Page last updated: 2024-09-04

naproxen and Gastrointestinal Hemorrhage

naproxen has been researched along with Gastrointestinal Hemorrhage in 63 studies

Research

Studies (63)

Timeframe	Studies, this research(%)	All Research%
pre-1990	23 (36.51)	18.7374
1990's	17 (26.98)	18.2507
2000's	14 (22.22)	29.6817
2010's	9 (14.29)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cogburn, JN; Collins, PW; Huff, RM; Isakson, PC; Khanna, IK; Koboldt, CM; Koszyk, FJ; Masferrer, JL; Perkins, WE; Seibert, K; Veenhuizen, AW; Weier, RM; Xu, X; Yang, DC; Yu, Y; Yuan, J; Zhang, YY	1
Onuora, S	1
Bernal Monterde, V; Fernández Bonilla, E; García Cámara, P; Gotor Delso, J; Llorente Barrio, M; Monzón Báez, RM; Sanz Segura, P	1
Bercik, P; Blackler, RW; Manko, A; Motta, JP; Surette, MG; Wallace, JL; Workentine, M	1
Dial, EJ; Lichtenberger, LM; Moore, JE; Romero, JJ	1
Etzion, O; Halevy, S; Horev, A	1
Bercik, P; Bolla, M; Collins, SM; de Palma, G; Denou, E; Jury, J; McKnight, W; Ongini, E; Syer, S; Verdu, E; Vong, L; Wallace, JL	1
Marshall, LL	1
Fernández Torrejón, GA; Landi, P	1
Baldelli, F; Bruno, A; Cipriani, S; Distrutti, E; Fiorucci, S; Mencarelli, A; Renga, B; Santucci, L	1
Adly, G; Plakogiannis, R	1
Dial, EJ; Dohrman, AJ; Lichtenberger, LM; Romero, JJ	1
McCarthy, DM	1
Ashworth, NL; Muhajarine, N; Peloso, PM; Stang, M	1
González-Cámpora, R; Herrerías-Gutiérrez, JM; Jiménez-Sáenz, M; Linares-Santiago, E	1
Brensinger, C; Farrar, JT; Kimmel, SE; Lewis, JD; Localio, AR; McGibney, K; Metz, DC; Nessel, L; Strom, BL	1
Nedjar, H; Rahme, E	1
Hitzenberger, G; Hulkenberg-Tromp, D; Liem, KS; Rameis, H	1
Hunt, JN; Jiang, CL; Smith, JL	1
Greenberg, BP; Lanza, FL; Nelson, RS	1
Watne, O	1
Smith, RE	1
Crabtree, RE; Johnson, DW; Ridolfo, AS; Rockhold, FW	1
Bell, CJ; McKnight, GW; Wallace, JL	1
Alfredsson, L; Kaufman, DW; Kelly, JP; Koff, RS; Laszlo, A; Shapiro, S; Sheehan, JE; Wiholm, BE	1
De Medici, A; De Siena, M; Giglio, A; Rodino', S; Sacca', N	1
Marcinkiewicz, M; Parolisi, S; Peura, DA; Sarosiek, J	1
Appleyard, CB; McCafferty, DM; Swain, MG; Tigley, AW; Wallace, JL	1
Cook, GA; Elliott, SL; Hawkey, CJ; McAlindon, ME; Yeomans, ND	1
Christophidis, N; Kwiatek, R; Scharf, S; Ugoni, A	1
Hawkey, CJ	1
Arnout, J; Cariou, R; De Schepper, PJ; Depré, M; van Hecken, A; Vanbilloen, H; Vanhove, P; Verbruggen, A; Wynants, K	1
Bjarnason, I; Thjodleifsson, B	1
Duque-Oliart, A; García-Rodríguez, LA; Pérez-Gutthann, S; Varas-Lorenzo, C	1
Jick, SS	1
Bombardier, C; Burgos-Vargas, R; Davis, B; Day, R; Ferraz, MB; Hawkey, CJ; Hochberg, MC; Kvien, TK; Laine, L; Reicin, A; Schnitzer, TJ; Shapiro, D	1
Chan, FK; Chan, LY; Ching, JY; Chung, SC; Hui, Y; Lai, AC; Lee, YT; Leung, WK; Sung, JJ; Wu, JC	1
Chan, FK; Chan, HL; Chung, SC; Hui, Y; Lai, MS; Lau, JY; Lee, YT; Leung, VK; Leung, WK; Suen, BY; Sung, JJ; Wu, JC	1
Delgado Fernández, M; Diez García, F; Zambrana García, JL	1
Lewis, JR	1
Uthgenannt, H	1
Arvidsson, B; Magnusson, B; Sölvell, L	1
Arsenault, A; Lussier, A; Varady, J	1
Pemberton, RE; Strand, LJ	1
Eidsaunet, W; Larsen, S; Osnes, M; Thom, E	1
Ito, T; Mori, E; Muroga, T; Nakajima, A; Tanaka, S	1
Lussier, A	1
Timm, H; Uthgenannt, H	1
Arsenault, A; LeBel, E; Lussier, A; Varady, J	1
Beró, T; Jávor, T; Nagy, L; Vincze, A	1
Leese, P	1
Roth, SH	1
Evans, DG; Graham, DY; Lanza, FL	1
Laine, L	1
Davis, RE; Graham, DY; Lanza, FL; Rack, MF	1
Correa, R; Fidalgo, I; Gómez Carrasco, JA; Martínez Quiroga, F	1
Johansson, C; Rubio, C; Slezak, P; Uribe, A	1
Giercksky, KE	1
Corstens, FH; Gribnau, FW; van de Putte, LB; van den Ouweland, FA	1
Rugstad, HE	1
Meisel, AD	1
Husby, G	1

