Page last updated: 2024-09-04

naproxen and Gastroduodenal Ulcer

naproxen has been researched along with Gastroduodenal Ulcer in 47 studies

Research

Studies (47)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (10.64)	18.7374
1990's	15 (31.91)	18.2507
2000's	23 (48.94)	29.6817
2010's	3 (6.38)	24.3611
2020's	1 (2.13)	2.80

Authors

Authors	Studies
Laverty, RB; Sokol, KK; Sparkman, BK; Yoon, BS	1
Danhof, M; Della Pasqua, O; Sahota, T; Sanderson, I	1
Aisenberg, J; Bamji, N; Bodian, C; Brooks, A; Cohen, L; Desai, J; Dikman, A; Miller, K; Sanyal, S; VON Althann, C; Whitson, M	1
Abreu, MT; Aisenberg, J; Brooks, A; Cohen, L; Desai, JC; Dikman, A; Fukata, M; Goo, T; Miller, K; Sanyal, S; Wang, Q	1
Fort, J; Sostek, M; Wang-Smith, L; Zhang, Y	1
Bercik, P; Bolla, M; Collins, SM; de Palma, G; Denou, E; Jury, J; McKnight, W; Ongini, E; Syer, S; Verdu, E; Vong, L; Wallace, JL	1
Evans, J; Hawkey, CJ; Laine, L; Quan, H; Shingo, S; Simon, T	1
Bias, P; Buchner, A; Klesser, B; Laufer, S	1
Ehrsam, E; Farkouh, M; Gitton, X; Hawkey, CJ; Huels, J; Richardson, P	1
Bolin, L; Genti, G; Kalla, A; Lohmander, LS; Malmenäs, M; McKeith, D; Ramos-Remus, C; Svensson, O; Szechinski, J	1
McCarthy, DM	1
Ashworth, NL; Muhajarine, N; Peloso, PM; Stang, M	1
Chan, AO; Chu, KM; Hu, WH; Hui, WM; Lai, KC; Lam, SK; Wong, BC; Wong, J; Wong, WM	1
Castellsague, J; Maguire, A; Perez-Gutthann, S; Varas-Lorenzo, C	1
Andriulli, A; Colaizzo, D; Dallapiccola, B; Di Mario, F; Franceschi, M; Grandone, E; Leandro, G; Niro, V; Pilotto, A; Scarcelli, C; Seripa, D	1
Bianchi Porro, G; Caruso, I; Imbesi, V; Montrone, F; Petrillo, M	1
Bennett, R; Caldron, P; Koepp, R; Mitchell, C; Roth, SH; Swenson, C	1
Bruyn, GA; Geis, GS; Melo Gomes, JA; Roth, SH; Woods, EM; Zeeh, J	1
Dobson, A; Henry, D; Turner, C	1
Devane, J; Hawkey, C; McCarthy, C; Murray, F; O'Morain, C; Tierney, D	1
Appleyard, CB; Calignano, A; Cirino, G; Davies, NM; Del Soldato, P; McKnight, W; Røseth, AG; Wallace, JL	1
Metz, DC	1
Lanas Arbeloa, A; Serrano Aulló, MT	1
Dajani, EZ	1
Fendrick, AM; Jeffries, MA; Scheiman, JM	1
Geis, GS; Graham, DY; Hubbard, RC; Isakson, PC; Kivitz, AJ; Lipsky, PE; Simon, LS; Verburg, KM; Weaver, AL; Yu, SS; Zhao, WW	1
Megeff, CE; Strayer, SM	1
Bombardier, C; Burgos-Vargas, R; Davis, B; Day, R; Ferraz, MB; Hawkey, CJ; Hochberg, MC; Kvien, TK; Laine, L; Reicin, A; Schnitzer, TJ; Shapiro, D	1
Tive, L	1
Burr, AM; Correa, P; Geis, GS; Goldstein, JL; Hubbard, RC; Verburg, KM; Zhao, WW	1
Kellner, H	1
Goldstein, JL; Harris, SI; Hubbard, RC; Kuss, M	1
Hawkey, CJ; Jones, JI	1
Miyake, K; Sakamoto, C	1
Shaughnessy, AF	1
Boyle, E; Freeman, PC; Goudie, AC; Mangan, FR; Thomson, M	1
Turner, R	1
Lambert, JR; Peacock, T; Sievert, W; Stern, AI	1
Laine, L	1
Roth, SH	1
Gerson, CD; Gupta, R; Kornbluth, A	1
Rugstad, HE	1
Meisel, AD	1
Husby, G	1

