Page last updated: 2024-11-12

pydrin, (s-(r*,r*))-isomer

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID10342051
CHEMBL ID1891190
CHEBI ID39346
SCHEMBL ID26507
MeSH IDM0313508

Synonyms (72)

Synonym
asana
(s-(r*,r*))-cyano(3-phenoxyphenyl)methyl 4-chloro-2-(1-methylethyl)benzeneacetate
fenvalerate alpha
brn 4275674
s 1844
(s)-alpha-cyano-3-phenoxybenzyl(s)-2-(4-chlorophenyl)-3-methylbutyrate
benzeneacetic acid, 4-chloro-alpha-(1-methylethyl)-, cyano(3-phenoxyphenyl)methyl ester, (s-(r*,r*))-
sumicidin a alpha
sumi-alfa
fenvalerate a alpha
s-1844 ,
a alpha
s 5602 a alpha
halmark
hsdb 6625
oms 3023
(s)-alpha-cyano-3-phenoxybenzyl (s)-2-(4-chlorophenyl)-3-methylbutyrate
s-5620a alpha
sumiciclin aalpha
asana xl
66230-04-4
(s)-cyano(3-phenoxyphenyl)methyl (2s)-2-(4-chlorophenyl)-3-methylbutanoate
CHEBI:39346 ,
esfenvalerate
fenvalerate (s,s)-isomer
NCGC00163956-01
NCGC00163956-02
C18147
[(s)-cyano-(3-phenoxyphenyl)methyl] (2s)-2-(4-chlorophenyl)-3-methyl-butanoate
A835377
(2s)-2-(4-chlorophenyl)-3-methylbutanoic acid [(s)-cyano-(3-phenoxyphenyl)methyl] ester
NCGC00163956-03
dtxsid4032667 ,
NCGC00254689-01
cas-66230-04-4
dtxcid2012667
tox21_300785
unii-7f07oxm0pp
esfenvalerate [iso]
7f07oxm0pp ,
benzeneacetic acid, 4-chloro-alpha-(1-methylethyl)-, (s)-cyano(3-phenoxyphenyl)methyl ester, (alphas)-
(s,s)-fenvalerate
CY15763700
niosh/cy1576370
benzeneacetic acid, 4-chloro-alpha-(1-methylethyl)-, cyano(3-phenoxyphenyl)methyl ester, (s,s)-
sumi-.alpha.
s-5602.alpha.
1s,1's-fenvalerate
fenvalerate (s,s)-isomer [mi]
benzeneacetic acid, 4-chloro-.alpha.-(1-methylethyl)-, (s)-cyano(3-phenoxyphenyl)methyl ester, (.alpha.s)-
a.alpha.
esfenvalerate, (-)-
oms-3023
(s)-.alpha.-cyano-3-phenoxybenzyl (s)-2-(4-chlorophenyl)isovalerate
AKOS025310580
SCHEMBL26507
NYPJDWWKZLNGGM-RPWUZVMVSA-N
ss/rr-fenvalerate
dl-norphenylephrinehydrochloride
CHEMBL1891190
esfenvalerate, pestanal(r), analytical standard
esfenvalerate 10 microg/ml in cyclohexane
[(s)-cyano-(3-phenoxyphenyl)methyl] (2s)-2-(4-chlorophenyl)-3-methylbutanoate
(s)-((s)-cyano(3-phenoxyphenyl)methyl) 2-(4-chlorophenyl)-3-methylbutanoate
Q424851
HY-129257
CS-0104423
benzeneacetic acid, 4-chloro-a-(1-methylethyl)-,(s)-cyano(3-phenoxyphenyl)methyl ester, (as)-
MS-27361
(s)-cyano(3-phenoxyphenyl)methyl (s)-2-(4-chlorophenyl)-3-methylbutanoate
esfenvalerate 100 microg/ml in acetonitrile
Z3244525280
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
pyrethroid ester insecticidenull
agrochemicalAn agrochemical is a substance that is used in agriculture or horticulture.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
fenvalerateA carboxylic ester obtained by formal condensation between 2-(4-chlorophenyl)-3-methylbutyric acid and cyano(3-phenoxyphenyl)methanol.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (22)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
pregnane X receptorRattus norvegicus (Norway rat)Potency14.12540.025127.9203501.1870AID651751
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency61.57693.189029.884159.4836AID1224846
RAR-related orphan receptor gammaMus musculus (house mouse)Potency43.23310.006038.004119,952.5996AID1159521; AID1159523
GLI family zinc finger 3Homo sapiens (human)Potency44.38430.000714.592883.7951AID1259369; AID1259392
AR proteinHomo sapiens (human)Potency42.93570.000221.22318,912.5098AID1259243; AID1259247; AID588516
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency54.66800.001022.650876.6163AID1224838; AID1224839; AID1224893
progesterone receptorHomo sapiens (human)Potency13.67150.000417.946075.1148AID1346795
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency30.89480.000214.376460.0339AID720691; AID720692
retinoid X nuclear receptor alphaHomo sapiens (human)Potency12.28620.000817.505159.3239AID1159527
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency53.74420.001530.607315,848.9004AID1224848; AID1224849; AID1259403
farnesoid X nuclear receptorHomo sapiens (human)Potency13.78540.375827.485161.6524AID743217
pregnane X nuclear receptorHomo sapiens (human)Potency17.97310.005428.02631,258.9301AID1346982; AID720659
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency35.38030.001019.414170.9645AID743094; AID743191
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency0.30860.023723.228263.5986AID743223
thyroid stimulating hormone receptorHomo sapiens (human)Potency33.38080.001628.015177.1139AID1224843; AID1224895
activating transcription factor 6Homo sapiens (human)Potency53.84740.143427.612159.8106AID1159516; AID1159519
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency54.880519.739145.978464.9432AID1159509
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency30.86160.057821.109761.2679AID1159526
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency66.60340.000323.4451159.6830AID743065; AID743067
heat shock protein beta-1Homo sapiens (human)Potency54.88050.042027.378961.6448AID743210
nuclear factor NF-kappa-B p105 subunit isoform 1Homo sapiens (human)Potency50.11874.466824.832944.6684AID651749
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency61.13060.000627.21521,122.0200AID651741
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (26)

