Page last updated: 2024-09-28

Hypertelorism

Abnormal increase in the interorbital distance due to overdevelopment of the lesser wings of the sphenoid.

Synonyms(1)

Synonym
Hypertelorism

Research Excerpts

Overview

ExcerptReference
"The correction of hypertelorism is surgery of the nose and of the midface."( Evans, CA; Kaban, LB; Mulliken, JB; Murray, JE; Strand, RD, 1986)
"Hypertelorism is the only congenital anomaly to be significantly more frequent in newborns of epileptics."( Heifetz, L; Neri, A; Nitke, S; Ovadia, J, 1983)
"The problem of hypertelorism is simply replaced by the problem of telecanthus."( Furnas, DW, 1980)
"Orbital hypertelorism is a major congenital malformation requiring early correction."( Alvarez, L; Dahan, P; Molina, F; Ortiz Monasterio, F; Sigler, A, 1996)
"Telecanthus and hypertelorism are frequent orbital dysmorphisms that, however, find conflicting definitions in the literature."( Gollogly, J; Krishnan, KG; Lauer, G; Pinzer, T; Schackert, G, 2008)
"Hypertelorism is a deformity characterized by an increase in interorbital distance."( Estolano, RT; Hidalgo, HM; Romo, GW, 2009)
"Orbital hypertelorism is a disease, which is most commonly associated with craniofacial malformations."( Xie, K; Yang, S; Zhu, YM, 2011)
"Orbital hypertelorism is defined as an abnormally wide bony interorbital distance."( Inoue, Y; Okumoto, T; Yoshimura, Y, 2012)
"Orbital hypertelorism is defined as an increased distance between both medial and lateral sides of the orbits."( Castrillon-Oberndorfer, G; Engel, M; Freudlsperger, C; Hoffmann, J, 2015)
"Orbital hypertelorism is a common congenital craniofacial anomaly in Asians."( Li, D; Mao, H; Wei, M; Xu, L; Yu, Z; Yuan, J, 2018)

Research

Studies (298)

TimeframeStudies, This Condition (%)All Conditions %
pre-1990109 (36.58)23.3326
1990's77 (25.84)12.5806
2000's59 (19.80)18.1394
2010's45 (15.10)28.8240
2020's8 (2.68)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low50
cytosine0low20
lactic acid0low20
diphosphoric acid0low10
pyridoxine0low10
thymine0low10
bisoprolol0low10
dicyclomine0low10
doxylamine0low10
fluphenazine0low10
flumazenil0low10
fluphenazine enanthate0low10
haloperidol0low10
2-propanol0low150
meclizine0low10
phenobarbital0low10
pifithrin0low10
primidone0low20
sumatriptan0low10
thalidomide0low20
mitomycin0low10
prednisolone0low10
bromodeoxyuridine0low10
leucine0low20
phenylalanine0low10
arginine0low10
mephobarbital0low10
acridines0low10
hydantoins0low30
durapatite0low10
titanium0low20
trolamine salicylate0low20
propiconazole0medium1331
methotrexate0low10
proline0low10
naproxen0low10
aminopterin0low30
methandriol0low10
inositol 3-phosphate0low120
pyrophosphate0low10
phenylephrine hydrochloride0low1010
acid phosphatase0low10
transforming growth factor beta0low10
technetium tc 99m medronate0low10
eye0low150