Reviews

5 review(s) available for naproxen and Gastrointestinal Hemorrhage

Article	Year
Gastrointestinal bleeding and possible hypothyroidism. The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 2012, Volume: 27, Issue:3 Topics: Aged, 80 and over; Amiodarone; Anemia; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Atenolol; Atrial Fibrillation; Duodenal Ulcer; Female; Gastrointestinal Hemorrhage; Humans; Hypothyroidism; Naproxen; Stomach Ulcer; Thyroxine	2012
Reinitiating aspirin therapy for primary prevention of cardiovascular events in a patient post-aspirin-induced upper gastrointestinal bleed: a case report and review of literature. The Annals of pharmacotherapy, 2013, Volume: 47, Issue:2 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Cyclooxygenase Inhibitors; Drug Interactions; Drug Monitoring; Gastrointestinal Hemorrhage; Humans; Male; Naproxen; Pantoprazole; Proton Pump Inhibitors; Treatment Outcome	2013
Ulcers, Helicobacter pylori infection, platelets and gastrointestinal complications of non-steroidal anti-inflammatory drugs: what are the connections? The European journal of surgery. Supplement. : = Acta chirurgica. Supplement, 2002, Issue:587 Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cyclooxygenase Inhibitors; Diclofenac; Gastrointestinal Hemorrhage; Helicobacter Infections; Humans; Ibuprofen; Lactones; Naproxen; Peptic Ulcer; Risk Factors; Sulfones	2002
Gastrointestinal toxicity of non-steroidal anti-inflammatory drugs: the effect of nimesulide compared with naproxen on the human gastrointestinal tract. Rheumatology (Oxford, England), 1999, Volume: 38 Suppl 1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Digestive System; Endoscopy, Gastrointestinal; Gastrointestinal Hemorrhage; Humans; Indans; Isoenzymes; Membrane Proteins; Naproxen; Prostaglandin-Endoperoxide Synthases; Severity of Illness Index; Sulfonamides; Time Factors	1999
Upper gastrointestinal safety with nabumetone. The Journal of rheumatology. Supplement, 1992, Volume: 36 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butanones; Chromium Radioisotopes; Clinical Trials as Topic; Digestive System; Double-Blind Method; Endoscopy; Gastrointestinal Hemorrhage; Humans; Longitudinal Studies; Nabumetone; Naproxen	1992

