naproxen has been researched along with colchicine in 28 studies
| Studies (naproxen) | Trials (naproxen) | Recent Studies (post-2010) (naproxen) | Studies (colchicine) | Trials (colchicine) | Recent Studies (post-2010) (colchicine) |
|---|---|---|---|---|---|
| 4,551 | 1,057 | 1,429 | 15,472 | 404 | 2,974 |
| Protein | Taxonomy | naproxen (IC50) | colchicine (IC50) |
|---|---|---|---|
| Tubulin alpha-1A chain | Sus scrofa (pig) | 3.7639 | |
| Tubulin beta chain | Sus scrofa (pig) | 3.8663 | |
| Tubulin beta-4A chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta chain | Homo sapiens (human) | 2.7244 | |
| Tubulin alpha-3C chain | Homo sapiens (human) | 2.4334 | |
| Serine/threonine-protein kinase pim-1 | Homo sapiens (human) | 4.3 | |
| Tubulin alpha-1B chain | Homo sapiens (human) | 2.4334 | |
| Tubulin alpha-4A chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta-4B chain | Homo sapiens (human) | 2.4334 | |
| Vesicular acetylcholine transporter | Tetronarce californica (Pacific electric ray) | 2.62 | |
| Tubulin beta-3 chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta-2A chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta-8 chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta-2B chain | Bos taurus (cattle) | 2.8255 | |
| Tubulin alpha-3E chain | Homo sapiens (human) | 2.4334 | |
| Tubulin alpha-1A chain | Homo sapiens (human) | 2.4334 | |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | 3.0611 | |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | 3.1553 | |
| Tubulin alpha-1C chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta-6 chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta-2B chain | Homo sapiens (human) | 2.4334 | |
| Tubulin beta-1 chain | Homo sapiens (human) | 2.4334 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (21.43) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (7.14) | 29.6817 |
| 2010's | 16 (57.14) | 24.3611 |
| 2020's | 4 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Millonig, RC; Rovnyak, GC; Schwartz, J; Shu, V | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Akbar, M; Burke, G; Park, S; Richman, R; Yu, S | 1 |
| Roe, RL | 1 |
| Emmerson, BT | 1 |
| Alvsaker, JO | 1 |
| Kelley, WN; Palella, TD | 1 |
| Kumar, A; Naidu, PS; Padi, SV; Seghal, N | 1 |
| Dutta, G; Ghosh, T; Goswami, AR; Sil, S | 1 |
| Khan, ZM; Mahmood, RK; Mehmood, Y; Raza, SA; Riaz, H; Saleem, N; Yousaf, H | 1 |
| Bucci, G; Gillen, M; Kerr, B; Lee, C; Shen, Z; Tieu, K; Wilson, D | 1 |
| Gittler, J; Kahn, P; Meehan, S; Oza, VS; Stringer, T | 1 |
| Becker, MA; Castillo, M; Gunawardhana, L; Hunt, B; Kisfalvi, K; Saag, KG; Whelton, A | 1 |
| Heck, A; Nolan, N; Rojas-Moreno, C | 1 |
| Avery, A; Blagojevic-Bucknall, M; Clarkson, K; Hartshorne, L; Hay, EM; Heneghan, C; Hooper, J; Hughes, G; Jowett, S; Lewis, M; Little, P; Mahtani, KR; Mallen, CD; McCartney, K; Mehta, R; Nunan, D; Oppong, R; Roddy, E; Santer, M; Williams, S | 1 |
| Parperis, K | 1 |
| Mallen, CD; Roddy, E | 1 |
| Ferraccioli, G; Gremese, E; Zanardi, R | 1 |
3 review(s) available for naproxen and colchicine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Drug therapy in rheumatic diseases.
Topics: Acetaminophen; Adrenal Cortex Hormones; Antimalarials; Aspirin; Colchicine; Fenoprofen; Gold; Humans; Ibuprofen; Indomethacin; Levamisole; Naproxen; Penicillamine; Phenylbutazone; Rheumatic Diseases; Tolmetin | 1977 |
Drug control of gout and hyperuricaemia.
Topics: Allopurinol; Arthritis; Chronic Disease; Colchicine; Gout; Humans; Indomethacin; Naproxen; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1978 |
2 trial(s) available for naproxen and colchicine
| Article | Year |
|---|---|
Efficacy and Safety of Febuxostat Extended and Immediate Release in Patients With Gout and Renal Impairment: A Phase III Placebo-Controlled Study.
Topics: Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Colchicine; Cough; Creatinine; Delayed-Action Preparations; Diarrhea; Double-Blind Method; Drug Therapy, Combination; Febuxostat; Female; gamma-Glutamyltransferase; Glomerular Filtration Rate; Gout; Gout Suppressants; Headache; Humans; Hypertension; Male; Middle Aged; Naproxen; Nasopharyngitis; Renal Insufficiency, Chronic; Respiratory Tract Infections; Severity of Illness Index; Treatment Outcome; Uric Acid | 2019 |
Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care.
