Compounds > matricin
Page last updated: 2024-09-24

matricin

Description

matricin: RN given refers to (3S-(3alpha,3aalpha,4alpha,9alpha,9aalpha,9bbeta))-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID92265
CHEMBL ID497441
CHEBI ID6699
SCHEMBL ID457856
MeSH IDM0119255

Synonyms (22)

Synonym
matricin
29041-35-8
C09499
LMPR0103410003
CHEMBL497441
chebi:6699 ,
(3s-(3alpha,3aalpha,4alpha,9alpha,9aalpha,9bbeta))-3a,4,5,9,9a,9b-hexahydro-9-hydroxy-3,6,9-trimethyl-2-oxoazuleno(4,5-b)-3h-furan-4-yl acetate
o034c3549s ,
unii-o034c3549s
einecs 249-384-3
proazulene
(-)-matricin
azuleno(4,5-b)furan-2(3h)-one, 4-(acetyloxy)-3a,4,5,9,9a,9b-hexahydro-9-hydroxy-3,6,9-trimethyl-, (3s,3ar,4s,9r,9as,9bs)-
matricin (constituent of chamomile) [dsc]
SCHEMBL457856
matricin, analytical standard
[3s-(3alpha,3aalpha,4alpha,9alpha,9aalpha,9bbeta)]-3a,4,5,9,9a,9b-hexahydro-9-hydroxy-3,6,9-trimethyl-2-oxoazuleno[4,5-b]-3h-furan-4-yl acetate
[(3s,3ar,4s,9r,9as,9bs)-9-hydroxy-3,6,9-trimethyl-2-oxo-3,3a,4,5,9a,9b-hexahydroazuleno[4,5-b]furan-4-yl]acetate
Q1908961
DTXSID50951639
matricin (constituent of chamomile)
matricine

Drug Classes (1)

