Page last updated: 2024-09-04

naproxen and lidocaine

naproxen has been researched along with lidocaine in 42 studies

Compound Research Comparison

Studies (naproxen)	Trials (naproxen)	Recent Studies (post-2010) (naproxen)	Studies (lidocaine)	Trials (lidocaine)	Recent Studies (post-2010) (lidocaine)
4,551	1,057	1,429	26,090	5,904	5,591

Protein Interaction Comparison

Protein	Taxonomy	naproxen (IC50)	lidocaine (IC50)
Sodium channel protein type 4 subunit alpha	Homo sapiens (human)		2

Research

Studies (42)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.38)	18.7374
1990's	4 (9.52)	18.2507
2000's	18 (42.86)	29.6817
2010's	18 (42.86)	24.3611
2020's	1 (2.38)	2.80

Authors

Authors	Studies
Duffy, EM; Jorgensen, WL	1
Topliss, JG; Yoshida, F	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Caron, G; Ermondi, G	1
Jolivette, LJ; Ward, KW	1
Carrupt, PA; Martel, S; Ottaviani, G	2
Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Balko, KM; Colby, DA; Mo, H	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U	1
Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Ang, HG; Goh, HS; Ho, YH; Seow-Choen, F	1
Abuzeid, M; Aksel, S; Alexander, SE; Lorino, CO; Prough, SG; Wiebe, RH	1
Dobrow, R; Neiman, R; Petri, M; Seaman, WE; Whiting-O'Keefe, Q	1
Dahl, C; Rasmussen, YH	1
Hartenbach, EM; Hunter, VJ; Sammarco, MJ	1
Fredholt, K; Larsen, C; Larsen, DH	2
Fredholt, K; Larsen, C; Larsen, DB	1
Celiloglu, M; Demir, A; Dogan, E; Sarihan, E	1
Friberg-Johansen, H; Jessen, MN; Larsen, C; Larsen, SW; Østergaard, J	1
Crockett, RS; Gammaitoni, AR; Gould, EM; Nalamachu, S	1
Ghosh, B; Gupta, N; Mittal, S	1
Konrádsdóttir, F; Loftsson, T; Sigfússon, SD	1
Dreiss, CA; Valero, M	1
Cohen, R; Glockenberg, A; Kaufman, MA; Shtofmakher, G	1
Allen, RH; Bartz, D; Bernholc, A; Hubacher, D; Lopez, LM; O'Brien, PA; Zeng, Y	1
Castiglione, F; da Silva, MA; Dreiss, CA; González-Gaitano, G; Grillo, I; Mele, A; Valero, M	1
Elkhouly, NI; Maher, MA	1
Abbas, AM; Abdallah, KM; Abdelbaky, WH; Ahmed, MAM; Badawy, MA; El-Naser Abd El-Gaber Ali, A; El-Rasheedy, MI; Elktatny, HH; Khodry, MM; Mohammed, AE; Raslan, OK; Samy, A	1
Dalwadi, G; Fiandaca, M; Gupta, P; Wigent, R	1

Reviews

3 review(s) available for naproxen and lidocaine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Interventions for pain with intrauterine device insertion. The Cochrane database of systematic reviews, 2015, Jul-29, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine; Misoprostol; Naproxen; Oxytocics; Pain; Prilocaine; Randomized Controlled Trials as Topic	2015
Medications for pain relief in outpatient endometrial sampling or biopsy: a systematic review and network meta-analysis. Fertility and sterility, 2019, Volume: 112, Issue:1 Topics: Ambulatory Care; Analgesics; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Endometrium; Female; Humans; Hysteroscopy; Lidocaine; Naproxen; Network Meta-Analysis; Pain; Pain Management; Pain Measurement; Randomized Controlled Trials as Topic; Suction; Time Factors; Treatment Outcome; Uterine Hemorrhage	2019