Topics: Colchicine; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Naproxen; Primary Health Care; Symptom Flare Up; Treatment Outcome | 2020 |
23 other study(ies) available for naproxen and colchicine
| Article | Year |
|---|---|
Synthesis and antiinflammatory activity of hexahydrothiopyrano[4,3-c]pyrazoles and related analogues.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthus Reaction; Chemical Phenomena; Chemistry; Edema; Guinea Pigs; Hypersensitivity, Delayed; Male; Mice; Pyrazoles; Rats; Rats, Inbred Lew; Rats, Inbred Strains | 1982 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Regulation of thyroid ornithine ornithine decarboxylase (ODC) by thyrotropin. I. The rat.
Topics: Animals; Arachidonic Acids; Aspirin; Bucladesine; Carboxy-Lyases; Colchicine; Cyclic AMP; Indomethacin; Kinetics; Male; Naproxen; Organ Size; Ornithine Decarboxylase; Phenylbutazone; Prostaglandins E; Putrescine; Rats; Thyroid Gland; Thyrotropin; Time Factors; Triiodothyronine; Vinblastine | 1975 |
[Pharmacotherapy in uratic arthritis. I].
Topics: Acute Disease; Colchicine; Gout; Humans; Indomethacin; Naphthaleneacetic Acids; Naproxen; Phenylbutazone | 1977 |
An approach to hyperuricemia and gout.
Topics: Allopurinol; Anti-Inflammatory Agents; Colchicine; Female; Gout; Humans; Male; Naproxen; Phenylbutazone; Prognosis; Sulfinpyrazone; Uric Acid | 1984 |
Differential effects of cyclooxygenase inhibitors on intracerebroventricular colchicine-induced dysfunction and oxidative stress in rats.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Cognition Disorders; Colchicine; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Injections, Intraventricular; Isoxazoles; Lipid Peroxidation; Male; Maze Learning; Memory; Naproxen; Nitrites; Oxidative Stress; Rats; Rats, Wistar; Space Perception; Spatial Behavior; Sulfonamides; Time Factors | 2006 |
Effects of naproxen on immune responses in a colchicine-induced rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Brain; Colchicine; Cytokines; Disease Models, Animal; Hydrocortisone; Lymphocytes; Male; Naproxen; Nitrites; Phagocytes; Plaque, Amyloid; Rats; Reactive Oxygen Species; Spleen; Time Factors; Tubulin Modulators | 2014 |
Formulation and in vitro evaluation of colchicines and naproxen sodium sustain release tablets in combination for treatment of gout.
Topics: Administration, Oral; Colchicine; Delayed-Action Preparations; Drug Combinations; Drug Compounding; Drug Stability; Gout Suppressants; Hypromellose Derivatives; Kinetics; Models, Chemical; Naproxen; Solubility; Tablets; Water | 2016 |
Evaluation of Pharmacokinetic Interactions Between Lesinurad, a New Selective Urate Reabsorption Inhibitor, and Commonly Used Drugs for Gout Treatment.
Topics: Adult; Aged; Aged, 80 and over; Colchicine; Drug Administration Schedule; Drug Interactions; Female; Gout Suppressants; Humans; Hyperuricemia; Indomethacin; Male; Middle Aged; Naproxen; Thioglycolates; Treatment Outcome; Triazoles; Uricosuric Agents; Young Adult | 2017 |
Neutrophilic urticarial dermatosis as a presenting feature of systemic juvenile idiopathic arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Child, Preschool; Colchicine; Glucocorticoids; Humans; Immunosuppressive Agents; Male; Methotrexate; Naproxen; Prednisolone; Skin; Sweet Syndrome; Tubulin Modulators | 2018 |
Crowned Dens Syndrome: Calcium Pyrophosphate Deposition Disease Masquerading as Osteomyelitis.
Topics: Aged; Calcinosis; Chondrocalcinosis; Colchicine; Diagnosis, Differential; Female; Gout Suppressants; Humans; Naproxen; Neck Pain; Odontoid Process; Osteomyelitis; Syndrome; Tomography Scanners, X-Ray Computed; Treatment Outcome | 2018 |
Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care.
Topics: Colchicine; Gout; Gout Suppressants; Humans; Naproxen; Primary Health Care; Symptom Flare Up | 2021 |
Response to: 'Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care' by Parperis
Topics: Colchicine; Gout; Gout Suppressants; Humans; Naproxen; Primary Health Care; Symptom Flare Up | 2021 |
Case report: crowned dens syndrome in a patient with seronegative rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Chondrocalcinosis; Colchicine; Humans; Methotrexate; Naproxen; Neck Pain; Syndrome | 2023 |