Page last updated: 2024-09-04

naproxen and sulindac

naproxen has been researched along with sulindac in 81 studies

Compound Research Comparison

Studies (naproxen)	Trials (naproxen)	Recent Studies (post-2010) (naproxen)	Studies (sulindac)	Trials (sulindac)	Recent Studies (post-2010) (sulindac)
4,551	1,057	1,429	1,462	202	305

Protein Interaction Comparison

Protein	Taxonomy	sulindac (IC50)
Aldo-keto reductase family 1 member B10	Homo sapiens (human)	2.69
Aldo-keto reductase family 1 member B1	Homo sapiens (human)	2.69
Aldo-keto reductase family 1 member B1	Bos taurus (cattle)	0.293
Prostaglandin G/H synthase 2	Homo sapiens (human)	8.8

Research

Studies (81)

Timeframe	Studies, this research(%)	All Research%
pre-1990	35 (43.21)	18.7374
1990's	14 (17.28)	18.2507
2000's	7 (8.64)	29.6817
2010's	25 (30.86)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Duffy, EM; Jorgensen, WL	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Fujiwara, R; Koga, T; Nakajima, M; Yokoi, T	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Horie, T; Horiguchi, A; Kitamura, S; Kotake, Y; Ohshita, H; Ohta, S; Sanoh, S; Sugihara, K; Tateno, C; Tayama, Y	1
Kumar, M; Sinha, VR; Thareja, S	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Alcaraz, B; Bratoeff, E; Cabeza, M; Camacho-Arroyo, I; Garrido, M; González-Arenas, A	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Akgul, O; Alfawaz Altamimi, AS; Angeli, A; Bartolucci, G; Carta, F; Di Cesare Mannelli, L; Ghelardini, C; Scozzafava, A; Supuran, CT; Vullo, D	1
Miehlke, K	1
Burdeĭnyĭ, AP	1
Pemberton, RE; Strand, LJ	1
de Pouvourville, G	1
Castonguay, A; Jalbert, G	1
Gupta, SK; Joshi, S	1
Freer, JP; Morris, ME; Watson, WA	1
Kazemifard, AG; Moore, DE	1
Andersson, KE; Eriksson, LO; Kullendorff, CM; Larsson, B	1
Eriksson, LO; Sturfelt, G; Thysell, H; Wollheim, FA	1
Abate, MA; D'Alessandri, R; Layne, RD; Neely, JL	1
Montenegro, MA; Palomino, H	1
Day, R; Goodfriend, TL; Hiatt, JG; Kochar, M; Schuna, AA; Vejraska, BD	1
Cook, L; Ternai, B	1
Freeman, D; Lamki, L; McDonald, JW; Spence, JD; Wong, DG	1
Beermann, B; Eriksson, LO; Kallner, M	3
Facoory, B; Faed, JM; McQueen, EG	1
Altman, R	1
Christensen, P; Kamper, AL; Strandgaard, S; Svendsen, UG	1
Anderson, SA; Brater, DC; Brown-Cartwright, D	1
Powell, AL; Ragheb, M	1
Brewerton, DA; Dixey, JJ; Lant, AF; Noormohamed, FH	1
Christensen, P; Gerstoft, J; Hansen, TM; Lorenzen, I; Svendsen, UG	2
Anderson, S; Baird, B; Brater, DC; Campbell, WB	1
Macauley, D	1
Bune, AJ; Chalmers, JP; Graham, JR; West, MJ; Wing, LM	1
Currie, WJ; Dasgupta, PK; Diggins, JB; Glick, EN; Janke, PG; Sheikh, NA	1
Altman, RD	1
Ward, JR	1
Chremos, AN; Dunn, MJ; Zambraski, EJ	1
Gribnau, FW; Koopmans, PP; Thien, T	1
Bhalla, AK; Simon, LS	1
Hunt, JN; Jiang, CL; Smith, JL	1
Porter, RS	1
Caruana, RJ; Semble, EL	1
Obel, AO	1
Mills, JA; Simon, LS	1
Crabtree, RE; Johnson, DW; Ridolfo, AS; Rockhold, FW	1
English, JR; Liyanage, SP; Macauley, DI	1
Pathy, MS	1
Nash, DP	1
Bilodeau, JF; Castonguay, A; Chung, FL; Wang, M	1
Backman, EA; Beckman, EA; Kulling, PE; Skagius, AS	1
Carson, JL; Manoukian, AV	1
Akatsu, T; Consolaro, A; Guimarães, SA; Tago, EM	1
Castonguay, A; Rioux, N	1
Fukuyama, T; Hayashi, I; Iwatsubo, T; Kan, T; Morohashi, Y; Natsugari, H; Rikimaru, K; Takahashi, Y; Tominari, Y; Tomita, T	1
Hughes, A; Smith, NI; Wallace, HM	1
Abdel-Aziz, AA; El-Kamel, AH; El-Subbagh, HI; Fatani, AJ	1
DeCastro, A; Janakiram, NB; Lee, HJ; Paul, S; Rao, CV; Reddy, BS; Simi, B; Smolarek, AK; So, JY; Steele, V; Suh, N; Wang, CX	1
Cheng, KW; Constantinides, PP; Rigas, B; Wong, CC; Xie, G; Zhou, D; Zhu, CH	1
Unlü, B; van Leeuwen, JS; Vermeulen, NP; Vos, JC	1
Boring, D; Chattopadhyay, M; Dastagirzada, YM; Kashfi, K; Kodela, R; Nath, N; Velázquez-Martínez, CA	1
Chai, MZ; Flanagan, JU; Squire, CJ; Teague, RM; Turnbull, AP; Yosaatmadja, Y	1
Fischer, SM; Lubet, RA; Mikulec, CD; Rundhaug, JE; Simper, MS	1
Bode, AM; Boring, D; Grubbs, CJ; Kim, MS; Lu, Y; Lubet, RA; Margaret Juliana, M; Milne, GL; Nicastro, HL; Steele, VE; You, M	1