Reviews

6 review(s) available for naproxen and Gastroduodenal Ulcer

Article	Year
Ulcers, Helicobacter pylori infection, platelets and gastrointestinal complications of non-steroidal anti-inflammatory drugs: what are the connections? The European journal of surgery. Supplement. : = Acta chirurgica. Supplement, 2002, Issue:587 Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cyclooxygenase Inhibitors; Diclofenac; Gastrointestinal Hemorrhage; Helicobacter Infections; Humans; Ibuprofen; Lactones; Naproxen; Peptic Ulcer; Risk Factors; Sulfones	2002
[Gastric lesion caused by NSAID and inflammation due to Helicobacter pylori. Is there potentiation or attenuation?]. Gastroenterologia y hepatologia, 1998, Volume: 21 Suppl 1 Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Clinical Trials as Topic; Confidence Intervals; Duodenal Ulcer; Enzyme Inhibitors; Gastritis; Helicobacter Infections; Helicobacter pylori; Histamine H2 Antagonists; Humans; Multicenter Studies as Topic; Naproxen; Omeprazole; Peptic Ulcer; Prospective Studies; Ranitidine; Risk Factors; Stomach Ulcer	1998
Celecoxib clinical profile. Rheumatology (Oxford, England), 2000, Volume: 39 Suppl 2 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cardiovascular Diseases; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Humans; Ibuprofen; In Vitro Techniques; Isoenzymes; Kidney Diseases; Membrane Proteins; Middle Aged; Naproxen; Osteoarthritis; Pain; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Randomized Controlled Trials as Topic; Sulfonamides; Treatment Outcome	2000
Gastrointestinal safety of COX-2 specific inhibitors. Gastroenterology clinics of North America, 2001, Volume: 30, Issue:4 Topics: Adrenal Cortex Hormones; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Synergism; Helicobacter Infections; Humans; Isoenzymes; Lactones; Membrane Proteins; Naproxen; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Sulfones	2001
[Prophylaxis against non-steroidal anti-inflammatory drug-associated ulcers and erosions]. Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Delivery Systems; Drug Therapy, Combination; Enzyme Inhibitors; Helicobacter Infections; Helicobacter pylori; Histamine H2 Antagonists; Humans; Isoenzymes; Lactones; Membrane Proteins; Naproxen; Omeprazole; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Proton Pump Inhibitors; Sulfones	2002
NSAID gastropathy. The central issue. Drugs, 1990, Volume: 40 Suppl 5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Butanones; Humans; Nabumetone; Naproxen; Peptic Ulcer	1990

