Compounds > naproxen
Page last updated: 2024-09-04

naproxen and sildenafil

naproxen has been researched along with sildenafil in 5 studies

Compound Research Comparison

Studies
(naproxen)		Trials
(naproxen)		Recent Studies (post-2010)
(naproxen)		Studies
(sildenafil)		Trials
(sildenafil)		Recent Studies (post-2010) (sildenafil)
4,5511,0571,429134060

Protein Interaction Comparison

ProteinTaxonomynaproxen (IC50)sildenafil (IC50)
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)20
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)20
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)20
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)20
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)20
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)20
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)20
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)20
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)20
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)20
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)20
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)20
Chain A, cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)20
Chain A, cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)20
Chain A, cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)0.0024
Chain A, cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)0.0024
Phosphodiesterase Bos taurus (cattle)9.2
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)2.881
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit deltaHomo sapiens (human)0.0187
cGMP-specific 3',5'-cyclic phosphodiesteraseRattus norvegicus (Norway rat)0.0012
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AHomo sapiens (human)2.881
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)0.2626
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AHomo sapiens (human)4.2
cGMP-specific 3',5'-cyclic phosphodiesteraseCanis lupus familiaris (dog)0.0024
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaBos taurus (cattle)0.0374
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus8.247
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 28.247
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alphaBos taurus (cattle)0.0545
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A Bos taurus (cattle)0.78
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Rattus norvegicus (Norway rat)4.6
cAMP-specific 3',5'-cyclic phosphodiesterase 4CRattus norvegicus (Norway rat)4.6
cAMP-specific 3',5'-cyclic phosphodiesterase 4BRattus norvegicus (Norway rat)4.6
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alphaHomo sapiens (human)0.0187
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'Bos taurus (cattle)0.0366
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaHomo sapiens (human)0.0187
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaBos taurus (cattle)0.0374
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit betaBos taurus (cattle)0.0374
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiens (human)7.9333
Adenosine receptor A2aHomo sapiens (human)0.253
Adenosine receptor A1Homo sapiens (human)1.493
Delta-type opioid receptorRattus norvegicus (Norway rat)0.04
Prostaglandin G/H synthase 2Homo sapiens (human)0.003
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit betaHomo sapiens (human)0.0187
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'Homo sapiens (human)0.0418
cAMP-specific 3',5'-cyclic phosphodiesterase 4ARattus norvegicus (Norway rat)4.6
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1AHomo sapiens (human)0.7199
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaCanis lupus familiaris (dog)0.0182
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BBos taurus (cattle)0.78
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)1.8841
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BRattus norvegicus (Norway rat)0.3
Synaptic vesicular amine transporterRattus norvegicus (Norway rat)0.01
cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)6.3336
cAMP-specific 3',5'-cyclic phosphodiesterase 4CHomo sapiens (human)8.52
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)5.7005
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)3.3075
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)4.7337
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7AHomo sapiens (human)4.69
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaHomo sapiens (human)0.0187
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CHomo sapiens (human)0.7398
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)4.6677
cGMP-specific 3',5'-cyclic phosphodiesteraseBos taurus (cattle)0.557
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CRattus norvegicus (Norway rat)0.3
Indoleamine 2,3-dioxygenase 2Mus musculus (house mouse)4.5
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit deltaBos taurus (cattle)0.0374
Phosphodiesterase Rattus norvegicus (Norway rat)0.3
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AHomo sapiens (human)4.1584
cAMP-specific 3',5'-cyclic phosphodiesterase 7BHomo sapiens (human)3.6006
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AHomo sapiens (human)4.2432

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1

Reviews

1 review(s) available for naproxen and sildenafil

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

4 other study(ies) available for naproxen and sildenafil

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012