Reviews

7 review(s) available for naproxen and sulindac

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Drug therapy of ankylosing spondyloarthritis (Bechterew's disease)]. Terapevticheskii arkhiv, 1978, Volume: 50, Issue:12 Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Apazone; Butadienes; Cyclophosphamide; Diclofenac; Drug Combinations; Drug Evaluation; Glycolates; Gold; Humans; Ibuprofen; Indomethacin; Ketoprofen; Levamisole; Naproxen; Oxyphenbutazone; Phenylbutazone; Salicylates; Spondylitis, Ankylosing; Sulindac	1978
Review of ibuprofen for osteoarthritis. The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A Topics: Acetaminophen; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Diflunisal; Drug Tolerance; Fenoprofen; Humans; Ibuprofen; Indomethacin; Meclofenamic Acid; Naproxen; Osteoarthritis; Phenylbutazone; Sulindac; Tolmetin	1984
Update on ibuprofen for rheumatoid arthritis. The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Tolerance; Fenoprofen; Humans; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Piroxicam; Sulindac; Thiazines; Tolmetin	1984
Practical therapeutics: the newer nonsteroidal anti-inflammatory drugs. East African medical journal, 1982, Volume: 59, Issue:6 Topics: Anti-Inflammatory Agents; Arthritis; Aspirin; Diclofenac; Humans; Ibuprofen; Indomethacin; Naproxen; Phenylbutazone; Phenylbutyrates; Piroxicam; Propionates; Sulindac; Thiazines	1982
Nonsteroidal antiinflammatory drugs (second of two parts). The New England journal of medicine, 1980, May-29, Volume: 302, Issue:22 Topics: Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Fenoprofen; Humans; Ibuprofen; Mefenamic Acid; Naproxen; Propionates; Sulindac; Tolmetin	1980
Nonsteroidal anti-inflammatory drug-induced hepatic disorders. Incidence and prevention. Drug safety, 1996, Volume: 15, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Chemical and Drug Induced Liver Injury; Cohort Studies; Diclofenac; Humans; Incidence; Indomethacin; Liver; Liver Diseases; Naproxen; Oxaprozin; Phenylbutazone; Propionates; Risk Factors; Sulindac	1996