Trials

23 trial(s) available for naproxen and Gastroduodenal Ulcer

Article	Year
A randomized, placebo-controlled study of the effects of naproxen, aspirin, celecoxib or clopidogrel on gastroduodenal mucosal healing. Alimentary pharmacology & therapeutics, 2009, Apr-01, Volume: 29, Issue:7 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Clopidogrel; Drug Administration Schedule; Female; Gastric Mucosa; Humans; Male; Middle Aged; Naproxen; Peptic Ulcer; Pilot Projects; Pyrazoles; Sulfonamides; Ticlopidine; Young Adult	2009
Pharmacokinetics and relative bioavailability of a fixed-dose combination of enteric-coated naproxen and non-enteric-coated esomeprazole magnesium. Journal of clinical pharmacology, 2012, Volume: 52, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Biological Availability; Capsules; Cross-Over Studies; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Esomeprazole; Female; Humans; Least-Squares Analysis; Male; Middle Aged; Models, Biological; Naproxen; Peptic Ulcer; Prospective Studies; Proton Pump Inhibitors; Tablets, Enteric-Coated; Young Adult	2012
Incidence of gastroduodenal ulcers in patients with rheumatoid arthritis after 12 weeks of rofecoxib, naproxen, or placebo: a multicentre, randomised, double blind study. Gut, 2003, Volume: 52, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Lactones; Life Tables; Male; Middle Aged; Naproxen; Peptic Ulcer; Risk Factors; Sulfones	2003
The gastrointestinal tolerability of the LOX/COX inhibitor, licofelone, is similar to placebo and superior to naproxen therapy in healthy volunteers: results from a randomized, controlled trial. The American journal of gastroenterology, 2004, Volume: 99, Issue:4 Topics: Acetates; Adult; Cyclooxygenase Inhibitors; Duodenoscopy; Duodenum; Female; Gastric Mucosa; Gastroscopy; Humans; Incidence; Intestinal Mucosa; Lipoxygenase Inhibitors; Male; Naproxen; Peptic Ulcer; Pyrroles	2004
Therapeutic arthritis research and gastrointestinal event trial of lumiracoxib - study design and patient demographics. Alimentary pharmacology & therapeutics, 2004, Jul-01, Volume: 20, Issue:1 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Health Status; Humans; Ibuprofen; Isoenzymes; Membrane Proteins; Middle Aged; Naproxen; Organic Chemicals; Osteoarthritis; Peptic Ulcer; Prognosis; Prostaglandin-Endoperoxide Synthases; Risk Factors	2004
A randomised, placebo controlled, comparative trial of the gastrointestinal safety and efficacy of AZD3582 versus naproxen in osteoarthritis. Annals of the rheumatic diseases, 2005, Volume: 64, Issue:3 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Male; Middle Aged; Naphthalenes; Naproxen; Osteoarthritis, Hip; Osteoarthritis, Knee; Peptic Ulcer; Quality of Life; Treatment Outcome	2005
Celecoxib compared with lansoprazole and naproxen to prevent gastrointestinal ulcer complications. The American journal of medicine, 2005, Volume: 118, Issue:11 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Dyspepsia; Female; Follow-Up Studies; Helicobacter Infections; Helicobacter pylori; Humans; Incidence; Lansoprazole; Male; Middle Aged; Naproxen; Omeprazole; Peptic Ulcer; Peptic Ulcer Hemorrhage; Prospective Studies; Proton Pump Inhibitors; Pyrazoles; Recurrence; Risk Factors; Sulfonamides; Treatment Outcome	2005
Gastroduodenal tolerability of nabumetone versus naproxen in the treatment of rheumatic patients. The American journal of gastroenterology, 1995, Volume: 90, Issue:9 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Butanones; Double-Blind Method; Duodenitis; Endoscopy, Gastrointestinal; Female; Gastric Mucosa; Gastritis; Humans; Intestinal Mucosa; Male; Middle Aged; Nabumetone; Naproxen; Peptic Ulcer	1995
A longterm endoscopic evaluation of patients with arthritis treated with nabumetone vs naproxen. The Journal of rheumatology, 1994, Volume: 21, Issue:6 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Butanones; Double-Blind Method; Female; Follow-Up Studies; Gastroscopy; Humans; Male; Middle Aged; Nabumetone; Naproxen; Osteoarthritis; Peptic Ulcer; Prospective Studies; Time Factors	1994
Double-blind comparison of efficacy and gastroduodenal safety of diclofenac/misoprostol, piroxicam, and naproxen in the treatment of osteoarthritis. Annals of the rheumatic diseases, 1993, Volume: 52, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Diclofenac; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Misoprostol; Naproxen; Osteoarthritis; Peptic Ulcer; Piroxicam	1993
Two comparative endoscopic evaluations of Naprelan. American journal of orthopedics (Belle Mead, N.J.), 1996, Volume: 25, Issue:9 Suppl Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Delayed-Action Preparations; Digestive System; Double-Blind Method; Endoscopy, Gastrointestinal; Humans; Male; Naproxen; Peptic Ulcer; Single-Blind Method	1996