Trials

27 trial(s) available for naproxen and Gastrointestinal Hemorrhage

Article	Year
Comparison of gastrointestinal blood loss induced by cloximate in two formulations and by naproxen. International journal of clinical pharmacology, therapy, and toxicology, 1984, Volume: 22, Issue:2 Topics: Acetates; Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Gastrointestinal Hemorrhage; Humans; Male; Naproxen; Random Allocation; Tablets, Enteric-Coated	1984
Gastric bleeding and gastric secretion with sulindac and naproxen. Digestive diseases and sciences, 1983, Volume: 28, Issue:2 Topics: Aspirin; Gastric Acid; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Indenes; Intestinal Absorption; Male; Naproxen; Placebos; Sulindac	1983
Effects of fenbufen, indomethacin, naproxen, and placebo on gastric mucosa of normal volunteers. A comparative endoscopic and photographic evaluation. The American journal of medicine, 1983, Oct-31, Volume: 75, Issue:4B Topics: Adult; Anti-Inflammatory Agents; Capsules; Drug Evaluation; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Indomethacin; Male; Naproxen; Phenylbutyrates; Placebos; Propionates; Stomach Ulcer; Tablets	1983
Gastrointestinal microbleeding: comparisons between benoxaprofen and other nonsteroidal antiinflammatory agents. The Journal of rheumatology. Supplement, 1980, Volume: 6 Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Benzoxazoles; Clinical Trials as Topic; Double-Blind Method; Gastrointestinal Hemorrhage; Humans; Indomethacin; Melena; Naproxen; Propionates; Prostaglandins; Sulindac; Time Factors	1980
Nonsteroidal anti-inflammatory drug use in relation to major upper gastrointestinal bleeding. Clinical pharmacology and therapeutics, 1993, Volume: 53, Issue:4 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Diclofenac; Female; Gastrointestinal Hemorrhage; Humans; Hungary; Ibuprofen; Indomethacin; Male; Middle Aged; Naproxen; Piroxicam; Risk Factors; Sweden; United States	1993
Prostaglandin E2 content in residual gastric juice reflects endoscopic damage to the gastric mucosa after naproxen sodium administration. The American journal of gastroenterology, 1996, Volume: 91, Issue:5 Topics: Adult; Cross-Over Studies; Dinoprostone; Double-Blind Method; Female; Gastric Juice; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Male; Middle Aged; Naproxen	1996
Gastric microbleeding following single and repeated dosing with naproxen. Alimentary pharmacology & therapeutics, 1995, Volume: 9, Issue:6 Topics: Adaptation, Physiological; Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Gastric Lavage; Gastrointestinal Hemorrhage; Humans; Male; Naproxen; Stomach Diseases; Thromboxanes	1995
NSAIDs and faecal blood loss in elderly patients with osteoarthritis: is plasma half-life relevant? Australian and New Zealand journal of medicine, 1998, Volume: 28, Issue:4 Topics: Aged; Aged, 80 and over; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Diclofenac; Double-Blind Method; Female; Gastrointestinal Hemorrhage; Half-Life; Humans; Male; Middle Aged; Naproxen; Occult Blood; Osteoarthritis; Piroxicam	1998
Effect of clopidogrel on naproxen-induced gastrointestinal blood loss in healthy volunteers. Drug metabolism and drug interactions, 1998, Volume: 14, Issue:3 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Bleeding Time; Clopidogrel; Double-Blind Method; Drug Interactions; Gastrointestinal Hemorrhage; Humans; Male; Naproxen; Occult Blood; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine	1998
Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. The New England journal of medicine, 2000, 11-23, Volume: 343, Issue:21 Topics: Adult; Arthritis, Rheumatoid; Cardiovascular Diseases; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Duodenal Obstruction; Female; Gastric Outlet Obstruction; Gastrointestinal Diseases; Gastrointestinal Hemorrhage; Humans; Isoenzymes; Lactones; Male; Membrane Proteins; Middle Aged; Naproxen; Peptic Ulcer; Proportional Hazards Models; Prostaglandin-Endoperoxide Synthases; Sulfones	2000
Randomized trial of low-dose misoprostol and naproxen vs. nabumetone to prevent recurrent upper gastrointestinal haemorrhage in users of non-steroidal anti-inflammatory drugs. Alimentary pharmacology & therapeutics, 2001, Volume: 15, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Misoprostol; Nabumetone; Naproxen; Prospective Studies; Recurrence	2001
Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen. The New England journal of medicine, 2001, Mar-29, Volume: 344, Issue:13 Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Helicobacter Infections; Helicobacter pylori; Humans; Metronidazole; Naproxen; Omeprazole; Organometallic Compounds; Secondary Prevention; Tetracycline	2001
[Gastrointestinal discharge of blood due to the administration of feprazon, naproxen, diclofenac]. Die Medizinische Welt, 1977, May-27, Volume: 28, Issue:21 Topics: Diclofenac; Feprazone; Gastrointestinal Hemorrhage; Humans; Melena; Naphthaleneacetic Acids; Naproxen; Phenylacetates; Phenylbutazone	1977
