Page last updated: 2024-09-04

naproxen and scopolamine hydrobromide

naproxen has been researched along with scopolamine hydrobromide in 12 studies

Compound Research Comparison

Studies (naproxen)	Trials (naproxen)	Recent Studies (post-2010) (naproxen)	Studies (scopolamine hydrobromide)	Trials (scopolamine hydrobromide)	Recent Studies (post-2010) (scopolamine hydrobromide)
4,551	1,057	1,429	7,548	563	1,401

Protein Interaction Comparison

Protein	Taxonomy	scopolamine hydrobromide (IC50)
Muscarinic acetylcholine receptor M4	Homo sapiens (human)	0.003
Muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	0.006
Muscarinic acetylcholine receptor M3	Rattus norvegicus (Norway rat)	0.006
Muscarinic acetylcholine receptor M4	Rattus norvegicus (Norway rat)	0.006
Cytochrome P450 3A4	Homo sapiens (human)	0.0006
Muscarinic acetylcholine receptor M5	Rattus norvegicus (Norway rat)	0.006
Muscarinic acetylcholine receptor M2	Rattus norvegicus (Norway rat)	0.006
Muscarinic acetylcholine receptor M1	Homo sapiens (human)	0.0026

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (16.67)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (41.67)	29.6817
2010's	5 (41.67)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Topliss, JG; Yoshida, F	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Campillo, NE; Guerra, A; Páez, JA	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Farewell, J; Johnson, WH; Mintz, L; Sunahara, FA	1
Jain, NK; Kulkarni, SK; Patil, CS; Singh, A	1
Ortiz, MI	1

Reviews

1 review(s) available for naproxen and scopolamine hydrobromide

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for naproxen and scopolamine hydrobromide

Article	Year
Pharmacological interventions for motion sickness: cardiovascular effects. Aviation, space, and environmental medicine, 1987, Volume: 58, Issue:9 Pt 2 Topics: Adult; Dextroamphetamine; Double-Blind Method; Drug Combinations; Ephedrine; Hemodynamics; Humans; Male; Motion Sickness; Naproxen; Promethazine; Scopolamine; Vestibule, Labyrinth	1987

Other Studies

10 other study(ies) available for naproxen and scopolamine hydrobromide

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22 Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption	2007
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Modulatory role of cyclooxygenase inhibitors in aging- and scopolamine or lipopolysaccharide-induced cognitive dysfunction in mice. Behavioural brain research, 2002, Jul-18, Volume: 133, Issue:2 Topics: Aging; Animals; Anxiety; Avoidance Learning; Cognition Disorders; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Gastrointestinal Diseases; Isoenzymes; Lactones; Lipopolysaccharides; Male; Membrane Proteins; Mice; Motor Activity; Muscarinic Antagonists; Naproxen; Postural Balance; Prostaglandin-Endoperoxide Synthases; Scopolamine; Sulfonamides; Sulfones	2002
Primary dysmenorrhea among Mexican university students: prevalence, impact and treatment. European journal of obstetrics, gynecology, and reproductive biology, 2010, Volume: 152, Issue:1 Topics: Absenteeism; Acetaminophen; Adolescent; Dipyrone; Drug Combinations; Dysmenorrhea; Female; Humans; Menarche; Mexico; Naproxen; Nonprescription Drugs; Pain; Prevalence; Propanolamines; Pyrilamine; Scopolamine; Severity of Illness Index; Students; Theophylline; Universities; Young Adult	2010