Page last updated: 2024-09-04

naproxen and prochlorperazine

naproxen has been researched along with prochlorperazine in 9 studies

Compound Research Comparison

Studies
(naproxen)
Trials
(naproxen)
Recent Studies (post-2010)
(naproxen)
Studies
(prochlorperazine)
Trials
(prochlorperazine)
Recent Studies (post-2010) (prochlorperazine)
4,5511,0571,4291,125206110

Protein Interaction Comparison

ProteinTaxonomynaproxen (IC50)prochlorperazine (IC50)
Mcl-1Homo sapiens (human)3.7733
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.078
Bile salt export pumpHomo sapiens (human)10
Cytochrome P450 1A2Homo sapiens (human)2
Tyrosine-protein kinase FynHomo sapiens (human)5.684
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)0.4
Muscarinic acetylcholine receptor M2Homo sapiens (human)3.112
Muscarinic acetylcholine receptor M4Homo sapiens (human)1.363
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.22
Alpha-2A adrenergic receptorHomo sapiens (human)0.169
Cytochrome P450 2D6Homo sapiens (human)0.3
Muscarinic acetylcholine receptor M1Homo sapiens (human)1.013
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)1.8481
D(2) dopamine receptorHomo sapiens (human)0.011
Alpha-2B adrenergic receptorHomo sapiens (human)0.01
Alpha-2C adrenergic receptorHomo sapiens (human)0.082
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.95
Muscarinic acetylcholine receptor M3Homo sapiens (human)1.514
D(1A) dopamine receptorHomo sapiens (human)0.155
D(4) dopamine receptorHomo sapiens (human)2.311
Sodium-dependent noradrenaline transporter Homo sapiens (human)0.4
Alpha-1D adrenergic receptorHomo sapiens (human)0.034
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.0071
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.078
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.95
Sodium-dependent serotonin transporterHomo sapiens (human)1.169
Pleiotropic ABC efflux transporter of multiple drugsSaccharomyces cerevisiae S288C1.7
Histamine H1 receptorHomo sapiens (human)0.024
D(3) dopamine receptorHomo sapiens (human)0.013
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.102
5-hydroxytryptamine receptor 6Homo sapiens (human)0.267
Sodium-dependent dopamine transporter Homo sapiens (human)1.735
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.8481
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)1.8481
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.054

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (11.11)29.6817
2010's7 (77.78)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Lau, CI; Wang, YF1

Reviews

1 review(s) available for naproxen and prochlorperazine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

8 other study(ies) available for naproxen and prochlorperazine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
2022 Taiwan Guidelines for Acute Treatment of Migraine.
    Acta neurologica Taiwanica, 2022, Jun-30, Volume: 31(2)

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Aspirin; Caffeine; Calcitonin Gene-Related Peptide Receptor Antagonists; Child; Diclofenac; Female; Headache; Humans; Ibuprofen; Migraine Disorders; Morphine Derivatives; Naproxen; Nasal Sprays; Pregnancy; Prochlorperazine; Taiwan; Tramadol; Tryptamines

2022