Protein Targets (684)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit4004
RAR-related orphan receptor gamma130013
GLI family zinc finger 3120012
AR protein210021
aldehyde dehydrogenase 1 family, member A1100010
retinoic acid nuclear receptor alpha variant 1110011
retinoid X nuclear receptor alpha120012
estrogen nuclear receptor alpha170017
peroxisome proliferator-activated receptor delta8008
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
activating transcription factor 63003
v-jun sarcoma virus 17 oncogene homolog (avian)7007
Histone H2A.x6006
thyroid hormone receptor beta isoform a5005
heat shock protein beta-13003
nuclear factor erythroid 2-related factor 2 isoform 1100010
lamin isoform A-delta108008
Voltage-dependent calcium channel gamma-2 subunit8008
Glutamate receptor 28008
Chain A, Ferritin light chain3003
thioredoxin reductase8008
TDP1 protein160016
Microtubule-associated protein tau6006
Smad31001
alpha-galactosidase3003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 14004
flap endonuclease 17007
DNA polymerase iota isoform a (long)7007
DNA topoisomerase 2-alpha0001
Acetylcholinesterase0202
SMAD family member 24004
SMAD family member 34004
nuclear receptor subfamily 1, group I, member 3120012
glucocorticoid receptor [Homo sapiens]120012
estrogen-related nuclear receptor alpha150015
farnesoid X nuclear receptor7007
pregnane X nuclear receptor8008
peroxisome proliferator activated receptor gamma7007
vitamin D (1,25- dihydroxyvitamin D3) receptor8008
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
thyroid hormone receptor beta isoform 29009
Dihydrofolate reductase0506
Dihydrofolate reductase0406
Dihydrofolate reductase0305
Cellular tumor antigen p539009
5-hydroxytryptamine receptor 2C0406
Dihydrofolate reductase0325
Folylpolyglutamate synthase, mitochondrial0205
Solute carrier organic anion transporter family member 1A30102
Folylpolyglutamate synthase, mitochondrial0105
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE9009
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
phosphopantetheinyl transferase5005
NFKB1 protein, partial3003
GLS protein4004
thyroid stimulating hormone receptor7007
euchromatic histone-lysine N-methyltransferase 2140014
cytochrome P450 2C19 precursor2002
chromobox protein homolog 1100010
muscarinic acetylcholine receptor M17007
lethal factor (plasmid)5005
Cytochrome P450 3A40204
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase4004
ATAD5 protein, partial6006
arylsulfatase A9009
DNA polymerase kappa isoform 12002
Beta-2 adrenergic receptor0112
Beta-1 adrenergic receptor0011
Beta-3 adrenergic receptor0213
Beta-1 adrenergic receptor0101
Chain H, Proteasome component PUP10101
Chain I, Proteasome component PUP30101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Proteasome subunit beta type-110101
Fumarate hydratase5005
PPM1D protein2002
caspase 7, apoptosis-related cysteine protease5005
estrogen receptor 2 (ER beta)6006
progesterone receptor9009
cytochrome P450 family 3 subfamily A polypeptide 49009
EWS/FLI fusion protein100010
polyprotein5005
caspase-35005
nuclear receptor subfamily 1, group I, member 25005
Caspase-73003
caspase-33003
26S proteasome non-ATPase regulatory subunit 110101
26S proteasome non-ATPase regulatory subunit 120101
26S proteasome non-ATPase regulatory subunit 140101
Proteasome subunit alpha type-70101
Histone deacetylase 30101
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40809
26S proteasome non-ATPase regulatory subunit 30101
Carbonic anhydrase 120203
Bile salt export pump015015
Prothrombin0101
Chymotrypsinogen A0101
Carbonic anhydrase 10506
Carbonic anhydrase 20517
Interferon beta7007
Carbonic anhydrase 30203
Cathepsin B0101
Neutrophil elastase0101
Cathepsin G0202
Lysosomal protective protein0101
Chymotrypsinogen B0101
26S proteasome regulatory subunit 6A0101
Nuclear factor NF-kappa-B p105 subunit0101
Proteasome subunit beta type-10102
Carbonic anhydrase 40203
Carbonic anhydrase 60203
Chymase0101
Proteasome subunit alpha type-10101
Proteasome subunit alpha type-20101
Proteasome subunit alpha type-30101
Proteasome subunit alpha type-40101
Proteasome subunit beta type-80101
