naproxen has been researched along with thromboxane b2 in 47 studies
| Studies (naproxen) | Trials (naproxen) | Recent Studies (post-2010) (naproxen) | Studies (thromboxane b2) | Trials (thromboxane b2) | Recent Studies (post-2010) (thromboxane b2) |
|---|---|---|---|---|---|
| 4,551 | 1,057 | 1,429 | 7,483 | 715 | 485 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (12.77) | 18.7374 |
| 1990's | 11 (23.40) | 18.2507 |
| 2000's | 20 (42.55) | 29.6817 |
| 2010's | 10 (21.28) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bendele, AM; Benslay, DN; Hom, JT; Lee, SJ; Lindstrom, TD; Naismith, RW; Ruterbories, KJ; Spaethe, SM | 1 |
| Basch, CM; Robinson, DR; Simon, LS; Young, DY | 1 |
| Goldhaber, P; Hall, CM; Howell, TH; Jeffcoat, MK; Johnson, HG; Odle, BM; Offenbacher, S; Smith, MA; Williams, RC | 1 |
| Barradas, MA; Dandona, P; Jeremy, JY; Kirk, RM; Mikhailidis, DP | 1 |
| Holland, PJ; Kelly, RW; McLaughlin, S; Russell, RI; Sturrock, RD; Taha, AS | 1 |
| Russell, RI | 1 |
| Gréen, K; Vesterqvist, O | 1 |
| Chan, WY | 1 |
| Condorelli, M; Cuocolo, A; De Simone, A; Patrono, C; Ricciardelli, B; Trimarco, B; Volpe, M | 1 |
| Isomäki, H; Laitinen, O; Nissilä, M; Nuotio, P; Nykänen, E; Seppälä, E; Vapaatalo, H | 1 |
| Bisordi, JE; Hays, RM; Schlondorff, D | 1 |
| Lefer, AM; Smith, EF | 1 |
| Bailleul, F; Bertin, P; Jaeger, S; Lapicque, F; Netter, P; Payan, E; Rigaud, M; Treves, R | 1 |
| Hill, RE; Hunt, RH; James, C; Johnson, DM; Rainsford, KD; Salena, BJ; Stetsko, PI | 1 |
| Awni, WM; Braeckman, RA; Cavanaugh, JH; Dubé, LM; Granneman, GR; Linnen, PJ; Locke, CS | 1 |
| Del Soldato, P; McKnight, W; Muscará, MN; Wallace, JL | 1 |
| Geis, GS; Hubbard, RC; Isakson, PC; Lanza, FL; Lipsky, PE; Schwartz, BD; Simon, LS; Talwalker, S | 1 |
| Cirino, G; Lovren, F; McKnight, W; Muscará, MN; Triggle, CR; Wallace, JL | 1 |
| Arnout, J; Buntinx, A; Dallob, A; De Lepeleire, I; De Schepper, PJ; Depré, M; Ebel, DL; Gertz, BJ; Schwartz, JI; Tanaka, W; Van Hecken, A; Wong, PH; Wynants, K | 1 |
| Barry, M; Bjarnason, I; Fitzgerald, DJ; Gudjonsson, H; Kay, E; Murray, FE; Oddsson, E; Price, AB; Shah, AA; Sigthorsson, G; Thjodleifsson, B | 1 |
| Atherton, CT; Calder, NA; Cote, J; Dallob, A; Garlick, NM; Gertz, BJ; Gottesdiener, K; Hawkey, CJ; Novak, S; Wight, NJ; Wong, P | 1 |
| Kalsbeek-Batenburg, EM; Knijff-Dutmer, EA; Koerts, J; van de Laar, MA | 1 |
| Kent, JD; Leese, PT; Recker, DP; Talwalker, S | 1 |
| Cmiel, A; Mejza, F; Szczeklik, A; Tuleja, E | 1 |
| Capone, ML; Di Gregorio, P; Grana, M; Merciaro, G; Minuz, P; Patrignani, P; Patrono, C; Ricciotti, E; Sciulli, MG; Tacconelli, S | 1 |
| Gross, GJ; Moore, J | 1 |