A comparative study of gastrointestinal bleeding during administration of ketoprofen and naproxen. Scandinavian journal of rheumatology, 1977, Volume: 6, Issue:1 Topics: Administration, Oral; Adult; Benzophenones; Capsules; Clinical Trials as Topic; Gastrointestinal Hemorrhage; Humans; Ketoprofen; Male; Naphthaleneacetic Acids; Naproxen; Placebos; Tablets	1977
Gastrointestinal microbleeding after aspirin and naproxen. Clinical pharmacology and therapeutics, 1978, Volume: 23, Issue:4 Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Double-Blind Method; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Naproxen	1978
A review of upper-gastrointestinal effects of the newer nonsteroidal antiinflammatory agents. Digestive diseases and sciences, 1979, Volume: 24, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Evaluation; Fenoprofen; Gastric Mucosa; Gastritis; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Ibuprofen; Ketoprofen; Naproxen; Phenylbutazone; Registries; Sulindac; Tolmetin	1979
Effect of diclofenac and naproxen on gastroduodenal mucosa. Clinical pharmacology and therapeutics, 1979, Volume: 26, Issue:3 Topics: Adult; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Duodenum; Female; Gastric Mucosa; Gastritis; Gastrointestinal Hemorrhage; Humans; Intestinal Mucosa; Male; Naproxen; Phenylacetates; Placebos	1979
Double-blind study of Naproxen in osteoarthritis of the knee joint. The Journal of rheumatology, 1976, Volume: 3, Issue:1 Topics: Activities of Daily Living; Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Evaluation; Female; Gastrointestinal Hemorrhage; Humans; Knee Joint; Male; Middle Aged; Movement; Naphthaleneacetic Acids; Naproxen; Osteoarthritis; Placebos; Radiography; Skin Temperature; Stomach Ulcer	1976
Long-term clinical assessment of naproxen on rheumatoid arthritis patients and 51-Cr gastrointestinal bleeding on volunteers. Arzneimittel-Forschung, 1975, Volume: 25, Issue:2A Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chromium Radioisotopes; Clinical Trials as Topic; Drug Evaluation; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Humans; Long-Term Care; Male; Middle Aged; Naphthaleneacetic Acids; Naproxen; Placebos; Salicylates	1975
Effect of naproxen on gastrointestinal microbleeding following acetylsalicylate medication. Journal of clinical pharmacology, 1975, Volume: 15, Issue:4 Pt. 2 Topics: Analysis of Variance; Anti-Inflammatory Agents; Aspirin; Gastrointestinal Hemorrhage; Humans; Naphthaleneacetic Acids; Naproxen; Placebos; Time Factors	1975
Comparison of the effects of etodolac SR and naproxen on gastro-intestinal blood loss. Current medical research and opinion, 1992, Volume: 13, Issue:1 Topics: Adult; Chromium Radioisotopes; Delayed-Action Preparations; Etodolac; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Naproxen; Occult Blood; Reference Values; Single-Blind Method	1992
Effect of Helicobacter pylori infection on the severity of gastroduodenal mucosal injury after the acute administration of naproxen or aspirin to normal volunteers. The American journal of gastroenterology, 1991, Volume: 86, Issue:6 Topics: Adult; Aspirin; Duodenal Ulcer; Duodenum; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Helicobacter Infections; Helicobacter pylori; Humans; Intestinal Mucosa; Male; Naproxen; Reference Values; Stomach Ulcer	1991
NSAID-induced gastroduodenal injury: what's the score? Gastroenterology, 1991, Volume: 101, Issue:2 Topics: Adult; Cimetidine; Duodenal Diseases; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Middle Aged; Naproxen; Peptic Ulcer; Prospective Studies; Stomach Diseases; Sucralfate	1991
Endoscopic comparison of cimetidine and sucralfate for prevention of naproxen-induced acute gastroduodenal injury. Effect of scoring method. Digestive diseases and sciences, 1990, Volume: 35, Issue:12 Topics: Adult; Cimetidine; Duodenal Diseases; Duodenal Ulcer; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Naproxen; Stomach Diseases; Stomach Ulcer; Sucralfate	1990
The Norway study: plasma concentrations, efficacy, and adverse events. The American journal of medicine, 1986, Nov-28, Volume: 81, Issue:5B Topics: Adult; Age Factors; Aged; Aged, 80 and over; Body Weight; Clinical Trials as Topic; Female; Gastrointestinal Hemorrhage; Heart Failure; Humans; Male; Middle Aged; Naproxen; Norway; Osteoarthritis; Peptic Ulcer; Piroxicam; Sex Factors	1986
Clinical benefits and comparative safety of piroxicam. Analysis of worldwide clinical trials data. The American journal of medicine, 1986, Nov-28, Volume: 81, Issue:5B Topics: Adult; Age Factors; Aged; Clinical Trials as Topic; Female; Gastrointestinal Hemorrhage; Humans; Ibuprofen; Information Systems; Male; Middle Aged; Naproxen; Norway; Osteoarthritis; Peptic Ulcer; Piroxicam; Product Surveillance, Postmarketing; United Kingdom	1986
The Norwegian multicenter study. The American journal of medicine, 1986, Nov-28, Volume: 81, Issue:5B Topics: Adult; Age Factors; Aged; Aged, 80 and over; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Female; Gastrointestinal Diseases; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Naproxen; Norway; Osteoarthritis; Peptic Ulcer; Piroxicam; Random Allocation; Sex Factors	1986

