Page last updated: 2024-09-28

Bornholm Disease

An acute, febrile, infectious disease generally occurring in epidemics. It is usually caused by coxsackieviruses B and sometimes by coxsackieviruses A; echoviruses; or other enteroviruses.

Synonyms(3)

Synonym
Pleurodynia, Epidemic
Bornholm Disease
Myalgia, Epidemic

Research

Studies (32)

TimeframeStudies, This Condition (%)All Conditions %
pre-199016 (50.00)23.3326
1990's8 (25.00)12.5806
2000's5 (15.63)18.1394
2010's3 (9.38)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
carnitine0low10
creatine0low10
amlodipine0low10
chloroquine0low10
lidocaine0low10
indomethacin0low10
succinylcholine0low10
prednisone0low10
2,3,4,6-tetrachlorophenol0low10
tryptophan0low30
fluorobenzenes0low20
2,5-dichloro-4-bromophenol0low10
trolamine salicylate0low30
triamcinolone0low10
zidovudine0low10
paclitaxel0low20
naproxen0low10
lanatosides0low10
fibrin0low10
s 17430low10
chlortetracycline0low10
oxytetracycline, anhydrous0low10
minocycline0low10
warfarin0low10
eye0low10

Protein Targets (460)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, HADH2 protein5005
Chain B, HADH2 protein5005
Luciferase3003
interleukin 82002
RAR-related orphan receptor gamma6006
GLI family zinc finger 37007
AR protein9009
thyroid stimulating hormone receptor4004
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor5005
glucocorticoid receptor [Homo sapiens]7007
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha6006
estrogen-related nuclear receptor alpha8008
farnesoid X nuclear receptor3003
pregnane X nuclear receptor7007
estrogen nuclear receptor alpha100010
peroxisome proliferator-activated receptor delta3003
peroxisome proliferator activated receptor gamma5005
aryl hydrocarbon receptor4004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
Histone H2A.x3003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
thyroid hormone receptor beta isoform 26006
heat shock protein beta-13003
mitogen-activated protein kinase 12002
nuclear factor erythroid 2-related factor 2 isoform 17007
Voltage-dependent calcium channel gamma-2 subunit2002
Cellular tumor antigen p536006
Glutamate receptor 22002
Nuclear receptor ROR-gamma3003
Peroxisome proliferator-activated receptor alpha1001
ATPase family AAA domain-containing protein 52002
Ataxin-23003
Chain A, Ferritin light chain2002
acid sphingomyelinase2002
TDP1 protein9009
Smad33003
cytochrome P450 family 3 subfamily A polypeptide 44004
G2002
cytochrome P450 2D62002
IDH14004
chromobox protein homolog 14004
NEDD8-activating enzyme E1 regulatory subunit isoform a0101
NEDD8-conjugating enzyme Ubc120101
nuclear receptor ROR-gamma isoform 13003
geminin7007
histone acetyltransferase KAT2A isoform 12002
ATP-binding cassette sub-family C member 30707
Multidrug resistance-associated protein 40708
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Potassium channel subfamily K member 20213
Bile salt export pump010010
Interferon beta5005
HLA class I histocompatibility antigen, B alpha chain 2002
ATP-dependent translocase ABCB10305
Alpha-2A adrenergic receptor0303
Alpha-2C adrenergic receptor0303
Alpha-2B adrenergic receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0101
Alpha-1A adrenergic receptor0101
Alpha-1B adrenergic receptor0101
5-hydroxytryptamine receptor 60202
Spike glycoprotein3115
Sodium-dependent dopamine transporter 0202
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Potassium channel subfamily K member 2 0101
Inositol hexakisphosphate kinase 12002
Canalicular multispecific organic anion transporter 10707
cytochrome P450 2C9, partial2002
Solute carrier family 22 member 50001
Solute carrier family 22 member 50001
Solute carrier family 22 member 160001
Solute carrier family 22 member 210001
Solute carrier family 22 member 50001
thioredoxin reductase6006
PPM1D protein2002
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