Trials

23 trial(s) available for naproxen and sulindac

Article	Year
A review of upper-gastrointestinal effects of the newer nonsteroidal antiinflammatory agents. Digestive diseases and sciences, 1979, Volume: 24, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Evaluation; Fenoprofen; Gastric Mucosa; Gastritis; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Ibuprofen; Ketoprofen; Naproxen; Phenylbutazone; Registries; Sulindac; Tolmetin	1979
Effects of sulindac and naproxen on prostaglandin excretion in patients with impaired renal function and rheumatoid arthritis. The American journal of medicine, 1990, Volume: 89, Issue:3 Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Arthritis, Rheumatoid; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; Kidney Diseases; Male; Middle Aged; Naproxen; Placebos; Potassium; Renal Circulation; Renin; Sodium; Sulindac	1990
Effect of naproxen and sulindac on blood pressure response to atenolol. DICP : the annals of pharmacotherapy, 1990, Volume: 24, Issue:9 Topics: Adult; Aged; Atenolol; Blood Pressure; Body Weight; Double-Blind Method; Drug Interactions; Female; Humans; Hypertension; Male; Middle Aged; Naproxen; Sulindac	1990
Lack of interaction between sulindac or naproxen and propranolol in hypertensive patients. Journal of clinical pharmacology, 1989, Volume: 29, Issue:6 Topics: Blood Pressure; Blood Urea Nitrogen; Body Weight; Clinical Trials as Topic; Creatinine; Drug Interactions; Humans; Hypertension; Indenes; Middle Aged; Naproxen; Potassium; Propranolol; Pulse; Random Allocation; Renin; Sodium; Sulindac	1989
Effect of non-steroidal anti-inflammatory drugs on control of hypertension by beta-blockers and diuretics. Lancet (London, England), 1986, May-03, Volume: 1, Issue:8488 Topics: 6-Ketoprostaglandin F1 alpha; Adrenergic beta-Antagonists; Adult; Amiloride; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Indenes; Male; Middle Aged; Naproxen; Piroxicam; Random Allocation; Sulindac; Thiazines; Thromboxane A2; Timolol	1986
Renal function and tubular transport effects of sulindac and naproxen in chronic heart failure. Clinical pharmacology and therapeutics, 1987, Volume: 42, Issue:6 Topics: Aged; Biological Transport; Body Water; Chronic Disease; Electrolytes; Female; Furosemide; Glomerular Filtration Rate; Heart Failure; Humans; Indenes; Kidney; Kidney Tubules; Naproxen; Prostaglandins; Renal Circulation; Renin; Sulindac	1987
Non-steroidal anti-inflammatory drugs and platelet function. The New Zealand medical journal, 1986, May-28, Volume: 99, Issue:802 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Diflunisal; Female; Humans; Male; Malondialdehyde; Middle Aged; Naproxen; Piroxicam; Sulindac; Time Factors	1986
International experiences with diclofenac in osteoarthritis. The American journal of medicine, 1986, Apr-28, Volume: 80, Issue:4B Topics: Aspirin; Clinical Trials as Topic; Diclofenac; Diflunisal; Double-Blind Method; Gastrointestinal Diseases; Humans; Ibuprofen; Indomethacin; Naproxen; Osteoarthritis; Random Allocation; Sulindac	1986
Effects of sulindac and naproxen in patients with chronic glomerular disease. Scandinavian journal of rheumatology. Supplement, 1986, Volume: 62 Topics: Adult; Chronic Disease; Clinical Trials as Topic; Creatinine; Dinoprost; Dinoprostone; Female; Glomerulonephritis; Humans; Indenes; Kidney; Male; Middle Aged; Naproxen; Prostaglandins E; Prostaglandins F; Random Allocation; Sulindac	1986
A double blind comparison of naproxen and sulindac in female patients with heart failure. Scandinavian journal of rheumatology. Supplement, 1986, Volume: 62 Topics: 6-Ketoprostaglandin F1 alpha; Aged; Chlorides; Clinical Trials as Topic; Diuresis; Double-Blind Method; Female; Glomerular Filtration Rate; Heart Failure; Humans; Indenes; Kidney; Naproxen; Sodium; Sulindac	1986
Lithium interaction with sulindac and naproxen. Journal of clinical psychopharmacology, 1986, Volume: 6, Issue:3 Topics: Aged; Drug Interactions; Humans; Indenes; Lithium; Male; Metabolic Clearance Rate; Middle Aged; Naproxen; Sulindac	1986