Other Studies

31 other study(ies) available for naproxen and Gastrointestinal Hemorrhage

Article	Year
Selective cyclooxygenase-2 inhibitors: heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents. Journal of medicinal chemistry, 2000, Aug-10, Volume: 43, Issue:16 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dogs; Edema; Gastrointestinal Hemorrhage; Humans; Hyperalgesia; Imidazoles; Intestines; Isoenzymes; Membrane Proteins; Mice; Nitriles; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Stomach; Structure-Activity Relationship; Sulfonamides	2000
Therapy: Celecoxib reduces risk of ulcer bleeding. Nature reviews. Rheumatology, 2017, Volume: 13, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Celecoxib; Double-Blind Method; Gastrointestinal Hemorrhage; Humans; Naproxen; Ulcer	2017
Upper gastrointestinal bleeding due to overdose of selective serotonin reuptake inhibitors and nonsteroidal anti-inflammatory drugs. Gastroenterologia y hepatologia, 2019, Volume: 42, Issue:10 Topics: Abdominal Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Depressive Disorder; Desvenlafaxine Succinate; Drug Synergism; Duloxetine Hydrochloride; Duodenal Ulcer; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Male; Melena; Methimazole; Naproxen; Selective Serotonin Reuptake Inhibitors; Stomach Ulcer	2019
Hydrogen sulphide protects against NSAID-enteropathy through modulation of bile and the microbiota. British journal of pharmacology, 2015, Volume: 172, Issue:4 Topics: Alanine; Allyl Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile; Cell Line; Cyclooxygenase 1; Gastrointestinal Hemorrhage; Humans; Hydrogen Sulfide; Intestinal Diseases; Intestinal Mucosa; Jejunum; Membrane Proteins; Microbiota; Naproxen; Protective Agents; Rats, Wistar; Sulfides; Ulcer	2015
Naproxen-PC: a GI safe and highly effective anti-inflammatory. Inflammopharmacology, 2009, Volume: 17, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Edema; Gastrointestinal Hemorrhage; Glycine max; Inflammation; Lecithins; Naproxen; Rats; Synovial Fluid	2009
[Necrotizing cutaneous vasculitis with massive gastrointestinal bleeding following naproxen treatment]. Harefuah, 2010, Volume: 149, Issue:3 Topics: Administration, Oral; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Naproxen; Vasculitis	2010
Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis. Gastroenterology, 2011, Volume: 141, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Actinobacteria; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bifidobacterium; Celecoxib; Colon; Denaturing Gradient Gel Electrophoresis; Disease Models, Animal; Drug Interactions; Gastrointestinal Hemorrhage; Hematocrit; Jejunum; Lansoprazole; Male; Naproxen; Omeprazole; Peptic Ulcer; Probiotics; Proton Pump Inhibitors; Pyrazoles; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Time Factors	2011
[Fever of unknown origin and digestive hemorrhage]. Medicina, 2011, Volume: 71, Issue:4 Topics: Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow; Fatal Outcome; Female; Fever of Unknown Origin; Gastrointestinal Hemorrhage; Hodgkin Disease; Humans; Liver; Naproxen; Neoplasm Invasiveness; Spleen	2011
Activation of the bile acid receptor GPBAR1 protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs and aspirin in mice. British journal of pharmacology, 2013, Volume: 168, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bile; Gastric Mucosa; Gastrointestinal Hemorrhage; Immunohistochemistry; Intestinal Mucosa; Intestine, Small; Male; Mice; Naproxen; Receptors, G-Protein-Coupled	2013
[Pain therapy in rheumatism. After 65 years of age coxibs are the best choice]. MMW Fortschritte der Medizin, 2003, Oct-16, Volume: 145, Issue:42 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Cyclooxygenase Inhibitors; Diclofenac; Gastrointestinal Hemorrhage; Humans; Isoxazoles; Naproxen; Prognosis; Rheumatic Diseases; Sulfonamides	2003