Assay IDTitleYearJournalArticle
AID1111087Resistant ratio, ratio of LC90 for F1 generation of adult of Helicoverpa zea (corn earworm) to LC90 for adult of corn earworm2010Pest management science, Feb, Volume: 66, Issue:2
Differential efficacy of three commonly used pyrethroids against laboratory and field-collected larvae and adults of Helicoverpa zea (Lepidoptera: Noctuidae) and significance for pyrethroid resistance management.
AID1111089Resistant ratio, ratio of LC50 for F1 generation of adult of Helicoverpa zea (corn earworm) to LC50 for adult of corn earworm2010Pest management science, Feb, Volume: 66, Issue:2
Differential efficacy of three commonly used pyrethroids against laboratory and field-collected larvae and adults of Helicoverpa zea (Lepidoptera: Noctuidae) and significance for pyrethroid resistance management.
AID1091363Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A2 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreated c2008Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15
DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
AID1110995Antifeedant activity against third-instar larval stage of Helicoverpa zea (corn earworm) infested compound-treated leaf assessed as reduction in feeding damage at 187 mg a.i/L after 48 hr by leaf disk assay relative to untreated control2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
AID1110962Antifeedant activity against third-instar larval stage of Trichoplusia ni (cabbage looper) infested compound-treated leaf assessed as reduction in feeding damage at 187 mg a.i/L after 48 hr by leaf disk assay relative to untreated control2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
AID1111092Insecticidal activity against F1 generation of third-instar of Helicoverpa zea (corn earworm) assessed as mortality per insecticide vial after 48 hr2010Pest management science, Feb, Volume: 66, Issue:2
Differential efficacy of three commonly used pyrethroids against laboratory and field-collected larvae and adults of Helicoverpa zea (Lepidoptera: Noctuidae) and significance for pyrethroid resistance management.
AID1111094Insecticidal activity against third-instar of Helicoverpa zea (corn earworm) assessed as mortality per insecticide vial after 48 hr2010Pest management science, Feb, Volume: 66, Issue:2
Differential efficacy of three commonly used pyrethroids against laboratory and field-collected larvae and adults of Helicoverpa zea (Lepidoptera: Noctuidae) and significance for pyrethroid resistance management.
AID1111093Insecticidal activity against adult of Helicoverpa zea (corn earworm) assessed as mortality per insecticide vial after 24 hr2010Pest management science, Feb, Volume: 66, Issue:2
Differential efficacy of three commonly used pyrethroids against laboratory and field-collected larvae and adults of Helicoverpa zea (Lepidoptera: Noctuidae) and significance for pyrethroid resistance management.
AID1112019Insecticidal activity against Drosophila suzukii assessed as mortality at 56.2 g/ha by direct application at 22 degC measured after 24 hr2011Pest management science, Nov, Volume: 67, Issue:11
Laboratory and field comparisons of insecticides to reduce infestation of Drosophila suzukii in berry crops.
AID1091383Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as HX-dG adducts using [32P]labeling based autoradiography2008Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15
DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
AID1110975Antifeedant activity against third-instar larval stage of Spodoptera exigua infested compound-treated leaf assessed as time required to stop feeding at 187 mg a.i/L after 48 hr by leaf disk assay (Rvb = > 2880 min)2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
AID1111007Antifeedant activity against third-instar larval stage of Trichoplusia ni (cabbage looper) infested compound-treated leaf assessed as time required to stop feeding at 187 mg a.i/L after 48 hr by leaf disk assay (Rvb = > 2880 min)2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
AID1111091Insecticidal activity against F1 generation of adult of Helicoverpa zea (corn earworm) assessed as mortality per insecticide vial after 24 hr2010Pest management science, Feb, Volume: 66, Issue:2