The effects of naproxen and sulindac on renal function and their interaction with hydrochlorothiazide and piretanide in man. British journal of clinical pharmacology, 1987, Volume: 23, Issue:1 Topics: Adult; Diuresis; Drug Interactions; Humans; Hydrochlorothiazide; Indenes; Kidney; Male; Naproxen; Natriuresis; Sulfonamides; Sulindac	1987
[Urinary excretion of prostaglandins and changes in plasma renin levels in patients with rheumatoid arthritis associated with cardiac decompensation treated with thiazides]. Ugeskrift for laeger, 1985, Feb-11, Volume: 147, Issue:7 Topics: Adult; Aged; Arthritis, Rheumatoid; Benzothiadiazines; Diuretics; Female; Humans; Indenes; Male; Middle Aged; Naproxen; Prostaglandins; Renin; Rheumatic Heart Disease; Sodium Chloride Symporter Inhibitors; Sulindac	1985
Effects of ibuprofen, naproxen, and sulindac on prostaglandins in men. Kidney international, 1985, Volume: 27, Issue:1 Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Furosemide; Humans; Ibuprofen; Indenes; Kidney; Male; Naproxen; Prostaglandins; Random Allocation; Renin; Sulindac; Thromboxanes	1985
Effects of indomethacin, sulindac, naproxen, aspirin, and paracetamol in treated hypertensive patients. Clinical and experimental hypertension. Part A, Theory and practice, 1984, Volume: 6, Issue:6 Topics: Acetaminophen; Aldosterone; Aspirin; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Heart Rate; Humans; Hypertension; Indenes; Indomethacin; Naproxen; Placebos; Random Allocation; Renin; Sodium; Sulindac; Time Factors	1984
A multi-centre study of sulindac versus naproxen in the treatment of elderly osteoarthritic patients. Pharmatherapeutica, 1984, Volume: 3, Issue:10 Topics: Aged; Clinical Trials as Topic; Female; Humans; Indenes; Male; Naproxen; Osteoarthritis; Sulindac; Time Factors	1984
Review of ibuprofen for osteoarthritis. The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A Topics: Acetaminophen; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Diflunisal; Drug Tolerance; Fenoprofen; Humans; Ibuprofen; Indomethacin; Meclofenamic Acid; Naproxen; Osteoarthritis; Phenylbutazone; Sulindac; Tolmetin	1984
Update on ibuprofen for rheumatoid arthritis. The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Tolerance; Fenoprofen; Humans; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Piroxicam; Sulindac; Thiazines; Tolmetin	1984
The renal excretion of prostaglandins and changes in plasma renin during treatment with either sulindac or naproxen in patients with rheumatoid arthritis and thiazide treated heart failure. The Journal of rheumatology, 1984, Volume: 11, Issue:6 Topics: Adult; Aged; Arthritis, Rheumatoid; Benzothiadiazines; Diuretics; Female; Heart Failure; Humans; Indenes; Kidney; Male; Middle Aged; Naproxen; Prostaglandins; Renin; Sodium Chloride Symporter Inhibitors; Sulindac	1984
Influence of non-steroidal anti-inflammatory drugs on diuretic treatment of mild to moderate essential hypertension. British medical journal (Clinical research ed.), 1984, Dec-01, Volume: 289, Issue:6457 Topics: Adult; Aged; Anti-Inflammatory Agents; Blood Pressure; Drug Interactions; Female; Humans; Hydrochlorothiazide; Hypertension; Indomethacin; Male; Middle Aged; Naproxen; Prospective Studies; Sulindac	1984
Gastric bleeding and gastric secretion with sulindac and naproxen. Digestive diseases and sciences, 1983, Volume: 28, Issue:2 Topics: Aspirin; Gastric Acid; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Indenes; Intestinal Absorption; Male; Naproxen; Placebos; Sulindac	1983
Gastrointestinal microbleeding: comparisons between benoxaprofen and other nonsteroidal antiinflammatory agents. The Journal of rheumatology. Supplement, 1980, Volume: 6 Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Benzoxazoles; Clinical Trials as Topic; Double-Blind Method; Gastrointestinal Hemorrhage; Humans; Indomethacin; Melena; Naproxen; Propionates; Prostaglandins; Sulindac; Time Factors	1980
Naproxen and sulindac in the treatment of osteoarthritis of the hip and knee. Rheumatology and rehabilitation, 1981, Volume: 20, Issue:3 Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Female; Hip Joint; Humans; Indenes; Knee Joint; Male; Middle Aged; Naproxen; Osteoarthritis; Random Allocation; Sulindac	1981

