Compounds > naproxen
Page last updated: 2024-09-04

naproxen and hydrogen sulfide

naproxen has been researched along with hydrogen sulfide in 22 studies

Compound Research Comparison

Studies
(naproxen)		Trials
(naproxen)		Recent Studies (post-2010)
(naproxen)		Studies
(hydrogen sulfide)		Trials
(hydrogen sulfide)		Recent Studies (post-2010) (hydrogen sulfide)
4,5511,0571,4298,039835,149

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (4.55)29.6817
2010's18 (81.82)24.3611
2020's3 (13.64)2.80

Authors

AuthorsStudies
Distrutti, E; Fiorucci, S; Santucci, L1
Caliendo, G; Cirino, G; Santagada, V; Wallace, JL1
Boring, D; Chattopadhyay, M; Dastagirzada, YM; Kashfi, K; Kodela, R; Nath, N; Velázquez-Martínez, CA1
Ferraz, JG; Flannigan, KL; McKnight, W; Tuitt, D; Wallace, JL; Wang, L1
Ahmad, A; Campolo, M; Cuzzocrea, S; Di Paola, R; Esposito, E; Wallace, JL1
Atkinson, TJ; Fudin, J; Jahn, HL; Kubotera, N; Rennick, AL; Rhorer, M1
Biletska, L; Bondarchuk, T; Fomenko, I; Panasyuk, N; Sklyarov, A; Wallace, JL1
Bercik, P; Blackler, RW; Manko, A; Motta, JP; Surette, MG; Wallace, JL; Workentine, M1
Ahmad, A; Bruschetta, G; Campolo, M; Cordaro, M; Cuzzocrea, S; Di Paola, R; Esposito, E; Paterniti, I; Wallace, JL1
Bula, N; Gavrilyuk, E; Khyrivska, D; Wallace, JL; Zayachkivska, O1
Gemici, B; Wallace, JL1
Bercik, P; Blackler, RW; Buret, AG; Da Silva, GJ; De Palma, G; Flannigan, KL; Manko, A; Surette, MG; Wallace, JL1
Bula, N; Havryluk, E; Hrytsevych, N; Khyrivska, D; Pshyk-Titko, I; Savytska, M; Zayachkivska, O1
Dief, AE; Mostafa, DK; Sharara, GM; Zeitoun, TH1
Chattopadhyay, M; Kashfi, K; Kodela, R; Nath, N; Nesbitt, DE; Velázquez-Martínez, CA1
Agbor, TA; Chan, M; Cheadle, C; Devchand, P; Elsheikh, W; Flannigan, KL; Freydin, M; Ianaro, A; Kirkby, N; Mitchell, JA; Paul-Clark, M; Wallace, JL1
El Azhary, NM; Mostafa, DK; Nasra, RA1
de Nucci, G; Dicay, M; MacNaughton, WK; Vaughan, D; Wallace, JL1
Allain, T; Buret, AG; de Nucci, G; Ditrói, T; Feener, TD; Muscara, MN; Nagy, P; Vaughan, DJ; Wallace, JL1
Pluth, MD; Steiger, AK; Zhao, Y1
Flint, JD; Gilroy, DW; Glanville, JRW; Hosin, AA; Jalali, P; Maini, AA; Patel, AA; Wallace, JL1
Caliendo, G; Corvino, A; Esposito, G; Fiorino, F; Frecentese, F; Magli, E; Migliaccio, M; Perissutti, E; Santagada, V; Scognamiglio, A; Severino, B; Sparaco, R1

Reviews

4 review(s) available for naproxen and hydrogen sulfide

ArticleYear
NSAIDs, coxibs, CINOD and H2S-releasing NSAIDs: what lies beyond the horizon.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2007, Volume: 39, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Disease Models, Animal; Duodenal Ulcer; Gastric Mucosa; Humans; Hydrogen Sulfide; Naproxen; Nitric Oxide; Nitric Oxide Donors; Stomach Ulcer

2007
What's new in NSAID pharmacotherapy: oral agents to injectables.
    Pain medicine (Malden, Mass.), 2013, Volume: 14 Suppl 1

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Humans; Hyaluronic Acid; Hydrogen Sulfide; Ibuprofen; Injections; Injections, Intra-Articular; Isoxazoles; Nanoparticles; Naproxen; Nitric Oxide Donors; Vasodilator Agents

2013
Hydrogen Sulfide-Releasing Therapeutics: Translation to the Clinic.
    Antioxidants & redox signaling, 2018, 06-01, Volume: 28, Issue:16