Recombinant human lactoferrin prevents NSAID-induced intestinal bleeding in rodents. The Journal of pharmacy and pharmacology, 2005, Volume: 57, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Gastrointestinal Hemorrhage; Humans; Indomethacin; Lactoferrin; Male; Naproxen; Pain Measurement; Protein Binding; Rats; Rats, Sprague-Dawley; Recombinant Proteins	2005
Risk of hospitalization with peptic ulcer disease or gastrointestinal hemorrhage associated with nabumetone, Arthrotec, diclofenac, and naproxen in a population based cohort study. The Journal of rheumatology, 2005, Volume: 32, Issue:11 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Cohort Studies; Databases, Factual; Diclofenac; Drug Combinations; Female; Gastrointestinal Hemorrhage; Hospitalization; Humans; Male; Middle Aged; Misoprostol; Nabumetone; Naproxen; Peptic Ulcer; Risk Factors; Saskatchewan	2005
Bleeding colonic ulcer and eosinophilic colitis: a rare complication of nonsteroidal anti-inflammatory drugs. Journal of clinical gastroenterology, 2006, Volume: 40, Issue:1 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Colitis; Colonic Diseases; Eosinophilia; Female; Gastrointestinal Hemorrhage; Humans; Naproxen; Ulcer	2006
Risk of serious upper gastrointestinal toxicity with over-the-counter nonaspirin nonsteroidal anti-inflammatory drugs. Gastroenterology, 2005, Volume: 129, Issue:6 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Gastrointestinal Diseases; Gastrointestinal Hemorrhage; Humans; Ibuprofen; Male; Middle Aged; Naproxen; Nonprescription Drugs; Random Allocation; Risk Factors; Upper Gastrointestinal Tract	2005
Risks and benefits of COX-2 inhibitors vs non-selective NSAIDs: does their cardiovascular risk exceed their gastrointestinal benefit? A retrospective cohort study. Rheumatology (Oxford, England), 2007, Volume: 46, Issue:3 Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Prescriptions; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Hospitalization; Humans; Lactones; Male; Myocardial Infarction; Naproxen; Pyrazoles; Quebec; Retrospective Studies; Risk Assessment; Sulfonamides; Sulfones	2007
[Gastrointestinal hemorrhage during naproxen treatment]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1981, Aug-20, Volume: 101, Issue:23 Topics: Aged; Gastrointestinal Hemorrhage; Humans; Male; Naproxen	1981
Naproxen toxicosis. Journal of the American Veterinary Medical Association, 1982, Jan-15, Volume: 180, Issue:2 Topics: Animals; Dog Diseases; Dogs; Gastrointestinal Hemorrhage; Male; Naproxen	1982
Adaptation of rat gastric mucosa to aspirin requires mucosal contact. The American journal of physiology, 1995, Volume: 268, Issue:1 Pt 1 Topics: Adaptation, Physiological; Animals; Aspirin; Dinoprostone; Gastric Mucosa; Gastritis; Gastrointestinal Hemorrhage; Indomethacin; Male; Naproxen; Ornithine Decarboxylase; Peroxidase; Rats; Rats, Wistar	1995
NSAIDs-induced digestive hemorrhage and esophageal pseudotumor: a case report. Endoscopy, 1995, Volume: 27, Issue:8 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Esophageal Diseases; Esophageal Neoplasms; Gastrointestinal Hemorrhage; Humans; Male; Naproxen; Ulcer	1995
Tumor necrosis factor mediation of NSAID-induced gastric damage: role of leukocyte adherence. The American journal of physiology, 1996, Volume: 270, Issue:1 Pt 1 Topics: Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Cell Movement; Gastrointestinal Hemorrhage; Indomethacin; Leukocytes; Male; Naproxen; Rats; Rats, Wistar; Stomach; Stomach Diseases; Stomach Ulcer; Tumor Necrosis Factor-alpha	1996
