Compounds > naproxen

Page last updated: 2024-09-04

naproxen and alprostadil

naproxen has been researched along with alprostadil in 14 studies

Compound Research Comparison

Studies (naproxen)	Trials (naproxen)	Recent Studies (post-2010) (naproxen)	Studies (alprostadil)	Trials (alprostadil)	Recent Studies (post-2010) (alprostadil)
4,551	1,057	1,429	7,136	864	761

Protein Interaction Comparison

Protein	Taxonomy	naproxen (IC50)	alprostadil (IC50)
Multidrug resistance-associated protein 4	Homo sapiens (human)		2.3
Solute carrier organic anion transporter family member 2B1	Rattus norvegicus (Norway rat)		0.0358

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (21.43)	18.7374
1990's	3 (21.43)	18.2507
2000's	1 (7.14)	29.6817
2010's	7 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Gerson, CD; Gupta, R; Kornbluth, A	1
Huq, M	1
Aadland, E; Cohen, H; Fausa, O; Quinlan, D; Vatn, M	1
Bendvold, E; Bygdeman, M; Cai, QH; Eneroth, P; Gottlieb, C; Svanborg, K	1
Day, RO; Francis, H; Geisslinger, G; Vial, J; Williams, KM	1
Baldelli, F; Cipriani, S; D'Amore, C; Distrutti, E; Fiorucci, S; Francisci, D; Mencarelli, A; Renga, B; Santucci, L	1
Atli, O; Burukoglu, D; Ilgin, S; Perk, BO; Uzun, B	1

Trials

1 trial(s) available for naproxen and alprostadil

Article	Year
Protection by misoprostol against naproxen-induced gastric mucosal damage. The American journal of medicine, 1987, Jul-27, Volume: 83, Issue:1A Topics: Adolescent; Adult; Alprostadil; Anti-Ulcer Agents; Female; Gastric Mucosa; Gastroscopy; Humans; Male; Middle Aged; Misoprostol; Naproxen	1987

Other Studies

13 other study(ies) available for naproxen and alprostadil

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Life-threatening diarrhea after short-term misoprostol use in a patient with Crohn ileocolitis. Annals of internal medicine, 1990, Sep-15, Volume: 113, Issue:6 Topics: Alprostadil; Anti-Ulcer Agents; Crohn Disease; Diarrhea; Female; Humans; Middle Aged; Misoprostol; Naproxen; Peptic Ulcer	1990
Neurological adverse effects of naproxen and misoprostol combination. The British journal of general practice : the journal of the Royal College of General Practitioners, 1990, Volume: 40, Issue:339 Topics: Alprostadil; Anti-Ulcer Agents; Ataxia; Drug Therapy, Combination; Humans; Male; Middle Aged; Misoprostol; Naproxen; Stomach Ulcer	1990
The effect of naproxen on the concentration of prostaglandins in human seminal fluid. Fertility and sterility, 1985, Volume: 43, Issue:6 Topics: Alprostadil; Dinoprost; Humans; Male; Naproxen; Prostaglandins; Prostaglandins E; Prostaglandins F; Semen; Sperm Count; Sperm Motility	1985
Naproxen concentrations in plasma and synovial fluid and effects on prostanoid concentrations. The Journal of rheumatology, 1995, Volume: 22, Issue:12 Topics: Adult; Aged; Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis; Auranofin; Blood Proteins; Dinoprostone; Drug Administration Schedule; Female; Half-Life; Humans; Male; Middle Aged; Naproxen; Nonlinear Dynamics; Platelet Aggregation Inhibitors; Prostaglandins E; Serum Albumin; Synovial Fluid	1995
In vivo administration of ritonavir worsens intestinal damage caused by cyclooxygease inhibitors. European journal of pharmacology, 2014, Jan-15, Volume: 723 Topics: Alprostadil; Animals; Apoptosis; Aspirin; Chemokine CCL2; Cyclooxygenase Inhibitors; Dinoprostone; Drug Synergism; HIV Protease Inhibitors; HT29 Cells; Humans; Integrin alpha1beta1; Intestinal Mucosa; Intestine, Small; Ketoprofen; Mice; Mice, Inbred C57BL; Misoprostol; Naproxen; Nitric Oxide Synthase Type II; Ritonavir; RNA, Messenger; Tumor Necrosis Factor-alpha	2014
Evaluation of the reproductive toxicity of naproxen sodium and meloxicam in male rats. Human & experimental toxicology, 2015, Volume: 34, Issue:4 Topics: Alprostadil; Animals; Catalase; Cyclooxygenase Inhibitors; Dinoprostone; Follicle Stimulating Hormone; Glutathione; Glutathione Peroxidase; Luteinizing Hormone; Male; Meloxicam; Naproxen; Rats, Wistar; Sperm Count; Sperm Motility; Superoxide Dismutase; Testis; Testosterone; Thiazines; Thiazoles	2015