naproxen has been researched along with Gastric Ulcer in 79 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (12.66) | 18.7374 |
| 1990's | 24 (30.38) | 18.2507 |
| 2000's | 25 (31.65) | 29.6817 |
| 2010's | 19 (24.05) | 24.3611 |
| 2020's | 1 (1.27) | 2.80 |
| Authors | Studies |
|---|---|
| Ackrell, J; Antonio, Y; Franco, F; Landeros, R; Leon, A; Maddox, ML; Muchowski, JM; Nelson, PH; Rooks, WH; Roszkowski, AP; Wallach, MB | 1 |
| Asselin, AA; Dobson, TA; Humber, LG; Komlossy, J | 1 |
| Amir, M; Javed, SA; Kumar, H | 2 |
| Abdellatif, KR; Chowdhury, MA; DuMond, JF; Huang, Z; King, SB; Knaus, EE; Reisz, JA; Velázquez, CA | 1 |
| Guo, L; He, G; He, J; Ouyang, L; Pan, J; Shi, J; Wei, J; Zhang, J; Zhou, R | 1 |
| Boixareu, N; Campanera, JM; Navarro, L; Pors, K; Pouplana, R; Pujol, MD; Rosell, G; Sánchez, S | 1 |
| Qureshi, IZ; Razzaq, A | 1 |
| Bernal Monterde, V; Fernández Bonilla, E; García Cámara, P; Gotor Delso, J; Llorente Barrio, M; Monzón Báez, RM; Sanz Segura, P | 1 |
| Ferraz, JG; Flannigan, KL; McKnight, W; Tuitt, D; Wallace, JL; Wang, L | 1 |
| Biletska, L; Bondarchuk, T; Fomenko, I; Panasyuk, N; Sklyarov, A; Wallace, JL | 1 |
| Kim, BW; Kim, JH; Kwon, HJ | 1 |
| Jin, S; Kim, BW; Kim, JH; Kwon, HJ | 1 |
| Berk, B; Erol, DD; Kupeli, E; Yesilada, E | 1 |
| Caliendo, G; Cirino, G; Santagada, V; Wallace, JL | 1 |
| Fort, JG; Goldstein, JL; Hochberg, MC; Hwang, C; Sostek, M; Zhang, Y | 1 |
| Abid, Z; Ahmad, A; Khan, AA; Kumar, BS; Kunwar, A; Manoj, G; Priyadarsini, KI; Saikant, R; Sivaram, G; Tiwari, SK | 1 |
| Bouchner, L; David, J; Goldstein, JL; Grim, J; Jungwirthová, A; Pešek, F; Searle, S; Sewell, KL; Skopek, J; Spindel, E; Ulč, I | 1 |
| Cariño-Cortés, R; Castañeda-Hernández, G; González-García, MP; Ortiz, MI; Ponce-Monter, HA; Ramírez-Montiel, ML | 1 |
| Estborn, L; Fort, JG; Sostek, MB; Vikman, K | 1 |
| Dhillon, S | 1 |
| Chang, HI; Kim, SJ; Paik, HD; Park, YS | 1 |
| Marshall, LL | 1 |
| Sheha, M | 1 |
| Bhise, KS; Bodhankar, SL; Ghosh, P; Kadam, SS; Paradkar, AR | 1 |
| Bonina, F; Puglia, C; Saija, A; Santagati, NA; Tita, B; Tomaino, A | 1 |
| Jain, NK; Kulkarni, SK; Singh, A | 1 |
| Ertan, M; Gökhan, N; Küpeli, E; Tozkoparan, B; Yeşilada, E | 1 |
| Cirino, G; Di Lorenzo, A; Farneti, S; Fiorucci, S; Morelli, A; Renga, B | 1 |
| Summerton, N | 1 |
| Chang, HI; Kim, JH; Kim, YS; Park, JJ; Song, GG | 1 |
| Fornstedt-Wallin, B; Hedman, A; Jonzon, B; Karlsson, P; Wilder-Smith, CH | 1 |
| Dodge, WE; Goldstein, JL; Lanza, FL; Lowry, SC; Schwartz, HI | 1 |
| Aisenberg, J; Berger, MF; Goldstein, JL; Lanza, F; Pan, S; Sands, GH; Schwartz, H | 1 |
| El-Fayomi, HM; El-Sadek, ME; Lashine, el-SM; Metwally, KA; Yaseen, SH | 1 |
| Breese, T; Dale, JC; Harris, SI; Lawson, J; McLaughlin, P; Moberly, JB; Riff, DS; Truitt, KE; Wan, Y; Xu, J | 1 |
| Gitton, X; Hawkey, CJ; Krammer, G; Matchaba, P; Mellein, B; Richard, D; Sallstig, P; Smalley, W; Stricker, K; Weinstein, WM | 1 |
