Page last updated: 2024-09-04

naproxen and ciprofloxacin

naproxen has been researched along with ciprofloxacin in 25 studies

Compound Research Comparison

Studies
(naproxen)
Trials
(naproxen)
Recent Studies (post-2010)
(naproxen)
Studies
(ciprofloxacin)
Trials
(ciprofloxacin)
Recent Studies (post-2010) (ciprofloxacin)
4,5511,0571,42916,0601,3316,092

Protein Interaction Comparison

ProteinTaxonomynaproxen (IC50)ciprofloxacin (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.41
DNA gyrase subunit BBacillus subtilis subsp. subtilis str. 1686.3
DNA gyrase subunit ABacillus subtilis subsp. subtilis str. 1686.3
Cytochrome P450 3A4Homo sapiens (human)0.31
DNA gyrase subunit BStaphylococcus aureus4.32
DNA gyrase subunit AEscherichia coli K-120.6845
DNA gyrase subunit BEscherichia coli K-120.5632
DNA topoisomerase 4 subunit BStaphylococcus aureus6.485
DNA topoisomerase 4 subunit AStaphylococcus aureus4.8011
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.41
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.41
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.41
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.41
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.41
DNA gyrase subunit AStaphylococcus aureus4.32
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.41
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.41
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.41
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.41
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.41
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.41
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.41
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.41
DNA topoisomerase 4 subunit ABacillus subtilis subsp. subtilis str. 1681.7
DNA topoisomerase 4 subunit BBacillus subtilis subsp. subtilis str. 1681.7
GABA theta subunitRattus norvegicus (Norway rat)0.41
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.41

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (24.00)29.6817
2010's15 (60.00)24.3611
2020's4 (16.00)2.80

Authors

AuthorsStudies
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL1
Caron, G; Ermondi, G1
Jolivette, LJ; Ward, KW1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Campillo, NE; Guerra, A; Páez, JA1
Avdeef, A; Tam, KY1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afzal, O; Bawa, S; Chawla, G; Deora, GS; Kalle, AM; Kumar, S; Mulakayala, N; Rajaram, A; Rathore, V; Tonk, RK1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Bellman, K; Knegtel, RM; Settimo, L1
Kazancioglu, MZ; Sacher, JR; Saha, J; Skoda, EM; Wipf, P1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Theodoridis, G1
Mihçiokur, H; Oğuz, M1
Adasme, MF; Adelmann, L; Bolz, SN; Castillo-Campos, V; De Fuentes-Vicente, JA; Haupt, VJ; Moreno-Rodríguez, A; Nogueda-Torres, B; Rivera, G; Salentin, S; Schroeder, M; Yepez-Mulia, L1
Boncz, MÁ; López-Serna, R; Muñoz, R; Ruas, G; Scarcelli, PG; Serejo, ML1
Kassie, GM; Kerr, M; Moffat, A; Pratt, N; Roughead, EE1
Miyagawa, A; Nagatomo, S; Nakatani, K; Oshiyama, K1

Reviews

1 review(s) available for naproxen and ciprofloxacin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

24 other study(ies) available for naproxen and ciprofloxacin

ArticleYear
Cheminformatic models to predict binding affinities to human serum albumin.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids

2001
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water

2005
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
    Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7

    Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution

2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
    Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9

    Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Synthesis and pharmacological evaluation of pyrazolo[4,3-c]cinnoline derivatives as potential anti-inflammatory and antibacterial agents.
    European journal of medicinal chemistry, 2012, Volume: 57

    Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 2; Edema; Escherichia coli; Heterocyclic Compounds, 2-Ring; Inflammation; Lipid Peroxidation; Microbial Sensitivity Tests; Molecular Docking Simulation; Naproxen; Pseudomonas aeruginosa; Pyrazoles; Rats; Rats, Wistar; Staphylococcus aureus; Structure-Activity Relationship; Ulcer

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
An uncharged oxetanyl sulfoxide as a covalent modifier for improving aqueous solubility.
    ACS medicinal chemistry letters, 2014, Aug-14, Volume: 5, Issue:8

    Topics:

2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
Application of solid-phase microextraction in the investigation of protein binding of pharmaceuticals.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2006, Jan-18, Volume: 830, Issue:2

    Topics: Binding, Competitive; Chromatography, High Pressure Liquid; Ciprofloxacin; Haloperidol; Humans; Kinetics; Naproxen; Nortriptyline; Paclitaxel; Pharmaceutical Preparations; Protein Binding; Quinidine; Quinine; Serum Albumin; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Ultrafiltration

2006
Environmental risk assessment of selected pharmaceuticals in Turkey.
    Environmental toxicology and pharmacology, 2014, Volume: 38, Issue:1

    Topics: 1-Octanol; Acetaminophen; Adsorption; Anti-Bacterial Agents; Anti-Infective Agents, Local; Anti-Inflammatory Agents, Non-Steroidal; Benzalkonium Compounds; Cefuroxime; Ciprofloxacin; Clarithromycin; Environmental Monitoring; Naproxen; Pharmaceutical Preparations; Risk Assessment; Sewage; Turkey; Water; Water Pollutants, Chemical

2014
Repositioned Drugs for Chagas Disease Unveiled via Structure-Based Drug Repositioning.
    International journal of molecular sciences, 2020, Nov-20, Volume: 21, Issue:22

    Topics: Animals; Cell Line; Chagas Disease; Ciprofloxacin; Drug Repositioning; Folic Acid; Mice; Naproxen; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi

2020
Influence of the hydraulic retention time on the removal of emerging contaminants in an anoxic-aerobic algal-bacterial photobioreactor coupled with anaerobic digestion.
    The Science of the total environment, 2022, Jun-25, Volume: 827

    Topics: Acetaminophen; Anaerobiosis; Bacteria, Aerobic; Bioreactors; Ciprofloxacin; Dexamethasone; Enrofloxacin; Ibuprofen; Naproxen; Photobioreactors; Progesterone; Sewage; Sulfamethoxazole; Tetracyclines; Trimethoprim; Tylosin; Waste Disposal, Fluid

2022
Medicine-Induced Acute Kidney Injury Findings from Spontaneous Reporting Systems, Sequence Symmetry Analysis and a Case-Control Study with a Focus on Medicines Used in Primary Care.
    Drug safety, 2022, Volume: 45, Issue:11

    Topics: Acute Kidney Injury; Adverse Drug Reaction Reporting Systems; Amlodipine; Amphotericin B; Australia; Case-Control Studies; Ciprofloxacin; Diclofenac; Furosemide; Humans; Ibuprofen; Metformin; Naproxen; Omeprazole; Primary Health Care; Ramipril; Simvastatin; Spironolactone; Sulfamethoxazole; Telmisartan; Trimethoprim; Valacyclovir; Zoledronic Acid

2022
Semi-quantification of the binding constant based on bond breaking in a combined acoustic-gravitational field.
    The Analyst, 2022, Oct-24, Volume: 147, Issue:21

    Topics: Acoustics; Ciprofloxacin; Glycogen; Ibuprofen; Mannans; Naproxen; Serum Albumin, Bovine

2022