De Quervain Disease

Stenosing tenosynovitis of the abductor pollicis longus and extensor pollicis brevis tendons in the first dorsal wrist compartment. The presenting symptoms are usually pain and tenderness at the radial styloid. The cause is almost always related to OVERUSE INJURY or is associated with RHEUMATOID ARTHRITIS.

Synonym
Stenosing Tenosynovitis, De Quervain
De Quervain Disease
De Quervain Stenosing Tenosynovitis
De Quervain's Disease

Excerpt	Reference
"de Quervain's disease is an inadequacy into the first extensor compartment of wrist between the osteofibrous tunnel and the tendons."	( Kumar, K, 2016)
"De Quervain's disease is tenosynovitis of the first dorsal compartment causing severely painful radial-side wrist pain and impaired function."	( Chuaychoosakoon, C; Fongsri, W; Suwannaphisit, S; Suwanno, P, 2022)

Excerpt	Reference
"De Quervain's disease has been described as an entrapment of the extensor pollicis brevis and abductor pollicis tendons in the first dorsal compartment of the wrist is a common cause of wrist and hand pain."	( Gohritz, A; Knobloch, K; Spies, M; Vogt, PM, 2008)

Excerpt	Reference
"The pathology of de Quervain's disease affects the tenosynovium and rarely the tendons."	( Morisaki, S; Oda, R; Takahashi, K; Tsuchida, S, 2023)
"The pathology of de Quervain's disease affects the tenosynovium and rarely the tendons."	( Morisaki, S; Oda, R; Takahashi, K; Tsuchida, S, 2023)

Excerpt	Reference
"Forty-eight patients with de Quervain's disease who did not respond to conservative treatment were operated with two different incisions."	( Kumar, K, 2016)
"The ultrasonographic features of de Quervain's disease requiring surgical treatment were a significantly thickened tendon sheath, an intercompartmental septum, and increased cross-sectional area of the APL and EPB."	( Morisaki, S; Oda, R; Takahashi, K; Tsuchida, S, 2023)
"The ultrasonographic features of de Quervain's disease requiring surgical treatment were a significantly thickened tendon sheath, an intercompartmental septum, and increased cross-sectional area of the APL and EPB."	( Morisaki, S; Oda, R; Takahashi, K; Tsuchida, S, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (1.45)	23.3326
1990's	0 (0.00)	12.5806
2000's	8 (11.59)	18.1394
2010's	52 (75.36)	28.8240
2020's	8 (11.59)	9.53

Drug	Relationship Strength	Studies	Trials
acetaminophen	low	1	0
bupivacaine	medium	2	1
celecoxib	low	1	0
ibuprofen	low	1	0
lidocaine	medium	6	3
ketorolac	medium	1	1
methylprednisolone acetate	medium	6	6
triamcinolone acetonide	medium	9	3
methylprednisolone	medium	17	5
trolamine salicylate	low	7	0
triamcinolone	medium	9	1
delphinidin	medium	1	1
naproxen	low	1	0
sodium bicarbonate	medium	1	1
polidocanol	low	1	0
hydrocodone	low	1	0

