Page last updated: 2024-09-04

naproxen and codeine

naproxen has been researched along with codeine in 29 studies

Compound Research Comparison

Studies
(naproxen)
Trials
(naproxen)
Recent Studies (post-2010)
(naproxen)
Studies
(codeine)
Trials
(codeine)
Recent Studies (post-2010) (codeine)
4,5511,0571,4294,815730952

Protein Interaction Comparison

ProteinTaxonomynaproxen (IC50)codeine (IC50)
Delta-type opioid receptorMus musculus (house mouse)10
Kappa-type opioid receptorMus musculus (house mouse)10
Mu-type opioid receptorHomo sapiens (human)0.105
Mu-type opioid receptorMus musculus (house mouse)10

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19905 (17.24)18.7374
1990's5 (17.24)18.2507
2000's6 (20.69)29.6817
2010's9 (31.03)24.3611
2020's4 (13.79)2.80

Authors

AuthorsStudies
Strassburg, CP; Tukey, RH1
Duffy, EM; Jorgensen, WL1
Topliss, JG; Yoshida, F1
Chang, TK; Ensom, MH; Kiang, TK1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Barden, TP; Bloomfield, SS; Mitchell, J1
Courtney, P; Coxhead, PF; Galasko, CS; Jayne, M; Russell, S1
Holden, P; McCulloch, PG; Norris, SH; Robson, DJ; Rowley, DI1
Buttram, VC; Gravlee, LC; Hale, RW; Lifshitz, S1
Bauer, P; Schmierer, G; Schneider, C; Stacher, G; Winklehner, S1
Kanui, TI; Karim, F; Mbugua, S1
Baslamisli, F; Kocak, R; Paydas, S; Tetiker, T1
Gaston, G1
Finley, GA; McGrath, P; Multari, J; Precious, DS1
Boer, C; de Lange, JJ; Treebus, AN; Zuurmond, WW1
Akkaya, T; Ergil, J; Gülöksüz, ÇT; Peker, K; Polat, R1
Cigerim, L; Eroglu, CN1
Robinson-Lane, SG; Vallerand, AH1
Antoniazzi, CTD; Dalenogare, DP; de Almeida, AS; De Prá, SD; Milioli, AM; Moresco, RN; Oliveira, SM; Pereira, GC; Peres, DS; Rigo, FK; Ritter, CDS; Stein, C; Trevisan, G1
Choi, HK; Dubreuil, M; LaRochelle, MR; Lei, G; Lin, J; Lu, N; Tomasson, G; Wei, J; Wood, MJ; Zeng, C; Zhang, Y1
Cattry, E; Paredes-Diaz, A; Troullos, E1
Cigerim, L; Kaplan, V1
Ding, X; Li, X; Lu, N; Wang, Y; Wu, Z1

Reviews

3 review(s) available for naproxen and codeine

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic

2000
UDP-glucuronosyltransferases and clinical drug-drug interactions.
    Pharmacology & therapeutics, 2005, Volume: 106, Issue:1

    Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic

2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

12 trial(s) available for naproxen and codeine

ArticleYear
Naproxen, aspirin, and codeine in postpartum uterine pain.
    Clinical pharmacology and therapeutics, 1977, Volume: 21, Issue:4

    Topics: Adolescent; Adult; Aspirin; Clinical Trials as Topic; Codeine; Delivery, Obstetric; Drug Evaluation; Female; Humans; Naphthaleneacetic Acids; Naproxen; Pain; Placebos; Postnatal Care; Pregnancy; Puerperal Disorders; Uterus

1977
Comparison of the efficacy of naproxen sodium and dihydrocodeine tartrate in the treatment of post-operative pain.
    Current medical research and opinion, 1988, Volume: 10, Issue:10

    Topics: Administration, Oral; Adult; Codeine; Female; Follow-Up Studies; Humans; Male; Middle Aged; Naproxen; Orthopedics; Pain, Postoperative; Random Allocation

1988
The value of mobilisation and non-steroidal anti-inflammatory analgesia in the management of inversion injuries of the ankle.
    The British journal of clinical practice, 1985, Volume: 39, Issue:2

    Topics: Adolescent; Adult; Ankle Injuries; Anti-Inflammatory Agents, Non-Steroidal; Casts, Surgical; Child; Codeine; Early Ambulation; Humans; Naproxen; Prospective Studies

1985
Naproxen sodium vs. a combination of aspirin, phenacetin, caffeine and codeine phosphate for pain after major gynecologic surgery. A multicenter comparison.
    The Journal of reproductive medicine, 1984, Volume: 29, Issue:3

    Topics: Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Double-Blind Method; Drug Combinations; Female; Genital Diseases, Female; Humans; Hysterectomy; Infertility, Female; Naproxen; Pain, Postoperative; Phenacetin

1984
Effects of a combination of oral naproxen sodium and codeine on experimentally induced pain.
    European journal of clinical pharmacology, 1982, Volume: 21, Issue:6

    Topics: Adult; Codeine; Drug Evaluation; Drug Therapy, Combination; Electric Stimulation; Female; Hot Temperature; Humans; Male; Naproxen; Pain

1982
Comparison of effect of an anti-inflammatory drug and a narcotic analgesic on renal function in sickle cell anemia.
    Nephron, 1996, Volume: 73, Issue:3

    Topics: Adolescent; Adult; Analgesics, Opioid; Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Steroidal; Codeine; Humans; Kidney Diseases; Kidney Function Tests; Naproxen

