Page last updated: 2024-09-04

naproxen and pimozide

naproxen has been researched along with pimozide in 10 studies

Compound Research Comparison

Studies
(naproxen)
Trials
(naproxen)
Recent Studies (post-2010)
(naproxen)
Studies
(pimozide)
Trials
(pimozide)
Recent Studies (post-2010) (pimozide)
4,5511,0571,4291,837143152

Protein Interaction Comparison

ProteinTaxonomynaproxen (IC50)pimozide (IC50)
XBP1Homo sapiens (human)10
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.201
Ubiquitin carboxyl-terminal hydrolase 1Homo sapiens (human)2
Potassium channel subfamily K member 2Homo sapiens (human)1.8
Bile salt export pumpHomo sapiens (human)10
Sodium channel protein type 2 subunit alphaRattus norvegicus (Norway rat)0.34
ATP-dependent translocase ABCB1Homo sapiens (human)2.2
Cytochrome P450 3A4Homo sapiens (human)9.7
DRattus norvegicus (Norway rat)0.0004
D(3) dopamine receptorRattus norvegicus (Norway rat)0.0004
ATP-dependent translocase ABCB1Mus musculus (house mouse)4.9
D(1B) dopamine receptorRattus norvegicus (Norway rat)0.0004
D(4) dopamine receptorRattus norvegicus (Norway rat)0.0004
Mu-type opioid receptorHomo sapiens (human)0.372
Sodium channel protein type 1 subunit alphaHomo sapiens (human)0.054
Sodium channel protein type 4 subunit alphaHomo sapiens (human)0.054
Delta-type opioid receptorHomo sapiens (human)3.76
Kappa-type opioid receptorHomo sapiens (human)0.99
D(2) dopamine receptorRattus norvegicus (Norway rat)0.0004
Sodium channel protein type 7 subunit alphaHomo sapiens (human)0.054
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.201
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.152
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.201
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.201
Sodium channel protein type 5 subunit alphaHomo sapiens (human)0.054
Sodium channel protein type 9 subunit alphaHomo sapiens (human)0.054
WD repeat-containing protein 48Homo sapiens (human)2
Sodium channel protein type 2 subunit alphaHomo sapiens (human)0.054
Sodium channel protein type 3 subunit alphaHomo sapiens (human)0.054
Sodium channel protein type 11 subunit alphaHomo sapiens (human)0.054
Sodium channel protein type 8 subunit alphaHomo sapiens (human)0.054
Sodium channel protein type 10 subunit alphaHomo sapiens (human)0.054

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19901 (10.00)18.7374
1990's0 (0.00)18.2507
2000's2 (20.00)29.6817
2010's7 (70.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andrews, PR; Craik, DJ; Martin, JL1
Topliss, JG; Yoshida, F1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1

Reviews

1 review(s) available for naproxen and pimozide

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

9 other study(ies) available for naproxen and pimozide

ArticleYear
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics

2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014