Other Studies

53 other study(ies) available for naproxen and sulindac

Article	Year
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22 Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption	2007
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Comet Assay; DNA Damage; Glucuronides; Glucuronosyltransferase; HEK293 Cells; Hepatocytes; Humans; Kidney	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Prediction of in vivo hepatic clearance and half-life of drug candidates in human using chimeric mice with humanized liver. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2 Topics: Animals; Cells, Cultured; Child, Preschool; Chimera; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Drugs, Investigational; Female; Half-Life; Hepatocytes; Humans; Immunomagnetic Separation; Liver; Male; Metabolic Clearance Rate; Mice; Mice, SCID; Recombinant Proteins; Species Specificity; Urokinase-Type Plasminogen Activator	2012
Self-organizing molecular field analysis of NSAIDs: assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach. European journal of medicinal chemistry, 2012, Volume: 53 Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Computational Biology; Least-Squares Analysis; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Effect of new hybrids based on 5,16-pregnadiene scaffold linked to an anti-inflammatory drug on the growth of a human astrocytoma cell line (U373). European journal of medicinal chemistry, 2015, Mar-26, Volume: 93 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Humans; Molecular Structure; Pregnadienes; Sulindac; Time Factors	2015
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Management of Rheumatoid Arthritis. Journal of medicinal chemistry, 2018, 06-14, Volume: 61, Issue:11 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Carbonic Anhydrase Inhibitors; Humans; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfonamides	2018
Old and new pharmaceutical non-steroidal compounds prescribed for the management of patients with rheumatic diseases. Rheumatology and rehabilitation, 1979, Volume: Suppl Topics: Anti-Inflammatory Agents; Fenoprofen; Humans; Ibuprofen; Ketoprofen; Naproxen; Rheumatic Diseases; Sulindac; Tolmetin	1979
The economic consequences of NSAID-induced gastropathy: the French context. Scandinavian journal of rheumatology. Supplement, 1992, Volume: 96 Topics: Ambulatory Care; Anti-Inflammatory Agents, Non-Steroidal; Cost of Illness; Diclofenac; Duodenal Ulcer; Economics, Hospital; Etodolac; France; Gastrointestinal Diseases; Humans; Ketoprofen; Naproxen; National Health Programs; Piroxicam; Rheumatic Diseases; Sulindac	1992
Effects of NSAIDs on NNK-induced pulmonary and gastric tumorigenesis in A/J mice. Cancer letters, 1992, Sep-14, Volume: 66, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Carcinogens; Drug Interactions; Female; Ibuprofen; Lung Neoplasms; Mice; Mice, Inbred A; Naproxen; Nitrosamines; Piroxicam; Stomach Neoplasms; Sulindac; Time Factors	1992
Relationship between aldose reductase inhibiting activity and anti-cataract action of various non-steroidal anti-inflammatory drugs. Developments in ophthalmology, 1991, Volume: 21 Topics: Aldehyde Reductase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cataract; Flurbiprofen; Galactose; Lens, Crystalline; Naproxen; Ophthalmic Solutions; Piroxicam; Rats; Sulindac	1991
Sulfate homeostasis. III. Effect of chronic naproxen or sulindac treatment on inorganic sulfate disposition in arthritic patients with renal impairment. Pharmaceutical research, 1991, Volume: 8, Issue:2 Topics: Aged; Arthritis; Creatinine; Female; Humans; Kidney Diseases; Male; Metabolic Clearance Rate; Middle Aged; Naproxen; Sulfates; Sulindac	1991
