Page last updated: 2024-09-04

naproxen and etodolac

naproxen has been researched along with etodolac in 58 studies

Compound Research Comparison

Studies
(naproxen)
Trials
(naproxen)
Recent Studies (post-2010)
(naproxen)
Studies
(etodolac)
Trials
(etodolac)
Recent Studies (post-2010) (etodolac)
4,5511,0571,429550125129

Protein Interaction Comparison

ProteinTaxonomynaproxen (IC50)etodolac (IC50)
Prostaglandin G/H synthase 1Homo sapiens (human)2.649
Prostaglandin G/H synthase 2Homo sapiens (human)0.561

Research

Studies (58)

TimeframeStudies, this research(%)All Research%
pre-199011 (18.97)18.7374
1990's18 (31.03)18.2507
2000's19 (32.76)29.6817
2010's9 (15.52)24.3611
2020's1 (1.72)2.80

Authors

AuthorsStudies
Asselin, AA; Dobson, TA; Humber, LG; Komlossy, J1
Topliss, JG; Yoshida, F1
Cihlar, T; Ho, ES; Mulato, AS1
Beroza, P; Cai, D; Damodaran, K; Gomez, RF; Hsu, N; Keck, JG; Laborde, E; Lum, RT; Macke, TJ; Martin, G; Schow, SR; Simon, RJ; Villar, HO; Wick, MM1
Brozic, P; Gobec, S; Rizner, TL1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Anderluh, M; Brunskole, M; Gobec, S; Lanisnik Rizner, T; Stefane, B; Stojan, J; Zorko, K1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Kumar, M; Sinha, VR; Thareja, S1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Huang, S; Li, Y; Liu, W; Zhang, K; Zheng, X1
DeRose, EF; Duff, MR; Gabel, SA; Howell, EE; Krahn, JM; London, RE; Pedersen, LC1
de Pouvourville, G1
Leese, P1
Mizraji, M1
Ardizzone, S; Bianchi Porro, G; Caruso, I; Montrone, F; Petrillo, M1
Di Giorgio, E; Maccagno, A; Romanowicz, A1
Holland, PJ; Kelly, RW; McLaughlin, S; Russell, RI; Sturrock, RD; Taha, AS1
Russell, RI1
Pena, M1
McLaughlin, S; Russell, RI; Sturrock, RD; Taha, AS1
Platt, PN1
Briancon, D1
Karbowski, A1
Lanza, F; Lynn, M; Rack, MF; Sanda, M; Wolf, J1
Waltham-Weeks, CD1
Dvornik, D; Lee, D1
Crittenden, N; Fitzpatrick, F; McGee, J; McGuire, J1
Klicius, J; Martel, RR; Metcalf, G1
Klicius, J; Martel, RR; Metcalf, G; Rona, GA1
Casini-Raggi, V; Cominelli, F; Laine, L; Marin-Sorensen, M; Sloane, R; Weinstein, WM1
Dainaka, J; Hashii, H; Inoue, K; Kimura, K; Motonaga, A; Nishimura, T; Ueda, F; Yamate, K1
Bacon, P1
Armstrong, G; Goodman, MJ; Lipscomb, GR; Rees, WD; Wallis, N1
Cominelli, F; Ferretti, M; Laine, L; Sloane, R1
Constantine, G; Schnitzer, TJ1
Yood, RA1
Caruso, FS; Frenk, H; Lu, J; Mao, J; Mayer, DJ; Price, DD1
Campbell, F; Lipscomb, GR; Rees, WD1
Wallace, JL1
Huskisson, EC1
de Nucci, G; Ferraz, JG; Giuliano, F; Pereira, R; Warner, TD1
Browning, RA; Burgess, FW1
Cryer, B; Cung, A; Kazi, S; Kelly, KC; Little, BB; Roberts, KW; Sarosi, GA; Smith, HJ; Weideman, RA1
Heydel, JM; Humbert, AC; Li, X; Little, JM; Magdalou, J; Radominska-Pandya, A; Sabolovic, N1
Cefle, K; Erkal, H; Koçak, H; Köseoglu, BG; Oztürk, S; Palanduz, S1
Arslan, M; Duymus, H; Kucukislamoglu, M; Zengin, M1
Cağici, CA; Calişkan, EE; Erkan, AN; Gencay, S; Ozlüoğlu, LN; Sener, M; Yavuz, H; Yilmaz, I; Yilmazer, C1
Barner, JC; Busti, AJ; Lawson, KA; Motsko, SP; Rascati, KL; Wilson, JP; Worchel, J1
Khan, NK; Radi, ZA1
Costa, D; Fernandes, E; Gomes, A; Lima, JL1
Banerjee, S; Brilakis, ES; Cryer, B; Cunningham, F; Harford, WV; Kazi, S; Kelly, KC; Little, BB; Warner, JJ; Weideman, RA1
Cefle, K; Kocak, H; Koseoglu, BG; Ozturk, S; Palanduz, S1
Ara, N; Ichikawa, T; Iijima, K; Ishihara, K; Iwabuchi, T; Kamata, Y; Koike, T; Shimosegawa, T; Shinkai, H1
Akbulut, N; Atakan, C; Çölok, G; Üstüner, E1