| Aisenberg, J; Berger, MF; Dodge, WE; Goldstein, JL; Zakko, SF | 1 |
| Amer, F; Cryer, B; Goldstein, JL; Hunt, B | 1 |
| Distrutti, E; Fiorucci, S; Santucci, L | 1 |
| Aisenberg, J; Benson, AA; Bodian, CA; Cohen, LB; Desai, JC; Goo, T; Miller, KM; Sanyal, SM | 1 |
| Boyle, EA; Freeman, PC; Mangan, FR; Thomson, MJ | 1 |
| Colombo, G; Glässer, A; Luzzani, F; Schiatti, P; Selva, D | 1 |
| Greenberg, BP; Lanza, FL; Nelson, RS | 1 |
| Ciofalo, VB; Diamantis, W; Melton, J; Sofia, RD | 1 |
| Barbanti, M; Bertoli, D; Lencioni, E; Rotini, L; Zannotti, A | 1 |
| Felder, M | 1 |
| Bijlsma, JW; Lems, WF; van Berge Henegouwen, GP | 1 |
| Casini-Raggi, V; Cominelli, F; Laine, L; Marin-Sorensen, M; Sloane, R; Weinstein, WM | 1 |
| Adami, A; Benoni, G; Conforti, A; Cuzzolin, L; Del Soldato, P; Lussignoli, S; Menestrina, F | 1 |
| Crider, AM; Khan, MA; Narurkar, MM; Tammara, VK | 1 |
| Cominelli, F; Ferretti, M; Laine, L; Sloane, R | 1 |
| Amiot, X; Bodin, F; Denis, M; Dominguez, S; Grangé, JD; Guillevin, L | 1 |
| Rioux, KP; Wallace, JL | 1 |
| Appleyard, CB; McCafferty, DM; Swain, MG; Tigley, AW; Wallace, JL | 1 |
| Ardizzone, S; Bianchi Porro, G; Brunetti, G; Frizziero, L; Grandinetti, G; Menegatti, M; Miglioli, M; Montrone, F; Petrillo, M; Vaira, D | 1 |
| Bianchi Porro, G; Lazzaroni, M; Petrillo, M | 1 |
| Chan, CS; Chan, FK; Chung, SC; Lee, YT; Leung, VK; Li, EK; Sung, JJ; To, KF; Woo, J; Yung, MY | 1 |
| Lanas Arbeloa, A; Serrano Aulló, MT | 1 |
| Del Soldato, P; McKnight, W; Muscará, MN; Wallace, JL | 1 |
| McKenna, F | 1 |
| Buret, A; Elliott, SN; McKnight, W; Miller, MJ; Wallace, JL | 1 |
| Geis, GS; Hubbard, RC; Isakson, PC; Lanza, FL; Lipsky, PE; Schwartz, BD; Simon, LS; Talwalker, S | 1 |
| Fitzpatrick, LR; Le, T; Sakurai, K | 1 |
| Brzozowski, T; Drozdowicz, D; Hahn, E; Konturek, PC; Konturek, SJ; Kwiecień, S; Pajdo, R; Pawlik, M; Ptak, A; Sliwowski, Z | 1 |
| Graham, DY; Malaty, HM | 1 |
| Gottlieb, S | 1 |
| Aktay, G; Berk, B; Ertan, M; Yesilada, E | 1 |
| El-Zimaity, HM; Graham, DY; Qureshi, WA; Saeed, MA; Shiotani, A; Yamaoka, Y | 1 |
| Ito, T; Mori, E; Muroga, T; Nakajima, A; Tanaka, S | 1 |
| Carrasco, E; Felipe, A; Grau, M; Guasch, J; Juliá, S; Montero, JL | 2 |
| Draz, U; Janjua, MZ | 1 |
| Evans, DG; Graham, DY; Lanza, FL | 1 |
| Huq, M | 1 |
| Bennett, R; Caldron, P; Doucette, M; Ekholm, B; Goldlust, B; Hartman, R; Lee, E; Mitchell, C; Roth, S; Wilson, R | 1 |
| Davis, RE; Graham, DY; Lanza, FL; Rack, MF | 1 |
| Faulkner, G; Langman, M; Somerville, K | 1 |
5 review(s) available for naproxen and Gastric Ulcer
| Article | Year |
|---|---|
Naproxen/esomeprazole fixed-dose combination: for the treatment of arthritic symptoms and to reduce the risk of gastric ulcers.
Topics: Animals; Arthritis; Drug Combinations; Drug Dosage Calculations; Esomeprazole; Humans; Naproxen; Stomach Ulcer | 2011 |
Gastrointestinal bleeding and possible hypothyroidism.
