naproxen has been researched along with ranitidine in 39 studies
| Studies (naproxen) | Trials (naproxen) | Recent Studies (post-2010) (naproxen) | Studies (ranitidine) | Trials (ranitidine) | Recent Studies (post-2010) (ranitidine) |
|---|---|---|---|---|---|
| 4,551 | 1,057 | 1,429 | 85 | 0 | 29 |
| 4,551 | 1,057 | 1,429 | 5,298 | 1,788 | 445 |
| Protein | Taxonomy | naproxen (IC50) | ranitidine (IC50) |
|---|---|---|---|
| Potassium-transporting ATPase alpha chain 1 | Homo sapiens (human) | 0.04 | |
| Acetylcholinesterase | Homo sapiens (human) | 1.475 | |
| Potassium-transporting ATPase subunit beta | Homo sapiens (human) | 0.04 | |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | 8.3 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (23.08) | 18.2507 |
| 2000's | 10 (25.64) | 29.6817 |
| 2010's | 20 (51.28) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Faller, B; Wohnsland, F | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Caron, G; Ermondi, G; Lorenti, M | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Avdeef, A; Tam, KY | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Akamatsu, M | 1 |
| Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Gudjónsson, H; Oddsson, E; Thjódleifsson, B | 1 |
| Doornbos, JF; Friedland, J; Launspach, J; Mitros, F; Soffer, EE; Summers, RW | 1 |
| Guelen, PJ; van den Biggelaar-Martea, M; Verwey-van Wissen, CP; Vree, ML; Vree, TB | 1 |
| Bianchi Porro, G; Lazzaroni, M; Petrillo, M | 1 |
| Agut, J; Conejo, L; Márquez, M; Ortiz, JA; Palop, D; Sacristán, A | 1 |
| Lanas Arbeloa, A; Serrano Aulló, MT | 1 |
| Gillott, T; Lipscomb, GR; Painter, J; Rees, W; Riley, S | 1 |
| Brunsden, AM; Grundy, D | 1 |
| Mateo, I; Pascual, J | 1 |
| Akay, C; Degim, T; Degim, Z; Zaimoglu, V | 1 |
| Fatema, K; Haque, T; Laila, S; Talukder, MM | 1 |
| Escribano, E; Navarro, CR; Regué, JQ; Sala, XG; Salamanca, J | 1 |
| Shi, NQ; Wang, XL; Yao, J | 1 |
3 review(s) available for naproxen and ranitidine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Gastric lesion caused by NSAID and inflammation due to Helicobacter pylori. Is there potentiation or attenuation?].
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Clinical Trials as Topic; Confidence Intervals; Duodenal Ulcer; Enzyme Inhibitors; Gastritis; Helicobacter Infections; Helicobacter pylori; Histamine H2 Antagonists; Humans; Multicenter Studies as Topic; Naproxen; Omeprazole; Peptic Ulcer; Prospective Studies; Ranitidine; Risk Factors; Stomach Ulcer | 1998 |
[The development of co-amorphous drug systems].
Topics: Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Cimetidine; Drug Combinations; Drug Compounding; Drug Stability; Glipizide; Indomethacin; Naproxen; Ranitidine; Simvastatin; Solubility; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Technology, Pharmaceutical; Temperature; X-Ray Diffraction | 2013 |
5 trial(s) available for naproxen and ranitidine
| Article | Year |
|---|---|
Comparison between ranitidine and omeprazole for protection against gastroduodenal damage caused by naproxen.
Topics: Acute Disease; Adult; Double-Blind Method; Duodenum; Endoscopy, Gastrointestinal; Female; Gastric Mucosa; Humans; Intestinal Mucosa; Male; Naproxen; Omeprazole; Ranitidine | 1992 |
Morphology and pathology of radiation-induced esophagitis. Double-blind study of naproxen vs placebo for prevention of radiation injury.
