naproxen has been researched along with promethazine in 13 studies
| Studies (naproxen) | Trials (naproxen) | Recent Studies (post-2010) (naproxen) | Studies (promethazine) | Trials (promethazine) | Recent Studies (post-2010) (promethazine) |
|---|---|---|---|---|---|
| 4,551 | 1,057 | 1,429 | 3,110 | 299 | 235 |
| Protein | Taxonomy | naproxen (IC50) | promethazine (IC50) |
|---|---|---|---|
| Spike glycoprotein | Betacoronavirus England 1 | 5.86 | |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | 5.86 | |
| Transmembrane protease serine 2 | Homo sapiens (human) | 5.86 | |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.012 | |
| Procathepsin L | Homo sapiens (human) | 5.86 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 4.238 | |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 0.035 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 0.0076 | |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | 0.0046 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.681 | |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | 5.86 | |
| Replicase polyprotein 1ab | Human coronavirus 229E | 5.86 | |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | 5.86 | |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | 5.86 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 0.014 | |
| D(2) dopamine receptor | Homo sapiens (human) | 0.4395 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.053 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 2.431 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 2.596 | |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | 0.02 | |
| D(1A) dopamine receptor | Homo sapiens (human) | 2.744 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 4.238 | |
| Histamine H2 receptor | Homo sapiens (human) | 1.165 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.183 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.045 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.012 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 2.596 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 5.8 | |
| Histamine H1 receptor | Homo sapiens (human) | 0.0041 | |
| D(3) dopamine receptor | Homo sapiens (human) | 0.559 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.068 | |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 2.429 | |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | 5.86 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.287 | |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | 5.86 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 6 (46.15) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Strassburg, CP; Tukey, RH | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Mathew, NT | 1 |
| Farewell, J; Johnson, WH; Mintz, L; Sunahara, FA | 1 |
| Rothrock, JF | 1 |
2 review(s) available for naproxen and promethazine
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
2 trial(s) available for naproxen and promethazine
| Article | Year |
|---|---|
Amelioration of ergotamine withdrawal symptoms with naproxen.
Topics: Adult; Clinical Trials as Topic; Ergotamine; Female; Headache; Humans; Male; Middle Aged; Naproxen; Promethazine; Substance Withdrawal Syndrome | 1987 |
Pharmacological interventions for motion sickness: cardiovascular effects.
Topics: Adult; Dextroamphetamine; Double-Blind Method; Drug Combinations; Ephedrine; Hemodynamics; Humans; Male; Motion Sickness; Naproxen; Promethazine; Scopolamine; Vestibule, Labyrinth | 1987 |
9 other study(ies) available for naproxen and promethazine
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Images from headache: a costly attack of migraine.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Brain; Drug Therapy, Combination; Electrocardiography; Emergency Service, Hospital; Female; Hematologic Tests; Humans; Migraine Disorders; Naproxen; Promethazine; Serotonin Receptor Agonists; Sumatriptan; Tomography, X-Ray Computed | 2008 |