naproxen has been researched along with nimesulide in 50 studies
| Studies (naproxen) | Trials (naproxen) | Recent Studies (post-2010) (naproxen) | Studies (nimesulide) | Trials (nimesulide) | Recent Studies (post-2010) (nimesulide) |
|---|---|---|---|---|---|
| 4,551 | 1,057 | 1,429 | 1,272 | 200 | 271 |
| Protein | Taxonomy | naproxen (IC50) | nimesulide (IC50) |
|---|---|---|---|
| Myeloperoxidase | Homo sapiens (human) | 2.1 | |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | 6.2 | |
| Procathepsin L | Homo sapiens (human) | 1.92 | |
| Leukotriene A-4 hydrolase | Homo sapiens (human) | 0.023 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 2.493 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 1.8947 | |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | 1.16 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (30.00) | 18.2507 |
| 2000's | 24 (48.00) | 29.6817 |
| 2010's | 11 (22.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bauer, R; Goeters, S; Hempel, B; Imming, P; Krause, E; Lohmann, K; Ramadan, M; Watzer, B | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Kourounakis, AP; Matralis, AN | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Cantarelli, A; Gallucci, M; Mapelli, A; Scaricabarozzi, I; Toscani, F; Veca, G | 1 |
| Cantarelli, A; Gallucci, M; Giannunzio, D; Ligorio, L; Mapelli, A; Toscani, F; Veca, G | 1 |
| Monti, T; Nouri, E | 1 |
| Gallucci, M; Scaricabarozzi, I; Toscani, F | 1 |
| Ferrari Parabita, G; Rossi, D; Scalvini, F; Scaricabarozzi, I; Zanetti, U | 1 |
| Bechi, P; Nava, ML; Panconesi, R; Scaricabarozzi, I; Zuckermann, M | 1 |
| Calligaris, A; Scaricabarozzi, I; Vecchiet, L | 1 |
| Arista Viveros, HA; Lopez, E; Lujan, ME; Maciel, RM; Salmòn Rodriguez, LE; Trujillo, CL | 1 |
| Martel-Pelletier, J; Pelletier, JP | 1 |
| Buyse, H; Lecomte, J; Monti, T; Taymans, J | 1 |
| Pirhonen, J; Pulkkinen, M | 1 |
| Hernández-Tobías, A; Piña, E; Saldaña-Balmori, Y; Zentella de Piña, M | 1 |
| Bjarnason, I; Thjodleifsson, B | 1 |
| Bracht, A; Ishii-Iwamoto, EL; Kelmer-Bracht, AM; Lopez, CH; Sampaio, E; Yamamoto, NS | 1 |
| Wallace, JL | 1 |
| Barry, M; Bjarnason, I; Fitzgerald, DJ; Gudjonsson, H; Kay, E; Murray, FE; Oddsson, E; Price, AB; Shah, AA; Sigthorsson, G; Thjodleifsson, B | 1 |
| Huskisson, EC | 1 |
| Di Battista, JA; Fahmi, H; He, Y; Martel-Pelletier, J; Pelletier, JP; Zhang, M | 1 |
| de Nucci, G; Ferraz, JG; Giuliano, F; Pereira, R; Warner, TD | 1 |
| Ehrlich, JC; Korff, KJ; Kriegel, W; Lehnhardt, K; Macciocchi, A; Moresino, C; Pawlowski, C | 1 |
| Jain, NK; Kulkarni, SK; Singh, A | 2 |
| de Zentella, PM; Pimentel, L; Piña, E; Piña-Zentella, G; Vázquez-Meza, H | 1 |
| Bisogno, S; Di Martino, S; Fioravanti, A; Marcolongo, R; Oldani, V; Scotti, A; Storri, L | 1 |
| Jain, NK; Kulkarni, SK; Patil, CS; Singh, A | 1 |
| Baylas, H; Huseyinov, A; Vardar, S | 1 |
| Backhouse, N; Bórquez, J; Delporte, C; Loyola, A; Salinas, P; San-Martín, A | 1 |