Topics: Aged, 80 and over; Amiodarone; Anemia; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Atenolol; Atrial Fibrillation; Duodenal Ulcer; Female; Gastrointestinal Hemorrhage; Humans; Hypothyroidism; Naproxen; Stomach Ulcer; Thyroxine | 2012 |
NSAIDs, coxibs, CINOD and H2S-releasing NSAIDs: what lies beyond the horizon.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Disease Models, Animal; Duodenal Ulcer; Gastric Mucosa; Humans; Hydrogen Sulfide; Naproxen; Nitric Oxide; Nitric Oxide Donors; Stomach Ulcer | 2007 |
['Stomach-friendly' NSAIDs: careful optimism?].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Butanones; Gastritis; Humans; Ibuprofen; Misoprostol; Nabumetone; Naproxen; Randomized Controlled Trials as Topic; Risk Factors; Stomach Ulcer | 1995 |
[Gastric lesion caused by NSAID and inflammation due to Helicobacter pylori. Is there potentiation or attenuation?].
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Clinical Trials as Topic; Confidence Intervals; Duodenal Ulcer; Enzyme Inhibitors; Gastritis; Helicobacter Infections; Helicobacter pylori; Histamine H2 Antagonists; Humans; Multicenter Studies as Topic; Naproxen; Omeprazole; Peptic Ulcer; Prospective Studies; Ranitidine; Risk Factors; Stomach Ulcer | 1998 |
25 trial(s) available for naproxen and Gastric Ulcer
| Article | Year |
|---|---|
Clinical trial: the incidence of NSAID-associated endoscopic gastric ulcers in patients treated with PN 400 (naproxen plus esomeprazole magnesium) vs. enteric-coated naproxen alone.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Esomeprazole; Humans; Incidence; Magnesium; Middle Aged; Naproxen; Osteoarthritis; Stomach Ulcer; Tablets, Enteric-Coated; Treatment Outcome; Young Adult | 2010 |
Clinical trial: endoscopic evaluation of naproxen etemesil, a naproxen prodrug, vs. naproxen - a proof-of-concept, randomized, double-blind, active-comparator study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Endoscopy, Gastrointestinal; Female; Gastric Mucosa; Humans; Male; Middle Aged; Naproxen; Prodrugs; Stomach Ulcer | 2010 |
Long-term safety of naproxen and esomeprazole magnesium fixed-dose combination: phase III study in patients at risk for NSAID-associated gastric ulcers.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Dosage Forms; Drug Combinations; Esomeprazole; Female; Humans; Magnesium Compounds; Male; Middle Aged; Naproxen; Osteoarthritis; Risk Factors; Stomach Ulcer; Time Factors | 2011 |
Dose-effect comparisons of the CINOD AZD3582 and naproxen on upper gastrointestinal tract mucosal injury in healthy subjects.
Topics: Adult; Cross-Over Studies; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Duodenal Ulcer; Endoscopy, Gastrointestinal; Female; Humans; Intestinal Mucosa; Male; Naphthalenes; Naproxen; Reference Values; Stomach Ulcer; Thromboxane B2; Treatment Outcome | 2006 |
The impact of low-dose aspirin on endoscopic gastric and duodenal ulcer rates in users of a non-selective non-steroidal anti-inflammatory drug or a cyclo-oxygenase-2-selective inhibitor.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Drug Administration Schedule; Duodenal Ulcer; Endoscopy, Gastrointestinal; Female; Humans; Male; Middle Aged; Naproxen; Prospective Studies; Pyrazoles; Stomach Ulcer; Sulfonamides; Treatment Outcome | 2006 |
A multicenter, randomized, double-blind, active-comparator, placebo-controlled, parallel-group comparison of the incidence of endoscopic gastric and duodenal ulcer rates with valdecoxib or naproxen in healthy subjects aged 65 to 75 years.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Duodenal Ulcer; Endoscopy, Gastrointestinal; Female; Humans; Isoxazoles; Male; Middle Aged; Naproxen; Stomach Ulcer; Sulfonamides | 2006 |
A randomized, double-blind, one-week study comparing effects of a novel COX-2 inhibitor and naproxen on the gastric mucosa.
Topics: Adult; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Duodenal Ulcer; Duodenum; Endoscopy, Gastrointestinal; Female; Gastric Mucosa; Humans; Intestinal Mucosa; Male; Membrane Proteins; Middle Aged; Naproxen; Pyrroles; Reference Values; Stomach Ulcer; Sulfonamides; Time Factors; United States | 2007 |
Effect of risk factors on complicated and uncomplicated ulcers in the TARGET lumiracoxib outcomes study.