Topics: Double-Blind Method; Esophagitis; Female; Humans; Lung Neoplasms; Male; Middle Aged; Naproxen; Prospective Studies; Radiation Injuries; Ranitidine | 1994 |
The effects of cimetidine, ranitidine and famotidine on the single-dose pharmacokinetics of naproxen and its metabolites in humans.
Topics: Adult; Cimetidine; Drug Interactions; Famotidine; Female; Glucuronates; Humans; Male; Middle Aged; Naproxen; Ranitidine | 1993 |
Double-blind, double-dummy endoscopic comparison of the mucosal protective effects of misoprostol versus ranitidine on naproxen-induced mucosal injury to the stomach and duodenum in rheumatic patients.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Double-Blind Method; Duodenal Ulcer; Duodenum; Endoscopy, Gastrointestinal; Female; Gastric Mucosa; Humans; Intestinal Mucosa; Male; Middle Aged; Misoprostol; Naproxen; Osteoarthritis; Placebos; Ranitidine; Stomach Ulcer | 1997 |
Role of acid and salivary epidermal growth factor in gastric mucosal adaptation to naproxen in man.
Topics: Adaptation, Physiological; Adult; Anti-Inflammatory Agents, Non-Steroidal; Epidermal Growth Factor; Female; Gastric Acid; Gastric Mucosa; Gastroscopy; Histamine H2 Antagonists; Humans; Male; Naproxen; Ranitidine; Reference Values; Saliva | 1998 |
31 other study(ies) available for naproxen and ranitidine
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Contribution of ionization and lipophilicity to drug binding to albumin: a preliminary step toward biodistribution prediction.
Topics: Chromatography, Affinity; Hydrogen-Ion Concentration; Ions; Models, Molecular; Molecular Conformation; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Serum Albumin, Bovine; Ultracentrifugation | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Histamine H2-receptor antagonist action of ebrotidine. Effects on gastric acid secretion, gastrin levels and NSAID-induced gastrotoxicity in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzenesulfonates; Diclofenac; Dose-Response Relationship, Drug; Female; Gastric Acid; Gastrins; Guinea Pigs; Heart Atria; Heart Rate; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Indomethacin; Ketoprofen; Male; Naproxen; Pentagastrin; Ranitidine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thiazoles | 1997 |
Sensitization of visceral afferents to bradykinin in rat jejunum in vitro.
Topics: Adenosine; Animals; Bradykinin; Bucladesine; Cyclooxygenase Inhibitors; Dinoprostone; Histamine; Histamine Antagonists; Histamine H2 Antagonists; In Vitro Techniques; Jejunum; Male; Membrane Potentials; Naproxen; Neurons, Afferent; Piperidines; Ranitidine; Rats; Rats, Inbred Strains; Serotonin; Stimulation, Chemical; Triazines; Triazoles; Xanthines | 1999 |
Coexistence of chronic paroxysmal hemicrania and benign cough headache.
Topics: Adult; Cough; Drug Therapy, Combination; Female; Headache; Humans; Indomethacin; Migraine Disorders; Naproxen; Ranitidine | 1999 |
pH-Metric log K calculations of famotidine, naproxen, nizatidine, ranitidine and salicylic acid.
Topics: Anti-Inflammatory Agents; Anti-Ulcer Agents; Aspirin; Chromatography, High Pressure Liquid; Computers; Famotidine; Hydrogen-Ion Concentration; Naproxen; Nizatidine; Ranitidine; Structure-Activity Relationship | 2001 |
Development and validation of a RP-HPLC method for simultaneous estimation of naproxen and ranitidinehydrochloride.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Buffers; Calibration; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Combinations; Histamine H2 Antagonists; Humans; Naproxen; Ranitidine; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet; Tablets | 2010 |
Single-pass intestinal perfusion to establish the intestinal permeability of model drugs in mouse.
Topics: Amoxicillin; Animals; Furosemide; Humans; Intestinal Absorption; Intestinal Mucosa; Male; Mice; Models, Animal; Naproxen; Perfusion; Permeability; Pharmaceutical Preparations; Piroxicam; Ranitidine; Rats | 2012 |