| Chen, BY; Cheng, NN; Li, D; Shi, W; Wang, YM | 1 |
| Alotti, N; Bodó, E; Gábor, V; Gombocz, K; Rashed, A | 1 |
| Jain, NK; Kulkarni, SK; Sharma, S | 1 |
| Dhir, A; Kulkarni, SK; Naidu, PS | 1 |
| Bjarnason, I; Bjornsson, E; Maiden, L; Premchand, P; Sherwood, R; Smale, S; Takeuchi, K; Thjodleifsson, B | 1 |
| Bishnoi, M; Kulkarni, SK; Kumar, A; Patil, CS | 1 |
| Kandefer-Szerszeń, M; Majdan, M; Parada-Turska, J; Rzeski, W; Turski, WA | 1 |
| Agundis, C; Pardo, JP; Pereyra, MA; Piña, E; Vázquez-Meza, H; Villalobos-Molina, R; Zentella de Piña, M | 1 |
| Barrett, TD; Hong, TT; Huang, J; Lucchesi, BR | 1 |
| Buyse, M; Farinotti, R; Zrieki, A | 1 |
| Cefle, K; Kocak, H; Koseoglu, BG; Ozturk, S; Palanduz, S | 1 |
| Kumar, A; Kumar, P; Kumari, B | 1 |
| Amazonas, RB; Bocchi de Oliveira, MF; Ecclissato, C; Macêdo, EA; Pott Júnior, H; Scheinberg, M | 1 |
5 review(s) available for naproxen and nimesulide
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Gastrointestinal toxicity of non-steroidal anti-inflammatory drugs: the effect of nimesulide compared with naproxen on the human gastrointestinal tract.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Digestive System; Endoscopy, Gastrointestinal; Gastrointestinal Hemorrhage; Humans; Indans; Isoenzymes; Membrane Proteins; Naproxen; Prostaglandin-Endoperoxide Synthases; Severity of Illness Index; Sulfonamides; Time Factors | 1999 |
Distribution and expression of cyclooxygenase (COX) isoenzymes, their physiological roles, and the categorization of nonsteroidal anti-inflammatory drugs (NSAIDs).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Controlled Clinical Trials as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Etodolac; Gene Expression; Humans; Ibuprofen; Indomethacin; Isoenzymes; Meloxicam; Membrane Proteins; Naproxen; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thiazines; Thiazoles | 1999 |
Nimesulide, a balanced drug for the treatment of osteoarthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Diclofenac; Etodolac; Humans; Naproxen; Osteoarthritis; Stomach Diseases; Sulfonamides; Treatment Outcome | 2001 |
[Meta-analysis on the effect and adverse reaction on patients with osteoarthritis and rheumatoid arthritis treated with non-steroidal anti-inflammatory drugs].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Butanones; China; Diclofenac; Humans; Ibuprofen; Meloxicam; Nabumetone; Naproxen; Osteoarthritis; Oxaprozin; Propionates; Randomized Controlled Trials as Topic; Sulfonamides; Thiazines; Thiazoles | 2003 |
18 trial(s) available for naproxen and nimesulide
| Article | Year |
|---|---|
Nimesulide in the treatment of advanced cancer pain. Double-blind comparison with naproxen.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Male; Middle Aged; Naproxen; Neoplasms; Pain, Intractable; Sulfonamides | 1992 |
[Comparison of nimesulide and naproxen sodium in the control of cancer pain].