Naproxen sodium did not lead to substantially more upper gastrointestinal tract bleeding than ibuprofen during short term use as an analgesic. Gut, 1998, Volume: 43, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Databases, Factual; Female; Gastrointestinal Hemorrhage; Humans; Ibuprofen; Male; Naproxen; Nonprescription Drugs; Risk	1998
Low-dose diclofenac, naproxen, and ibuprofen cohort study. Pharmacotherapy, 1999, Volume: 19, Issue:7 Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cohort Studies; Diclofenac; Dose-Response Relationship, Drug; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Female; Gastrointestinal Hemorrhage; Hematologic Diseases; Humans; Ibuprofen; Male; Middle Aged; Naproxen	1999
The risk of gastrointestinal bleed, myocardial infarction, and newly diagnosed hypertension in users of meloxicam, diclofenac, naproxen, and piroxicam. Pharmacotherapy, 2000, Volume: 20, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Databases, Factual; Diclofenac; Gastrointestinal Hemorrhage; Humans; Hypertension; Isoenzymes; Meloxicam; Membrane Proteins; Myocardial Infarction; Naproxen; Piroxicam; Prostaglandin-Endoperoxide Synthases; Risk Assessment; Thiazines; Thiazoles; United Kingdom	2000
Upper gastrointestinal toxicity of rofecoxib and naproxen. The New England journal of medicine, 2001, May-03, Volume: 344, Issue:18 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Ethics, Medical; Gastrointestinal Hemorrhage; Histamine H2 Antagonists; Humans; Lactones; Middle Aged; Misoprostol; Naproxen; Proton Pump Inhibitors; Risk Factors; Sulfones	2001
New antirheumatic agents: Fenoprofen calcium (Nalfon), naproxen (Naprosyn), and tolmetin sodium (Tolectin). JAMA, 1977, Mar-21, Volume: 237, Issue:12 Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Fenoprofen; Gastrointestinal Hemorrhage; Humans; Naphthaleneacetic Acids; Naproxen; Osteoarthritis; Phenylpropionates; Pyrroles; Rheumatic Diseases; Spondylitis, Ankylosing; Tolmetin	1977
[The effect of Voltaren on the gastrointestinal excretion of blood (author's transl)]. MMW, Munchener medizinische Wochenschrift, 1975, Dec-12, Volume: 117, Issue:50 Topics: Adult; Anti-Inflammatory Agents; Aspirin; Chromium Radioisotopes; Erythrocytes; Feces; Gastrointestinal Hemorrhage; Humans; Male; Naproxen; Occult Blood; Radionuclide Imaging	1975
Measurement of non-steroid antiinflammatory drugs induced gastric microbleeding. Acta physiologica Hungarica, 1992, Volume: 80, Issue:1-4 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Apazone; Diclofenac; Gastric Juice; Gastrointestinal Hemorrhage; Humans; Indomethacin; Middle Aged; Naproxen	1992
[Acute anemia, rectorrhagia and hematuria caused by ingestion of naproxen]. Anales espanoles de pediatria, 1989, Volume: 30, Issue:4 Topics: Anemia; Breast Feeding; Gastrointestinal Hemorrhage; Hematuria; Humans; Infant, Newborn; Male; Milk, Human; Naproxen; Rectum	1989
Ulcerations of the colon associated with naproxen and acetylsalicylic acid treatment. Gastrointestinal endoscopy, 1986, Volume: 32, Issue:3 Topics: Aspirin; Back Pain; Colonic Diseases; Colonoscopy; Female; Gastrointestinal Hemorrhage; Humans; Middle Aged; Naproxen; Ulcer	1986
Piroxicam and gastrointestinal bleeding. The American journal of medicine, 1986, Nov-28, Volume: 81, Issue:5B Topics: Adult; Aged; Aged, 80 and over; Aspirin; Drug Utilization; Female; Gastrointestinal Hemorrhage; Hospitalization; Humans; Ibuprofen; Indomethacin; Male; Middle Aged; Naproxen; Norway; Piroxicam; Prospective Studies	1986
Gastrointestinal blood loss during treatment with naproxen for rheumatoid arthritis. Scandinavian journal of rheumatology, 1987, Volume: 16, Issue:5 Topics: Arthritis, Rheumatoid; Chromium Radioisotopes; Erythrocytes; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Naproxen; Occult Blood	1987