Proteasome subunit beta type-80101
Proteasome subunit beta type-90101
Proteasome subunit alpha type-50101
Proteasome subunit beta type-40101
Proteasome subunit beta type-60101
Proteasome subunit beta type-50203
Carbonic anhydrase 5A, mitochondrial0203
26S proteasome regulatory subunit 70101
Lon protease homolog, mitochondrial0101
Proteasome subunit beta type-100101
Carbonic anhydrase 70203
26S proteasome regulatory subunit 6B0101
26S proteasome non-ATPase regulatory subunit 80101
Proteasome subunit beta type-30101
Proteasome subunit beta type-20102
26S proteasome non-ATPase regulatory subunit 70101
26S proteasome non-ATPase regulatory subunit 40101
26S proteasome complex subunit SEM10101
Proteasome subunit alpha type-60101
26S proteasome regulatory subunit 40101
26S proteasome regulatory subunit 80101
26S proteasome regulatory subunit 10B0101
Beta-carbonic anhydrase 10101
Nuclear factor NF-kappa-B p100 subunit 0101
Transcription factor p650101
26S proteasome non-ATPase regulatory subunit 20101
Histone deacetylase 10101
26S proteasome non-ATPase regulatory subunit 60101
Proteasomal ubiquitin receptor ADRM10101
Carbonic anhydrase 90203
ATP-dependent Clp protease proteolytic subunit0112
Carbonic anhydrase 130102
NACHT, LRR and PYD domains-containing protein 3 0101
Proteasome subunit alpha-type 80101
Histone deacetylase 20101
Canalicular multispecific organic anion transporter 10808
ATPase family AAA domain-containing protein 56006
Proteasome subunit beta type-70101
26S proteasome non-ATPase regulatory subunit 10101
Ataxin-28008
Carbonic anhydrase 150203
Histone deacetylase 80101
Histone deacetylase 60101
Carbonic anhydrase 140203
26S proteasome non-ATPase regulatory subunit 130101
Carbonic anhydrase 5B, mitochondrial0203
interleukin 81001
pregnane X receptor3003
bromodomain adjacent to zinc finger domain 2B1001
IDH14004
cellular tumor antigen p53 isoform a5005
Nuclear hormone receptor family member daf-120011
nuclear factor erythroid 2-related factor 2 isoform 26006
serine/threonine-protein kinase mTOR isoform 13003
oxysterols receptor LXR-beta isoform 10011
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
geminin120012
peripheral myelin protein 228008
survival motor neuron protein isoform d5005
Thymidine kinase, cytosolic0101
Thymidine phosphorylase0001
Thymidylate kinase0101
Nuclear receptor ROR-gamma1001
Spike glycoprotein7119
Thymidine kinase0001
Thymidylate kinase0101
Deoxycytidine kinase0001
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Thrombopoietin3003
G4004
cytochrome P450 2D66006
thyroid stimulating hormone receptor6006
cytochrome P450 2D6 isoform 14004
cytochrome P450 2C9 precursor3003
D(1A) dopamine receptor3003
cytochrome P450 3A4 isoform 14004
Gamma-aminobutyric acid receptor subunit pi4307
Polyunsaturated fatty acid lipoxygenase ALOX15B3003
5-hydroxytryptamine receptor 40606
HLA class I histocompatibility antigen, B alpha chain 4004
Muscarinic acetylcholine receptor M20505
Muscarinic acetylcholine receptor M40505
Muscarinic acetylcholine receptor M50404
Muscarinic acetylcholine receptor M10606
Angiotensin-converting enzyme0505
Gamma-aminobutyric acid receptor subunit beta-14307
Gamma-aminobutyric acid receptor subunit delta4307
Gamma-aminobutyric acid receptor subunit gamma-24307
Gamma-aminobutyric acid receptor subunit alpha-54307
Gamma-aminobutyric acid receptor subunit alpha-34307
Muscarinic acetylcholine receptor M30505
Gamma-aminobutyric acid receptor subunit gamma-14307
Gamma-aminobutyric acid receptor subunit alpha-24307
Histamine H2 receptor0606
5-hydroxytryptamine receptor 2A0808
5-hydroxytryptamine receptor 2C0707
Gamma-aminobutyric acid receptor subunit alpha-44307
Gamma-aminobutyric acid receptor subunit gamma-34307
Gamma-aminobutyric acid receptor subunit alpha-64307
D(3) dopamine receptor0619
5-hydroxytryptamine receptor 2B0606
Histamine H2 receptor4005
5-hydroxytryptamine receptor 60505
Gamma-aminobutyric acid receptor subunit alpha-14307
Gamma-aminobutyric acid receptor subunit beta-34307
Gamma-aminobutyric acid receptor subunit beta-24307
Potassium voltage-gated channel subfamily H member 20808
Nuclear receptor subfamily 3 group C member 3 0404
GABA theta subunit4307