Topics: Age Distribution; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Diclofenac; Duodenal Ulcer; Female; Humans; Ibuprofen; Male; Middle Aged; Naproxen; Osteoarthritis; Risk Factors; Risk Reduction Behavior; Stomach Ulcer | 2007 |
Endoscopic ulcer rates in healthy subjects associated with use of aspirin (81 mg q.d.) alone or coadministered with celecoxib or naproxen: a randomized, 1-week trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Double-Blind Method; Drug Therapy, Combination; Duodenal Ulcer; Endoscopy, Gastrointestinal; Female; Humans; Male; Middle Aged; Naproxen; Pyrazoles; Random Allocation; Stomach Ulcer; Sulfonamides | 2008 |
Celecoxib plus aspirin versus naproxen and lansoprazole plus aspirin: a randomized, double-blind, endoscopic trial.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Celecoxib; Confidence Intervals; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Duodenal Ulcer; Endoscopy, Gastrointestinal; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Incidence; Lansoprazole; Male; Middle Aged; Naproxen; Osteoarthritis; Proton Pump Inhibitors; Pyrazoles; Retrospective Studies; Risk Factors; Stomach Ulcer; Sulfonamides; United States | 2007 |
Primary prevention of adverse gastroduodenal effects from short-term use of non-steroidal anti-inflammatory drugs by omeprazole 20 mg in healthy subjects: a randomized, double-blind, placebo-controlled study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Duodenal Ulcer; Duodenoscopy; Dyspepsia; Female; Gastroscopy; Helicobacter pylori; Humans; Male; Middle Aged; Naproxen; Omeprazole; Pilot Projects; Proton Pump Inhibitors; Reference Values; Stomach Ulcer; Treatment Outcome | 2008 |
Effects of fenbufen, indomethacin, naproxen, and placebo on gastric mucosa of normal volunteers. A comparative endoscopic and photographic evaluation.
Topics: Adult; Anti-Inflammatory Agents; Capsules; Drug Evaluation; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Indomethacin; Male; Naproxen; Phenylbutyrates; Placebos; Propionates; Stomach Ulcer; Tablets | 1983 |
Interaction of NSAIDs and Helicobacter pylori on gastrointestinal injury and prostaglandin production: a controlled double-blind trial.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Etodolac; Gastrointestinal Diseases; Helicobacter Infections; Helicobacter pylori; Humans; Inflammation; Middle Aged; Naproxen; Prostaglandins; Stomach Ulcer | 1995 |
A randomized double-blind comparison of placebo, etodolac, and naproxen on gastrointestinal injury and prostaglandin production.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Dinoprostone; Double-Blind Method; Drug Administration Schedule; Endoscopy, Gastrointestinal; Etodolac; Female; Gastric Mucosa; Humans; Male; Naproxen; Prospective Studies; Stomach Ulcer; Time Factors | 1995 |
Prevention with sucralfate gel of NSAID-induced gastroduodenal damage in arthritic patients.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Diclofenac; Double-Blind Method; Duodenal Ulcer; Female; Gels; Humans; Male; Middle Aged; Naproxen; Osteoarthritis; Stomach Ulcer; Sucralfate | 1996 |
Double-blind, double-dummy endoscopic comparison of the mucosal protective effects of misoprostol versus ranitidine on naproxen-induced mucosal injury to the stomach and duodenum in rheumatic patients.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Double-Blind Method; Duodenal Ulcer; Duodenum; Endoscopy, Gastrointestinal; Female; Gastric Mucosa; Humans; Intestinal Mucosa; Male; Middle Aged; Misoprostol; Naproxen; Osteoarthritis; Placebos; Ranitidine; Stomach Ulcer | 1997 |
Randomised trial of eradication of Helicobacter pylori before non-steroidal anti-inflammatory drug therapy to prevent peptic ulcers.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bismuth; Drug Administration Schedule; Duodenal Ulcer; Female; Helicobacter Infections; Helicobacter pylori; Humans; Male; Metronidazole; Middle Aged; Naproxen; Organometallic Compounds; Prospective Studies; Stomach Ulcer; Tetracycline | 1997 |
Diclofenac/misoprostol: the European clinical experience.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Diclofenac; Double-Blind Method; Drug Combinations; Duodenal Ulcer; Duodenoscopy; Gastroscopy; Humans; Misoprostol; Naproxen; Osteoarthritis; Piroxicam; Stomach Ulcer | 1998 |
Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Aspirin; Celecoxib; Cyclooxygenase Inhibitors; Endoscopy; Female; Humans; Knee Joint; Male; Middle Aged; Naproxen; Osteoarthritis; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrazoles; Safety; Severity of Illness Index; Stomach Ulcer; Sulfonamides; Thromboxane B2; Treatment Outcome | 1998 |
Alendronate and naproxen are synergistic for development of gastric ulcers.
Topics: Adult; Alendronate; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Drug Synergism; Duodenal Ulcer; Female; Gastric Mucosa; Gastroscopy; Humans; Male; Middle Aged; Naproxen; Single-Blind Method; Stomach Ulcer | 2001 |
Risk of ulcer soars with combination of arthritis drugs.
Topics: Administration, Oral; Adult; Alendronate; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Interactions; Drug Therapy, Combination; Duodenal Ulcer; Gastric Mucosa; Gastroscopy; Humans; Naproxen; Prognosis; Risk Assessment; Stomach Ulcer | 2001 |
Double-blind study of Naproxen in osteoarthritis of the knee joint.