| Capone, ML; Di Gregorio, P; Grana, M; Merciaro, G; Patrignani, P; Renda, G; Ricciotti, E; Sciulli, MG; Tacconelli, S | 1 |
| Laufer, S; Link, A; Malfertheiner, P; Treiber, G; Vieth, M; Wex, T | 1 |
| Berti, F; Brini, AT; Clement, MG; De Gennaro Colonna, V; Manfredi, B; Polvani, G; Rossoni, G | 1 |
| Fornstedt-Wallin, B; Hedman, A; Jonzon, B; Karlsson, P; Wilder-Smith, CH | 1 |
| Danhof, M; Della Pasqua, OE; Huntjens, DR; Spalding, DJ | 2 |
| Flipo, RM | 1 |
| Anzellotti, P; Capone, ML; Di Francesco, L; Di Gregorio, P; Merciaro, G; Patrignani, P; Sciulli, MG; Tacconelli, S | 1 |
| Acuto, G; Allais, G; Benedetto, C; Borgogno, P; Bussone, G; Castagnoli Gabellari, I; De Lorenzo, C; Mana, O; Zonca, M | 1 |
| Gertz, BJ; Gottesdiener, KM; Hilliard, DA; Hreniuk, D; Lasseter, KC; Miller, J; Schwartz, JI; Snyder, KM; Thach, C | 1 |
| Besz, D; Brune, K; Cheremina, O; Hinz, B; Zlotnick, S | 1 |
| Brune, K; Hochberg, MC; Oldenhof, J; Schiff, M | 1 |
| Baker, LD; Breitner, JC; Milne, G; Montine, TJ; Sonnen, JA | 1 |
| Brune, K; Hochberg, M; Oldenhof, J; Schiff, M | 1 |
| Anzellotti, P; Bruno, A; Capone, ML; Di Francesco, L; Di Gregorio, P; Garcia Rodriguez, LA; Grossi, L; Jeyam, A; Merciaro, G; Patrignani, P; Price, TS; Renda, G; Tacconelli, S; Tontodonati, P | 1 |
| Angiolillo, DJ; Datto, C; Desai, B; Hwang, C; Sostek, M | 1 |
| Danhof, M; Della Pasqua, O; Sahota, T; Sanderson, I | 2 |
| Blackler, RW; Elsheikh, W; Flannigan, KL; Wallace, JL | 1 |
| Borhade, N; Burhan, A; Desai, DC; Dhiman, M; Gaikwad, P; Gund, M; Nemmani, KVS; Patil, M; Satyam, A; Sharma, A; Sharma, S; Sheikh, J; Thakre, G; Tipparam, SG | 1 |
| Bliden, KP; Centofanti, R; Gurbel, PA; Jarvis, S; Tantry, US; Troullos, E; Venkataraman, P; Zhu, J | 1 |
2 review(s) available for naproxen and thromboxane b2
| Article | Year |
|---|---|
Pharmacodynamic interaction of naproxen with low-dose aspirin in healthy subjects.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspirin; Cardiovascular Diseases; Cyclooxygenase 1; Drug Interactions; Drug Therapy, Combination; Humans; In Vitro Techniques; Membrane Proteins; Naproxen; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Thromboxane B2 | 2005 |
[Are the NSAIDs able to compromising the cardio-preventive efficacy of aspirin?].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Cyclooxygenase Inhibitors; Drug Interactions; Follow-Up Studies; Humans; Ibuprofen; MEDLINE; Middle Aged; Multivariate Analysis; Naproxen; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk; Thromboxane B2; Ticlopidine; Time Factors | 2006 |
22 trial(s) available for naproxen and thromboxane b2
| Article | Year |
|---|---|
Effects of naproxen on renal function in older patients with mild to moderate renal dysfunction.