Eradicate the bug before you start the drug? The American journal of gastroenterology, 1998, Volume: 93, Issue:2 Topics: Antacids; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Helicobacter Infections; Helicobacter pylori; Humans; Metronidazole; Naproxen; Organometallic Compounds; Peptic Ulcer; Prospective Studies; Tetracycline	1998
Helicobacter pylori eradication: kill the bug and save the pill? The American journal of gastroenterology, 1998, Volume: 93, Issue:7 Topics: Antacids; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bismuth; Follow-Up Studies; Helicobacter Infections; Helicobacter pylori; Humans; Metronidazole; Naproxen; Peptic Ulcer; Prospective Studies; Risk Factors; Single-Blind Method; Tetracycline	1998
Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial. JAMA, 1999, Nov-24, Volume: 282, Issue:20 Topics: Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Duodenum; Endoscopy, Gastrointestinal; Female; Gastric Mucosa; Humans; Intestinal Mucosa; Isoenzymes; Male; Membrane Proteins; Middle Aged; Naproxen; Peptic Ulcer; Prospective Studies; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides	1999
Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. The New England journal of medicine, 2000, 11-23, Volume: 343, Issue:21 Topics: Adult; Arthritis, Rheumatoid; Cardiovascular Diseases; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Duodenal Obstruction; Female; Gastric Outlet Obstruction; Gastrointestinal Diseases; Gastrointestinal Hemorrhage; Humans; Isoenzymes; Lactones; Male; Membrane Proteins; Middle Aged; Naproxen; Peptic Ulcer; Proportional Hazards Models; Prostaglandin-Endoperoxide Synthases; Sulfones	2000
Reduced incidence of gastroduodenal ulcers with celecoxib, a novel cyclooxygenase-2 inhibitor, compared to naproxen in patients with arthritis. The American journal of gastroenterology, 2001, Volume: 96, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Celecoxib; Cyclooxygenase Inhibitors; Double-Blind Method; Endoscopy, Gastrointestinal; Female; Humans; Incidence; Male; Middle Aged; Naproxen; Peptic Ulcer; Pyrazoles; Risk Factors; Sulfonamides	2001
[The selective Cox-2 inhibition by rofecoxib reduces risk of severe gastrointestinal complications of anti-inflammatory therapy by more than 50%]. Zeitschrift fur Gastroenterologie, 2001, Volume: 39, Issue:5 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Endoscopy, Gastrointestinal; Female; Humans; Lactones; Male; Middle Aged; Naproxen; Peptic Ulcer; Prospective Studies; Sulfones	2001
Upper gastrointestinal safety evaluation of parecoxib sodium, a new parenteral cyclooxygenase-2-specific inhibitor, compared with ketorolac, naproxen, and placebo. Clinical therapeutics, 2001, Volume: 23, Issue:9 Topics: Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Gastric Mucosa; Humans; Infusions, Parenteral; Isoenzymes; Isoxazoles; Ketorolac; Male; Membrane Proteins; Naproxen; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases	2001
Low-dose antacids and nonsteroidal anti-inflammatory drug-induced gastropathy in humans. Journal of clinical gastroenterology, 1991, Volume: 13 Suppl 1 Topics: Adolescent; Adult; Aged; Aluminum Hydroxide; Analysis of Variance; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Combinations; Duodenoscopy; Female; Gastric Mucosa; Gastroscopy; Humans; Magnesium Hydroxide; Male; Middle Aged; Naproxen; Peptic Ulcer	1991
NSAID-induced gastroduodenal injury: what's the score? Gastroenterology, 1991, Volume: 101, Issue:2 Topics: Adult; Cimetidine; Duodenal Diseases; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Middle Aged; Naproxen; Peptic Ulcer; Prospective Studies; Stomach Diseases; Sucralfate	1991
The Norway study: plasma concentrations, efficacy, and adverse events. The American journal of medicine, 1986, Nov-28, Volume: 81, Issue:5B Topics: Adult; Age Factors; Aged; Aged, 80 and over; Body Weight; Clinical Trials as Topic; Female; Gastrointestinal Hemorrhage; Heart Failure; Humans; Male; Middle Aged; Naproxen; Norway; Osteoarthritis; Peptic Ulcer; Piroxicam; Sex Factors	1986
Clinical benefits and comparative safety of piroxicam. Analysis of worldwide clinical trials data. The American journal of medicine, 1986, Nov-28, Volume: 81, Issue:5B Topics: Adult; Age Factors; Aged; Clinical Trials as Topic; Female; Gastrointestinal Hemorrhage; Humans; Ibuprofen; Information Systems; Male; Middle Aged; Naproxen; Norway; Osteoarthritis; Peptic Ulcer; Piroxicam; Product Surveillance, Postmarketing; United Kingdom	1986
The Norwegian multicenter study. The American journal of medicine, 1986, Nov-28, Volume: 81, Issue:5B Topics: Adult; Age Factors; Aged; Aged, 80 and over; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Female; Gastrointestinal Diseases; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Naproxen; Norway; Osteoarthritis; Peptic Ulcer; Piroxicam; Random Allocation; Sex Factors	1986

