Page last updated: 2024-09-04

naproxen and rhein

naproxen has been researched along with rhein in 2 studies

Compound Research Comparison

Studies (naproxen)	Trials (naproxen)	Recent Studies (post-2010) (naproxen)	Studies (rhein)	Trials (rhein)	Recent Studies (post-2010) (rhein)
4,551	1,057	1,429	620	7	368

Protein Interaction Comparison

Protein	Taxonomy	rhein (IC50)
90-kda heat shock protein beta HSP90 beta, partial	Homo sapiens (human)	3.3393
heat shock protein HSP 90-alpha isoform 2	Homo sapiens (human)	3.3393
tyrosine-protein phosphatase non-receptor type 7 isoform 2	Homo sapiens (human)	19.62

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (50.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Duval, N; Fernandes, JC; Martel-Pelletier, J; Mineau, F; Pelletier, JP	1
Ohmori, K; Tamura, T	1

Other Studies

2 other study(ies) available for naproxen and rhein

Article	Year
Diacerhein and rhein reduce the interleukin 1beta stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes. The Journal of rheumatology, 1998, Volume: 25, Issue:12 Topics: Aged; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Chondrocytes; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; Isoenzymes; Male; Membrane Proteins; Middle Aged; Naproxen; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Osteoarthritis; Prostaglandin-Endoperoxide Synthases	1998
Rhein, an active metabolite of diacerein, suppresses the interleukin-1alpha-induced proteoglycan degradation in cultured rabbit articular chondrocytes. Japanese journal of pharmacology, 2001, Volume: 85, Issue:1 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Cells, Cultured; Chondrocytes; Enzyme Inhibitors; Female; Interleukin-1; Joints; Knee; Matrix Metalloproteinases; Naproxen; Proteoglycans; Rabbits; Shoulder	2001

Article

Year

Diacerhein and rhein reduce the interleukin 1beta stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes.

The Journal of rheumatology, 1998, Volume: 25, Issue:12

Topics: Aged; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Chondrocytes; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; Isoenzymes; Male; Membrane Proteins; Middle Aged; Naproxen; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Osteoarthritis; Prostaglandin-Endoperoxide Synthases

1998

Rhein, an active metabolite of diacerein, suppresses the interleukin-1alpha-induced proteoglycan degradation in cultured rabbit articular chondrocytes.

Japanese journal of pharmacology, 2001, Volume: 85, Issue:1

Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Cells, Cultured; Chondrocytes; Enzyme Inhibitors; Female; Interleukin-1; Joints; Knee; Matrix Metalloproteinases; Naproxen; Proteoglycans; Rabbits; Shoulder

2001