Topics: Aged; Aging; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Creatine; Dinoprostone; Dose-Response Relationship, Drug; Epoprostenol; Hemodynamics; Humans; Kidney; Kidney Diseases; Middle Aged; Naproxen; Prostaglandins F; Thromboxane B2 | 1992 |
Effect on gastric and duodenal mucosal prostaglandins of repeated intake of therapeutic doses of naproxen and etodolac in rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Dinoprostone; Double-Blind Method; Duodenum; Epoprostenol; Etodolac; Female; Gastric Mucosa; Humans; Indoleacetic Acids; Intestinal Mucosa; Male; Middle Aged; Naproxen; Prospective Studies; Prostaglandins; Thromboxane B2 | 1990 |
Endoscopic evaluation of etodolac and naproxen, and their relative effects on gastric and duodenal prostaglandins.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dinoprostone; Dose-Response Relationship, Drug; Duodenum; Endoscopy; Epoprostenol; Etodolac; Female; Gastric Mucosa; Humans; Indoleacetic Acids; Male; Middle Aged; Mucous Membrane; Naproxen; Osteoarthritis; Patient Compliance; Prostaglandins; Stomach; Thromboxane B2; Time Factors | 1990 |
Effects of chronic NSAIDs on gastric mucosal injury related to mucosal prostanoids, and plasma drug concentrations in human volunteers.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Anti-Inflammatory Agents, Non-Steroidal; Apazone; Dinoprostone; Gastric Fundus; Gastric Mucosa; Humans; Indomethacin; Male; Naproxen; Piroxicam; Pyloric Antrum; Thromboxane B2 | 1993 |
The pharmacokinetic and pharmacodynamic interactions between the 5-lipoxygenase inhibitor zileuton and the cyclo-oxygenase inhibitor naproxen in human volunteers.
Topics: Administration, Oral; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Digestive System; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Endoscopy; Humans; Hydroxyurea; Intestinal Mucosa; Leukotriene B4; Lipoxygenase Inhibitors; Male; Naproxen; Thromboxane B2 | 1995 |
Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Aspirin; Celecoxib; Cyclooxygenase Inhibitors; Endoscopy; Female; Humans; Knee Joint; Male; Middle Aged; Naproxen; Osteoarthritis; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrazoles; Safety; Severity of Illness Index; Stomach Ulcer; Sulfonamides; Thromboxane B2; Treatment Outcome | 1998 |
Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers.
Topics: Adolescent; Adult; Bleeding Time; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Female; Humans; Ibuprofen; Isoenzymes; Lactones; Lipopolysaccharides; Meloxicam; Membrane Proteins; Middle Aged; Naproxen; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfones; Thiazines; Thiazoles; Thromboxane B2 | 2000 |
Selective inhibition of COX-2 in humans is associated with less gastrointestinal injury: a comparison of nimesulide and naproxen.
Topics: Adolescent; Adult; Aged; Biomarkers; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Gastric Mucosa; Gastrointestinal Diseases; Humans; Intestinal Mucosa; Male; Middle Aged; Naproxen; Permeability; Platelet Aggregation; Prostaglandins E; Sulfonamides; Thromboxane B2 | 2001 |
Rofecoxib, a COX-2 inhibitor, does not inhibit human gastric mucosal prostaglandin production.
Topics: Adult; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Gastric Mucosa; Humans; Isoenzymes; Lactones; Lipopolysaccharides; Male; Membrane Proteins; Naproxen; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfones; Thromboxane B2 | 2001 |
Platelet function is inhibited by non-selective non-steroidal anti-inflammatory drugs but not by cyclo-oxygenase-2-selective inhibitors in patients with rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Bleeding Time; Blood Platelets; Cross-Over Studies; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Male; Meloxicam; Middle Aged; Naproxen; Platelet Aggregation; Random Allocation; Thiazines; Thiazoles; Thromboxane B2 | 2002 |
Valdecoxib does not impair platelet function.
Topics: Adolescent; Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Bleeding Time; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Female; Humans; Isoxazoles; Male; Middle Aged; Naproxen; Platelet Aggregation; Statistics, Nonparametric; Sulfonamides; Thromboxane B2 | 2002 |
Effects of cyclooxygenases inhibitors on vasoactive prostanoids and thrombin generation at the site of microvascular injury in healthy men.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bleeding Time; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Endothelium, Vascular; Fibrinolytic Agents; Humans; Isoenzymes; Lactones; Male; Membrane Proteins; Naproxen; Prostaglandin-Endoperoxide Synthases; Sulfones; Thrombin; Thromboxane B2 | 2003 |
Clinical pharmacology of platelet, monocyte, and vascular cyclooxygenase inhibition by naproxen and low-dose aspirin in healthy subjects.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Blood Platelets; Cardiotonic Agents; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Endothelial Cells; Endothelium, Vascular; Female; Humans; Isoenzymes; Male; Membrane Proteins; Middle Aged; Monocytes; Naproxen; Prostaglandin-Endoperoxide Synthases; Prostaglandins I; Thromboxane B2 | 2004 |
Dose-effect comparisons of the CINOD AZD3582 and naproxen on upper gastrointestinal tract mucosal injury in healthy subjects.
Topics: Adult; Cross-Over Studies; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Duodenal Ulcer; Endoscopy, Gastrointestinal; Female; Humans; Intestinal Mucosa; Male; Naphthalenes; Naproxen; Reference Values; Stomach Ulcer; Thromboxane B2; Treatment Outcome | 2006 |
Human pharmacology of naproxen sodium.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Epoprostenol; Humans; Lipopolysaccharides; Monocytes; Naproxen; Platelet Aggregation; Thromboxane B2 | 2007 |
Effects of etoricoxib and comparator nonsteroidal anti-inflammatory drugs on urinary sodium excretion, blood pressure, and other renal function indicators in elderly subjects consuming a controlled sodium diet.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Body Weight; Celecoxib; Constipation; Creatinine; Diarrhea; Dose-Response Relationship, Drug; Double-Blind Method; Electrolytes; Etoricoxib; Female; Headache; Humans; Male; Middle Aged; Naproxen; Potassium; Prostaglandins; Pyrazoles; Pyridines; Sodium; Sulfonamides; Sulfones; Thromboxane B2 | 2007 |
Platelet inhibitory effects of OTC doses of naproxen sodium compared with prescription dose naproxen sodium and low-dose aspirin.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Naproxen; Nonprescription Drugs; Placebos; Platelet Aggregation Inhibitors; Reference Values; Thromboxane B2 | 2009 |
Elevated ratio of urinary metabolites of thromboxane and prostacyclin is associated with adverse cardiovascular events in ADAPT.
Topics: 6-Ketoprostaglandin F1 alpha; Aged; Aged, 80 and over; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Celecoxib; Drug Therapy, Combination; F2-Isoprostanes; Female; Humans; Male; Naproxen; Pyrazoles; Sulfonamides; Thromboxane B2; Treatment Outcome | 2010 |
Effect of maximum OTC doses of naproxen sodium or acetaminophen on low-dose aspirin inhibition of serum thromboxane B2.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Aspirin; Cyclooxygenase Inhibitors; Female; Humans; Male; Middle Aged; Naproxen; Nonprescription Drugs; Platelet Aggregation Inhibitors; Thromboxane B2; Young Adult | 2010 |
Low-dose naproxen interferes with the antiplatelet effects of aspirin in healthy subjects: recommendations to minimize the functional consequences.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Naproxen; Platelet Aggregation Inhibitors; Platelet-Rich Plasma; Reference Values; Thromboxane B2; Young Adult | 2011 |
Impact of a fixed-dose combination of naproxen and esomeprazole magnesium on serum thromboxane B2 inhibition by low-dose aspirin over 5 days in healthy adults: a phase I, randomized, double-blind, placebo-controlled, noninferiority trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Combinations; Esomeprazole; Female; Humans; Male; Middle Aged; Naproxen; Pilot Projects; Placebos; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Tablets, Enteric-Coated; Thromboxane B2; Time Factors; United States | 2011 |
Thromboxane inhibition during concurrent therapy with low-dose aspirin and over-the-counter naproxen sodium.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Middle Aged; Naproxen; Platelet Aggregation Inhibitors; Thromboxane B2; Thromboxanes | 2018 |
23 other study(ies) available for naproxen and thromboxane b2
| Article | Year |
|---|---|
Anti-inflammatory activity of BF389, a Di-T-butylphenol, in animal models of arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arthritis, Experimental; Collagen; Diamines; Diclofenac; Dinoprostone; Disease Models, Animal; Female; Interleukin-1; Leukotriene B4; Male; Naproxen; Oxazines; Phenols; Piroxicam; Rats; Rats, Inbred Lew; Thromboxane B2 | 1992 |
Effects of NSAIDs on beagle crevicular cyclooxygenase metabolites and periodontal bone loss.
Topics: Administration, Oral; Administration, Topical; Alveolar Bone Loss; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Flurbiprofen; Gingival Crevicular Fluid; Ibuprofen; Naproxen; Prostaglandins F; Thromboxane B2 | 1992 |
The effect of nabumetone and its principal active metabolite on in vitro human gastric mucosal prostanoid synthesis and platelet function.
Topics: 6-Ketoprostaglandin F1 alpha; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Butanones; Culture Techniques; Dinoprostone; Epoprostenol; Gastric Mucosa; Humans; Indomethacin; Nabumetone; Naphthaleneacetic Acids; Naproxen; Platelet Aggregation; Thromboxane A2; Thromboxane B2 | 1990 |
Effects of naproxen on the in vivo synthesis of thromboxane and prostacyclin in man.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Epoprostenol; Female; Humans; Male; Naproxen; Thromboxane A2; Thromboxane B2 | 1989 |
Enhanced prostaglandin synthesis in the parturient rat uterus and its effects on myometrial oxytocin receptor concentrations.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dinoprost; Dinoprostone; Female; Labor, Obstetric; Microsomes; Myometrium; Naproxen; Pregnancy; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Prostaglandins E; Prostaglandins F; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Receptors, Oxytocin; Thromboxane B2; Uterine Contraction; Uterus | 1987 |
Indomethacin blunts the late phase of nitroglycerin-induced coronary vasodilatation in dogs.
Topics: Animals; Blood Pressure; Coronary Vessels; Cyclooxygenase Inhibitors; Dogs; Female; Heart Rate; Indomethacin; Injections, Intra-Arterial; Male; Naproxen; Nitroglycerin; Thromboxane B2; Vasodilation | 1985 |
Comparison of the effects of different anti-inflammatory drugs on synovial fluid prostanoid concentrations in patients with rheumatoid arthritis.
Topics: 6-Ketoprostaglandin F1 alpha; Acetaminophen; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Carbazoles; Diclofenac; Dinoprostone; Guanidines; Humans; Indomethacin; Naproxen; ortho-Aminobenzoates; Prednisolone; Prostaglandins; Prostaglandins E; Quinazolines; Synovial Fluid; Thromboxane B2 | 1985 |
Interaction of vasopressin and prostaglandins in the toad urinary bladder.
Topics: Acetaminophen; Animals; Arachidonic Acids; Arginine Vasopressin; Bufo marinus; Deamino Arginine Vasopressin; Epithelium; Naproxen; Prostaglandins; Thromboxane B2; Urinary Bladder; Water-Electrolyte Balance | 1980 |
Stabilization of cardiac lysosomal and cellular membranes in protection of ischemic myocardium due to coronary occlusion:efficacy of the nonsteroidal anti-inflammatory agent, naproxen.
Topics: Animals; Anti-Inflammatory Agents; Arterial Occlusive Diseases; Cats; Cell Membrane; Coronary Disease; Creatine Kinase; Lysosomes; Male; Naproxen; Platelet Aggregation; Thromboxane B2; Thromboxanes | 1981 |
Sodium naproxen: concentration and effect on inflammatory response mediators in human rheumatoid synovial fluid.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Arthritis, Rheumatoid; Biomarkers; Chromatography, High Pressure Liquid; Dinoprostone; Female; Humans; Hyaluronic Acid; Immunoenzyme Techniques; Knee Joint; Leukotriene B4; Male; Middle Aged; Naproxen; Protein Binding; Synovial Fluid; Thromboxane B2 | 1994 |
Effect of a nitric oxide-releasing naproxen derivative on hypertension and gastric damage induced by chronic nitric oxide inhibition in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Gastric Mucosa; Hypertension; Male; Naproxen; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Stomach Ulcer; Thromboxane B2 | 1998 |
Antihypertensive properties of a nitric oxide-releasing naproxen derivative in two-kidney, one-clip rats.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Endothelin-1; Hypertension, Renovascular; In Vitro Techniques; Isometric Contraction; Male; Muscle, Smooth, Vascular; Naproxen; Nitrates; Nitric Oxide Donors; Nitrites; Nitroglycerin; Nitroprusside; Phenylephrine; Rats; Rats, Wistar; Renal Artery; Thromboxane B2 | 2000 |
Effect of COX-1/COX-2 inhibition versus selective COX-2 inhibition on coronary vasodilator responses to arachidonic acid and acetylcholine.