Reviews

6 review(s) available for naproxen and etodolac

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Etodolac: analgesic effects in musculoskeletal and postoperative pain.
    Rheumatology international, 1990, Volume: 10 Suppl

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Aspirin; Athletic Injuries; Back Pain; Bursitis; Diclofenac; Dose-Response Relationship, Drug; Etodolac; Humans; Indoleacetic Acids; Musculoskeletal System; Naproxen; Pain, Postoperative; Piroxicam; Tendinopathy

1990
A global safety evaluation of etodolac.
    Clinical rheumatology, 1989, Volume: 8 Suppl 1

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Etodolac; Female; Humans; Indoleacetic Acids; Male; Middle Aged; Naproxen; Osteoarthritis; Piroxicam

1989
Distribution and expression of cyclooxygenase (COX) isoenzymes, their physiological roles, and the categorization of nonsteroidal anti-inflammatory drugs (NSAIDs).
    The American journal of medicine, 1999, Dec-13, Volume: 107, Issue:6A

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Controlled Clinical Trials as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Etodolac; Gene Expression; Humans; Ibuprofen; Indomethacin; Isoenzymes; Meloxicam; Membrane Proteins; Naproxen; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thiazines; Thiazoles

1999
Nimesulide, a balanced drug for the treatment of osteoarthritis.
    Clinical and experimental rheumatology, 2001, Volume: 19, Issue:1 Suppl 22

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Diclofenac; Etodolac; Humans; Naproxen; Osteoarthritis; Stomach Diseases; Sulfonamides; Treatment Outcome

2001
Effects of cyclooxygenase inhibition on the gastrointestinal tract.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2006, Volume: 58, Issue:2-3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clonixin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Etodolac; Gastrointestinal Tract; Humans; Indomethacin; Naproxen; Species Specificity

2006

Trials

23 trial(s) available for naproxen and etodolac

ArticleYear
Comparison of the effects of etodolac SR and naproxen on gastro-intestinal blood loss.
    Current medical research and opinion, 1992, Volume: 13, Issue:1

    Topics: Adult; Chromium Radioisotopes; Delayed-Action Preparations; Etodolac; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Naproxen; Occult Blood; Reference Values; Single-Blind Method

1992
Clinical response to etodolac in the management of pain.
    European journal of rheumatology and inflammation, 1990, Volume: 10, Issue:1

    Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Athletic Injuries; Bursitis; Diclofenac; Etodolac; Female; Gout; Humans; Indoleacetic Acids; Male; Naproxen; Pain, Postoperative; Palliative Care; Tendinopathy

1990
A double-blind gastroscopic evaluation of the effects of etodolac and naproxen on the gastrointestinal mucosa of rheumatic patients.
    Journal of internal medicine, 1991, Volume: 229, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Double-Blind Method; Etodolac; Female; Gastric Mucosa; Gastroscopy; Humans; Indoleacetic Acids; Intestinal Mucosa; Male; Middle Aged; Naproxen

1991
Effectiveness of etodolac ('Lodine') compared with naproxen in patients with acute gout.
    Current medical research and opinion, 1991, Volume: 12, Issue:7

    Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Double-Blind Method; Etodolac; Female; Humans; Indoleacetic Acids; Male; Middle Aged; Naproxen; Pain Measurement; Range of Motion, Articular

1991
Effect on gastric and duodenal mucosal prostaglandins of repeated intake of therapeutic doses of naproxen and etodolac in rheumatoid arthritis.
    Annals of the rheumatic diseases, 1990, Volume: 49, Issue:6