Topics: Activities of Daily Living; Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Evaluation; Female; Gastrointestinal Hemorrhage; Humans; Knee Joint; Male; Middle Aged; Movement; Naphthaleneacetic Acids; Naproxen; Osteoarthritis; Placebos; Radiography; Skin Temperature; Stomach Ulcer | 1976 |
Effect of Helicobacter pylori infection on the severity of gastroduodenal mucosal injury after the acute administration of naproxen or aspirin to normal volunteers.
Topics: Adult; Aspirin; Duodenal Ulcer; Duodenum; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Helicobacter Infections; Helicobacter pylori; Humans; Intestinal Mucosa; Male; Naproxen; Reference Values; Stomach Ulcer | 1991 |
Reduced risk of NSAID gastropathy (GI mucosal toxicity) with nonacetylated salicylate (salsalate): an endoscopic study.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Double-Blind Method; Duodenal Ulcer; Female; Gastric Mucosa; Gastroscopy; Humans; Intestinal Mucosa; Linear Models; Male; Middle Aged; Multicenter Studies as Topic; Naproxen; Prospective Studies; Randomized Controlled Trials as Topic; Salicylates; Stomach Ulcer | 1990 |
Endoscopic comparison of cimetidine and sucralfate for prevention of naproxen-induced acute gastroduodenal injury. Effect of scoring method.
Topics: Adult; Cimetidine; Duodenal Diseases; Duodenal Ulcer; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Naproxen; Stomach Diseases; Stomach Ulcer; Sucralfate | 1990 |
49 other study(ies) available for naproxen and Gastric Ulcer
| Article | Year |
|---|---|
Synthesis and antiinflammatory activity of 6,11-dihydro-11-oxodibenzo[b,e]thiepinalkanoic acids and related compounds.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Chemical Phenomena; Chemistry; Dibenzothiepins; Dogs; Edema; Female; Gossypium; Granuloma; Male; Mice; Quinones; Rats; Stomach Ulcer; Structure-Activity Relationship | 1978 |
Cycloalkanoindoles. 1. Syntheses and antiinflammatory actions of some acidic tetrahydrocarbazoles, cyclopentindoles, and cycloheptindoles.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carbazoles; Cycloheptanes; Cyclopentanes; Edema; Indoles; Rats; Stomach Ulcer; Structure-Activity Relationship | 1976 |
Synthesis and pharmacological evaluation of condensed heterocyclic 6-substituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives of naproxen.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Lipid Peroxidation; Liver; Molecular Structure; Naproxen; Rats; Stomach Ulcer; Structure-Activity Relationship | 2007 |
Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase Inhibitors; Edema; Esters; Gastric Mucosa; Humans; Hydroxamic Acids; Ibuprofen; Indomethacin; Male; Naproxen; Nitric Oxide Donors; Nitrogen Oxides; Prodrugs; Rats; Rats, Sprague-Dawley; Stereoisomerism; Stomach Ulcer; Structure-Activity Relationship | 2011 |
Design, synthesis and biological evaluation of enzymatically cleavable NSAIDs prodrugs derived from self-immolative dendritic scaffolds for the treatment of inflammatory diseases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dendrimers; Drug Delivery Systems; Drug Design; Humans; Inflammation; Magnetic Resonance Spectroscopy; Mice; Naproxen; Prodrugs; Stomach Ulcer | 2013 |
Synthesis and biological properties of aryl methyl sulfones.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Edema; Humans; Male; Mice; Models, Molecular; Molecular Structure; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Structure-Activity Relationship; Sulfones; Thermodynamics | 2018 |
Naproxen sodium nanoparticles are less toxic and gastroprotective agents than the conventional NSAID drug naproxen sodium in Balb/c mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caspase 3; Cyclooxygenase 2; Gastric Mucosa; Interleukin-6; Magnesium Oxide; Mice; Mice, Inbred BALB C; Nanoparticles; Naproxen; Pharmaceutical Preparations; Rats; Rats, Wistar; Reactive Oxygen Species; RNA, Messenger; Stomach Ulcer; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2022 |
Upper gastrointestinal bleeding due to overdose of selective serotonin reuptake inhibitors and nonsteroidal anti-inflammatory drugs.