Trials

8 trial(s) available for naproxen and lidocaine

Article	Year
Prospective, randomized trial comparing pain and clinical function after conventional scissors excision/ligation vs. diathermy excision without ligation for symptomatic prolapsed hemorrhoids. Diseases of the colon and rectum, 1992, Volume: 35, Issue:12 Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Aged; Electrocoagulation; Female; Follow-Up Studies; Hemorrhoids; Humans; Injections, Intramuscular; Lidocaine; Ligation; Male; Meperidine; Middle Aged; Naproxen; Pain, Postoperative; Prolapse; Prospective Studies; Wound Healing	1992
Randomized, double-blind, placebo-controlled study of the treatment of the painful shoulder. Arthritis and rheumatism, 1987, Volume: 30, Issue:9 Topics: Bursa, Synovial; Bursitis; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Humans; Injections; Lidocaine; Male; Naproxen; Pain; Placebos; Random Allocation; Shoulder Joint; Tendinopathy; Triamcinolone	1987
Analgesic requirements for ESWL treatment. A double blind study. Scandinavian journal of urology and nephrology, 1994, Volume: 28, Issue:3 Topics: Analgesia; Double-Blind Method; Female; Fentanyl; Humans; Lidocaine; Lithotripsy; Male; Middle Aged; Naproxen; Pain Measurement; Premedication; Urinary Calculi	1994
Local anesthesia for cryosurgery on the cervix. The Journal of reproductive medicine, 1993, Volume: 38, Issue:3 Topics: Anesthesia, Local; Cervix Uteri; Colposcopy; Cryosurgery; Female; Humans; Injections, Subcutaneous; Ketoprofen; Lidocaine; Naproxen; Preanesthetic Medication; Prospective Studies; Uterine Cervical Dysplasia	1993
Anesthetic effect of intrauterine lidocaine plus naproxen sodium in endometrial biopsy. Obstetrics and gynecology, 2004, Volume: 103, Issue:2 Topics: Administration, Oral; Adult; Aged; Ambulatory Care; Anesthetics, Local; Biopsy, Needle; Double-Blind Method; Drug Therapy, Combination; Endometrium; Female; Humans; Injections, Intralesional; Lidocaine; Middle Aged; Naproxen; Pain Measurement; Pain, Postoperative; Probability; Reference Values; Uterine Diseases	2004
A comparison of the lidocaine patch 5% vs naproxen 500 mg twice daily for the relief of pain associated with carpal tunnel syndrome: a 6-week, randomized, parallel-group study. MedGenMed : Medscape general medicine, 2006, Aug-09, Volume: 8, Issue:3 Topics: Administration, Cutaneous; Adult; Aged; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Carpal Tunnel Syndrome; Drug Administration Schedule; Female; Humans; Lidocaine; Male; Middle Aged; Naproxen; Palliative Care; Pilot Projects; Treatment Outcome	2006
Comparison of oral naproxen and intrauterine lignocaine instillation for pain relief during hysterosalpingography. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2008, Volume: 102, Issue:3 Topics: Administration, Oral; Adult; Analgesics; Anesthetics, Local; Female; Humans; Hysterosalpingography; Lidocaine; Naproxen; Pain; Uterus	2008
Different analgesics prior to intrauterine device insertion: is there any evidence of efficacy? The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception, 2017, Volume: 22, Issue:3 Topics: Adult; Analgesics; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Intrauterine Devices; Lidocaine; Misoprostol; Naproxen; Oxytocics; Pain Management; Pain, Procedural; Pelvic Pain; Prosthesis Implantation; Treatment Outcome; Young Adult	2017

