Page last updated: 2024-12-11

19-hydroxyprostaglandin e1

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

## 19-Hydroxyprostaglandin E1 (19-OH-PGE1): An Important Research Molecule

19-Hydroxyprostaglandin E1 (19-OH-PGE1) is a **metabolite of prostaglandin E1 (PGE1)**, a naturally occurring lipid mediator involved in various physiological processes, such as inflammation, pain, fever, and vascular regulation.

**Here's what makes 19-OH-PGE1 important for research:**

**1. Potential Therapeutic Applications:**

* **Cardiovascular Disease:** Studies suggest 19-OH-PGE1 could potentially protect against cardiovascular disease by improving vascular function, reducing blood pressure, and inhibiting platelet aggregation.
* **Cancer:** 19-OH-PGE1 shows promise in inhibiting tumor growth and promoting apoptosis (programmed cell death) in certain cancer cell lines.
* **Neurological Disorders:** Research indicates that 19-OH-PGE1 may have neuroprotective effects and could be beneficial in treating conditions like Alzheimer's disease and stroke.
* **Gastrointestinal Disorders:** 19-OH-PGE1 might be beneficial in treating inflammatory bowel diseases and peptic ulcers.

**2. Unique Properties and Mechanisms:**

* **Higher Stability:** 19-OH-PGE1 exhibits greater stability than its precursor, PGE1, making it potentially more effective in therapeutic applications.
* **Distinct Receptor Binding:** While both PGE1 and 19-OH-PGE1 bind to the same receptors (EP1-4), 19-OH-PGE1 displays a different affinity and activation profile, leading to different biological responses.
* **Multiple Targets:** 19-OH-PGE1 might exert its effects by targeting multiple pathways and interacting with various cellular components, making it a multifaceted therapeutic agent.

**3. Research Opportunities:**

* **Understanding its Mechanisms:** More research is needed to understand the exact mechanisms by which 19-OH-PGE1 exerts its therapeutic effects. This will help refine its application and develop more targeted treatment strategies.
* **Developing Novel Therapeutics:** Identifying the precise pathways and receptors involved in 19-OH-PGE1's actions could lead to the development of new drugs for various conditions.
* **Optimizing Delivery:** Research on the optimal delivery methods for 19-OH-PGE1 is crucial for maximizing its therapeutic potential and minimizing any potential side effects.

**Overall, 19-OH-PGE1 presents a promising therapeutic opportunity for various diseases. Ongoing research aims to understand its mechanisms, explore its potential applications, and ultimately develop safe and effective treatments based on this unique molecule.**

19-hydroxyprostaglandin E1: RN given refers to (11alpha,13E,15S)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6438402
MeSH IDM0084143

Synonyms (11)

Synonym
1-oh-pge1
gtpl1944
PDSP2_001678
19-hydroxyprostaglandin e1
7-[(1r,2r,3r)-2-[(e,3s)-3,7-dihydroxyoct-1-enyl]-3-hydroxy-5-oxocyclopentyl]heptanoic acid
prost-13-en-1-oic acid, 11,15,19-trihydroxy-9-oxo-, (11alpha,13e,15s)-
55123-67-6
19-hydroxy-pge1
19-oh pge1
Q27071074
PD046358
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1346307Mouse EP4 receptor (Prostanoid receptors)1997British journal of pharmacology, Sep, Volume: 122, Issue:2
Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-199014 (73.68)18.7374
1990's5 (26.32)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.24

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.24 (24.57)
Research Supply Index3.09 (2.92)
Research Growth Index4.33 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.24)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.76%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other20 (95.24%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]