Topics: Abdominal Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Depressive Disorder; Desvenlafaxine Succinate; Drug Synergism; Duloxetine Hydrochloride; Duodenal Ulcer; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Male; Melena; Methimazole; Naproxen; Selective Serotonin Reuptake Inhibitors; Stomach Ulcer | 2019 |
Pro-resolution, protective and anti-nociceptive effects of a cannabis extract in the rat gastrointestinal tract.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cannabis; Colitis; Gastrointestinal Tract; Hydrogen Sulfide; Indoles; Male; Naproxen; Piperidines; Plant Extracts; Protective Agents; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Stomach Ulcer; Visceral Pain | 2013 |
Effects of conventional and hydrogen sulfide-releasing non-steroidal anti-inflammatory drugs in rats with stress-induced and epinephrine-induced gastric damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Celecoxib; Disease Models, Animal; Epinephrine; Gastric Mucosa; Hydrogen Sulfide; Lipid Peroxidation; Male; Naproxen; Nitric Oxide; Nitric Oxide Synthase; Pyrazoles; Rats, Wistar; Restraint, Physical; Severity of Illness Index; Stomach Ulcer; Stress, Psychological; Sulfonamides | 2014 |
Protective Effect of 4-(3,4-Dihydroxyphenyl)-3-Buten-2-One from Phellinus linteus on Naproxen-Induced Gastric Antral Ulcers in Rats.
Topics: Agaricales; Animals; Anti-Ulcer Agents; Antioxidants; Butanones; Catalase; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Gastric Mucosa; Glutathione Peroxidase; Lipid Peroxidation; Male; Naproxen; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Superoxide Dismutase | 2016 |
Curcumin Blocks Naproxen-Induced Gastric Antral Ulcerations through Inhibition of Lipid Peroxidation and Activation of Enzymatic Scavengers in Rats.
Topics: Animals; Catalase; Curcumin; Gastric Mucosa; Glutathione Peroxidase; Lipid Peroxidation; Male; Naproxen; Oxidative Stress; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Superoxide Dismutase | 2016 |
Design and synthesis of some (S)-2-(6-methoxynaphthalen-2-yl)-N-substituted ethyl propanamide derivatives as potent non-ulcerogenic anti-inflammatory and analgesic agents.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Carrageenan; Drug Delivery Systems; Drug Design; Edema; Foot; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Naphthalenes; Naproxen; Pain; Spectrophotometry, Infrared; Stomach Ulcer; Structure-Activity Relationship | 2009 |
Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Blood Pressure; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Gastric Mucosa; Hydrogen Sulfide; Hypertension; Intestinal Mucosa; Intestine, Small; Male; Mice; Molecular Structure; Naproxen; Rats; Rats, Wistar; Stomach Ulcer | 2010 |
Antibacterial and ulcer healing effects of organoselenium compounds in naproxen induced and Helicobacter pylori infected Wistar rat model.
Topics: Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; Antioxidants; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Helicobacter Infections; Helicobacter pylori; Immunoglobulin G; Interleukin-10; Interleukin-6; Naproxen; Organoselenium Compounds; Oxidative Stress; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Stomach Ulcer; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2010 |
The combination of naproxen and citral reduces nociception and gastric damage in rats.
Topics: Acyclic Monoterpenes; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Gastric Mucosa; Monoterpenes; Naproxen; Pain Measurement; Rats; Rats, Wistar; Severity of Illness Index; Stomach Ulcer | 2010 |
Effect of anthocyanins on expression of matrix metalloproteinase-2 in naproxen-induced gastric ulcers.
Topics: Animals; Anthocyanins; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Female; Gastric Mucosa; Gene Expression; Interleukin-1beta; Lipid Peroxidation; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Naproxen; Oryza; Oxidative Stress; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Tumor Necrosis Factor-alpha | 2011 |
Pharmacokinetic and ulcerogenic studies of naproxen prodrugs designed for specific brain delivery.
Topics: Administration, Oral; Animals; Ascorbic Acid; Biological Availability; Blood-Brain Barrier; Brain; Dihydropyridines; Drug Design; Male; Naproxen; Neuroprotective Agents; Prodrugs; Protein Binding; Rats; Rats, Sprague-Dawley; Stomach Ulcer | 2012 |
Reduced ulcerogenic potential and antiarthritic effect of chitosan-naproxen sodium complexes.