euchromatic histone-lysine N-methyltransferase 27007
Spike glycoprotein0112
Replicase polyprotein 1ab0112
glucose-6-phosphate 1-dehydrogenase isoform b0101
flap endonuclease 14004
Transmembrane protease serine 20112
Dihydrofolate reductase 0101
DNA ligase0101
Riboflavin-binding protein0011
Major prion protein0011
Amyloid-beta precursor protein0101
Histidine-rich protein PFHRP-II0102
Procathepsin L0213
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M40101
Cytochrome P450 3A40101
Muscarinic acetylcholine receptor M50101
Replicase polyprotein 1a0112
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0112
Spike glycoprotein0101
Replicase polyprotein 1ab0112
Muscarinic acetylcholine receptor M10101
Ribosyldihydronicotinamide dehydrogenase [quinone]0101
Alpha-2B adrenergic receptor0101
DNA ligase 10101
Muscarinic acetylcholine receptor M30101
Serine/threonine-protein kinase mTOR0101
Nuclear receptor subfamily 4 group A member 20011
Beta-secretase 10101
Calcium-dependent protein kinase 10011
MO15-related protein kinase Pfmrk 0101
DNA ligase A0101
Potassium voltage-gated channel subfamily H member 20404
Sigma intracellular receptor 20101
Phosphoethanolamine N-methyltransferase0101
Sigma non-opioid intracellular receptor 10101
Angiotensin-converting enzyme 2 0112
Cysteine proteinase falcipain 2a 0101
Cysteine proteinase falcipain 2a 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
P2Y purinoceptor 120101
Protein-arginine deiminase type-40404
Sodium- and chloride-dependent creatine transporter 10101
Proton-coupled amino acid transporter 10101
vitamin D (1,25- dihydroxyvitamin D3) receptor8008
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, Dihydrofolate reductase0011
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
Chain A, 2-oxoglutarate Oxygenase5005
glp-1 receptor, partial2002
USP1 protein, partial2002
aldehyde dehydrogenase 1 family, member A15005
glucocerebrosidase2002
alpha-galactosidase1001
activating transcription factor 61001
lysosomal alpha-glucosidase preproprotein2002
nuclear factor erythroid 2-related factor 2 isoform 24004
DNA polymerase beta2002
Thymidylate synthase0202
Thymidylate synthase0101
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10202
Alpha-synuclein1001
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30203
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
Chain A, membrane-associated prostaglandin E synthase-20101
Chain A, Cruzipain1001
hypoxia-inducible factor 1 alpha subunit1001
SMAD family member 24004
SMAD family member 34004
Microtubule-associated protein tau4004
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
EWS/FLI fusion protein3003
67.9K protein3003
Parkin1001
bromodomain adjacent to zinc finger domain 2B3003
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
cytochrome P450 2D6 isoform 11001
peripheral myelin protein 22 isoform 13003
cytochrome P450 2C9 precursor1001
vitamin D3 receptor isoform VDRA3003
thyroid hormone receptor beta isoform a3003
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 12002
DNA polymerase iota isoform a (long)4004
DNA polymerase kappa isoform 12002
M-phase phosphoprotein 82002
lamin isoform A-delta105005
neuropeptide S receptor isoform A1001
Prostaglandin-H2 D-isomerase0101
Prostaglandin E synthase0101
Solute carrier family 22 member 60203
Prostaglandin G/H synthase 1 0203
Prostaglandin G/H synthase 2 0102
3',5'-cyclic-AMP phosphodiesterase 0101
Solute carrier organic anion transporter family member 2B1 0202
Cytochrome c oxidase subunit 20101
Epidermal growth factor receptor0202
Phospholipase A2, major isoenzyme0101
Albumin0145
Prostaglandin G/H synthase 10304
Neuronal acetylcholine receptor subunit alpha-41102
Interleukin-80101
Androgen receptor0011
Neuronal acetylcholine receptor subunit beta-21102
Polyunsaturated fatty acid 5-lipoxygenase0205
