naproxen has been researched along with tretinoin in 12 studies
| Studies (naproxen) | Trials (naproxen) | Recent Studies (post-2010) (naproxen) | Studies (tretinoin) | Trials (tretinoin) | Recent Studies (post-2010) (tretinoin) |
|---|---|---|---|---|---|
| 4,551 | 1,057 | 1,429 | 23,654 | 1,083 | 6,085 |
| Protein | Taxonomy | naproxen (IC50) | tretinoin (IC50) |
|---|---|---|---|
| Bile salt export pump | Homo sapiens (human) | 10 | |
| Amyloid-beta precursor protein | Homo sapiens (human) | 0.18 | |
| Adenosine receptor A3 | Homo sapiens (human) | 5.275 | |
| Retinoic acid receptor alpha | Homo sapiens (human) | 2.2542 | |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | 5.3 | |
| Retinoic acid receptor beta | Homo sapiens (human) | 0.7537 | |
| Retinoic acid receptor alpha | Mus musculus (house mouse) | 0.0057 | |
| Retinoic acid receptor gamma | Homo sapiens (human) | 0.0064 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 5.275 | |
| Retinoic acid receptor gamma | Mus musculus (house mouse) | 0.004 | |
| Retinoic acid receptor beta | Mus musculus (house mouse) | 0.005 | |
| Mitogen-activated protein kinase 1 | Homo sapiens (human) | 0.576 | |
| Nuclear receptor ROR-alpha | Homo sapiens (human) | 0.1995 | |
| Alpha-synuclein | Homo sapiens (human) | 3 | |
| Cellular retinoic acid-binding protein 1 | Gallus gallus (chicken) | 0.5233 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.358 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 5.275 | |
| Retinoic acid receptor RXR-gamma | Homo sapiens (human) | 0.35 | |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | 0.1995 | |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | 5.3 | |
| Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | 0.82 | |
| 60 kDa chaperonin | Escherichia coli | 6.7 | |
| 10 kDa chaperonin | Escherichia coli | 6.7 | |
| Nuclear receptor ROR-beta | Homo sapiens (human) | 0.1259 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 8 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Strassburg, CP; Tukey, RH | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Avdeef, A; Tam, KY | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Ballaron, SJ; De Young, LM; Puhvel, SM; Spires, DA; Young, JM | 1 |
2 review(s) available for naproxen and tretinoin
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
10 other study(ies) available for naproxen and tretinoin
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Intradermal injection of Propionibacterium acnes: a model of inflammation relevant to acne.
Topics: Acne Vulgaris; Animals; Benzoyl Peroxide; Disease Models, Animal; Erythromycin; Female; Fluocinolone Acetonide; Inflammation; Injections, Intradermal; Naproxen; Propionibacterium acnes; Pyrazoles; Rats; Rats, Inbred Strains; Tetracycline; Tretinoin | 1984 |