Topics: Animals; Anti-Ulcer Agents; Antirheumatic Agents; Chitosan; Drug Combinations; Edema; Female; Naproxen; Rats; Rats, Wistar; Sodium; Stomach Ulcer; Treatment Outcome | 2012 |
Oligoethylene ester derivatives of ketoprofen, naproxen and diclofenac as oral prodrugs: a pharmacological evaluation.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Edema; Esters; Hydrolysis; Ketoprofen; Male; Mice; Naproxen; Pain Measurement; Pharmaceutical Vehicles; Polyethylene Glycols; Prodrugs; Rats; Rats, Sprague-Dawley; Stomach Ulcer | 2002 |
Modulation of NSAID-induced antinociceptive and anti-inflammatory effects by alpha2-adrenoceptor agonists with gastroprotective effects.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Drug Synergism; Drug Therapy, Combination; Meloxicam; Mice; Naproxen; Pain; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Stomach Ulcer; Sulfonamides; Thiazines; Thiazoles; Yohimbine | 2002 |
[Adverse effects of NSAID are insidious. No pain--despite life threatening gastric hemorrhage].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Humans; Isoxazoles; Naproxen; Peptic Ulcer Hemorrhage; Risk Factors; Stomach Ulcer; Sulfonamides | 2002 |
Synthesis, characterization and antiinflammatory-analgesic properties of 6-(alpha-amino-4-chlorobenzyl)thiazolo [3,2-b]-1,2,4-triazol-5-ols.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoquinones; Capillary Permeability; Carrageenan; Chemical Phenomena; Chemistry, Physical; Edema; Foot; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Mice; Models, Molecular; Molecular Conformation; Naproxen; Pain; Spectroscopy, Fourier Transform Infrared; Stomach Ulcer; Structure-Activity Relationship; Thiazoles; Triazoles | 2004 |
Nitric oxide (NO)-releasing naproxen (HCT-3012 [(S)-6-methoxy-alpha-methyl-2-naphthaleneacetic Acid 4-(nitrooxy)butyl ester]) interactions with aspirin in gastric mucosa of arthritic rats reveal a role for aspirin-triggered lipoxin, prostaglandins, and NO
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Eicosanoids; Freund's Adjuvant; Gastric Mucosa; Isoenzymes; Lipoxins; Male; Membrane Proteins; Naproxen; Nitric Oxide; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Rats; Rats, Inbred Lew; Reverse Transcriptase Polymerase Chain Reaction; Stomach Ulcer; Sulfonamides | 2004 |
Evidence in practice--number 3: Cox 2 inhibitors.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diclofenac; Evidence-Based Medicine; Humans; Ibuprofen; Middle Aged; Naproxen; Organic Chemicals; Osteoarthritis; Stomach Ulcer | 2004 |
Protective effect of astaxanthin on naproxen-induced gastric antral ulceration in rats.
Topics: Adjuvants, Immunologic; Animals; beta Carotene; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione Peroxidase; Male; Malondialdehyde; Naproxen; Pyloric Antrum; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Superoxide Dismutase; Time Factors; Xanthophylls | 2005 |
Non-carboxylic analogues of arylpropionic acids: synthesis, anti-inflammatory activity and ulcerogenic potential.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Ibuprofen; Male; Naproxen; Propionates; Rats; Stomach Ulcer; Structure-Activity Relationship; Thiadiazoles; Thiazoles | 2007 |
Non-carboxylic analogues of naproxen: design, synthesis, and pharmacological evaluation of some 1,3,4-oxadiazole/thiadiazole and 1,2,4-triazole derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Drug Design; Edema; Liver; Liver Function Tests; Male; Mice; Molecular Structure; Naproxen; Oxadiazoles; Pain; Rats; Stomach Ulcer; Thiadiazoles; Triazoles | 2007 |
Nabumetone (BRL 14777, 4-[6-methoxy-2-naphthyl]-butan-2-one): a new anti-inflammatory agent.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Female; Granuloma; Indomethacin; Nabumetone; Naproxen; Prostaglandins; Rats; Rats, Inbred Strains; Stomach Ulcer | 1982 |
Inhibition of PG production by MDL 035, a new non-steroidal non-acidic anti-inflammatory compound, in rat gastric mucosa and inflammatory exudate.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dinoprostone; Dose-Response Relationship, Drug; Exudates and Transudates; Gastric Mucosa; Imidazoles; In Vitro Techniques; Indomethacin; Inflammation; Male; Naproxen; Prostaglandins; Prostaglandins E; Rats; Stomach Ulcer | 1984 |
Comparative gastric ulcerogenic effects of meseclazone, 5-chlorosalicylic acid and other nonsteroidal anti-inflammatory drugs following acute and repeated oral administration to rats.
Topics: Animals; Anti-Inflammatory Agents; Benzoxazines; Biotransformation; Fenoprofen; Ibuprofen; Indomethacin; Male; Naproxen; Oxazines; Peptic Ulcer Hemorrhage; Phenylbutazone; Rats; Salicylates; Stomach Ulcer; Time Factors; Tolmetin | 1980 |
The influence of formulation excipients on the gastro-lesivity of a drug.
Topics: Animals; Drug Compounding; Excipients; Male; Naproxen; Rats; Rats, Inbred Strains; Stomach Ulcer | 1983 |
[Non-steroidal antirheumatics: side-effects and interactions].
Topics: Anemia, Aplastic; Anti-Inflammatory Agents, Non-Steroidal; Coumarins; Drug Interactions; Gastrointestinal Diseases; Humans; Indomethacin; Naproxen; ortho-Aminobenzoates; Phenylbutazone; Prostaglandins; Rheumatic Diseases; Salicylates; Stomach Ulcer | 1982 |
Anti-inflammatory potency and gastrointestinal toxicity of a new compound, nitronaproxen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Digestive System; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Female; Male; Naproxen; Rats; Rats, Sprague-Dawley; Stomach Ulcer | 1995 |
Synthesis and evaluation of morpholinoalkyl ester prodrugs of indomethacin and naproxen.
