Page last updated: 2024-12-05

acridan

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Acridan is a tricyclic heterocyclic compound with a central ring consisting of three carbons and a nitrogen atom. It is a parent compound for a variety of acridine derivatives, which exhibit a wide range of biological activities. Acridan itself is not typically found in nature, but it can be synthesized through various chemical reactions. One common method involves the reduction of acridine using reducing agents like sodium borohydride. Acridan derivatives have been extensively studied for their potential applications in medicine, including as anti-cancer agents, anti-bacterial agents, and anti-inflammatory agents. Some acridan derivatives have also been explored for their use as dyes and pigments due to their fluorescent properties. The study of acridan and its derivatives is driven by their potential medicinal and technological applications.'

Cross-References

ID SourceID
PubMed CID7106
CHEMBL ID304205
SCHEMBL ID183367
MeSH IDM0058091

Synonyms (35)

Synonym
nsc 41239
einecs 202-192-3
LS-14187
ai3-09022
carbazine
acridane
acridan
nsc-41239
wln: t c666 bm ihj
nsc41239
acridine,10-dihydro-
inchi=1/c13h11n/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)14-12/h1-8,14h,9h
92-81-9
acridine, 9,10-dihydro-
9,10-dihydroacridine
CHEMBL304205 ,
9,10-dihydro-acridine
FT-0693016
bdbm50012868
AKOS006272322
itv7ra4y9p ,
unii-itv7ra4y9p
SCHEMBL183367
9,10-dihydroacridin
9,10 dihydroacridine
9,10-dihydroacridine #
DTXSID4073887
9,10-dihydroacridine, aldrichcpr
D5058
9-aza-9,10-dihydroanthracene
Q63408668
mfcd00022256
D90359
CS-0187293
SY056562
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Polyunsaturated fatty acid 5-lipoxygenaseRattus norvegicus (Norway rat)IC50 (µMol)1.60000.00462.018210.0000AID6824
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)IC50 (µMol)1.90000.00291.786810.0000AID160880
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)IC50 (µMol)1.90000.00291.823210.0000AID160880
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID160880In vitro inhibition of Prostaglandin G/H synthase pathway in rat basophilic leukemia (RBL-1) cells1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
1,2-Dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with antiinflammatory activity.
AID6824In vitro inhibition of 5-lipoxygenase pathway in rat basophilic leukemia (RBL-1) cells1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
1,2-Dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with antiinflammatory activity.
AID673777Cytotoxicity in UV-irradiated human U937 cells exposed to photosensitizer for 2 hrs before irradiation for 20 mins by WST-1 assay2012ACS medicinal chemistry letters, Apr-12, Volume: 3, Issue:4
Type 1 Phototherapeutic Agents. 2. Cancer Cell Viability and ESR Studies of Tricyclic Diarylamines.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (25.00)18.2507
2000's1 (12.50)29.6817
2010's4 (50.00)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 52.09

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index52.09 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.73 (4.65)
Search Engine Demand Index79.51 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (52.09)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (10.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]