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Dinoprostone; Double-Blind Method; Duodenum; Epoprostenol; Etodolac; Female; Gastric Mucosa; Humans; Indoleacetic Acids; Intestinal Mucosa; Male; Middle Aged; Naproxen; Prospective Studies; Prostaglandins; Thromboxane B2

1990
Endoscopic evaluation of etodolac and naproxen, and their relative effects on gastric and duodenal prostaglandins.
    Rheumatology international, 1990, Volume: 10 Suppl

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dinoprostone; Dose-Response Relationship, Drug; Duodenum; Endoscopy; Epoprostenol; Etodolac; Female; Gastric Mucosa; Humans; Indoleacetic Acids; Male; Middle Aged; Mucous Membrane; Naproxen; Osteoarthritis; Patient Compliance; Prostaglandins; Stomach; Thromboxane B2; Time Factors

1990
Etodolac: analgesic effects in musculoskeletal and postoperative pain.
    Rheumatology international, 1990, Volume: 10 Suppl

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Aspirin; Athletic Injuries; Back Pain; Bursitis; Diclofenac; Dose-Response Relationship, Drug; Etodolac; Humans; Indoleacetic Acids; Musculoskeletal System; Naproxen; Pain, Postoperative; Piroxicam; Tendinopathy

1990
Evaluation of the efficacy and comparative effects on gastric and duodenal mucosa of etodolac and naproxen in patients with rheumatoid arthritis using endoscopy.
    British journal of rheumatology, 1989, Volume: 28, Issue:4

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Double-Blind Method; Drug Administration Schedule; Drug Evaluation; Duodenoscopy; Duodenum; Etodolac; Female; Gastric Mucosa; Gastroscopy; Humans; Indoleacetic Acids; Intestinal Mucosa; Male; Middle Aged; Naproxen

1989
Recent clinical experience with etodolac in the treatment of osteoarthritis of the knee.
    Clinical rheumatology, 1989, Volume: 8 Suppl 1

    Topics: Activities of Daily Living; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Etodolac; Female; Humans; Indoleacetic Acids; Knee Joint; Male; Middle Aged; Multicenter Studies as Topic; Naproxen; Osteoarthritis; Piroxicam; Random Allocation

1989
International experience with etodolac therapy for rheumatoid arthritis: an interim report of comparative efficacy.
    Clinical rheumatology, 1989, Volume: 8 Suppl 1

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diclofenac; Double-Blind Method; Etodolac; Female; Humans; Indoleacetic Acids; Male; Middle Aged; Multicenter Studies as Topic; Naproxen; Piroxicam; Prospective Studies; Random Allocation

1989
A global safety evaluation of etodolac.
    Clinical rheumatology, 1989, Volume: 8 Suppl 1

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Etodolac; Female; Humans; Indoleacetic Acids; Male; Middle Aged; Naproxen; Osteoarthritis; Piroxicam

1989
An endoscopic comparison of the effects of etodolac, indomethacin, ibuprofen, naproxen, and placebo on the gastrointestinal mucosa.
    The Journal of rheumatology, 1987, Volume: 14, Issue:2

    Topics: Acetates; Adolescent; Adult; Endoscopy; Etodolac; Gastric Mucosa; Humans; Ibuprofen; Indomethacin; Intestinal Mucosa; Middle Aged; Naproxen; Placebos

1987
Etodolac versus naproxen in rheumatoid arthritis: a double-blind crossover study.
    Current medical research and opinion, 1987, Volume: 10, Issue:8

    Topics: Acetates; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Double-Blind Method; Etodolac; Female; Humans; Male; Middle Aged; Naproxen; Random Allocation

1987
Interaction of NSAIDs and Helicobacter pylori on gastrointestinal injury and prostaglandin production: a controlled double-blind trial.
    Alimentary pharmacology & therapeutics, 1995, Volume: 9, Issue:2

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Etodolac; Gastrointestinal Diseases; Helicobacter Infections; Helicobacter pylori; Humans; Inflammation; Middle Aged; Naproxen; Prostaglandins; Stomach Ulcer

1995
Worldwide experience with etodolac (Lodine) 300 mg b.i.d. in the treatment of osteoarthritis.
    Rheumatology international, 1993, Volume: 13, Issue:2 Suppl

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Delayed-Action Preparations; Diclofenac; Double-Blind Method; Etodolac; Global Health; Hip Joint; Humans; Indomethacin; Knee Joint; Middle Aged; Naproxen; Osteoarthritis; Pain; Piroxicam; Time Factors