Inositol hexakisphosphate kinase 14004
Sigma non-opioid intracellular receptor 10707
Gamma-aminobutyric acid receptor subunit epsilon4307
cytochrome P450 2C9, partial4004
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Bloom syndrome protein isoform 16006
Ornithine transcarbamylase, mitochondrial0101
Farnesyl pyrophosphate synthase0202
Nociceptin receptor0101
endonuclease IV2002
regulator of G-protein signaling 45005
nuclear receptor ROR-gamma isoform 15005
muscleblind-like protein 1 isoform 12002
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Bile salt export pump0404
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-10202
Neuronal acetylcholine receptor subunit alpha-41102
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit alpha-30202
Neuronal acetylcholine receptor subunit beta-21102
Gamma-aminobutyric acid receptor subunit alpha-10213
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit gamma-20213
5-hydroxytryptamine receptor 1A0819
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit gamma-20202
Gamma-aminobutyric acid receptor subunit beta-30213
Gamma-aminobutyric acid receptor subunit alpha-50213
Gamma-aminobutyric acid receptor subunit alpha-30213
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit beta-20202
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit epsilon0202
Neuronal acetylcholine receptor subunit alpha-70101
TAR DNA-binding protein 435005
Gamma-aminobutyric acid receptor subunit alpha-60202
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit theta0202
acetylcholinesterase4004
USP1 protein, partial4004
NADPH oxidase 10101
glucocerebrosidase3003
Snq2p0001
Spike glycoprotein0112
Replicase polyprotein 1ab0112
potassium voltage-gated channel subfamily H member 2 isoform d2002
mitogen-activated protein kinase 12002
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
M-phase phosphoprotein 82002
Solute carrier family 22 member 1 0203
Transmembrane protease serine 20112
Potassium channel subfamily K member 20213
Epidermal growth factor receptor0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Receptor tyrosine-protein kinase erbB-20101
Integrin beta-34004
Tyrosine-protein kinase Fyn0101
Procathepsin L0112
Aldo-keto reductase family 1 member B10404
ATP-dependent translocase ABCB10304
Integrin alpha-IIb4004
Alpha-2A adrenergic receptor0404
Replicase polyprotein 1a0112
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0112
Adenosine receptor A30202
Replicase polyprotein 1ab0112
D(2) dopamine receptor0518
Androgen receptor0202
Alpha-1B adrenergic receptor0505
Alpha-2B adrenergic receptor0404
Alpha-2C adrenergic receptor0404
Substance-K receptor0202
D(1A) dopamine receptor0405
D(4) dopamine receptor0417
D(1B) dopamine receptor0304
Sodium-dependent noradrenaline transporter 0404
Alpha-1D adrenergic receptor0404
5-hydroxytryptamine receptor 1B0505
Trypanothione reductase0202
Sodium-dependent serotonin transporter0404
Melanocortin receptor 50202
Pleiotropic ABC efflux transporter of multiple drugs0102
Histamine H1 receptor0404
Mu-type opioid receptor0415
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
Alpha-1A adrenergic receptor0505
D(1A) dopamine receptor2103
5-hydroxytryptamine receptor 70202
Disintegrin and metalloproteinase domain-containing protein 171001
Inositol monophosphatase 12002
Sodium-dependent dopamine transporter 0202
Angiotensin-converting enzyme 2 0112
Histamine H3 receptor0101
glp-1 receptor, partial3003
15-lipoxygenase, partial3003
nonstructural protein 12002
Adenylate cyclase type 1 0101
peripheral myelin protein 22 isoform 12002
transient receptor potential cation channel subfamily V member 11001
Cocaine esterase0101
Transient receptor potential cation channel subfamily V member 10101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
UDP-glucuronosyltransferase 1A90102
Voltage-dependent L-type calcium channel subunit alpha-1F0213
Albumin0011
Major prion protein0011
Vitamin D-binding protein0101
HLA class I histocompatibility antigen, A alpha chain 0011
Integrin beta-10101
Muscarinic acetylcholine receptor M10202
Muscarinic acetylcholine receptor M30202
Muscarinic acetylcholine receptor M40202