Topics: Double-Blind Method; Humans; Naproxen; Neoplasms; Pain; Sulfonamides | 1991 |
Nimesulide granules for the treatment of acute inflammation of the ear, nose or throat.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Male; Middle Aged; Naproxen; Otitis; Pharyngitis; Rhinitis; Sulfonamides | 1993 |
Nimesulide in the treatment of advanced cancer pain. Double-blind comparison with naproxen.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Male; Middle Aged; Naproxen; Neoplasms; Pain, Intractable; Sulfonamides | 1993 |
A controlled clinical study of the efficacy and tolerability of nimesulide vs naproxen in maxillo-facial surgery.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Face; Female; Humans; Inflammation; Male; Maxilla; Middle Aged; Naproxen; Postoperative Complications; Sulfonamides; Surgery, Oral | 1993 |
Clinical efficacy and tolerability of nimesulide compared with naproxen in the treatment of posthaemorrhoidectomy pain and inflammation.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Hemorrhoids; Humans; Inflammation; Male; Middle Aged; Naproxen; Pain, Postoperative; Postoperative Complications; Sulfonamides | 1993 |
A multicentre double-blind investigation comparing nimesulide and naproxen in the treatment of minor sport injuries.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Athletic Injuries; Double-Blind Method; Female; Humans; Male; Middle Aged; Naproxen; Sulfonamides | 1993 |
Assessment of the efficacy and safety of nimesulide vs naproxen in paediatric patients with respiratory tract infections. A comparative single-blind study.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Female; Humans; Infant; Male; Naproxen; Respiratory Tract Infections; Single-Blind Method; Sulfonamides | 1993 |
Treatment of tendinitis and bursitis: a comparison of nimesulide and naproxen sodium in a double-blind parallel trial.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Bursitis; Double-Blind Method; Female; Humans; Male; Movement; Naproxen; Pain; Sulfonamides; Tendinopathy | 1994 |
The effect of nimesulide and naproxen on the uterine and ovarian arterial blood flow velocity. A Doppler study.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arteries; Blood Flow Velocity; Double-Blind Method; Dysmenorrhea; Female; Humans; Middle Aged; Naproxen; Ovary; Pulsatile Flow; Sulfonamides; Ultrasonography, Doppler, Color; Ultrasonography, Doppler, Pulsed; Uterus | 1995 |
Selective inhibition of COX-2 in humans is associated with less gastrointestinal injury: a comparison of nimesulide and naproxen.
Topics: Adolescent; Adult; Aged; Biomarkers; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Gastric Mucosa; Gastrointestinal Diseases; Humans; Intestinal Mucosa; Male; Middle Aged; Naproxen; Permeability; Platelet Aggregation; Prostaglandins E; Sulfonamides; Thromboxane B2 | 2001 |
Cyclooxygenase selectivity of non-steroid anti-inflammatory drugs in humans: ex vivo evaluation.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Cyclooxygenase 1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Etodolac; Humans; Isoenzymes; Male; Meloxicam; Membrane Proteins; Nabumetone; Naproxen; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfonamides; Thiazines; Thiazoles; Time Factors; Tumor Cells, Cultured | 2001 |
Double-blind study comparing the long-term efficacy of the COX-2 inhibitor nimesulide and naproxen in patients with osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Male; Middle Aged; Naproxen; Osteoarthritis; Severity of Illness Index; Sulfonamides; Treatment Outcome | 2001 |
A randomized, double-blind, multicenter trial of nimesulide-beta-cyclodextrin versus naproxen in patients with osteoarthritis.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextrins; Cyclodextrins; Double-Blind Method; Female; Humans; Male; Middle Aged; Naproxen; Osteoarthritis; Pain Measurement; Sulfonamides | 2002 |
Effects of selective cyclooxygenase-2 inhibition on gingival tissue levels of prostaglandin E2 and prostaglandin F2alpha and clinical parameters of chronic periodontitis.
Topics: Adult; Chronic Disease; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dental Plaque Index; Dental Scaling; Dinoprost; Dinoprostone; Double-Blind Method; Female; Follow-Up Studies; Gingiva; Humans; Isoenzymes; Male; Matched-Pair Analysis; Membrane Proteins; Middle Aged; Naproxen; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Placebos; Prostaglandin-Endoperoxide Synthases; Root Planing; Statistics as Topic; Statistics, Nonparametric; Sulfonamides | 2003 |
[Management of postoperative inflammatory response and pain with nimesulide after cardiac surgery].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; C-Reactive Protein; Cardiac Surgical Procedures; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Female; Humans; Interleukin-6; Isoenzymes; Leukocyte Count; Male; Membrane Proteins; Middle Aged; Naproxen; Pain Measurement; Pain, Postoperative; Prospective Studies; Prostaglandin-Endoperoxide Synthases; Receptors, Tumor Necrosis Factor; Sulfonamides; Systemic Inflammatory Response Syndrome; Treatment Outcome | 2003 |
The effects of etodolac, nimesulid and naproxen sodium on the frequency of sister chromatid exchange after enclused third molars surgery.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Etodolac; Female; Humans; Male; Molar, Third; Mutagenicity Tests; Naproxen; Prospective Studies; Sister Chromatid Exchange; Sulfonamides | 2008 |
Efficacy and safety of a fixed-dose combination of nimesulide/pantoprazole compared to naproxen/esomeprazole for pain relief in patients with osteoarticular diseases and dyspeptic symptoms.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Double-Blind Method; Dyspepsia; Esomeprazole; Female; Humans; Male; Middle Aged; Naproxen; Osteoporosis; Pain; Pain Management; Pantoprazole; Sulfonamides; Tablets | 2018 |
27 other study(ies) available for naproxen and nimesulide
| Article | Year |
|---|---|
Chamazulene carboxylic acid and matricin: a natural profen and its natural prodrug, identified through similarity to synthetic drug substances.