Liquid chromatography with amperometric detection for the determination of non-steroidal anti-inflammatory drugs in plasma. Journal of chromatography, 1990, Nov-30, Volume: 533 Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Diflunisal; Electric Conductivity; Humans; Indomethacin; Naproxen; Piroxicam; Sulindac	1990
Influence of renal sympathectomy, sodium depletion and prostaglandin synthetase inhibition on prostaglandin production and [3H]PGE2 binding characteristics in rat kidney. Acta physiologica Scandinavica, 1990, Volume: 138, Issue:4 Topics: Animals; Cyclooxygenase Inhibitors; Denervation; Dinoprostone; Kidney; Male; Naproxen; Prostaglandins; Rats; Rats, Inbred Strains; Sodium; Sulindac; Sympathectomy; Tritium	1990
Induction of cleft palate in mice by inhibitors of prostaglandin synthesis. Journal of craniofacial genetics and developmental biology, 1990, Volume: 10, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cleft Palate; Diclofenac; Female; Indomethacin; Injections, Intramuscular; Maternal-Fetal Exchange; Mice; Microscopy; Naproxen; Organ Culture Techniques; Palate; Pregnancy; Sulindac	1990
Effect of Cu2+ and Zn2+ on the inhibition of human leucocyte elastase by 6-alkyl-3-(omega-carboxyalkyl)-2-pyrone, oleic acid and sulindac sulfide. Biological chemistry Hoppe-Seyler, 1989, Volume: 370, Issue:1 Topics: Copper; Diflunisal; Humans; Indenes; Indomethacin; Leukocytes; Naproxen; Oleic Acid; Oleic Acids; Pancreatic Elastase; Pyrans; Pyrones; Structure-Activity Relationship; Sulindac; Zinc	1989
Reversible acute decrease in renal function by NSAIDs in cirrhosis. The American journal of the medical sciences, 1987, Volume: 294, Issue:3 Topics: Acute Disease; Creatinine; Female; Humans; Ibuprofen; Indenes; Kidney; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Naproxen; Prostaglandins; Sulindac; Urodynamics	1987
Aspects of the effects of NSAID's on renal function in congestive heart failure. Agents and actions. Supplements, 1985, Volume: 17 Topics: Anti-Inflammatory Agents; Arthritis; Diuresis; Drug Interactions; Furosemide; Heart Failure; Humans; Kidney; Naproxen; Prostaglandins; Sulindac	1985
Worldwide experience with diclofenac in rheumatoid arthritis and osteoarthritis. Seminars in arthritis and rheumatism, 1985, Volume: 15, Issue:2 Suppl 1 Topics: Arthritis, Rheumatoid; Aspirin; Diclofenac; Double-Blind Method; Humans; Indomethacin; Naproxen; Osteoarthritis; Sulindac; Tolmetin	1985
Comparison of the effects of sulindac with other cyclooxygenase inhibitors on prostaglandin excretion and renal function in normal and chronic bile duct-ligated dogs and swine. The Journal of pharmacology and experimental therapeutics, 1984, Volume: 228, Issue:3 Topics: Animals; Bile Ducts; Cyclooxygenase Inhibitors; Dogs; Female; Glomerular Filtration Rate; Ibuprofen; Indenes; Kidney; Ligation; Liver Diseases; Naproxen; Prostaglandins; Sulindac; Swine; Swine, Miniature	1984
A clinical evaluation of the antiarthritic agents. Comprehensive therapy, 1984, Volume: 10, Issue:8 Topics: Anti-Inflammatory Agents; Antimalarials; Arthritis; Aspirin; Diflunisal; Fenoprofen; Glucocorticoids; Gold; Humans; Ibuprofen; Immunosuppressive Agents; Indomethacin; Naproxen; ortho-Aminobenzoates; Penicillamine; Piroxicam; Prostaglandin Antagonists; Salicylates; Sulindac; Thiazines; Tolmetin	1984
Factors determining efficacy of NSAIDs. Drug intelligence & clinical pharmacy, 1984, Volume: 18, Issue:1 Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Indomethacin; Kinetics; Naproxen; Piroxicam; Prostaglandin Antagonists; Salicylates; Sulindac; Thiazines	1984