Other Studies

31 other study(ies) available for naproxen and lidocaine

Article	Year
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water	2005
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7 Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution	2005
Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability. Journal of medicinal chemistry, 2006, Jun-29, Volume: 49, Issue:13 Topics: 1-Octanol; Diffusion; Dimethylpolysiloxanes; Humans; In Vitro Techniques; Membranes, Artificial; Myristates; Permeability; Skin; Skin Absorption; Water	2006
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. Journal of medicinal chemistry, 2007, Feb-22, Volume: 50, Issue:4 Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water	2007
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22 Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption	2007
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
A practical deuterium-free NMR method for the rapid determination of 1-octanol/water partition coefficients of pharmaceutical agents. Bioorganic & medicinal chemistry letters, 2010, Nov-15, Volume: 20, Issue:22 Topics: 1-Octanol; Magnetic Resonance Spectroscopy; Pharmaceutical Preparations; Water	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests	2012
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:2 Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Pain relief in hysterosalpingography. A comparison of analgesics. The Journal of reproductive medicine, 1990, Volume: 35, Issue:5 Topics: Analgesics; Benzocaine; Dose-Response Relationship, Drug; Drug Combinations; Female; Gels; Humans; Hysterosalpingography; Lidocaine; Naproxen; Pain	1990
Assessment of rate of drug release from oil vehicle using a rotating dialysis cell. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2000, Volume: 11, Issue:3 Topics: Coconut Oil; Cocos; Delayed-Action Preparations; Dialysis; Drug Carriers; Kinetics; Lidocaine; Models, Biological; Naproxen; Plant Oils	2000
Modification of in vitro drug release rate from oily parenteral depots using a formulation approach. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2000, Volume: 11, Issue:3 Topics: Castor Oil; Coconut Oil; Delayed-Action Preparations; Drug Carriers; Kinetics; Lidocaine; Myristates; Naproxen; Peanut Oil; Plant Oils; Sesame Oil	2000
Addition of hydrogen bond donating excipients to oil solution: effect on in vitro drug release rate and viscosity. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2001, Volume: 13, Issue:4 Topics: Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Excipients; Hydrogen Bonding; In Vitro Techniques; Lidocaine; Naproxen; Oils; Solutions; Viscosity	2001
In vitro assessment of drug release rates from oil depot formulations intended for intra-articular administration. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2006, Volume: 29, Issue:5 Topics: Delayed-Action Preparations; Dialysis; Hydrogen-Ion Concentration; Injections, Intra-Articular; Kinetics; Lidocaine; Models, Biological; Naproxen; Rotation; Sesame Oil	2006
Fish skin as a model membrane: structure and characteristics. The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:1 Topics: 2-Hydroxypropyl-beta-cyclodextrin; Algorithms; Animals; Benzocaine; beta-Cyclodextrins; Catfishes; Diethylstilbestrol; Diffusion; Hydrocortisone; In Vitro Techniques; Kinetics; Lidocaine; Membranes; Models, Biological; Naproxen; Nitrates; Permeability; Picrates; Skin; Skin Absorption	2009
Growth, shrinking, and breaking of pluronic micelles in the presence of drugs and/or beta-cyclodextrin, a study by small-angle neutron scattering and fluorescence spectroscopy. Langmuir : the ACS journal of surfaces and colloids, 2010, Jul-06, Volume: 26, Issue:13 Topics: beta-Cyclodextrins; Lidocaine; Micelles; Molecular Structure; Naproxen; Pentobarbital; Poloxamer; Scattering, Small Angle; Sodium Salicylate; Spectrometry, Fluorescence	2010
Autoamputation of the fifth digit: ainhum (dactylolysis spontanea). BMJ case reports, 2014, May-20, Volume: 2014 Topics: Adult; Ainhum; Anesthetics, Local; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Humans; Lidocaine; Naproxen; Radiography; Toes; Triamcinolone	2014
Competitive and Synergistic Interactions between Polymer Micelles, Drugs, and Cyclodextrins: The Importance of Drug Solubilization Locus. Langmuir : the ACS journal of surfaces and colloids, 2016, 12-13, Volume: 32, Issue:49 Topics: Cyclodextrins; Lidocaine; Micelles; Naproxen; Pentobarbital; Pharmaceutical Preparations; Poloxamer; Scattering, Small Angle; Sodium Salicylate	2016
Ionic liquid formation with deep eutectic forces at an atypical ratio (2:1) of naproxen to lidocaine in the solid-state, thermal characterization and FTIR investigation. International journal of pharmaceutics, 2020, Feb-15, Volume: 575 Topics: Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Furans; Ionic Liquids; Lidocaine; Naproxen; Solubility; Spectroscopy, Fourier Transform Infrared; Temperature	2020