Page last updated: 2024-12-06

o,o-diisopropyl-s-benzylthiophosphate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

O,O-diisopropyl-S-benzylthiophosphate: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

iprobenfos : An organic thiophosphate that is the S-benzyl O,O-diisopropyl ester of phosphorothioic acid. Used as a rice fungicide to control leaf and ear blast, stem rot and sheath blight. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID33294
CHEMBL ID388384
CHEBI ID79737
SCHEMBL ID22179
MeSH IDM0054970

Synonyms (52)

Synonym
BIDD:ER0434
phosphorothioic acid, o,o-bis(1-methylethyl) s-(phenylmethyl) ester
kitazin p
einecs 247-449-0
o,o-bis(1-methylethyl) s-phenylmethyl phosphorothioate
s-benzyl diisopropylphosphorothiolate
o,o-diisopropyl-s-benzylthiophosphate
phosphorothioic acid, s-benzyl o,o-diisopropyl ester
o,o-diisopropyl s-benzyl thiophosphate
o,o-diisopropyl s-benzyl phosphorothiolate
o,o-diisopropyl-s-benzylester kyseliny thiofosforecne [czech]
o,o-bis(1-methylethyl) s-(phenylmethyl)phosphorothioate
brn 1974687
iprofenfos
s-benzyl diisopropyl phosphorothioate
ricid p
ricid ii
kitazin l
iprobenfos [bsi:iso]
iprobenfos
s-benzyl o,o-diisopropyl phosphorothioate
26087-47-8
CHEMBL388384
chebi:79737 ,
di(propan-2-yloxy)phosphorylsulfanylmethylbenzene
ov3yoe2895 ,
s-benzyl-o,o'-diisopropylphosphorothiolate
o,o-diisopropyl-s-benzylester kyseliny thiofosforecne
unii-ov3yoe2895
FT-0630522
AKOS015888320
iprobenfos [iso]
o,o-bis(1-methylethyl) s-(phenylmethyl) phosphorothioate
SCHEMBL22179
s-benzyl o,o-dipropan-2-yl phosphorothioate
o,o-diisopropyl s-benzyl phosphorothioate
s-benzyl o,o-diisopropyl thiophosphate
DTXSID7058040
bis(propan-2-yl) (benzylsulfanyl)phosphonate
iprobenfos, pestanal(r), analytical standard
iprobenfos 10 microg/ml in acetonitrile
iprobenfos 10 microg/ml in cyclohexane
o,o-bis(1-methylethyl) s-phenylmethyl phosphorothioate, 9ci
s-benzyl o,o-diisopropyl phosphorothioate, 8ci
J-016247
Q15632755
CS-0013929
iprobenfos 1000 microg/ml in acetone
isokitazine; kitazin 17; kitazin l; kitazin p;ibp
HY-B1863
BBA08747
s-benzyl-o,o-di-isopropyl phosphorothioate

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" A clear dose-response relationship was determined between inhibited ChE in adductor muscle of clams and four OPs (methidathion, chlorpyrifos, diazinon, IBP) which are heavily used OPs in Korea."( Acetylthiocholine (ATC)--cleaving cholinesterase (ChE) activity as a potential biomarker of pesticide exposure in the Manila clam, Ruditapes philippinarum, of Korea.
Choi, JY; Hong, GH; Kim, KT; Ra, K; Shin, KH; Yang, DB; Yu, J, 2011
)
0.37
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
phospholipid biosynthesis inhibitorAny compound that inhibits the biosynthesis of any phospholipid.
antifungal agrochemicalAny substance used in acriculture, horticulture, forestry, etc. for its fungicidal properties.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
organic thiophosphate
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID1099189Antimicrobial activity against Pythium sp. assessed as growth inhibition at 100 ppm by agar dilution method1996Bioscience, biotechnology, and biochemistry, May, Volume: 60, Issue:5
Synthesis and antifungal activity of cinnamic acid esters.
AID288188Permeability from apical to basolateral side of the Caco-2 cell membrane2007Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11
QSAR study on permeability of hydrophobic compounds with artificial membranes.
AID1099208Fungicidal activity against Pythium sp. assessed as fungal growth inhibition at 100 ppm by agar dilution method1997Bioscience, biotechnology, and biochemistry, Jan, Volume: 61, Issue:12
Synthesis and Fungicidal Activity of 6-Alkyl Six-membered Cyclic Thiophosphates.
AID1099206Fungicidal activity against Athelia rolfsii assessed as fungal growth inhibition at 100 ppm by agar dilution method1997Bioscience, biotechnology, and biochemistry, Jan, Volume: 61, Issue:12
Synthesis and Fungicidal Activity of 6-Alkyl Six-membered Cyclic Thiophosphates.
AID288185Permeability coefficient through artificial membrane in presence of stirred water layer2007Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11
QSAR study on permeability of hydrophobic compounds with artificial membranes.
AID1099187Antimicrobial activity against Athelia rolfsii assessed as growth inhibition at 10 ppm by agar dilution method1996Bioscience, biotechnology, and biochemistry, May, Volume: 60, Issue:5
Synthesis and antifungal activity of cinnamic acid esters.
AID288191Membrane retention in permeability experiment with artificial membrane2007Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11
QSAR study on permeability of hydrophobic compounds with artificial membranes.
AID1099207Fungicidal activity against Athelia rolfsii assessed as fungal growth inhibition at 10 ppm by agar dilution method1997Bioscience, biotechnology, and biochemistry, Jan, Volume: 61, Issue:12
Synthesis and Fungicidal Activity of 6-Alkyl Six-membered Cyclic Thiophosphates.
AID288184Permeability coefficient through artificial membrane in presence of unstirred water layer by PAMPA2007Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11
QSAR study on permeability of hydrophobic compounds with artificial membranes.
AID1099209Fungicidal activity against Pythium sp. assessed as fungal growth inhibition at 10 ppm by agar dilution method1997Bioscience, biotechnology, and biochemistry, Jan, Volume: 61, Issue:12
Synthesis and Fungicidal Activity of 6-Alkyl Six-membered Cyclic Thiophosphates.
AID1099188Antimicrobial activity against Pythium sp. assessed as growth inhibition at 10 ppm by agar dilution method1996Bioscience, biotechnology, and biochemistry, May, Volume: 60, Issue:5
Synthesis and antifungal activity of cinnamic acid esters.
AID288192Partition coefficient, log P of the compound2007Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11
QSAR study on permeability of hydrophobic compounds with artificial membranes.
AID288189Permeability from basolateral to apical side of the Caco-2 cell membrane2007Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11
QSAR study on permeability of hydrophobic compounds with artificial membranes.
AID1099186Antimicrobial activity against Athelia rolfsii assessed as growth inhibition at 100 ppm by agar dilution method1996Bioscience, biotechnology, and biochemistry, May, Volume: 60, Issue:5
Synthesis and antifungal activity of cinnamic acid esters.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (26)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (38.46)18.7374
1990's4 (15.38)18.2507
2000's6 (23.08)29.6817
2010's6 (23.08)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.16

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.16 (24.57)
Research Supply Index3.33 (2.92)
Research Growth Index4.49 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.16)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other27 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]