Differential efficacy of three commonly used pyrethroids against laboratory and field-collected larvae and adults of Helicoverpa zea (Lepidoptera: Noctuidae) and significance for pyrethroid resistance management.
AID1091386Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as HNE-dG adducts measured per 10'9 nucleotides using [32P]labeling based autoradiography (Rvb = 2 no unit)2008Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15
DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
AID1091369Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A2 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control2008Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15
DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
AID1111088Resistant ratio, ratio of LC90 for F1 generation of third-instar of Helicoverpa zea (corn earworm) to LC90 for third-instar of corn earworm2010Pest management science, Feb, Volume: 66, Issue:2
Differential efficacy of three commonly used pyrethroids against laboratory and field-collected larvae and adults of Helicoverpa zea (Lepidoptera: Noctuidae) and significance for pyrethroid resistance management.
AID1091362Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A3 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreated c2008Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15
DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
AID1091364Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A1 measured per 10'9 nucleotides using HX-dG internal standard using [32P]labeling based autoradiography relative to untreated c2008Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15
DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
AID1091371Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as HNE-dG adducts using [32P]labeling based autoradiography (Rvb = 34 cpm)2008Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15
DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
AID1110991Antifeedant activity against third-instar larval stage of Helicoverpa zea (corn earworm) infested compound-treated leaf assessed as time required to stop feeding at 187 mg a.i/L after 48 hr by leaf disk assay (Rvb = > 2880 min)2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
AID390723Inhibition of HSL in Wistar rat isolated fat cells at 1 uM by spectrophotometric assay2008Journal of medicinal chemistry, Oct-23, Volume: 51, Issue:20
Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of new potent hormone sensitive lipase inhibitors.
AID1110983Antifeedant activity against third-instar larval stage of Spodoptera exigua infested compound-treated leaf assessed as reduction in feeding damage at 187 mg a.i/L after 48 hr by leaf disk assay relative to untreated control2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
AID1091368Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A3 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control2008Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15
DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
AID1091370Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as relative adduct level A1 measured per 10'9 nucleotides using [32P]labeling based autoradiography relative to untreated control2008Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15
DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
AID1111090Resistant ratio, ratio of LC50 for F1 generation of third-instar of Helicoverpa zea (corn earworm) to LC50 for third-instar of corn earworm2010Pest management science, Feb, Volume: 66, Issue:2
Differential efficacy of three commonly used pyrethroids against laboratory and field-collected larvae and adults of Helicoverpa zea (Lepidoptera: Noctuidae) and significance for pyrethroid resistance management.
AID1091389Genotoxicity in Glycine max (soybean) exposed to compound through spray 4 times over 2 weeks assessed as HX-dG adducts measured per 10'9 nucleotides using [32P]labeling based autoradiography2008Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15
DNA adducts as biomarkers for oxidative and genotoxic stress from pesticides in crop plants.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.50 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.30 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]