Page last updated: 2024-12-11
19-hydroxyprostaglandin f
Description
You're likely referring to **19-hydroxyprostaglandin F2α (19-OH-PGF2α)**. This compound is a metabolite of prostaglandin F2α (PGF2α), a hormone-like substance involved in various physiological processes, including:
* **Reproduction:** PGF2α plays a crucial role in uterine contractions during labor and menstruation.
* **Inflammation:** PGF2α is involved in the inflammatory response, contributing to pain, swelling, and redness.
* **Blood pressure regulation:** PGF2α can constrict blood vessels, potentially influencing blood pressure.
**19-OH-PGF2α is important for research because:**
* **It is a biomarker for PGF2α activity:** Measuring 19-OH-PGF2α levels in biological samples (such as urine or blood) can provide insights into the activity of PGF2α in the body.
* **It helps understand PGF2α metabolism:** Studying 19-OH-PGF2α formation can shed light on the metabolic pathways of PGF2α and its degradation products.
* **Potential therapeutic implications:** Understanding the role of 19-OH-PGF2α might lead to the development of drugs that modulate PGF2α activity for therapeutic purposes, such as managing labor, inflammation, or blood pressure.
**Research on 19-OH-PGF2α has focused on areas like:**
* **Reproductive health:** Investigating the role of 19-OH-PGF2α in labor induction and other reproductive processes.
* **Inflammation:** Exploring its contribution to inflammatory disorders and potential therapeutic applications for managing inflammation.
* **Cardiovascular disease:** Analyzing its potential role in blood pressure regulation and its connection to cardiovascular diseases.
In summary, 19-OH-PGF2α is a significant metabolite of PGF2α with implications for various physiological functions. Research on this compound is valuable for understanding PGF2α activity, metabolism, and potential therapeutic applications.
19-hydroxyprostaglandin F: RN given refers to (5Z,9alpha,11alpha,13E,15S)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 6443315 |
| MeSH ID | M0084255 |
Synonyms (8)
| Synonym |
|---|
| 19-hydroxyprostaglandin f |
| (z)-7-[(1r,2r,3r,5s)-2-[(e,3s)-3,7-dihydroxyoct-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoic acid |
| 19-hydroxy-pgf |
| 19-hydroxy-pgf1 alpha |
| 19-oh pgf |
| 19-hydroxy-pgf2 alpha |
| prosta-5,13-dien-1-oic acid, 9,11,15,19-tetrahydroxy-, (5z,9alpha,11alpha,13e,15s)- |
| 56932-60-6 |
Research
Studies (15)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 14 (93.33) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 11.38
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 11.38 (24.57) | | Research Supply Index | 2.89 (2.92) | | Research Growth Index | 4.27 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (5.88%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 16 (94.12%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |