naproxen has been researched along with clomipramine in 15 studies
| Studies (naproxen) | Trials (naproxen) | Recent Studies (post-2010) (naproxen) | Studies (clomipramine) | Trials (clomipramine) | Recent Studies (post-2010) (clomipramine) |
|---|---|---|---|---|---|
| 4,551 | 1,057 | 1,429 | 2,929 | 541 | 304 |
| Protein | Taxonomy | naproxen (IC50) | clomipramine (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.034 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.071 | |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 0.241 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 0.091 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.005 | |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | 0.053 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.707 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 3.9465 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 0.091 | |
| D(2) dopamine receptor | Homo sapiens (human) | 0.413 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.005 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.0505 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.7065 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.005 | |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | 0.17 | |
| D(1A) dopamine receptor | Homo sapiens (human) | 1.113 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 0.0678 | |
| Histamine H2 receptor | Homo sapiens (human) | 2.049 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.18 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.067 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.034 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.005 | |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | 0.005 | |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | 0.005 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.005 | |
| 5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | 0.005 | |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | 0.0002 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.035 | |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | 0.005 | |
| 5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | 0.005 | |
| 5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | 0.005 | |
| Histamine H1 receptor | Homo sapiens (human) | 0.085 | |
| D(3) dopamine receptor | Homo sapiens (human) | 0.139 | |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | 0.005 | |
| Trypanothione reductase | Trypanosoma brucei brucei | 3.4 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.239 | |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | 0.72 | |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 0.245 | |
| Voltage-dependent N-type calcium channel subunit alpha-1B | Homo sapiens (human) | 9 | |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | 2.7615 | |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | 0.005 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 1.362 | |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | 0.005 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 9 (60.00) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Chang, TK; Ensom, MH; Kiang, TK | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Abate, C; Amantea, B; Belfiore, F; Brando, G; Celano, S; Celentano, L; Cuocolo, R; Orlando, C; Santangelo, E; Savoia, G | 1 |
| Breadmore, MC; Gooley, AA; Guijt, RM; Mikhail, IE; Tehranirokh, M | 1 |
2 review(s) available for naproxen and clomipramine
| Article | Year |
|---|---|
UDP-glucuronosyltransferases and clinical drug-drug interactions.
Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
13 other study(ies) available for naproxen and clomipramine
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
[Potentiating drugs in postoperative pain control with opiates for patient controlled analgesia].
Topics: Analgesia; Anti-Anxiety Agents; Benzamides; Benzodiazepines; Buprenorphine; Clomipramine; Drug Synergism; Humans; Morphine; Naproxen; Nordazepam; Pain, Postoperative; Patients; Trazodone | 1988 |
In-Syringe Electrokinetic Protein Removal from Biological Samples prior to Electrospray Ionization Mass Spectrometry.
Topics: Acetaminophen; Atenolol; Blood Proteins; Chlorpheniramine; Clomipramine; Humans; Kinetics; Naproxen; Pindolol; Spectrometry, Mass, Electrospray Ionization; Syringes | 2020 |