    Topics: Animals; Arthritis; Captopril; Cardiovascular Agents; Cardiovascular Diseases; Dose-Response Relationship, Drug; Humans; Hydrogen Sulfide; Naproxen

2018
H
    Biomolecules, 2021, 12-18, Volume: 11, Issue:12

    Topics: Animals; Benzenesulfonates; Chemistry, Pharmaceutical; Drug Discovery; Gasotransmitters; Humans; Hydrogen Sulfide; Morpholines; Naproxen; Organothiophosphorus Compounds

2021

Trials

2 trial(s) available for naproxen and hydrogen sulfide

ArticleYear
A proof-of-concept, Phase 2 clinical trial of the gastrointestinal safety of a hydrogen sulfide-releasing anti-inflammatory drug.
    British journal of pharmacology, 2020, Volume: 177, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Double-Blind Method; Humans; Hydrogen Sulfide; Naproxen; Pharmaceutical Preparations

2020
Potent anti-inflammatory effects of an H
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:10

    Topics: Adolescent; Adult; Dinoprostone; Escherichia coli; Humans; Hydrogen Sulfide; Inflammation; Male; Middle Aged; Monocytes; Naproxen; Neutrophils; Pain; Phenotype; Solubility; Ultraviolet Rays; Vasoconstriction; Young Adult

2021

Other Studies

16 other study(ies) available for naproxen and hydrogen sulfide

ArticleYear
Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346).
    British journal of pharmacology, 2010, Volume: 159, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Blood Pressure; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Gastric Mucosa; Hydrogen Sulfide; Hypertension; Intestinal Mucosa; Intestine, Small; Male; Mice; Molecular Structure; Naproxen; Rats; Rats, Wistar; Stomach Ulcer

2010
Hydrogen sulfide-releasing NSAIDs inhibit the growth of human cancer cells: a general property and evidence of a tissue type-independent effect.
    Biochemical pharmacology, 2012, Mar-15, Volume: 83, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Aspirin; Cell Line, Tumor; Cell Proliferation; Growth Inhibitors; Humans; Hydrogen Sulfide; Ibuprofen; Naproxen; Sulindac; Thiones

2012
Pro-resolution, protective and anti-nociceptive effects of a cannabis extract in the rat gastrointestinal tract.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2013, Volume: 64, Issue:2

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cannabis; Colitis; Gastrointestinal Tract; Hydrogen Sulfide; Indoles; Male; Naproxen; Piperidines; Plant Extracts; Protective Agents; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Stomach Ulcer; Visceral Pain

2013
A hydrogen sulfide-releasing cyclooxygenase inhibitor markedly accelerates recovery from experimental spinal cord injury.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013, Volume: 27, Issue:11

    Topics: Administration, Oral; Animals; Apoptosis; Cyclooxygenase Inhibitors; Cytokines; Hydrogen Sulfide; Locomotion; Male; Mice; Naproxen; Recovery of Function; Spinal Cord; Spinal Cord Injuries

2013
Effects of conventional and hydrogen sulfide-releasing non-steroidal anti-inflammatory drugs in rats with stress-induced and epinephrine-induced gastric damage.
    Stress (Amsterdam, Netherlands), 2014, Volume: 17, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Celecoxib; Disease Models, Animal; Epinephrine; Gastric Mucosa; Hydrogen Sulfide; Lipid Peroxidation; Male; Naproxen; Nitric Oxide; Nitric Oxide Synthase; Pyrazoles; Rats, Wistar; Restraint, Physical; Severity of Illness Index; Stomach Ulcer; Stress, Psychological; Sulfonamides

2014
Hydrogen sulphide protects against NSAID-enteropathy through modulation of bile and the microbiota.
    British journal of pharmacology, 2015, Volume: 172, Issue:4

    Topics: Alanine; Allyl Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile; Cell Line; Cyclooxygenase 1; Gastrointestinal Hemorrhage; Humans; Hydrogen Sulfide; Intestinal Diseases; Intestinal Mucosa; Jejunum; Membrane Proteins; Microbiota; Naproxen; Protective Agents; Rats, Wistar; Sulfides; Ulcer

2015
Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice.
    Journal of neuroinflammation, 2014, Dec-04, Volume: 11

    Topics: Animals; Brain Injuries; Cerebral Cortex; Cyclooxygenase Inhibitors; Hydrogen Sulfide; Male; Mice; Motor Skills Disorders; Naproxen; Organ Size; Random Allocation

