesarean Section; Female; Humans; Indomethacin; Injections, Spinal; Morphine; Naproxen; Pain Measurement; Pain, Postoperative | 1999 |
A comparative study of the effect of rofecoxib (a COX 2 inhibitor) and naproxen sodium on analgesic requirements after abdominal hysterectomy.
Topics: Adult; Analgesia; Cyclooxygenase Inhibitors; Dyspepsia; Female; Gastrointestinal Diseases; Heartburn; Humans; Hysterectomy; Lactones; Middle Aged; Morphine; Naproxen; Placebos; Postoperative Nausea and Vomiting; Premedication; Sulfones | 2003 |
[The effects of application of rectal naproxen on postoperative analgesia, sedation and morphine use in heart surgery operations].
Topics: Administration, Rectal; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Coronary Artery Bypass; Double-Blind Method; Female; Humans; Male; Middle Aged; Morphine; Naproxen; Pain Measurement; Pain, Postoperative; Treatment Outcome | 2004 |
The post-operative analgesic efficacy and tolerability of lumiracoxib compared with placebo and naproxen after total knee or hip arthroplasty.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Cyclooxygenase 2 Inhibitors; Diclofenac; Double-Blind Method; Female; Humans; Male; Middle Aged; Morphine; Naproxen; Organic Chemicals; Pain Measurement; Pain, Postoperative; Sample Size | 2005 |
27 other study(ies) available for naproxen and morphine
| Article | Year |
|---|---|
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Discovery of pyridyl urea sulfonamide inhibitors of Na
Topics: Humans; NAV1.7 Voltage-Gated Sodium Channel; Pain; Quinolones; Structure-Activity Relationship; Sulfanilamide; Sulfonamides; Urea; Voltage-Gated Sodium Channel Blockers | 2022 |
[Pharmacological studies on drug interaction. VI. Combined effect of adenyl compounds with anti-pyretics and analgesics (author's transl)].
Topics: Adenosine Monophosphate; Aminopyrine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Drug Antagonism; Drug Synergism; Female; Male; Mice; Morphine; Naproxen; Rats | 1978 |
In vitro inhibition studies of the glucuronidation of 3'-azido-3'-deoxythymidine catalysed by human liver UDP-glucuronosyl transferase.
Topics: Acquired Immunodeficiency Syndrome; Diazepam; Didanosine; Dose-Response Relationship, Drug; Flunitrazepam; Glucuronosyltransferase; Humans; Kinetics; Microsomes, Liver; Morphine; Naproxen; Zidovudine | 1992 |
[Potentiating drugs in postoperative pain control with opiates for patient controlled analgesia].
Topics: Analgesia; Anti-Anxiety Agents; Benzamides; Benzodiazepines; Buprenorphine; Clomipramine; Drug Synergism; Humans; Morphine; Naproxen; Nordazepam; Pain, Postoperative; Patients; Trazodone | 1988 |
Compliance in administration of prescribed analgesics.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Codeine; Drug Administration Schedule; Female; Guideline Adherence; Hospitals, University; Humans; Middle Aged; Morphine; Naproxen; Netherlands; Pain, Postoperative | 1997 |
Pharmacological characterisation of a rat model of incisional pain.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Evaluation, Preclinical; Etoricoxib; Foot; Gabapentin; gamma-Aminobutyric Acid; Hindlimb; Hyperalgesia; Indomethacin; Male; Morphine; Muscle, Skeletal; Naproxen; Nociceptors; Pain Threshold; Pain, Postoperative; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sulfonamides; Sulfones; Time Factors; Weight-Bearing | 2004 |
Characterization of the chick carrageenan response.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Animals, Newborn; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Chickens; Cyclooxygenase Inhibitors; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Edema; Hyperalgesia; Inflammation; Morphine; Naproxen; Pain Measurement; Reaction Time; Time Factors | 2003 |
Possible analgesic and anti-inflammatory interactions of aspartame with opioids and NSAIDs.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspartame; Carrageenan; Drug Interactions; Edema; Inflammation; Mice; Morphine; Naproxen; Narcotics; Pain; Pain Measurement; Pentazocine; Rats; Rats, Wistar; Sulfonamides; Sweetening Agents; Time Factors | 2005 |
Effect of laparoscopic versus open gastric bypass surgery on postoperative pain and bowel function.
Topics: Administration, Rectal; Adult; Analgesia, Patient-Controlled; Anti-Inflammatory Agents, Non-Steroidal; Female; Gastric Bypass; Gastrointestinal Motility; Humans; Laparoscopy; Male; Middle Aged; Morphine; Naproxen; Narcotics; Obesity, Morbid; Pain Measurement; Pain, Postoperative; Postoperative Period; Prospective Studies; Recovery of Function | 2006 |
Pharmacologic evaluation of pressor and visceromotor reflex responses to bladder distension.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Blood Pressure; Cardiovascular System; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Mandelic Acids; Mexiletine; Models, Animal; Morphine; Muscarinic Antagonists; Muscle Contraction; Muscle, Skeletal; Naproxen; Nociceptors; Pressure; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Sodium Channel Blockers; Sodium Channels; Urinary Bladder | 2008 |
Pharmacological validation of early and late phase of rat mono-iodoacetate model using the Tekscan system.
Topics: Alkylating Agents; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Chronic Disease; Dexamethasone; Dinoprostone; Disease Models, Animal; Duloxetine Hydrochloride; Hindlimb; Iodoacetates; Male; Morphine; Muscle Fibers, Skeletal; Naproxen; Neurons, Afferent; Pain Measurement; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Restraint, Physical; Synovial Fluid; Thiophenes; Weight-Bearing | 2013 |
Minimizing pain medication use and its associated costs following robotic surgery.
Topics: Acetaminophen; Aged; Analgesia, Patient-Controlled; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Drug Costs; Electronic Health Records; Endometrial Neoplasms; Female; Humans; Ibuprofen; Middle Aged; Minimally Invasive Surgical Procedures; Morphine; Naproxen; Pain, Postoperative; Retrospective Studies; Robotic Surgical Procedures | 2017 |
Characterization of Cancer-Induced Nociception in a Murine Model of Breast Carcinoma.
Topics: Acetaminophen; Analgesics; Animals; Benzoxazines; Bone Neoplasms; Calcium; Cannabinoids; Cell Line, Tumor; Codeine; Disease Models, Animal; Female; Hyperalgesia; Locomotion; Mammary Neoplasms, Animal; Mice, Inbred BALB C; Morphine; Morpholines; Naphthalenes; Naproxen; Nociception; Pain Measurement | 2019 |
Analysis of nonsteroidal antiinflammatory drugs in meconium and its relation to persistent pulmonary hypertension of the newborn.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bronchodilator Agents; Extracorporeal Membrane Oxygenation; Female; Gas Chromatography-Mass Spectrometry; Humans; Ibuprofen; Infant, Newborn; Logistic Models; Meconium; Naproxen; Nitric Oxide; Persistent Fetal Circulation Syndrome; Pregnancy; Prenatal Exposure Delayed Effects; Risk | 2001 |