Topics: Achillea; Anti-Inflammatory Agents, Non-Steroidal; Azulenes; Carboxylic Acids; Cycloheptanes; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Germany; Lactones; Matricaria; Molecular Structure; Pharmaceutical Preparations; Prodrugs; Sesquiterpenes; Sesquiterpenes, Guaiane | 2006 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Design of novel potent antihyperlipidemic agents with antioxidant/anti-inflammatory properties: exploiting phenothiazine's strong antioxidant activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Atherosclerosis; Biphenyl Compounds; Carrageenan; Cholesterol, Dietary; Cyclooxygenase Inhibitors; Diet, High-Fat; Drug Design; Edema; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Hypolipidemic Agents; In Vitro Techniques; Indicators and Reagents; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Male; Mice; Microsomes; Phenothiazines; Picrates; Rats | 2014 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Effects of nimesulide and naproxen on the degradation and metalloprotease synthesis of human osteoarthritic cartilage.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cartilage; Collagenases; Humans; In Vitro Techniques; Matrix Metalloproteinase 3; Metalloendopeptidases; Naproxen; Osteoarthritis; Proteoglycans; Sulfonamides | 1993 |
Nonsteroidal antiinflammatory drugs lower ethanol-mediated liver increase in lipids and thiobarbituric acid reactive substances.
Topics: Alcoholic Intoxication; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dipyrone; Ethanol; Fatty Liver, Alcoholic; Free Radicals; Lipid Metabolism; Lipid Peroxidation; Male; Metabolic Clearance Rate; Naproxen; Rats; Rats, Wistar; Sulfonamides; Thiobarbiturates; Triglycerides | 1993 |
The action of flufenamic acid and other nonsteroidal anti-inflammatories on sulfate transport in the isolated perfused rat liver.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Dose-Response Relationship, Drug; Flufenamic Acid; In Vitro Techniques; Liver; Male; Mefenamic Acid; Naproxen; Niflumic Acid; Perfusion; Piroxicam; Rats; Rats, Wistar; Sulfates; Sulfonamides; Sulfur Radioisotopes; Time Factors | 1999 |
Differential regulation of interleukin-1 beta-induced cyclooxygenase-2 gene expression by nimesulide in human synovial fibroblasts.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Naproxen; Nitrobenzenes; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides; Synovial Membrane | 2001 |
Lipopolysaccharide-mediated immobility in mice: reversal by cyclooxygenase enzyme inhibitors.
Topics: Animals; Antidepressive Agents, Tricyclic; Cyclooxygenase Inhibitors; Desipramine; Enterotoxins; Female; Fluoxetine; Lactones; Lipopolysaccharides; Male; Mice; Motor Activity; Naproxen; Reserpine; Selective Serotonin Reuptake Inhibitors; Sulfonamides; Sulfones; Swimming | 2001 |
Non-steroidal anti-inflammatory drugs inhibit epinephrine- and cAMP-mediated lipolysis in isolated rat adipocytes.
Topics: Adipocytes; Adrenergic beta-Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bucladesine; Dihydroalprenolol; Dose-Response Relationship, Drug; Drug Interactions; Epinephrine; Ethanol; Glycerol; Guinea Pigs; Lipolysis; Male; Naproxen; Piroxicam; Rats; Rats, Wistar; Sulfonamides; Thiobarbituric Acid Reactive Substances; Triglycerides | 2002 |
Modulatory role of cyclooxygenase inhibitors in aging- and scopolamine or lipopolysaccharide-induced cognitive dysfunction in mice.