5-hydroxytryptamine receptor 1A0415
Muscarinic acetylcholine receptor M50202
Beta-2 adrenergic receptor0202
Muscarinic acetylcholine receptor M20202
Cytochrome P450 2C9 0404
Integrin alpha-40101
5-hydroxytryptamine receptor 2A0404
Carbonyl reductase [NADPH] 10001
UDP-glucuronosyltransferase 2B70102
Beta-1 adrenergic receptor0101
D0202
D(3) dopamine receptor0202
Alpha-2B adrenergic receptor0101
D(2) dopamine receptor0202
Adenylate cyclase type 30101
Alpha-2C adrenergic receptor0101
UDP-glucuronosyltransferase 1A40001
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0303
Sodium-dependent dopamine transporter0101
5-hydroxytryptamine receptor 3A0101
Adenosine receptor A10203
D(1B) dopamine receptor0202
Beta-3 adrenergic receptor0101
Adenylate cyclase type 20101
Adenylate cyclase type 40101
5-hydroxytryptamine receptor 1D0213
D(4) dopamine receptor0202
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0202
Histamine H1 receptor0202
Sodium-dependent serotonin transporter0101
5-hydroxytryptamine receptor 7 0101
C-8 sterol isomerase0101
Delta-type opioid receptor0202
Mu-type opioid receptor0202
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 70202
Kappa-type opioid receptor0202
Alpha-1A adrenergic receptor0202
5-hydroxytryptamine receptor 2A0101
Alpha-1B adrenergic receptor0101
Glutamate receptor ionotropic, NMDA 1 0203
Sodium channel protein type 1 subunit alpha0303
Sodium channel protein type 4 subunit alpha0203
Adenylate cyclase type 80101
Kappa-type opioid receptor0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 2J20303
D(2) dopamine receptor0101
D(3) dopamine receptor0101
Gastrin/cholecystokinin type B receptor0101
D(2) dopamine receptor0303
AP-2 complex subunit sigma0101
N-acetyltransferase Eis0202
Glutamate receptor ionotropic, NMDA 2A 0102
Glutamate receptor ionotropic, NMDA 2B0102
Glutamate receptor ionotropic, NMDA 2C0102
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0213
5-hydroxytryptamine receptor 2B0101
Adenylate cyclase type 60101
Adenylate cyclase type 50101
5-hydroxytryptamine receptor 40101
Voltage-dependent L-type calcium channel subunit alpha-1S0213
Voltage-dependent L-type calcium channel subunit alpha-1C0213
Sodium channel protein type 5 subunit alpha0202
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sodium channel protein type 9 subunit alpha0202
Calcitonin gene-related peptide type 1 receptor0101
Genome polyprotein 0202
Sigma intracellular receptor 20101
Sigma intracellular receptor 20101
Sigma non-opioid intracellular receptor 10101
Zinc finger protein 6640101
Glutamate receptor ionotropic, NMDA 2D0102
Vesicular acetylcholine transporter0101
Transporter0101
Cholecystokinin receptor type A0101
Protease 0202
Adenylyl cyclase 7 0101
Glutamate receptor ionotropic, NMDA 3B0102
D0101
Sodium channel protein type 2 subunit alpha0303
Transient receptor potential cation channel subfamily V member 40101
Sodium channel protein type 3 subunit alpha0303
Sigma non-opioid intracellular receptor 10202
Glutamate receptor ionotropic, NMDA 3A0102
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Transient receptor potential cation channel subfamily V member 20101
Sodium channel protein type 10 subunit alpha0101
DNA polymerase beta3003
Glycogen synthase kinase-3 alpha0101
Glycogen synthase kinase-3 beta0101
Protein cereblon0416
Chain A, AMINOPEPTIDASE0202
Chain A, AMINOPEPTIDASE0202
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0202
Intestinal-type alkaline phosphatase0202
Large neutral amino acids transporter small subunit 10203
Proton-coupled amino acid transporter 10203
Phospholipase A-2-activating protein0202
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, 2-oxoglutarate Oxygenase4004
acid sphingomyelinase1001
dopamine D1 receptor2002
ClpP1001
67.9K protein2002
Thymidylate synthase 0101
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
vitamin D3 receptor isoform VDRA2002
transcriptional regulator ERG isoform 32002
importin subunit beta-1 isoform 11001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
histone acetyltransferase KAT2A isoform 12002
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase 0202
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