1993
Gastric mucosal adaptation to etodolac and naproxen.
    Alimentary pharmacology & therapeutics, 1995, Volume: 9, Issue:4

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Duodenum; Endoscopy; Etodolac; Gastric Mucosa; Humans; Middle Aged; Naproxen; Stomach; Time Factors

1995
A randomized double-blind comparison of placebo, etodolac, and naproxen on gastrointestinal injury and prostaglandin production.
    Gastrointestinal endoscopy, 1995, Volume: 42, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Dinoprostone; Double-Blind Method; Drug Administration Schedule; Endoscopy, Gastrointestinal; Etodolac; Female; Gastric Mucosa; Humans; Male; Naproxen; Prospective Studies; Stomach Ulcer; Time Factors

1995
Etodolac (Lodine) in the treatment of osteoarthritis: recent studies.
    The Journal of rheumatology. Supplement, 1997, Volume: 47

    Topics: Administration, Oral; Aged; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Double-Blind Method; Etodolac; Female; Humans; Male; Middle Aged; Nabumetone; Naproxen; Osteoarthritis; Pain Measurement; Placebos

1997
Cyclooxygenase selectivity of non-steroid anti-inflammatory drugs in humans: ex vivo evaluation.
    European journal of pharmacology, 2001, Aug-24, Volume: 426, Issue:1-2

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Cyclooxygenase 1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Etodolac; Humans; Isoenzymes; Male; Meloxicam; Membrane Proteins; Nabumetone; Naproxen; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfonamides; Thiazines; Thiazoles; Time Factors; Tumor Cells, Cultured

2001
[Postoperative pain management in clinics of otolaryngology].
    Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat, 2006, Volume: 16, Issue:1

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Dipyrone; Etodolac; Female; Humans; Lactones; Male; Meloxicam; Middle Aged; Naproxen; Otorhinolaryngologic Surgical Procedures; Pain Measurement; Pain, Postoperative; Postoperative Period; Sulfones; Thiazines; Thiazoles; Treatment Outcome

2006
The effects of etodolac, nimesulid and naproxen sodium on the frequency of sister chromatid exchange after enclused third molars surgery.
    Yonsei medical journal, 2008, Oct-31, Volume: 49, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Etodolac; Female; Humans; Male; Molar, Third; Mutagenicity Tests; Naproxen; Prospective Studies; Sister Chromatid Exchange; Sulfonamides

2008
Increased gastric mucus secretion alleviates non-steroidal anti-inflammatory drug-induced abdominal pain.
    The Tohoku journal of experimental medicine, 2013, Volume: 231, Issue:1

    Topics: Abdominal Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Etodolac; Gastric Mucosa; Humans; Male; Mucus; Naproxen; Stomach; Young Adult

2013
Comparison of the effect of naproxen, etodolac and diclofenac on postoperative sequels following third molar surgery: a randomised, double-blind, crossover study.
    Medicina oral, patologia oral y cirugia bucal, 2014, Mar-01, Volume: 19, Issue:2

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Diclofenac; Double-Blind Method; Edema; Etodolac; Female; Humans; Male; Molar, Third; Naproxen; Pain, Postoperative; Tooth Extraction; Tooth, Impacted; Trismus; Young Adult

2014

Other Studies

31 other study(ies) available for naproxen and etodolac

ArticleYear
Cycloalkanoindoles. 1. Syntheses and antiinflammatory actions of some acidic tetrahydrocarbazoles, cyclopentindoles, and cycloheptindoles.
    Journal of medicinal chemistry, 1976, Volume: 19, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carbazoles; Cycloheptanes; Cyclopentanes; Edema; Indoles; Rats; Stomach Ulcer; Structure-Activity Relationship

1976
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:1

    Topics: Adenine; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Biological Transport; Carrier Proteins; Humans; Kidney; Organophosphonates; Structure-Activity Relationship

2000
Novel cyclooxygenase-1 inhibitors discovered using affinity fingerprints.
    Journal of medicinal chemistry, 2004, Sep-23, Volume: 47, Issue:20

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Combinatorial Chemistry Techniques; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Design; Drug Evaluation, Preclinical; Ibuprofen; Inhibitory Concentration 50; Isoenzymes; Models, Molecular; Models, Theoretical; Molecular Structure; Prospective Studies; Prostaglandin-Endoperoxide Synthases; Quantitative Structure-Activity Relationship