Topics: Aging; Animals; Anxiety; Avoidance Learning; Cognition Disorders; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Gastrointestinal Diseases; Isoenzymes; Lactones; Lipopolysaccharides; Male; Membrane Proteins; Mice; Motor Activity; Muscarinic Antagonists; Naproxen; Postural Balance; Prostaglandin-Endoperoxide Synthases; Scopolamine; Sulfonamides; Sulfones | 2002 |
Modulation of NSAID-induced antinociceptive and anti-inflammatory effects by alpha2-adrenoceptor agonists with gastroprotective effects.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Drug Synergism; Drug Therapy, Combination; Meloxicam; Mice; Naproxen; Pain; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Stomach Ulcer; Sulfonamides; Thiazines; Thiazoles; Yohimbine | 2002 |
Pharmaco-toxicological study of diterpenoids.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Apiaceae; Arachidonic Acid; Chile; Diterpenes; Dose-Response Relationship, Drug; Edema; Female; Indicators and Reagents; Indomethacin; Lipoxygenase Inhibitors; Male; Mice; Molecular Conformation; Naproxen; Pain Measurement; Plants, Medicinal; Structure-Activity Relationship; Sulfonamides; Tetradecanoylphorbol Acetate | 2003 |
Possible analgesic and anti-inflammatory interactions of aspartame with opioids and NSAIDs.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspartame; Carrageenan; Drug Interactions; Edema; Inflammation; Mice; Morphine; Naproxen; Narcotics; Pain; Pain Measurement; Pentazocine; Rats; Rats, Wistar; Sulfonamides; Sweetening Agents; Time Factors | 2005 |
Protective effect of cyclooxygenase-2 (COX-2) inhibitors but not non-selective cyclooxygenase (COX)-inhibitors on ethanol withdrawal-induced behavioural changes.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Behavior, Animal; Brain; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Injections, Intraperitoneal; Lactones; Male; Mice; Naproxen; Neuroprotective Agents; Sulfonamides; Sulfones | 2005 |
Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease.
Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butanones; Colitis, Ulcerative; Crohn Disease; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Female; Humans; Indomethacin; Inflammatory Bowel Diseases; Male; Middle Aged; Nabumetone; Naproxen; Prevalence; Recurrence; Sulfonamides | 2006 |
Potentiation of antinociceptive effect of NSAIDs by a specific lipooxygenase inhibitor, acetyl 11-keto-beta boswellic acid.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Lactones; Lipoxygenase Inhibitors; Mice; Naproxen; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Sulfones; Triterpenes | 2006 |
Effect of glutamate receptor antagonists and antirheumatic drugs on proliferation of synoviocytes in vitro.
Topics: Animals; Antirheumatic Agents; Benzodiazepines; Benzodiazepinones; Celecoxib; Cell Line; Cell Proliferation; Cell Survival; Diclofenac; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Inhibitory Concentration 50; Methotrexate; Naproxen; Pyrazoles; Quinoxalines; Sulfasalazine; Sulfonamides; Synovial Membrane | 2006 |
Inhibition of cAMP-dependent protein kinase A: a novel cyclo-oxygenase-independent effect of non-steroidal anti-inflammatory drugs in adipocytes.
Topics: Adipocytes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cattle; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Male; Myocardium; Naproxen; Piroxicam; Prostaglandin-Endoperoxide Synthases; Protein Kinase Inhibitors; Rats; Rats, Wistar; Sterol Esterase; Sulfonamides | 2007 |
Effects of cyclooxygenase inhibition on canine coronary artery blood flow and thrombosis.
Topics: Acetylcholine; Animals; Arachidonic Acid; Benzofurans; Carotid Arteries; Coronary Circulation; Coronary Vessels; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Epoprostenol; Inflammation; Ligation; Lipopolysaccharides; Naproxen; Platelet Aggregation; Propionates; Pyrazoles; Receptors, Epoprostenol; Sulfonamides; Thrombosis; Time Factors; Vasodilation; Vasodilator Agents | 2008 |
Cyclooxygenase inhibitors down regulate P-glycoprotein in human colorectal Caco-2 cell line.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Caco-2 Cells; Celecoxib; Colorectal Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Down-Regulation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Naproxen; Neoplasm Proteins; Pyrazoles; Reproducibility of Results; RNA, Messenger; Sulfonamides; Time Factors | 2008 |
Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress.
Topics: Animals; Anxiety; Catalase; Chronic Disease; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Glutathione; Isoxazoles; Lactones; Lipid Peroxidation; Male; Meloxicam; Memory; Mice; Motor Activity; Naproxen; Nitrites; Random Allocation; Stress, Psychological; Sulfonamides; Sulfones; Thiazines; Thiazoles | 2010 |