2014
Exposure to non-steroid anti-inflammatory drugs (NSAIDs) and suppressing hydrogen sulfide synthesis leads to altered structure and impaired function of the oesophagus and oesophagogastric junction.
    Inflammopharmacology, 2015, Volume: 23, Issue:2-3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease Models, Animal; Esophagogastric Junction; Hydrogen Sulfide; Naproxen; Rats; Sulfides

2015
Anti-inflammatory and cytoprotective properties of hydrogen sulfide.
    Methods in enzymology, 2015, Volume: 555

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Gastrointestinal Tract; Gene Expression Regulation; Humans; Hydrogen Sulfide; Inflammation; Inflammatory Bowel Diseases; Intestinal Mucosa; Naproxen; Neurodegenerative Diseases; Pain; Protective Agents; Signal Transduction; Spinal Cord Injuries

2015
Deciphering the pathogenesis of NSAID enteropathy using proton pump inhibitors and a hydrogen sulfide-releasing NSAID.
    American journal of physiology. Gastrointestinal and liver physiology, 2015, Jun-15, Volume: 308, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Hepatobiliary Elimination; Hydrogen Sulfide; Inflammation; Intestinal Diseases; Male; Naproxen; Proton Pump Inhibitors; Rats, Wistar; RNA, Ribosomal, 16S

2015
Effect of CCl4 and blocking H2S biosynthesis on oesophageal mucosa rats: model of nonerosive oesophagitis.
    Folia medica Cracoviensia, 2014, Volume: 54, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Tetrachloride; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Esophagitis, Peptic; Esophagus; Hydrogen Sulfide; Interleukin-10; Interleukin-17; Mucous Membrane; Naproxen; Nitric Oxide; Rats; Rats, Wistar

2014
Hydrogen sulfide releasing naproxen offers better anti-inflammatory and chondroprotective effect relative to naproxen in a rat model of zymosan induced arthritis.
    European review for medical and pharmacological sciences, 2015, Volume: 19, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Hydrogen Sulfide; Injections, Intra-Articular; Male; Naproxen; Neutrophils; Pain; Rats; Rats, Wistar; Zymosan

2015
Hydrogen sulfide-releasing naproxen suppresses colon cancer cell growth and inhibits NF-κB signaling.
    Drug design, development and therapy, 2015, Volume: 9

    Topics: Animals; Anticarcinogenic Agents; Apoptosis; Cell Cycle; Cell Proliferation; Colorectal Neoplasms; Dose-Response Relationship, Drug; HT29 Cells; Humans; Hydrogen Sulfide; Male; Mice, Nude; Naproxen; NF-kappa B; Signal Transduction; Thioredoxin-Disulfide Reductase; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays

2015
Profound Chemopreventative Effects of a Hydrogen Sulfide-Releasing NSAID in the APCMin/+ Mouse Model of Intestinal Tumorigenesis.
    PloS one, 2016, Volume: 11, Issue:2

    Topics: Adenomatous Polyposis Coli Protein; Animals; Anti-Inflammatory Agents, Non-Steroidal; beta Catenin; Carcinogenesis; Chemoprevention; Colon; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Hydrogen Sulfide; Intestinal Neoplasms; Intestinal Polyps; Male; Mice; Mice, Inbred C57BL; Naproxen; Proto-Oncogene Proteins c-myc

2016
The hydrogen sulfide releasing compounds ATB-346 and diallyl trisulfide attenuate streptozotocin-induced cognitive impairment, neuroinflammation, and oxidative stress in rats: involvement of asymmetric dimethylarginine.
    Canadian journal of physiology and pharmacology, 2016, Volume: 94, Issue:7

    Topics: Allyl Compounds; Animals; Arginine; Cognitive Dysfunction; Hydrogen Sulfide; Inflammation; Inflammation Mediators; Male; Maze Learning; Naproxen; Oxidative Stress; Rats; Rats, Wistar; Streptozocin; Sulfides

2016
Cyclic Sulfenyl Thiocarbamates Release Carbonyl Sulfide and Hydrogen Sulfide Independently in Thiol-Promoted Pathways.
    Journal of the American Chemical Society, 2019, 08-28, Volume: 141, Issue:34

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Carbonic Anhydrases; Cyclization; HeLa Cells; Humans; Hydrogen Sulfide; Naproxen; Sulfhydryl Compounds; Sulfur Oxides; Thiocarbamates

2019