1996
A double-blind, randomized, parallel-group study of the pharmacokinetics and onset of action of Naprelan in patients following oral surgery.
    American journal of orthopedics (Belle Mead, N.J.), 1996, Volume: 25, Issue:9 Suppl

    Topics: Adolescent; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Codeine; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Male; Naproxen; Pain, Postoperative; Surgery, Oral

1996
A comparison of patient-controlled and fixed schedule analgesia after orthognathic surgery.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1997, Volume: 55, Issue:1

    Topics: Adolescent; Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Codeine; Female; Humans; Jaw Abnormalities; Male; Middle Aged; Naproxen; Pain, Postoperative; Prospective Studies

1997
Comparison of the postoperative analgesic effects of paracetamol-codeine phosphate and naproxen sodium-codeine phosphate for lumbar disk surgery.
    The Kaohsiung journal of medical sciences, 2015, Volume: 31, Issue:9

    Topics: Acetaminophen; Adult; Analgesics, Opioid; Codeine; Female; Humans; Lumbar Vertebrae; Male; Middle Aged; Naproxen; Pain, Postoperative; Postoperative Period; Tramadol

2015
Comparison of Clinical Efficacies of Preoperatively Initiated Naproxen Sodium-Codeine Phosphate in Combination, Diclofenac Potassium, and Benzydamine Hydrochloride for Pain, Edema, and Trismus After Extraction of Impacted Lower Third Molar: A Randomized D
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2018, Volume: 76, Issue:3

    Topics: Adolescent; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Benzydamine; Codeine; Diclofenac; Double-Blind Method; Drug Therapy, Combination; Edema; Female; Humans; Male; Molar, Third; Naproxen; Pain, Postoperative; Preoperative Care; Tooth Extraction; Trismus; Young Adult

2018
Efficacy and safety of naproxen sodium 440 mg versus acetaminophen 600 mg/codeine phosphate 60 mg in the treatment of postoperative dental pain.
    American journal of dentistry, 2020, Volume: 33, Issue:2

    Topics: Acetaminophen; Codeine; Dental Care; Double-Blind Method; Humans; Naproxen; Pain, Postoperative

2020
Analgesic efficacy of naproxen-codeine, naproxen+dexamethasone, and naproxen on myofascial pain: A randomized double-blind controlled trial.
    Cranio : the journal of craniomandibular practice, 2023, Volume: 41, Issue:2

    Topics: Adolescent; Adult; Analgesics; Codeine; Dexamethasone; Double-Blind Method; Female; Humans; Male; Naproxen; Pain, Postoperative; Prospective Studies; Young Adult

2023

Other Studies

14 other study(ies) available for naproxen and codeine

ArticleYear
Prediction of drug solubility from Monte Carlo simulations.
    Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11

    Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility

2000
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
    Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22

    Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption

2007
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics

2011
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Effects of codeine, naproxen and dexamethasone on formalin-induced pain in the naked mole-rat.
    Neuroreport, 1993, Volume: 4, Issue:1

    Topics: Animals; Behavior, Animal; Codeine; Dexamethasone; Dose-Response Relationship, Drug; Formaldehyde; Injections, Intraperitoneal; Injections, Subcutaneous; Muscle Rigidity; Naloxone; Naproxen; Pain; Rodentia

1993
Compliance in administration of prescribed analgesics.
    Anaesthesia, 1997, Volume: 52, Issue:12

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Codeine; Drug Administration Schedule; Female; Guideline Adherence; Hospitals, University; Humans; Middle Aged; Morphine; Naproxen; Netherlands; Pain, Postoperative

1997
Pain Treatment Practices of Community-Dwelling Black Older Adults.
    Pain management nursing : official journal of the American Society of Pain Management Nurses, 2018, Volume: 19, Issue:1

    Topics: Aged; Anthropology, Cultural; Black or African American; Codeine; Exercise Therapy; Faith Healing; Female; Healthcare Disparities; Housing for the Elderly; Humans; Hydrocodone; Ibuprofen; Male; Medicine, Traditional; Middle Aged; Naproxen; Pain; Pain Management; Pain Measurement; Psychometrics; Qualitative Research; Surveys and Questionnaires; Tramadol

2018
Characterization of Cancer-Induced Nociception in a Murine Model of Breast Carcinoma.
    Cellular and molecular neurobiology, 2019, Volume: 39, Issue:5

    Topics: Acetaminophen; Analgesics; Animals; Benzoxazines; Bone Neoplasms; Calcium; Cannabinoids; Cell Line, Tumor; Codeine; Disease Models, Animal; Female; Hyperalgesia; Locomotion; Mammary Neoplasms, Animal; Mice, Inbred BALB C; Morphine; Morpholines; Naphthalenes; Naproxen; Nociception; Pain Measurement

2019
Association of tramadol with risk of myocardial infarction among patients with osteoarthritis.
    Osteoarthritis and cartilage, 2020, Volume: 28, Issue:2

    Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Codeine; Diclofenac; Female; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Naproxen; Osteoarthritis; Propensity Score; Proportional Hazards Models; Risk Factors; Tramadol

2020
Association between tramadol use and risk of pneumonia in the middle-aged and elderly populations: a propensity-score matched cohort study.
    European journal of pain (London, England), 2022, Volume: 26, Issue:6

    Topics: Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Codeine; Cohort Studies; Diclofenac; Etoricoxib; Humans; Middle Aged; Naproxen; Pneumonia; Tramadol

2022