Topics: Acetylcholine; Animals; Arachidonic Acid; Blood Pressure; Coronary Circulation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Isoenzymes; Lipopolysaccharides; Male; Naproxen; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thromboxane B2; Vasodilation; Vasodilator Agents | 2004 |
The effect of single-dose naproxen on eicosanoid formation in human gastroduodenal mucosa.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Eicosanoids; Female; Gastric Mucosa; Humans; Leukotriene B4; Male; Naproxen; Prostaglandins E; Reverse Transcriptase Polymerase Chain Reaction; Thromboxane B2 | 2006 |
Nitric oxide and prostacyclin pathways: an integrated mechanism that limits myocardial infarction progression in anaesthetized rats.
Topics: Animals; Arginine; Arrhythmias, Cardiac; Cardiotonic Agents; Creatine Kinase; Epoprostenol; Isosorbide Dinitrate; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Naproxen; Nitric Oxide; Peroxidase; Polydeoxyribonucleotides; Random Allocation; Rats; Rats, Wistar; Thromboxane B2 | 2006 |
Correlation between in vitro and in vivo concentration-effect relationships of naproxen in rats and healthy volunteers.
Topics: Adult; Animals; Blood Proteins; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Humans; Male; Naproxen; Protein Binding; Rats; Rats, Sprague-Dawley; Thromboxane B2 | 2006 |
Naproxen sodium in short-term prophylaxis of pure menstrual migraine: pathophysiological and clinical considerations.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Adult; Cyclooxygenase Inhibitors; Dinoprostone; Down-Regulation; Drug Administration Schedule; Female; Humans; Menstruation Disturbances; Middle Aged; Migraine Disorders; Naproxen; Predictive Value of Tests; Thromboxane B2; Time Factors; Treatment Outcome | 2007 |
Impact of naproxen sodium at over-the-counter doses on cyclooxygenase isoforms in human volunteers.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Escherichia coli; Female; Humans; In Vitro Techniques; Isoenzymes; Lipopolysaccharides; Male; Middle Aged; Naproxen; Platelet Aggregation; Thromboxane B2 | 2008 |
Impact of chronic inflammation on the pharmacokinetic-pharmacodynamic relationship of naproxen.
Topics: Animals; Dinoprostone; Dose-Response Relationship, Drug; Freund's Adjuvant; Inflammation; Naproxen; Rats; Rats, Sprague-Dawley; Thromboxane B2 | 2010 |
Model-based analysis of thromboxane B₂ and prostaglandin E₂ as biomarkers in the safety evaluation of naproxen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Biomarkers; Computer Simulation; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Feasibility Studies; Humans; Intestinal Absorption; Male; Metabolic Clearance Rate; Models, Biological; Naproxen; Rats; Rats, Sprague-Dawley; Risk Assessment; Species Specificity; Thromboxane B2 | 2014 |
Enhanced chemopreventive effects of a hydrogen sulfide-releasing anti-inflammatory drug (ATB-346) in experimental colorectal cancer.
Topics: Aberrant Crypt Foci; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Colon; Colorectal Neoplasms; Dinoprostone; Male; Mice; Naproxen; Protective Agents; Rats; Thromboxane B2 | 2014 |
Gastric-sparing nitric oxide-releasable 'true' prodrugs of aspirin and naproxen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Aspirin; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase 2; Drug Design; Drug Stability; Gastric Mucosa; Half-Life; Humans; Naproxen; Nitrates; Nitric Oxide; Platelet Aggregation Inhibitors; Prodrugs; Rats; Rats, Sprague-Dawley; ROC Curve; Thromboxane B2 | 2014 |
Model-based prediction of the acute and long-term safety profile of naproxen in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Dinoprostone; Dose-Response Relationship, Drug; Male; Models, Biological; Naproxen; Peptic Ulcer; Rats; Thromboxane B2 | 2015 |