Renal papillary necrosis due to naproxen. The Journal of rheumatology, 1984, Volume: 11, Issue:1 Topics: Adult; Arthritis, Rheumatoid; Humans; Kidney Papillary Necrosis; Male; Naproxen; Sulindac	1984
Osteoarthritis and non-steroidal and anti-inflammatory drugs: a multi-centre comparative study. Current medical research and opinion, 1982, Volume: 7, Issue:Suppl 1 Topics: Aged; Diclofenac; Female; Hip Joint; Humans; Ibuprofen; Indenes; Knee Joint; Male; Naproxen; Osteoarthritis; Sulindac	1982
Current review and comparison of the new nonsteroidal anti-inflammatory agents. The Journal of foot surgery, 1980,Winter, Volume: 19, Issue:4 Topics: Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Drug Administration Schedule; Fenoprofen; Humans; Ibuprofen; Naproxen; Prostaglandins; Sulindac; Tolmetin	1980
Effects of nonsteroidal antiinflammatory drugs on oxidative pathways in A/J mice. Free radical biology & medicine, 1995, Volume: 18, Issue:1 Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Deoxyguanosine; Dinoprostone; DNA; DNA Damage; Female; Ibuprofen; Lipid Peroxidation; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Naproxen; Nitrosamines; Oxidation-Reduction; Oxidative Stress; Piroxicam; Sulindac	1995
Renal impairment after acute diclofenac, naproxen, and sulindac overdoses. Journal of toxicology. Clinical toxicology, 1995, Volume: 33, Issue:2 Topics: Acute Kidney Injury; Adolescent; Adult; Alcoholic Intoxication; Creatinine; Diclofenac; Drug Interactions; Female; Humans; Male; Middle Aged; Naproxen; Sulindac	1995
Assessment of the antiexudative and antiproliferative activities of non-steroidal anti-inflammatory drugs in inflammatory models developed in rats by subcutaneous implantation of bacterial cell walls from the dental plaque. Inflammation, 1996, Volume: 20, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Cell Division; Cell Wall; Child; Dental Plaque; DNA Replication; Duodenum; Edema; Exudates and Transudates; Granuloma; Growth Inhibitors; Humans; Ibuprofen; Indomethacin; Inflammation; Intestinal Mucosa; Naproxen; Rats; Sulindac	1996
Recovery from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced immunosuppression in A/J mice by treatment with nonsteroidal anti-inflammatory drugs. Journal of the National Cancer Institute, 1997, Jun-18, Volume: 89, Issue:12 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Antibody-Producing Cells; Aspirin; Carcinogens; Dinoprostone; Female; Immunity, Cellular; Killer Cells, Natural; Mice; Mice, Inbred A; Naproxen; Nitrosamines; Spleen; Sulindac	1997
Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation. The Journal of biological chemistry, 2003, May-16, Volume: 278, Issue:20 Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Anti-Inflammatory Agents, Non-Steroidal; Aspartic Acid Endopeptidases; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Endopeptidases; Enzyme-Linked Immunosorbent Assay; HeLa Cells; Humans; Membrane Proteins; Naproxen; Peptide Fragments; Peptides; Protein Binding; Protein Structure, Tertiary; Receptors, Notch; Sulindac	2003
Polyamines reverse non-steroidal anti-inflammatory drug-induced toxicity in human colorectal cancer cells. The Biochemical journal, 2003, Sep-01, Volume: 374, Issue:Pt 2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Division; Cell Membrane; Cell Survival; Colorectal Neoplasms; DNA Fragmentation; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; Indoles; Intercalating Agents; Naproxen; Polyamines; Putrescine; Salicylates; Spermidine; Spermine; Sulindac; Tumor Cells, Cultured	2003