Topics: Animals; Biological Availability; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Gastric Mucosa; Hydrolysis; Indomethacin; Male; Naproxen; Prodrugs; Rats; Rats, Sprague-Dawley; Solubility; Solutions; Stomach Ulcer | 1993 |
[Still disease in adults revealed by a digestive manifestation].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Glucocorticoids; Humans; Male; Middle Aged; Naproxen; Peritonitis; Prednisolone; Still's Disease, Adult-Onset; Stomach Ulcer | 1995 |
Mast cells do not contribute to nonsteroidal anti-inflammatory drug-induced gastric mucosal injury in rodents.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Degranulation; Dexamethasone; Disease Models, Animal; Gastric Mucosa; Indomethacin; Male; Mast Cells; Mice; Naproxen; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stomach Ulcer | 1996 |
Tumor necrosis factor mediation of NSAID-induced gastric damage: role of leukocyte adherence.
Topics: Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Cell Movement; Gastrointestinal Hemorrhage; Indomethacin; Leukocytes; Male; Naproxen; Rats; Rats, Wistar; Stomach; Stomach Diseases; Stomach Ulcer; Tumor Necrosis Factor-alpha | 1996 |
Effect of a nitric oxide-releasing naproxen derivative on hypertension and gastric damage induced by chronic nitric oxide inhibition in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Gastric Mucosa; Hypertension; Male; Naproxen; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Stomach Ulcer; Thromboxane B2 | 1998 |
Bacteria rapidly colonize and modulate healing of gastric ulcers in rats.
Topics: Acetic Acid; Animals; Anti-Bacterial Agents; Bacitracin; Escherichia coli; Gastric Acid; Lactobacillus; Male; Naproxen; Pentagastrin; Rats; Rats, Wistar; Stomach Ulcer; Streptomycin; Time Factors; Wound Healing | 1998 |
Effect of naproxen on the hamster gastric antrum: ulceration, adaptation and efficacy of anti-ulcer drugs.
Topics: Adaptation, Physiological; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Division; Cricetinae; Famotidine; Gastric Acid; Male; Mesocricetus; Misoprostol; Naproxen; Pyloric Antrum; Stomach Ulcer; Time Factors | 1999 |
Gastroprotective and ulcer healing effects of nitric oxide-releasing non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Ethanol; Gastric Mucosa; Isoenzymes; Male; Membrane Proteins; Microcirculation; Models, Animal; Naproxen; Nitric Oxide; Nitrobenzenes; Nitroso Compounds; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Stomach; Stomach Ulcer; Sulfonamides | 2000 |
Synthesis and pharmacological activities of some new 2-[1-(6-methoxy-2-naphthyl)ethyl]-6-(substituted)benzylidene thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chromatography, Thin Layer; Cyclization; Edema; Female; Gastric Mucosa; Male; Mice; Naphthalenes; Naproxen; Stomach Ulcer; Thiazoles | 2001 |
NSAID gastric ulceration: predictive value of gastric pH, mucosal density of polymorphonuclear leukocytes, or levels of IL-8 or nitrite.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cell Count; Female; Gastric Acidity Determination; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Humans; Hydrogen-Ion Concentration; Interleukin-8; Male; Middle Aged; Naproxen; Neutrophils; Nitrites; Stomach Ulcer | 2002 |
Pharmacology of the potent new non-steroidal anti-inflammatory agent aceclofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzoquinones; Capillary Permeability; Carrageenan; Diclofenac; Edema; Female; Granuloma; Indomethacin; Male; Mice; Naproxen; Pain; Phenylbutazone; Pleurisy; Rats; Rats, Inbred Strains; Silver Nitrate; Stomach Ulcer; Synovitis | 1991 |
The effect of paracetamol on naprosyn induced damage to gastric mucosa in albino rat.
Topics: Acetaminophen; Animals; Gastric Mucosa; Male; Naproxen; Prostaglandins; Rats; Stomach Ulcer | 1991 |
The pharmacological profile of aceclofenac, a new nonsteroidal antiinflammatory and analgesic drug.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dogs; Female; Indomethacin; Male; Mice; Naproxen; Phenylbutazone; Rats; Rats, Inbred Strains; Stomach Ulcer | 1991 |
Neurological adverse effects of naproxen and misoprostol combination.
Topics: Alprostadil; Anti-Ulcer Agents; Ataxia; Drug Therapy, Combination; Humans; Male; Middle Aged; Misoprostol; Naproxen; Stomach Ulcer | 1990 |
Non-steroidal anti-inflammatory drugs and bleeding peptic ulcer.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Duodenal Ulcer; Female; Humans; Ibuprofen; Indomethacin; Male; Middle Aged; Naproxen; Osteoarthritis; Peptic Ulcer Hemorrhage; Piroxicam; Smoking; Stomach Ulcer; Surveys and Questionnaires; Thiazines | 1986 |