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member C40202
Prostaglandin G/H synthase 10101
Prostaglandin G/H synthase 10202
Sodium-dependent dopamine transporter0101
Sodium- and chloride-dependent GABA transporter 10101
Thromboxane-A synthase 0101
Adenosine receptor A10202
Serum paraoxonase/arylesterase 10303
Indoleamine 2,3-dioxygenase 10101
Caspase-10102
Nitric oxide synthase, inducible0101
Adenosine receptor A2a0202
Substance-P receptor0202
Prostaglandin E2 receptor EP3 subtype0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Prostaglandin E2 receptor EP4 subtype0101
Multidrug resistance-associated protein 1 0101
Bifunctional epoxide hydrolase 20101
Prostaglandin G/H synthase 20314
Prostaglandin G/H synthase 2 0203
Prostaglandin E2 receptor EP1 subtype0101
Peroxisome proliferator-activated receptor gamma0011
Aldo-keto reductase family 1 member C30303
Histamine H2 receptor1001
Sodium- and chloride-dependent betaine transporter0101
C-X-C chemokine receptor type 30101
Aldo-keto reductase family 1 member C2 0202
Guanine nucleotide-binding protein G1001
Prostaglandin D2 receptor 0202
Prostaglandin G/H synthase 20303
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10202
Prostaglandin G/H synthase 20102
Uracil nucleotide/cysteinyl leukotriene receptor0202
Solute carrier family 22 member 60203
Solute carrier family 22 member 70002
Sigma intracellular receptor 20101
Prostaglandin E2 receptor EP2 subtype0101
Rho-associated protein kinase 20101
Prostaglandin G/H synthase 1 0203
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 80102
Multidrug and toxin extrusion protein 10202
Dehydrogenase/reductase SDR family member 90101
P2Y purinoceptor 120101
Solute carrier organic anion transporter family member 1B30404
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Solute carrier organic anion transporter family member 1B10404
PAX80001
Chain A, Beta-lactamase4004
GLS protein4004
cytochrome P450 3A4 isoform 12002
muscarinic acetylcholine receptor M11001
Gamma-aminobutyric acid receptor subunit pi2002
Potassium channel subfamily K member 30101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Gamma-aminobutyric acid receptor subunit beta-12002
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Potassium voltage-gated channel subfamily A member 50101
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Sodium channel protein type 4 subunit alpha0101
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
GABA theta subunit2002
Gamma-aminobutyric acid receptor subunit epsilon2002
Sodium channel protein type 3 subunit alpha0101
Stromelysin-10202
Matrilysin0101
Multidrug transporter MdfA0101
Cytochrome P450 2C9 0404
Matrix metalloproteinase-90101
Cytochrome P450 2J20303
Protein mono-ADP-ribosyltransferase PARP150101
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
Dihydrofolate reductase0303
Hormone-sensitive lipase0101
Caspase-30101
Caspase-40101
Caspase-50101
Caspase-90101
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
WRN1001
phosphopantetheinyl transferase4004
Valosin-containing protein0101
thioredoxin glutathione reductase4004
apical membrane antigen 1, AMA11001
regulator of G-protein signaling 41001
thyroid stimulating hormone receptor2002
v-jun sarcoma virus 17 oncogene homolog (avian)2002
transcriptional regulator ERG isoform 31001
microphthalmia-associated transcription factor isoform 90101
importin subunit beta-1 isoform 11001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
serine/threonine-protein kinase PLK12002
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 11001
eukaryotic translation initiation factor 4E isoform 10101
muscleblind-like protein 1 isoform 12002
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
Rap guanine nucleotide exchange factor 31001
phosphoglycerate kinase1001
Genome polyprotein 0101
pregnane X receptor2002
