Page last updated: 2024-12-07

ketoprofen glucuronide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

ketoprofen glucuronide: principal metabolite of ketoprofen [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID131281
CHEMBL ID3526739
CHEBI ID165194
SCHEMBL ID21594802
MeSH IDM0129328

Synonyms (22)

Synonym
beta-d-glucopyranuronic acid, 1-(3-benzoyl-alpha-methylbenzeneacetate)
ketoprofen glucuronide
CHEBI:165194
76690-94-3
(2s,3s,4s,5r,6s)-6-[2-(3-benzoylphenyl)propanoyloxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
(+/-)-ketoprofen glucuronide
dl-ketoprofen glucuronide
rac ketoprofen acyl-beta-d-glucuronide
ketoprofen acyl-b-d-glucuronide
W-203754
CHEMBL3526739
(2s,3s,4s,5r,6s)-6-{[2-(3-benzoylphenyl)propanoyl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acid
1-(3-benzoyl-alpha-methylbenzeneacetate) beta-delta-glucopyranuronic acid
1-(3-benzoyl-alpha-methylbenzeneacetate) beta-d-glucopyranuronic acid
SCHEMBL21594802
rac ketoprofen acyl-b-d-glucuronide
1-o-[2-(3-benzoylphenyl)propanoyl]hexopyranuronic acid
DTXSID30998002
(2s,3s,4s,5r,6s)-6-((2-(3-benzoylphenyl)propanoyl)oxy)-3,4,5-trihydroxytetrahydro-2h-pyran-2-carboxylic acid
rac ketoprofen acyl-?-d-glucuronide
rac ketoprofen acyl- beta -d-glucuronide
1-(3-benzoly-alpha-methylbenzeneacetate)-beta-d-glucopyranuronic acid

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" A disproportionately large degree of elimination of free ketoprofen was observed between 0-6 h after dosing with ketoprofen capsules."( Urinary pharmacokinetics of orally administered ketoprofen in man.
Dennis, MJ; Houghton, GW; Parsons, RL; Rigler, ED,
)
0.13
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
benzophenonesAny aromatic ketone in which the carbonyl group is bonded to 2 phenyl groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID1221834Activity of human UGT1A3 expressed in HEK293 cells assessed as enzyme-mediated compound formation per 2 x 10'5 cells treated with ketoprofen at 1 mM measured at 24 hrs by LC-MS/MS analysis2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.
AID1221824Drug level in human hepatocytes assessed per 2 x 10'5 cells treated with ketoprofen at 1 mM measured at 6 hrs by LC-MS/MS analysis in presence of acyl glucuronidation inhibitor (-)-borneol2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.
AID1221844Drug level in cell culture medium treated with ketoprofen at 1 mM measured at 6 hrs by LC-MS/MS analysis in presence of acyl glucuronidation inhibitor (-)-borneol2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.
AID1221809Activity of human UGT1A3 expressed in HEK293 cells assessed as enzyme-mediated compound formation in cell culture medium treated with ketoprofen at 1 mM by LC-MS/MS analysis2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.
AID1221805Activity of human UGT1A3 expressed in HEK293 cells assessed as enzyme-mediated compound formation in cell culture medium treated with ketoprofen at 1 mM measured at 6 to 24 hrs by LC-MS/MS analysis2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.
AID1221840Drug level in cell culture medium treated with ketoprofen at 1 mM measured at 6 hrs by LC-MS/MS analysis in absence of acyl glucuronidation inhibitor (-)-borneol2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.
AID1221786Ratio of drug level in human hepatocytes to HEK293 cells expressing UGT1A3 treated with ketoprofen at 1 mM2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.
AID1221837Drug level in human hepatocytes assessed per 2 x 10'5 cells treated with ketoprofen at 1 mM measured at 6 hrs by LC-MS/MS analysis in absence of acyl glucuronidation inhibitor (-)-borneol2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's7 (46.67)18.2507
2000's5 (33.33)29.6817
2010's3 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.40

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.40 (24.57)
Research Supply Index2.94 (2.92)
Research Growth Index4.35 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.40)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (5.88%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (94.12%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]