2004
Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of anticancer agents.
    Bioorganic & medicinal chemistry letters, 2005, Dec-01, Volume: 15, Issue:23

    Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Drug Design; Enzyme Inhibitors; Humans; Hydroxyprostaglandin Dehydrogenases; Molecular Structure; Tumor Cells, Cultured

2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Towards the first inhibitors of trihydroxynaphthalene reductase from Curvularia lunata: synthesis of artificial substrate, homology modelling and initial screening.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Amino Acid Sequence; Ascomycota; Benzopyrans; Enzyme Inhibitors; Fungal Proteins; Melanins; Models, Molecular; Molecular Sequence Data; Oxidoreductases Acting on CH-CH Group Donors; Recombinant Proteins; Structural Homology, Protein; Substrate Specificity

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics

2011
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Self-organizing molecular field analysis of NSAIDs: assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach.
    European journal of medicinal chemistry, 2012, Volume: 53

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Computational Biology; Least-Squares Analysis; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship

2012
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
Synergistic effect of tolfenamic acid and glycyrrhizic acid on TPA-induced skin inflammation in mice.
    MedChemComm, 2019, Oct-01, Volume: 10, Issue:10

    Topics:

2019
The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase.
    Journal of medicinal chemistry, 2020, 08-13, Volume: 63, Issue:15

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Crystallography, X-Ray; Drug Design; Folic Acid; Folic Acid Antagonists; Humans; Models, Molecular; Tetrahydrofolate Dehydrogenase

2020
The economic consequences of NSAID-induced gastropathy: the French context.
    Scandinavian journal of rheumatology. Supplement, 1992, Volume: 96

    Topics: Ambulatory Care; Anti-Inflammatory Agents, Non-Steroidal; Cost of Illness; Diclofenac; Duodenal Ulcer; Economics, Hospital; Etodolac; France; Gastrointestinal Diseases; Humans; Ketoprofen; Naproxen; National Health Programs; Piroxicam; Rheumatic Diseases; Sulindac

1992
Etodolac: effect on prostaglandin concentrations in gastric mucosa of rats.
    Life sciences, 1985, Mar-25, Volume: 36, Issue:12

    Topics: 6-Ketoprostaglandin F1 alpha; Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Etodolac; Gastric Mucosa; Male; Naproxen; Piroxicam; Prostaglandins; Prostaglandins E; Rats; Rats, Inbred Strains; Thiazines; Time Factors

1985
Cell damage unmasks 15-lipoxygenase activity in human neutrophils.
    The Journal of biological chemistry, 1985, Jul-15, Volume: 260, Issue:14

    Topics: Acetates; Arachidonate Lipoxygenases; Aspirin; Dose-Response Relationship, Drug; Etodolac; Fluorometry; Flurbiprofen; Humans; Hydroxyeicosatetraenoic Acids; Ibuprofen; L-Lactate Dehydrogenase; Lipoxygenase; Naproxen; Neutrophils; Phenylbutazone

1985
Effect of etodolac on articular and bone pathology associated with adjuvant arthritis in rats: a comparison with aspirin and naproxen.
    Agents and actions, 1984, Volume: 14, Issue:2

    Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Aspirin; Bone and Bones; Cartilage, Articular; Drug Evaluation, Preclinical; Etodolac; Male; Naproxen; Rats; Rats, Inbred Lew

1984
Comparative effects of long term treatment with etodolac, naproxen and ibuprofen on articular and bone changes associated with adjuvant arthritis in rats.
    Agents and actions, 1984, Volume: 15, Issue:3-4

    Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Body Weight; Bone and Bones; Cartilage, Articular; Etodolac; Ibuprofen; Naproxen; Radiography; Rats; Rats, Inbred Strains; Time Factors

1984
Effect of etodolac on prostaglandin E2 biosynthesis, active oxygen generation and bradykinin formation.
    Prostaglandins, leukotrienes, and essential fatty acids, 1994, Volume: 51, Issue:6

    Topics: Animals; Aspirin; Bradykinin; Bromelains; Cartilage, Articular; Cell Line; Concanavalin A; Depression, Chemical; Diclofenac; Dinoprostone; Dogs; Etodolac; Gastric Mucosa; Guinea Pigs; Indomethacin; Interleukin-1; Ketoprofen; Kidney; Naproxen; Oxygen; Pain; Piroxicam; Rabbits; Rats

1994
NSAID gastropathy.
    Archives of internal medicine, 1997, Feb-10, Volume: 157, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Digestive System; Etodolac; Humans; Naproxen