nuclear receptor subfamily 1, group I, member 22002
NPC intracellular cholesterol transporter 1 precursor1001
peripheral myelin protein 222002
Tyrosine-protein kinase ABL10101
Tubulin alpha-1A chain0012
Tubulin beta chain0011
Tubulin beta-4A chain0113
Receptor tyrosine-protein kinase erbB-20101
Integrin beta-30101
Tyrosine-protein kinase Fyn0101
Integrin alpha-V 0101
Tubulin beta chain0113
60 kDa chaperonin0101
Tubulin alpha-3C chain0113
Botulinum neurotoxin type A 0101
Apoptosis regulator Bcl-20101
60 kDa heat shock protein, mitochondrial0101
Fibroblast growth factor receptor 10101
Proto-oncogene tyrosine-protein kinase Src0101
UDP-glucuronosyltransferase 2B70102
UDP-glucuronosyltransferase 1-60101
ATP-dependent translocase ABCB10101
Substance-K receptor0202
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40101
Cholecystokinin receptor type A0202
Melanocortin receptor 50202
UDP-glucuronosyltransferase 2B10 0101
Delta-type opioid receptor0202
10 kDa heat shock protein, mitochondrial0101
Tubulin alpha-1B chain0113
Tubulin alpha-4A chain0113
Tubulin beta-4B chain0113
Bcl-2-like protein 10101
Tyrosine-protein kinase Mer0101
Tubulin beta-3 chain0214
Tubulin beta-2A chain0113
Thiosulfate sulfurtransferase0101
Beta-tubulin 0101
Tubulin beta-8 chain0113
60 kDa chaperonin 0101
Tubulin beta-2B chain0013
Tubulin alpha-3E chain0113
Tubulin alpha-1A chain0113
10 kDa chaperonin 0101
Similar to alpha-tubulin isoform 1 0013
Similar to alpha-tubulin isoform 1 0002
Tubulin alpha-1C chain0113
Tubulin beta-6 chain0113
Tubulin beta-2B chain0113
Tubulin beta-1 chain0113
Nucleotide-binding oligomerization domain-containing protein 20101
Glucocorticoid receptor0415
Glycine receptor subunit alpha-10404
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
D(1A) dopamine receptor1001
Acetylcholinesterase0101
ATAD5 protein, partial1001
NFKB1 protein, partial1001
arylsulfatase A2002
Bloom syndrome protein isoform 12002
procathepsin L isoform 1 preproprotein0101
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
Carbonic anhydrase 120001
Carbonic anhydrase 10001
Carbonic anhydrase 20001
Plasma kallikrein0001
Myeloperoxidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Carbonic anhydrase 30001
Intestinal-type alkaline phosphatase0101
Indoleamine 2,3-dioxygenase 10102
Carbonic anhydrase 40001
Carbonic anhydrase 60001
Carbonic anhydrase 5A, mitochondrial0001
Glutamate receptor ionotropic, NMDA 1 0001
Carbonic anhydrase0001
Carbonic anhydrase 70001
Tryptophan 2,3-dioxygenase0102
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Carbonic anhydrase 90001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Tryprostatin B synthase0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2D0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Carbonic anhydrase 0001
Glutamate receptor ionotropic, NMDA 3B0001
Monocarboxylate transporter 100001
Carbonic anhydrase 150001
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3A0001
Carbonic anhydrase 140001
Phospholipase A-2-activating protein0101
Carbonic anhydrase 5B, mitochondrial0001
ATP-dependent phosphofructokinase2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Albumin0011
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Protease 0213
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
caspase 7, apoptosis-related cysteine protease1001
caspase-31001
Caspase-71001
caspase-31001
pyruvate kinase PKM isoform a1001
tyrosine-protein kinase Yes1001
Ectonucleoside triphosphate diphosphohydrolase 10001
Thymidine kinase, cytosolic0203
Protein kinase C beta type0101
DNA polymerase beta0101
Thymidine kinase, cytosolic 0001
Thymidylate kinase0101
Protein kinase C epsilon type0101
Thymidine kinase 0102
Reverse transcriptase/RNaseH 0126
Solute carrier family 22 member 110001
Thymidine kinase0102
Solute carrier family 22 member 70001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]