ClassDescription
sesquiterpene lactoneAny member of a diverse class of complex, multicyclic phytochemicals showing a variety of skeleton arrangements and bioactivities, and having in common a sesquiterpenoid structure including a lactone ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID377734Metabolic stability in artificial gastric fluid assessed as transformation to chamazulene carboxylic acid after 60 mins2006Journal of natural products, Jul, Volume: 69, Issue:7
Chamazulene carboxylic acid and matricin: a natural profen and its natural prodrug, identified through similarity to synthetic drug substances.
AID377733Metabolic stability in artificial gastric fluid assessed as transformation to chamazulene carboxylic acid after 30 mins2006Journal of natural products, Jul, Volume: 69, Issue:7
Chamazulene carboxylic acid and matricin: a natural profen and its natural prodrug, identified through similarity to synthetic drug substances.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (22.22)18.7374
1990's1 (11.11)18.2507
2000's3 (33.33)29.6817
2010's3 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (10.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
aspirin[no description available]medium10benzoic acids;
phenyl acetates;
salicylates		anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent
flurbiprofen[no description available]medium10fluorobiphenyl;
monocarboxylic acid		antipyretic;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
nimesulide[no description available]medium10aromatic ether;
C-nitro compound;
sulfonamide		cyclooxygenase 2 inhibitor;
non-steroidal anti-inflammatory drug
dexibuprofen[no description available]medium10ibuprofennon-narcotic analgesic;
non-steroidal anti-inflammatory drug
naproxen[no description available]medium10methoxynaphthalene;
monocarboxylic acid		antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
gout suppressant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
warfarin[no description available]medium10benzenes;
hydroxycoumarin;
methyl ketone
bisabolol[no description available]medium10
chamazulene[no description available]medium50sesquiterpenoid
beta-farnesene[no description available]medium10beta-farnesene
sesquiterpenes[no description available]medium100
deoxycytidine[no description available]medium10pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
gemcitabine[no description available]medium10organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
environmental contaminant;
immunosuppressive agent;
photosensitizing agent;
prodrug;
radiosensitizing agent;
xenobiotic
apigenin[no description available]medium10trihydroxyflavoneantineoplastic agent;
metabolite
apigetrin[no description available]medium10beta-D-glucoside;
dihydroxyflavone;
glycosyloxyflavone;
monosaccharide derivative		antibacterial agent;
metabolite;
non-steroidal anti-inflammatory drug
betadex[no description available]medium10cyclodextrin
leukotriene b4[no description available]medium10dihydroxy monocarboxylic acid;
hydroxy polyunsaturated fatty acid;
leukotriene;
long-chain fatty acid		human metabolite;
mouse metabolite;
plant metabolite;
vasoconstrictor agent
damsin[no description available]low00sesquiterpene lactone
helenalin[no description available]low00cyclic ketone;
gamma-lactone;
organic heterotricyclic compound;
secondary alcohol;
sesquiterpene lactone		anti-inflammatory agent;
antineoplastic agent;
metabolite;
plant metabolite
artemisinin[no description available]low00organic peroxide;
sesquiterpene lactone		antimalarial;
plant metabolite
zaluzanin C[no description available]low00gamma-lactone;
guaiane sesquiterpenoid;
organic heterotricyclic compound;
secondary alcohol;
sesquiterpene lactone		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
metabolite
alantolactone[no description available]low00naphthofuran;
olefinic compound;
sesquiterpene lactone		antineoplastic agent;
apoptosis inducer;
plant metabolite
dehydrocostus lactone[no description available]low00gamma-lactone;
guaiane sesquiterpenoid;
organic heterotricyclic compound;
sesquiterpene lactone		antimycobacterial drug;
antineoplastic agent;
apoptosis inducer;
cyclooxygenase 2 inhibitor;
metabolite;
trypanocidal drug
isoalantolactone[no description available]low00eudesmane sesquiterpenoid;
sesquiterpene lactone		antifungal agent;
apoptosis inducer;
plant metabolite
bilobalide[no description available]low00sesquiterpene lactone
ambrosin[no description available]low00sesquiterpene lactone
Mexicanin I[no description available]low00sesquiterpene lactone
6-Hydroxy-5a-methyl-3,9-dimethylidenedecahydronaphtho[1,2-b]furan-2(3h)-one[no description available]low00sesquiterpene lactone
eremanthin[no description available]low00sesquiterpene lactone
megestrol acetate[no description available]low00bridged compound;
organic heterotetracyclic compound;
secondary alcohol;
sesquiterpene lactone;
spiro compound;
tertiary alcohol;
tetrol		GABA antagonist;
neurotoxin;
phytogenic insecticide;
plant metabolite
cynaropicrin[no description available]low00sesquiterpene lactone
2-hydroxyalantolactone[no description available]low00sesquiterpene lactone
tomentosin[no description available]low00sesquiterpene lactone
leucodin[no description available]low00sesquiterpene lactone
inuviscolide[no description available]low00gamma-lactone;
organic heterotricyclic compound;
sesquiterpene lactone;
tertiary alcohol		anti-inflammatory agent;
plant metabolite
arnicolide d[no description available]low00sesquiterpene lactone
ergolide[no description available]low00acetate ester;
cyclic ketone;
gamma-lactone;
organic heterotricyclic compound;
sesquiterpene lactone		anti-inflammatory agent;
antineoplastic agent;
metabolite;
NF-kappaB inhibitor;
plant metabolite
santamarine[no description available]low00sesquiterpene lactone
tenulin[no description available]low00sesquiterpene lactone
coronopilin[no description available]low00sesquiterpene lactone
gaillardin[no description available]low00sesquiterpene lactone
aromaticin[no description available]low00cyclic ketone;
gamma-lactone;
organic heterotricyclic compound;
sesquiterpene lactone		anti-inflammatory agent;
metabolite;
plant metabolite
Cadabicilone[no description available]low00sesquiterpene lactone
absynthin[no description available]low00organic heteroheptacyclic compound;
sesquiterpene lactone;
triterpenoid		anti-inflammatory agent;
plant metabolite
angustibalin[no description available]low00sesquiterpene lactone
Canin[no description available]low00sesquiterpene lactone
eremophilenolide[no description available]low00sesquiterpene lactone
grosheimin[no description available]low00sesquiterpene lactone
lactucin[no description available]low00azulenofuran;
cyclic terpene ketone;
enone;
primary alcohol;
secondary alcohol;
sesquiterpene lactone		antimalarial;
plant metabolite;
sedative
micheliolide[no description available]low00sesquiterpene lactone
microlenin[no description available]low00sesquiterpene lactone
parthenin[no description available]low00sesquiterpene lactone
11alpha,13-dihydrohelenalin[no description available]low00sesquiterpene lactone
thapsigargin[no description available]low00butyrate ester;
organic heterotricyclic compound;
sesquiterpene lactone		calcium channel blocker;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor
reynosin[no description available]low00organic heterotricyclic compound;
sesquiterpene lactone		metabolite
bigelovin[no description available]low00acetate ester;
cyclic ketone;
gamma-lactone;
organic heterotricyclic compound;
sesquiterpene lactone		antineoplastic agent;
apoptosis inducer;
immunomodulator;
plant metabolite
Artemin[no description available]low00sesquiterpene lactone
Euparotin acetate[no description available]low00sesquiterpene lactone
trilobolide[no description available]low00sesquiterpene lactone
xanthatin[no description available]low00sesquiterpene lactone
arglabin[no description available]low00epoxide;
gamma-lactone;
organic heterotetracyclic compound;
sesquiterpene lactone		antineoplastic agent;
metabolite
parthenolide[no description available]low00sesquiterpene lactonedrug allergen;
inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
peripheral nervous system drug
pentalenolactone f[no description available]low00alpha,beta-unsaturated monocarboxylic acid;
organic heterotricyclic compound;
sesquiterpene lactone;
spiro-epoxide		bacterial metabolite
eudesmanolide[no description available]low00sesquiterpene lactone
atractylenolide ii[no description available]low00sesquiterpene lactone
(2S,5S,6S,9S)-5,9,13-Trimethyl-3-oxatricyclo[7.4.0.0<2,6>]trideca-1(13),10-die ne-4,12-dione[no description available]low00sesquiterpene lactone
arenaemycin e[no description available]low00alpha,beta-unsaturated monocarboxylic acid;
organic heterotricyclic compound;
sesquiterpene lactone;
spiro-epoxide		antimicrobial agent;
bacterial metabolite;
EC 1.2.1.12 [glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)] inhibitor
ainsliadimer a[no description available]low00sesquiterpene lactone;
spiro compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
metabolite
enhydrin[no description available]low00sesquiterpene lactone
ConditionIndicatedRelationship StrengthStudiesTrials
Bacterial Disease0low10
Bacterial Infection0low10
Bacterial Infections0low10
Cancer of Pancreas0low20
Cancer of the Pancreas0low20
Infection, Bacterial0low10
Infections, Bacterial0low10
Invasiveness, Neoplasm0low10
Neoplasm Invasion0low10
Neoplasm Invasiveness0low10
Neoplasms, Pancreatic0low20
Pancreas Cancer0low20
Pancreas Neoplasms0low20
Pancreatic Cancer0low20
Pancreatic Neoplasms0low20