chlordecone reductase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: chlordecone alcohol + NADP+ = chlordecone + H+ + NADPH. [EC:1.1.1.225, RHEA:14401]

Chlordecone reductase activity refers to the enzymatic process of reducing the pesticide chlordecone (Kepone), a highly persistent organochlorine insecticide. This reduction is typically achieved by a specific type of enzyme known as a chlordecone reductase. These enzymes often belong to the NAD(P)H-dependent oxidoreductase family and utilize NADH or NADPH as electron donors. They catalyze the transfer of electrons from the electron donor to chlordecone, resulting in the formation of a less toxic, reduced form of the insecticide. The reduction mechanism involves the addition of hydrogen atoms to the chlordecone molecule, leading to the breaking of its chemical bonds and ultimately its degradation. This process is crucial for detoxifying chlordecone in organisms, such as bacteria and fungi, which can metabolize the insecticide. The precise mechanisms of chlordecone reduction can vary depending on the specific enzyme and its active site. Some chlordecone reductases have been shown to exhibit stereospecificity, meaning they prefer to reduce specific isomers of chlordecone. The activity of chlordecone reductases is important in environmental remediation efforts, where they contribute to the breakdown of chlordecone in contaminated soils and water. Understanding the molecular function of chlordecone reductase activity is crucial for developing strategies to mitigate the toxic effects of this persistent pesticide.'
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Proteins (1)

Compounds (12)