Other Studies

18 other study(ies) available for naproxen and Gastroduodenal Ulcer

Article	Year
Perforated Peptic Ulcer of the Duodenum After the Laparoscopic Roux-en-Y Gastric Bypass. The American surgeon, 2023, Volume: 89, Issue:6 Topics: Abdominal Pain; Adult; Duodenum; Gastric Bypass; Humans; Laparoscopy; Male; Naproxen; Obesity, Morbid; Peptic Ulcer; Peptic Ulcer Perforation	2023
Model-based prediction of the acute and long-term safety profile of naproxen in rats. British journal of pharmacology, 2015, Volume: 172, Issue:15 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Dinoprostone; Dose-Response Relationship, Drug; Male; Models, Biological; Naproxen; Peptic Ulcer; Rats; Thromboxane B2	2015
NSAID-induced antral ulcers are associated with distinct changes in mucosal gene expression. Alimentary pharmacology & therapeutics, 2009, Volume: 30, Issue:1 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Gastric Mucosa; Gene Expression; Humans; Male; Middle Aged; Naproxen; Peptic Ulcer	2009
Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis. Gastroenterology, 2011, Volume: 141, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Actinobacteria; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bifidobacterium; Celecoxib; Colon; Denaturing Gradient Gel Electrophoresis; Disease Models, Animal; Drug Interactions; Gastrointestinal Hemorrhage; Hematocrit; Jejunum; Lansoprazole; Male; Naproxen; Omeprazole; Peptic Ulcer; Probiotics; Proton Pump Inhibitors; Pyrazoles; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Time Factors	2011
[Coxib instead of NSAID plus gastric acid inhibitor. Protection for the small intestine]. MMW Fortschritte der Medizin, 2004, Mar-25, Volume: 146, Issue:13 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Lactones; Naproxen; Peptic Ulcer; Peptic Ulcer Hemorrhage; Proton Pump Inhibitors; Risk; Sulfones	2004
[Selective cox-2 inhibitors. Better tolerance than NSAID plus antacid]. MMW Fortschritte der Medizin, 2004, Apr-08, Volume: 146, Issue:15 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Endoscopy, Digestive System; Gastric Mucosa; Humans; Intestinal Mucosa; Isoenzymes; Membrane Proteins; Middle Aged; Naproxen; Omeprazole; Osteoarthritis; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Proton Pump Inhibitors; Pyrazoles; Randomized Controlled Trials as Topic; Sulfonamides	2004
Risk of hospitalization with peptic ulcer disease or gastrointestinal hemorrhage associated with nabumetone, Arthrotec, diclofenac, and naproxen in a population based cohort study. The Journal of rheumatology, 2005, Volume: 32, Issue:11 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Cohort Studies; Databases, Factual; Diclofenac; Drug Combinations; Female; Gastrointestinal Hemorrhage; Hospitalization; Humans; Male; Middle Aged; Misoprostol; Nabumetone; Naproxen; Peptic Ulcer; Risk Factors; Saskatchewan	2005
[Study results of routine clinical practice. Do rheumatism patients get substandard care?]. MMW Fortschritte der Medizin, 2005, Nov-24, Volume: 147, Issue:47 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygenase 2 Inhibitors; Germany; Humans; Ibuprofen; Myocardial Infarction; Naproxen; Peptic Ulcer; Quality Assurance, Health Care; Retrospective Studies; Risk Assessment; Risk Factors	2005
