naproxen has been researched along with ascorbic acid in 17 studies
| Studies (naproxen) | Trials (naproxen) | Recent Studies (post-2010) (naproxen) | Studies (ascorbic acid) | Trials (ascorbic acid) | Recent Studies (post-2010) (ascorbic acid) |
|---|---|---|---|---|---|
| 4,551 | 1,057 | 1,429 | 45,261 | 2,497 | 11,176 |
| Protein | Taxonomy | naproxen (IC50) | ascorbic acid (IC50) |
|---|---|---|---|
| Chain A, Hyaluronidase, phage associated | Streptococcus pyogenes | 1000 | |
| Urease | Canavalia ensiformis (jack bean) | 8.59 | |
| Solute carrier family 23 member 1 | Homo sapiens (human) | 156 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 11 (64.71) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Ameen, BAH; Dissanayake, AA; Nair, MG | 1 |
| Ding, F; Gao, Y; Guo, Y; He, X; Li, S; Li, X; Liu, Z; Nie, Y; Wen, D; Zhang, Y; Zhong, M | 1 |
| van der Meer, J | 1 |
| Awazu, S; Horie, T; Yokoyama, H | 1 |
| Dhir, A; Kulkarni, SK; Naidu, PS; Padi, SS | 1 |
| Gemeiner, P; Kogan, G; Mendichi, R; Sasinková, V; Soltés, L; Stankovská, M; Volpi, N | 1 |
| Mahmoud, S; Mohammad, A | 1 |
| Sheha, M | 1 |
| Kruhlak, NL; Zhu, X | 1 |
| Fu, Q; Guo, L; Hai, L; Lu, R; Wang, L; Wu, Y; Xiao, W; Zhang, L; Zhao, Y | 1 |
| Cai, T; Chen, L; Feng, R; Jiang, C; Li, W | 1 |
1 review(s) available for naproxen and ascorbic acid
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
16 other study(ies) available for naproxen and ascorbic acid
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Lipid Peroxidation and Cyclooxygenase Enzyme Inhibitory Compounds from Prangos haussknechtii.
Topics: Anti-Inflammatory Agents; Antioxidants; Coumarins; Cyclooxygenase Inhibitors; Lipid Peroxidation; Molecular Structure; Plant Extracts; Tetrazoles; Tetrazolium Salts; Thiazoles | 2017 |
New organoselenides (NSAIDs-Se derivatives) as potential anticancer agents: Synthesis, biological evaluation and in silico calculations.
Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Organoselenium Compounds; Structure-Activity Relationship; Tumor Cells, Cultured | 2021 |
[New drugs. 20: Blocadren, Diprosone, Eryfer, Ludiomil and Naprpsyne].
Topics: Adrenergic beta-Antagonists; Anthracenes; Ascorbic Acid; Betamethasone; Bicarbonates; Drug Combinations; Ferrous Compounds; Iron; Maprotiline; Naphthaleneacetic Acids; Naproxen; Propanolamines; Sulfates; Thiadiazoles | 1975 |
Lipid peroxidation and chemiluminescence during naproxen metabolism in rat liver microsomes.
Topics: Animals; Antimutagenic Agents; Antioxidants; Ascorbic Acid; Cobalt; Electrophoresis, Polyacrylamide Gel; Ferrous Compounds; Histidine; Lipid Peroxidation; Luminescent Measurements; Magnesium Chloride; Male; Microsomes, Liver; Molecular Weight; NADP; Naproxen; Piperonyl Butoxide; Proadifen; Rats; Rats, Wistar; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances; Vitamin E | 1994 |
Protective effect of naproxen (non-selective COX-inhibitor) or rofecoxib (selective COX-2 inhibitor) on immobilization stress-induced behavioral and biochemical alterations in mice.
Topics: Adrenal Glands; Analysis of Variance; Animals; Anxiety; Ascorbic Acid; Behavior, Animal; Biomarkers; Brain; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Administration Schedule; Glutathione; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Lactones; Lipid Peroxidation; Male; Maze Learning; Mice; Motor Activity; Naproxen; Nitrites; Protective Agents; Restraint, Physical; Stress, Psychological; Sulfones | 2006 |
Degradation of high-molar-mass hyaluronan by an oxidative system comprising ascorbate, Cu(II), and hydrogen peroxide: inhibitory action of antiinflammatory drugs--naproxen and acetylsalicylic acid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Ascorbic Acid; Aspirin; Cations, Divalent; Chromatography, Gel; Chromatography, High Pressure Liquid; Copper; Hyaluronic Acid; Hydrogen Peroxide; Molecular Structure; Molecular Weight; Naproxen; Oxidants; Oxidation-Reduction; Solutions; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Viscosity | 2007 |
Brain-specific delivery of naproxen using different carrier systems.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Body Fluids; Brain; Cyclooxygenase Inhibitors; Dihydropyridines; Drug Carriers; Humans; Hydrolysis; Naproxen; Prodrugs; Solutions | 2010 |
Pharmacokinetic and ulcerogenic studies of naproxen prodrugs designed for specific brain delivery.
Topics: Administration, Oral; Animals; Ascorbic Acid; Biological Availability; Blood-Brain Barrier; Brain; Dihydropyridines; Drug Design; Male; Naproxen; Neuroprotective Agents; Prodrugs; Protein Binding; Rats; Rats, Sprague-Dawley; Stomach Ulcer | 2012 |
Construction and analysis of a human hepatotoxicity database suitable for QSAR modeling using post-market safety data.
Topics: Algorithms; Ampicillin; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Bile Duct Diseases; Calibration; Chemical and Drug Induced Liver Injury; Cholestasis; Data Mining; Databases, Factual; Drug Labeling; Endpoint Determination; Humans; Levofloxacin; Liver; Naproxen; Product Surveillance, Postmarketing; Quantitative Structure-Activity Relationship; Toxicity Tests; Vitamins | 2014 |
Design, synthesis, and neuroprotective effects of dual-brain targeting naproxen prodrug.
Topics: Animals; Ascorbic Acid; Brain; Drug Delivery Systems; Drug Design; Drug Liberation; Glucose; Male; Mice; Naproxen; Neuroprotective Agents; Prodrugs; Rats; Rats, Wistar | 2018 |
Activation of persulfate with natural organic acids (ascorbic acid/catechin hydrate) for naproxen degradation in water and soil: Mechanism, pathway, and toxicity assessment.
Topics: Ascorbic Acid; Catechin; Escherichia coli; Naproxen; Oxidation-Reduction; Soil; Water; Water Pollutants, Chemical | 2023 |