Oral colon targeted delivery systems for treatment of inflammatory bowel diseases: synthesis, in vitro and in vivo assessment. International journal of pharmaceutics, 2008, Jun-24, Volume: 358, Issue:1-2 Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartic Acid; Buffers; Chromatography, High Pressure Liquid; Colon; Cyclodextrins; Drug Carriers; Drug Delivery Systems; Flurbiprofen; Gastrointestinal Transit; Hydrogen-Ion Concentration; Hydrolysis; In Vitro Techniques; Inflammatory Bowel Diseases; Male; Naproxen; Prodrugs; Rats; Sulindac	2008
Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinomas by suppressing the p65/β-catenin/cyclin D1 signaling pathway in rats. Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:11 Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Antineoplastic Combined Chemotherapy Protocols; Atorvastatin; Azoxymethane; beta Catenin; Carcinogens; Colonic Neoplasms; Cyclin D1; eIF-2 Kinase; Enzyme-Linked Immunosorbent Assay; Heptanoic Acids; Immunoenzyme Techniques; Interleukin-4; Male; Naproxen; Nitric Oxide Synthase Type II; Pyrroles; Rats; Rats, Inbred F344; Signal Transduction; Sulindac; Tumor Necrosis Factor-alpha	2011
Carboxylesterases 1 and 2 hydrolyze phospho-nonsteroidal anti-inflammatory drugs: relevance to their pharmacological activity. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carboxylesterase; Carboxylic Ester Hydrolases; Cell Line, Tumor; Cell Survival; Drug Interactions; Drug Therapy, Combination; Enzyme Inhibitors; Female; HEK293 Cells; Humans; Hydrolysis; Ibuprofen; Indomethacin; Inhibitory Concentration 50; Kinetics; Mice; Mice, Inbred BALB C; Mice, Nude; Naproxen; Nitrophenols; Organophosphates; Organophosphorus Compounds; Phenylglyoxal; Stomach Neoplasms; Sulindac; Transfection; Valproic Acid; Xenograft Model Antitumor Assays	2012
Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs. Toxicology in vitro : an international journal published in association with BIBRA, 2012, Volume: 26, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; ATP-Binding Cassette Transporters; Biological Transport, Active; Cytochrome P-450 Enzyme System; Diclofenac; Electron Transport; Genes, MDR; Ibuprofen; Indomethacin; Ketoprofen; Ketorolac; Mitochondria; Naproxen; Reactive Oxygen Species; Sulindac; Tolmetin; Yeasts	2012
Hydrogen sulfide-releasing NSAIDs inhibit the growth of human cancer cells: a general property and evidence of a tissue type-independent effect. Biochemical pharmacology, 2012, Mar-15, Volume: 83, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Aspirin; Cell Line, Tumor; Cell Proliferation; Growth Inhibitors; Humans; Hydrogen Sulfide; Ibuprofen; Naproxen; Sulindac; Thiones	2012
Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3. PloS one, 2012, Volume: 7, Issue:8 Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Anti-Inflammatory Agents, Non-Steroidal; Flufenamic Acid; Flurbiprofen; Hydroxyprostaglandin Dehydrogenases; Ibuprofen; Indomethacin; Meclofenamic Acid; Mefenamic Acid; Naproxen; Sulindac; Tolmetin	2012
The chemopreventive efficacies of nonsteroidal anti-inflammatory drugs: the relationship of short-term biomarkers to long-term skin tumor outcome. Cancer prevention research (Philadelphia, Pa.), 2013, Volume: 6, Issue:7 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Biomarkers, Tumor; Blotting, Western; Cell Proliferation; Cells, Cultured; Dinoprostone; Female; Humans; Keratinocytes; Mice; Mice, Hairless; Naproxen; Skin Neoplasms; Sulindac; Ultraviolet Rays	2013
Preventive effects of NSAIDs, NO-NSAIDs, and NSAIDs plus difluoromethylornithine in a chemically induced urinary bladder cancer model. Cancer prevention research (Philadelphia, Pa.), 2014, Volume: 7, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Chemoprevention; Drug Evaluation, Preclinical; Eflornithine; Female; Naproxen; Neoplasms, Experimental; Nitric Oxide; Rats; Rats, Inbred F344; Sulindac; Urinary Bladder Neoplasms	2014