Quantitative assessment of the gastrointestinal and cardiovascular risk-benefit of celecoxib compared to individual NSAIDs at the population level. Pharmacoepidemiology and drug safety, 2007, Volume: 16, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Celecoxib; Computer Simulation; Coronary Disease; Cyclooxygenase Inhibitors; Diclofenac; Female; Heart Failure; Humans; Ibuprofen; Male; Middle Aged; Models, Statistical; Naproxen; Peptic Ulcer; Population Surveillance; Pyrazoles; Risk Assessment; Risk Factors; Stroke; Sulfonamides; United States	2007
Genetic susceptibility to nonsteroidal anti-inflammatory drug-related gastroduodenal bleeding: role of cytochrome P450 2C9 polymorphisms. Gastroenterology, 2007, Volume: 133, Issue:2 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Case-Control Studies; Celecoxib; Cytochrome P-450 CYP2C9; Diclofenac; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Ibuprofen; Male; Middle Aged; Naproxen; Odds Ratio; Peptic Ulcer; Peptic Ulcer Hemorrhage; Piroxicam; Polymorphism, Single Nucleotide; Pyrazoles; Risk Assessment; Risk Factors; Sulfonamides	2007
Variability in the risk of major gastrointestinal complications from nonaspirin nonsteroidal anti-inflammatory drugs. Gastroenterology, 1993, Volume: 105, Issue:4 Topics: Administration, Oral; Administration, Rectal; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Alcohol Drinking; Aspirin; Case-Control Studies; Dose-Response Relationship, Drug; Female; Gastrointestinal Diseases; Humans; Incidence; Ketoprofen; Male; Middle Aged; Naproxen; Peptic Ulcer; Piroxicam; Prospective Studies; Risk Factors; Sex Factors; Time Factors	1993
NO-naproxen vs. naproxen: ulcerogenic, analgesic and anti-inflammatory effects. Alimentary pharmacology & therapeutics, 1997, Volume: 11, Issue:1 Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ileal Diseases; Male; Metabolic Clearance Rate; Naproxen; Peptic Ulcer; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha	1997
Gastrointestinal toxicity of over-the-counter analgesics. The American journal of gastroenterology, 1998, Volume: 93, Issue:7 Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Gastric Mucosa; Humans; Ibuprofen; Intestinal Mucosa; Intestines; Ketoprofen; Naproxen; Nonprescription Drugs; Peptic Ulcer; Stomach; Time Factors	1998
Celecoxib for rheumatoid arthritis. The Journal of family practice, 2000, Volume: 49, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Naproxen; Peptic Ulcer; Pyrazoles; Randomized Controlled Trials as Topic; Reproducibility of Results; Sulfonamides; Treatment Outcome	2000
Right ballpark, wrong base: assessing safety of NSAIDs. The Journal of family practice, 2002, Volume: 51, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Isoxazoles; Lactones; Naproxen; Osteoarthritis; Peptic Ulcer; Sulfonamides; Sulfones	2002
The role of copper in preventing gastrointestinal damage by acidic anti-inflammatory drugs. The Journal of pharmacy and pharmacology, 1976, Volume: 28, Issue:12 Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chelating Agents; Copper; Edema; Female; In Vitro Techniques; Indomethacin; Ketoprofen; Male; Naproxen; Niflumic Acid; Peptic Ulcer; Prostaglandins E; Pyrroles; Rats	1976
Aspirin and newer anti-inflammatory agents in rheumatoid arthritis. American family physician, 1977, Volume: 16, Issue:1 Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Fenoprofen; Humans; Ibuprofen; Indomethacin; Naproxen; Peptic Ulcer; Phenylbutazone; Tolmetin	1977
Life-threatening diarrhea after short-term misoprostol use in a patient with Crohn ileocolitis. Annals of internal medicine, 1990, Sep-15, Volume: 113, Issue:6 Topics: Alprostadil; Anti-Ulcer Agents; Crohn Disease; Diarrhea; Female; Humans; Middle Aged; Misoprostol; Naproxen; Peptic Ulcer	1990