Page last updated: 2024-09-04

naproxen and leukotriene b4

naproxen has been researched along with leukotriene b4 in 15 studies

Compound Research Comparison

Studies (naproxen)	Trials (naproxen)	Recent Studies (post-2010) (naproxen)	Studies (leukotriene b4)	Trials (leukotriene b4)	Recent Studies (post-2010) (leukotriene b4)
4,551	1,057	1,429	5,886	232	717

Protein Interaction Comparison

Protein	Taxonomy	naproxen (IC50)	leukotriene b4 (IC50)
Leukotriene B4 receptor 1	Homo sapiens (human)		0.0019

Research

Studies (15)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	12 (80.00)	18.2507
2000's	3 (20.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Gale, D; Keenan, CM; Shoupe, TS; Wallace, JL	1
Bendele, AM; Benslay, DN; Hom, JT; Lee, SJ; Lindstrom, TD; Naismith, RW; Ruterbories, KJ; Spaethe, SM	1
Ferrell, JB; Fleisher, LN; McGahan, MC; Smith, MG	1
Bachetti, T; Bucolo, C; Canossa, M; Mangiafico, S; Marino, A; Spampinato, S	1
Freedman, R; Swinney, DC; Webb, AS	1
Breton, J; Griswold, DE; Marshall, PJ; Torphy, TJ; Webb, EF; White, JR	1
Fraser, L; Larkin, SW; Showell, HJ; Warren, JB; Williams, TJ	1
Bailleul, F; Bertin, P; Jaeger, S; Lapicque, F; Netter, P; Payan, E; Rigaud, M; Treves, R	1
Colombo, C; DiPasquale, G; Fryer, LR; Greenspan, PD; Haston, W; Healy, C; Kotyuk, B; Pastor, G; Pellas, TC; Raychaudhuri, A	1
Bucolo, C; Spadaro, A	1
Medvedeff, ED; Nickerson-Nutter, CL	1
Awni, WM; Braeckman, RA; Cavanaugh, JH; Dubé, LM; Granneman, GR; Linnen, PJ; Locke, CS	1
Brady, MT; David, KC; Graff, G; Hellberg, MR; Nixon, JC; Weimer, LK	1
Guévremont, M; Laufer, S; Marcouiller, P; Martel-Pelletier, J; Pelletier, JP; Ranger, P; Reboul, P	1
Laufer, S; Link, A; Malfertheiner, P; Treiber, G; Vieth, M; Wex, T	1

Trials

2 trial(s) available for naproxen and leukotriene b4

Article	Year
Prolonged microvascular vasodilation induced by leukotriene B4 in human skin is cyclooxygenase independent. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:1 Topics: Administration, Oral; Administration, Topical; Adult; Arachidonic Acid; Dose-Response Relationship, Drug; Erythema; Humans; Indoles; Indomethacin; Leukotriene B4; Male; Microcirculation; Naproxen; Oxindoles; Regional Blood Flow; Skin; Vasodilation	1995
The pharmacokinetic and pharmacodynamic interactions between the 5-lipoxygenase inhibitor zileuton and the cyclo-oxygenase inhibitor naproxen in human volunteers. Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2 Topics: Administration, Oral; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Digestive System; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Endoscopy; Humans; Hydroxyurea; Intestinal Mucosa; Leukotriene B4; Lipoxygenase Inhibitors; Male; Naproxen; Thromboxane B2	1995

Article

Year

Prolonged microvascular vasodilation induced by leukotriene B4 in human skin is cyclooxygenase independent.

The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:1

Topics: Administration, Oral; Administration, Topical; Adult; Arachidonic Acid; Dose-Response Relationship, Drug; Erythema; Humans; Indoles; Indomethacin; Leukotriene B4; Male; Microcirculation; Naproxen; Oxindoles; Regional Blood Flow; Skin; Vasodilation

1995

The pharmacokinetic and pharmacodynamic interactions between the 5-lipoxygenase inhibitor zileuton and the cyclo-oxygenase inhibitor naproxen in human volunteers.

Clinical pharmacokinetics, 1995, Volume: 29 Suppl 2

Topics: Administration, Oral; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Digestive System; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Endoscopy; Humans; Hydroxyurea; Intestinal Mucosa; Leukotriene B4; Lipoxygenase Inhibitors; Male; Naproxen; Thromboxane B2