Protein Targets (323)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
RAR-related orphan receptor gamma	6	0	0	6
ATAD5 protein, partial	3	0	0	3
GLS protein	3	0	0	3
Microtubule-associated protein tau	2	0	0	2
Smad3	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
thyroid stimulating hormone receptor	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
progesterone receptor	6	0	0	6
EWS/FLI fusion protein	3	0	0	3
retinoic acid nuclear receptor alpha variant 1	4	0	0	4
retinoid X nuclear receptor alpha	7	0	0	7
estrogen-related nuclear receptor alpha	7	0	0	7
estrogen nuclear receptor alpha	9	0	0	9
peroxisome proliferator activated receptor gamma	4	0	0	4
aryl hydrocarbon receptor	3	0	0	3
chromobox protein homolog 1	6	0	0	6
thyroid hormone receptor beta isoform 2	4	0	0	4
peripheral myelin protein 22	4	0	0	4
cytochrome P450 3A4 isoform 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	4	0	0	4
ATP-binding cassette sub-family C member 3	0	6	0	6
Multidrug resistance-associated protein 4	0	6	0	6
Solute carrier family 22 member 6	0	3	0	3
Carbonic anhydrase 12	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Bile salt export pump	0	7	0	7
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	4	0	4
Carbonic anhydrase 2	0	4	0	4
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	0	0	1
Prostaglandin G/H synthase 1	0	5	0	5
Carbonic anhydrase 3	0	2	0	2
Cytochrome P450 3A4	0	1	0	1
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2C9	0	6	0	6
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	4	0	0	4
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	4	0	0	4
UDP-glucuronosyltransferase 1-6	0	0	0	1
Glutamate receptor 2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	4	0	0	4
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Carbonic anhydrase 4	0	3	0	3
Prostaglandin G/H synthase 1	0	5	0	6
Carbonic anhydrase 6	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	4	0	0	4
Carbonic anhydrase 5A, mitochondrial	0	3	0	3
Prostaglandin G/H synthase 2	0	5	1	8
Carbonic anhydrase 7	0	2	0	2
Nuclear receptor ROR-gamma	2	0	0	2
Cytochrome P450 2J2	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	4	1	0	5
Gamma-aminobutyric acid receptor subunit beta-3	4	0	0	4
Gamma-aminobutyric acid receptor subunit beta-2	4	0	0	4
Carbonic anhydrase 9	0	4	0	4
GABA theta subunit	4	0	0	4
Canalicular multispecific organic anion transporter 1	0	6	0	6
Carbonic anhydrase 15	0	2	0	2
Carbonic anhydrase 13	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	4	0	0	4
Carbonic anhydrase 14	0	2	0	2
Carbonic anhydrase 5B, mitochondrial	0	3	0	3
toxin B	0	0	0	1
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	1	2
Potassium channel subfamily K member 9	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Cruzipain	1	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	2	0	2
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
glp-1 receptor, partial	2	0	0	2
pregnane X receptor	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
SMAD family member 2	5	0	0	5
USP1 protein, partial	4	0	0	4
PPM1D protein	2	0	0	2
SMAD family member 3	5	0	0	5
TDP1 protein	4	0	0	4
GLI family zinc finger 3	5	0	0	5
AR protein	9	0	0	9
caspase 7, apoptosis-related cysteine protease	2	0	0	2
estrogen receptor 2 (ER beta)	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	3	0	0	3
glucocorticoid receptor [Homo sapiens]	6	0	0	6
farnesoid X nuclear receptor	2	0	0	2
pregnane X nuclear receptor	5	0	0	5
G	3	0	0	3
cytochrome P450 2D6	3	0	0	3
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
67.9K protein	2	0	0	2
peroxisome proliferator-activated receptor delta	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
Carbonic anhydrase	0	1	0	1
Rac1 protein	0	0	1	1
caspase-3	2	0	0	2
IDH1	6	0	0	6
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	6	0	0	6
thyroid stimulating hormone receptor	2	0	0	2
activating transcription factor 6	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	2	0	0	2
Histone H2A.x	1	0	0	1
Caspase-7	1	0	0	1
interferon gamma precursor	0	0	0	1
prostaglandin E2 receptor EP2 subtype	0	0	0	1
thyroid hormone receptor beta isoform a	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
caspase-3	1	0	0	1
heat shock protein beta-1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	4	0	0	4
geminin	8	0	0	8
lamin isoform A-delta10	6	0	0	6
Prostaglandin E synthase	0	1	0	1
Histone deacetylase 3	0	1	0	1
3-phosphoinositide-dependent protein kinase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Prostaglandin G/H synthase 2	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Interferon beta	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Cellular tumor antigen p53	4	0	0	4
Procathepsin L	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Quinolone resistance protein NorA	0	1	0	1
Adenosine receptor A3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Beta-3 adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Calpain-2 catalytic subunit	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
D(1A) dopamine receptor	0	2	0	2
Prostaglandin G/H synthase 1	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
Adenosine receptor A1	0	3	0	3
Cruzipain	0	1	0	1
Sodium/hydrogen exchanger 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Sodium-dependent serotonin transporter	0	0	1	1
Delta-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	5
Carbonic anhydrase	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Urotensin-2 receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Histone deacetylase 4	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
D(2) dopamine receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	5	0	5
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	3	0	3
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Histone deacetylase 1	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	5
Carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Histone deacetylase 7	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Inositol hexakisphosphate kinase 1	3	0	0	3
Histone deacetylase 2	0	1	0	1
Carbonic anhydrase 4	0	2	0	2
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
ATPase family AAA domain-containing protein 5	5	0	0	5
Ataxin-2	6	0	0	6
Histone deacetylase 8	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
cytochrome P450 2C9, partial	3	0	0	3
Epidermal growth factor receptor	0	2	0	2
Vascular endothelial growth factor receptor 2	0	1	0	1
Alpha-synuclein	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
CREB-binding protein	0	1	0	1
phosphopantetheinyl transferase	2	0	0	2
Solute carrier family 22 member 1	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Luciferase	2	0	0	2
NFKB1 protein, partial	2	0	0	2
nonstructural protein 1	2	0	0	2
arylsulfatase A	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	5	0	0	5
transcriptional regulator ERG isoform 3	1	0	0	1
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
DNA polymerase kappa isoform 1	1	0	0	1
muscleblind-like protein 1 isoform 1	3	0	0	3
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Fatty acid-binding protein, liver	0	2	0	2
Albumin	0	2	1	3
Albumin	0	1	0	1
Albumin	0	0	1	1
Cholinesterase	0	1	0	1
Fatty acid-binding protein, intestinal	0	2	1	3
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	5
UDP-glucuronosyltransferase 2B7	0	0	0	1
Acetylcholinesterase	0	1	0	1
Caspase-1	0	3	0	3
Adenosine receptor A2a	0	2	0	2
Substance-P receptor	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
Aldo-keto reductase family 1 member C3	0	2	0	2
Caspase-3	0	3	0	3
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Caspase-4	0	3	0	3
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	3	0	3
Caspase-9	0	3	0	3
Acid-sensing ion channel 1	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
TAR DNA-binding protein 43	2	0	0	2
Solute carrier family 22 member 6	0	2	0	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
thioredoxin reductase	3	0	0	3
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
Cell division control protein 42 homolog	0	1	0	1
Ras-related C3 botulinum toxin substrate 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	3	0	0	3
Chain A, Beta-lactamase	2	0	0	2
mitogen-activated protein kinase 1	1	0	0	1
flap endonuclease 1	1	0	0	1
muscarinic acetylcholine receptor M1	1	0	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
acetylcholinesterase	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Glucocorticoid receptor	0	6	0	6
Glycine receptor subunit alpha-1	0	6	0	6
Androgen receptor	0	2	0	2
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
ATP-dependent phosphofructokinase	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Hormone-sensitive lipase	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
huntingtin isoform 2	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
Spike glycoprotein	1	0	0	1
Carbonic anhydrase	0	1	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
thioredoxin glutathione reductase	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research Excerpts

Overview

Context

Actions

Treatment

Research

Studies (69)

Protein Targets (323)

De Quervain Disease

Synonyms(4)

Research Excerpts

Overview

Context

Actions

Treatment

Research

Studies (69)

Drugs Studied (23)

Protein Targets (323)