High mobility group protein B10022
Dihydrofolate reductase0101
Thymidylate synthase0101
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Reduced folate transporter0202
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Dihydrofolate reductase0101
Pteridine reductase 10101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60203
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200202
Dihydrofolate reductase 0101
Solute carrier family 22 member 80102
Solute carrier family 22 member 60202
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Broad substrate specificity ATP-binding cassette transporter ABCG20001
aryl hydrocarbon receptor3003
Indoleamine 2,3-dioxygenase 10101
Solute carrier family 22 member 60202
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 10202
Polyunsaturated fatty acid 5-lipoxygenase0103
Hormone-sensitive lipase0101
Aldo-keto reductase family 1 member C40101
Prostaglandin G/H synthase 10202
Caspase-10101
Adenosine receptor A2a0102
Prostaglandin G/H synthase 20303
Prostaglandin G/H synthase 2 0102
Aldo-keto reductase family 1 member C30101
Caspase-30101
Caspase-40101
Caspase-50101
Aldo-keto reductase family 1 member C2 0101
Caspase-90101
Prostaglandin G/H synthase 20202
Aldo-keto reductase family 1 member C10101
Prostaglandin G/H synthase 1 0102
Luciferase1001
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Plasma kallikrein0001
Alkaline phosphatase, tissue-nonspecific isozyme 0101
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
Carbonic anhydrase0102
Carbonic anhydrase0001
E3 ubiquitin-protein ligase XIAP0101
SLC16A10 protein0001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Large neutral amino acids transporter small subunit 1 0101
Carbonic anhydrase 0001
Monocarboxylate transporter 100001
Carbonic anhydrase 130102
GALC protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
beta-2 adrenergic receptor1001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
Vpr1001
5-hydroxytryptamine receptor 2A0011
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Gamma-aminobutyric acid 0101
atrial natriuretic peptide receptor 1 precursor1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Sodium channel protein type 2 subunit alpha0101
Aldo-keto reductase family 1 member B10101
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit theta0101
Gamma-aminobutyric acid receptor subunit gamma-10101
luciferase1001
Luciferin 4-monooxygenase0101
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Glucocorticoid receptor0218
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Histamine H1 receptor0011
Nociceptin receptor0011
Estrogen receptor beta0202
Rap guanine nucleotide exchange factor 31001
Glutamate 5-kinase0001
Angiotensin-converting enzyme 0101
Neutral amino acid transporter A0101
Neutral amino acid transporter B(0)0101
Amino acid transporter0101
Chain A, Beta-lactamase2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
heat shock protein HSP 90-alpha isoform 20001
Guanine nucleotide-binding protein G1001
heat shock protein 90, putative0001
Pyridoxal kinase0001
Chain A, dATP pyrophosphohydrolase0101
Chain A, Adenylate cyclase type 50101
Chain B, Adenylate cyclase type 20101
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Polyphenol oxidase 20102
5'-AMP-activated protein kinase subunit beta-20001
Albumin0101
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase0101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
5-hydroxytryptamine receptor 3E0101
5-hydroxytryptamine receptor 3B0101
Carboxypeptidase M0101
5-hydroxytryptamine receptor 1D0214
5-hydroxytryptamine receptor 1B0213
5-hydroxytryptamine receptor 1E0101
5-hydroxytryptamine receptor 1F0213
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1A0101
5-hydroxytryptamine receptor 3D0101
5-hydroxytryptamine receptor 3C0101
Multidrug and toxin extrusion protein 10101
5-hydroxytryptamine receptor 3B0101
5-hydroxytryptamine receptor 1B0101
Cereblon isoform 40202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
DNA-binding protein Ikaros0001
DNA damage-binding protein 10112
Thymidine phosphorylase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]