1995

Other Studies

13 other study(ies) available for naproxen and leukotriene b4

Article	Year
Exacerbation of experimental colitis by nonsteroidal anti-inflammatory drugs is not related to elevated leukotriene B4 synthesis. Gastroenterology, 1992, Volume: 102, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Dinoprostone; Drug Combinations; Indomethacin; Leukotriene B4; Male; Misoprostol; Naproxen; Peroxidase; Quinolines; Rats; Rats, Inbred Strains	1992
Anti-inflammatory activity of BF389, a Di-T-butylphenol, in animal models of arthritis. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arthritis, Experimental; Collagen; Diamines; Diclofenac; Dinoprostone; Disease Models, Animal; Female; Interleukin-1; Leukotriene B4; Male; Naproxen; Oxazines; Phenols; Piroxicam; Rats; Rats, Inbred Lew; Thromboxane B2	1992
Lipid mediators of tumor necrosis factor-alpha-induced uveitis. Investigative ophthalmology & visual science, 1991, Volume: 32, Issue:8 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Eicosanoids; Eye Proteins; Indomethacin; Leukocyte Count; Leukotriene B4; Male; Naproxen; Platelet Activating Factor; Prostaglandins E; Quinolinium Compounds; Rabbits; Recombinant Proteins; Tumor Necrosis Factor-alpha; Uveitis, Anterior; Vitreous Body	1991
Effects of sodium naproxen eye drops on rabbit ocular inflammation induced by sodium arachidonate. Journal of ocular pharmacology, 1991,Summer, Volume: 7, Issue:2 Topics: Animals; Arachidonic Acid; Conjunctivitis; Dinoprostone; Eye; Eye Proteins; Intraocular Pressure; Iritis; Leukotriene B4; Male; Naproxen; Neutrophils; Ophthalmic Solutions; Rabbits	1991
A novel rat hepatic clofibrate-inducible cytochrome P450 that is not a lauric acid hydroxylase. Biochemical pharmacology, 1991, Nov-27, Volume: 42, Issue:12 Topics: Animals; Clofibrate; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Detergents; Enzyme Induction; Fatty Acids; Kinetics; Lauric Acids; Leukotriene B4; Male; Microsomes, Liver; Mixed Function Oxygenases; Naproxen; Oxidation-Reduction; Rats	1991
Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response. Inflammation, 1993, Volume: 17, Issue:3 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Calcimycin; Cells, Cultured; Colforsin; Cyclic Nucleotide Phosphodiesterases, Type 4; Ear, External; Eicosanoids; Histamine Release; Humans; Imidazoles; Inflammation; Leukotriene B4; Male; Mast Cells; Mice; Mice, Inbred BALB C; Monocytes; Nadolol; Naproxen; Neutrophils; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazoles; Pyrrolidinones; Receptors, Adrenergic, beta; Rolipram; SRS-A; Thiazoles	1993
Sodium naproxen: concentration and effect on inflammatory response mediators in human rheumatoid synovial fluid. European journal of clinical pharmacology, 1994, Volume: 46, Issue:1 Topics: 6-Ketoprostaglandin F1 alpha; Adult; Arthritis, Rheumatoid; Biomarkers; Chromatography, High Pressure Liquid; Dinoprostone; Female; Humans; Hyaluronic Acid; Immunoenzyme Techniques; Knee Joint; Leukotriene B4; Male; Middle Aged; Naproxen; Protein Binding; Synovial Fluid; Thromboxane B2	1994
LTB4-induced transient neutropenia in the rat: a model for evaluating efficacy and bioavailability of LTB4 receptor antagonists. Journal of pharmacological and toxicological methods, 1993, Volume: 30, Issue:3 Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Dexamethasone; Hydroxyurea; Indomethacin; Leukocyte Count; Leukotriene B4; Male; Models, Biological; Naproxen; Neutropenia; Neutrophils; Rats; Rats, Sprague-Dawley; Receptors, Leukotriene B4	1993
Effect of sodium naproxen on inflammatory response induced by anterior chamber paracentesis in the rabbit. The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:9 Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Atropine; Ciliary Body; Cyclooxygenase Inhibitors; Dinoprostone; Drug Interactions; Female; Leukotriene B4; Mydriatics; Naproxen; Neutrophils; Ophthalmic Solutions; Peroxidase; Phenylephrine; Rabbits	1995
The effect of leukotriene synthesis inhibitors in models of acute and chronic inflammation. Arthritis and rheumatism, 1996, Volume: 39, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chronic Disease; Disease Models, Animal; Drug Combinations; Exudates and Transudates; Female; Hydroxyurea; Inflammation; Leukotriene B4; Lipoxygenase; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Naproxen; Prostaglandin-Endoperoxide Synthases; Quinolines; Time Factors; Zymosan	1996
Characterization of the in vitro anti-inflammatory activity of AL-5898 and related benzopyranyl esters and amides. Inflammation, 2003, Volume: 27, Issue:1 Topics: Amides; Anti-Inflammatory Agents; Benzopyrans; Cell Adhesion; Child, Preschool; Cyclooxygenase Inhibitors; Cytokines; Dose-Response Relationship, Drug; Endothelial Cells; Esters; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Male; Monocytes; Naproxen; Neutrophil Activation; U937 Cells	2003
Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis. The Journal of rheumatology, 2005, Volume: 32, Issue:4 Topics: Acetates; Aged; Arachidonic Acid; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; In Vitro Techniques; Leukotriene B4; Lipopolysaccharides; Male; Masoprocol; Naproxen; Osteoarthritis, Knee; Pyrroles; Signal Transduction; Synovial Membrane	2005
The effect of single-dose naproxen on eicosanoid formation in human gastroduodenal mucosa. Alimentary pharmacology & therapeutics, 2006, Jan-01, Volume: 23, Issue:1 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Eicosanoids; Female; Gastric Mucosa; Humans; Leukotriene B4; Male; Naproxen; Prostaglandins E; Reverse Transcriptase Polymerase Chain Reaction; Thromboxane B2	2006