1997
Effects of the combined oral administration of NSAIDs and dextromethorphan on behavioral symptoms indicative of arthritic pain in rats.
    Pain, 1996, Volume: 68, Issue:1

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Behavior, Animal; Dextromethorphan; Diclofenac; Drug Interactions; Drug Therapy, Combination; Etodolac; Ibuprofen; Injections, Intraperitoneal; Male; Naproxen; Pain; Piroxicam; Rats; Rats, Sprague-Dawley

1996
The influence of age, gender, Helicobacter pylori and smoking on gastric mucosal adaptation to non-steroidal anti-inflammatory drugs.
    Alimentary pharmacology & therapeutics, 1997, Volume: 11, Issue:5

    Topics: Adolescent; Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Tolerance; Etodolac; Female; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Humans; Male; Middle Aged; Naproxen; Retrospective Studies; Sex Factors; Smoking; Stomach Diseases

1997
Nonsteroidal anti-inflammatory drugs for perioperative pain control.
    Medicine and health, Rhode Island, 2001, Volume: 84, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Butanones; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Etodolac; Humans; Ibuprofen; Indomethacin; Ketorolac; Lactones; Nabumetone; Naproxen; Pain, Postoperative; Piroxicam; Pyrazoles; Sulfonamides; Sulfones; Time Factors

2001
Risks of clinically significant upper gastrointestinal events with etodolac and naproxen: a historical cohort analysis.
    Gastroenterology, 2004, Volume: 127, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cohort Studies; Cyclooxygenase Inhibitors; Etodolac; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Naproxen

2004
Carboxyl nonsteroidal anti-inflammatory drugs are efficiently glucuronidated by microsomes of the human gastrointestinal tract.
    Biochimica et biophysica acta, 2004, Nov-18, Volume: 1675, Issue:1-3

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Etodolac; Gastrointestinal Tract; Gene Expression Regulation, Enzymologic; Glucuronides; Glucuronosyltransferase; Humans; Ketoprofen; Microsomes; Naproxen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2004
In vitro effects of selective and non-selective nonsteroidal anti-inflammatory drugs on the frequency of sister chromatid exchanges.
    Drugs in R&D, 2004, Volume: 5, Issue:6

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Etodolac; Female; Humans; Lymphocytes; Male; Meloxicam; Membrane Proteins; Middle Aged; Naproxen; Prostaglandin-Endoperoxide Synthases; Sister Chromatid Exchange; Thiazines; Thiazoles

2004
Charge transfer complex studies between some non-steroidal anti-inflammatory drugs and pi-electron acceptors.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2006, Volume: 65, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Chloranil; Ethylenes; Etodolac; Models, Biological; Naproxen; Nitriles; Oxidants; Oxidation-Reduction; Spectrum Analysis; Temperature

2006
Temporal relationship between use of NSAIDs, including selective COX-2 inhibitors, and cardiovascular risk.
    Drug safety, 2006, Volume: 29, Issue:7

    Topics: Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Celecoxib; Cohort Studies; Cyclooxygenase 2 Inhibitors; Etodolac; Female; Humans; Ibuprofen; Lactones; Male; Middle Aged; Naproxen; Pyrazoles; Sulfonamides; Sulfones; Time Factors; United States; Veterans

2006
Singlet oxygen scavenging activity of non-steroidal anti-inflammatory drugs.
    Redox report : communications in free radical research, 2008, Volume: 13, Issue:4

    Topics: Aminopyrine; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Dose-Response Relationship, Drug; Etodolac; Free Radical Scavengers; Indoprofen; Ketorolac; Molecular Structure; Naproxen; Oxaprozin; Propionates; Singlet Oxygen; Tolmetin

2008
The risk of acute myocardial infarction with etodolac is not increased compared to naproxen: a historical cohort analysis of a generic COX-2 selective inhibitor.
    Journal of cardiovascular pharmacology and therapeutics, 2008, Volume: 13, Issue:4

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cohort Studies; Cyclooxygenase 2 Inhibitors; Drug Utilization Review; Drugs, Generic; Etodolac; Humans; Incidence; Lactones; Male; Medical Records; Middle Aged; Myocardial Infarction; Naproxen; Prevalence; Prognosis; Pyrazoles; Retrospective Studies; Risk Assessment; Risk Factors; Sulfonamides; Sulfones; Texas; Veterans

2008