Page last updated: 2024-09-27

Femoracetabular Impingement

A pathological mechanical process that can lead to hip failure. It is caused by abnormalities of the ACETABULUM and/or FEMUR combined with rigorous hip motion, leading to repetitive collisions that damage the soft tissue structures.

Synonyms(4)

Synonym
Femoroacetabular Impingement
Femoroacetabular Impingement Syndrome
Femoro-Acetabular Impingement
Femoracetabular Impingement

Research Excerpts

Overview

ExcerptReference
"Femoroacetabular impingement is a well-described pre-arthritic condition with two main types; cam and pincer."( Apprich, S; Beck, M; Bittersohl, B; Kain, MS; Mamisch, TC; Siebenrock, KA; Werlen, S, 2011)

Treatment

ExcerptReference
"Open treatment of femoroacetabular impingement (FAI) through a surgical hip dislocation (SHD) approach has been reported to allow for improvement in pain and function."( Carry, PM; Kestel, L; Novais, EN; Sink, E; Strupp, K, 2018)

Research

Studies (112)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's71 (63.39)28.8240
2020's41 (36.61)9.53
DrugIndicatedRelationship StrengthStudiesTrials
acetaminophen0medium21
bupivacaine0medium42
celecoxib0medium21
glyphosate0low280
lidocaine0medium41
indomethacin0low10
iohexol0low10
ioversol0low10
tranexamic acid0medium11
methylprednisolone acetate0low10
triamcinolone acetonide0low10
methylprednisolone0low10
meglumine0low10
betamethasone0low10
hematoxylin0low10
s,n,n'-tripropylthiocarbamate0low10
chromium0low10
gadolinium0low110
gold0low10
trolamine salicylate0low90
fluorides0medium11
triamcinolone0medium11
cobalt0low10
naproxen0medium21
ropivacaine0low10
cortisone0low20
fibrin0low10
oxycodone0medium21
gadolinium dtpa0medium71
vendex0low60
chitosan0low30
mme0medium11
transforming growth factor beta0low10
alcian blue0low10

Protein Targets (427)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma7007
ATAD5 protein, partial4004
GLS protein3003
Microtubule-associated protein tau4004
Smad33003
aldehyde dehydrogenase 1 family, member A14004
thyroid stimulating hormone receptor3003
nuclear receptor subfamily 1, group I, member 32002
progesterone receptor9009
EWS/FLI fusion protein5005
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha7007
estrogen-related nuclear receptor alpha9009
estrogen nuclear receptor alpha130013
peroxisome proliferator activated receptor gamma4004
aryl hydrocarbon receptor4004
chromobox protein homolog 17007
thyroid hormone receptor beta isoform 23003
peripheral myelin protein 222002
cytochrome P450 3A4 isoform 16006
Gamma-aminobutyric acid receptor subunit pi6006
ATP-binding cassette sub-family C member 30909
Multidrug resistance-associated protein 40909
Solute carrier family 22 member 60303
Carbonic anhydrase 120202
UDP-glucuronosyltransferase 1A90001
Bile salt export pump0101
Voltage-dependent calcium channel gamma-2 subunit4004
Bile salt export pump011011
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 10404
Carbonic anhydrase 20404
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20001
Prostaglandin G/H synthase 10506
Carbonic anhydrase 30202
Cytochrome P450 3A40101
Cytochrome P450 2D60202
Cytochrome P450 2C9 0404
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit beta-16006
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta6006
Gamma-aminobutyric acid receptor subunit gamma-26006
UDP-glucuronosyltransferase 1-60001
Glutamate receptor 24004
Gamma-aminobutyric acid receptor subunit alpha-56006
Gamma-aminobutyric acid receptor subunit alpha-36006
Arachidonate 5-lipoxygenase-activating protein0101
UDP-glucuronosyltransferase 1A1 0001
Carbonic anhydrase 40303
Prostaglandin G/H synthase 10506
Carbonic anhydrase 60202
Gamma-aminobutyric acid receptor subunit gamma-16006
Gamma-aminobutyric acid receptor subunit alpha-26006
Gamma-aminobutyric acid receptor subunit alpha-46006
Gamma-aminobutyric acid receptor subunit gamma-36006
Gamma-aminobutyric acid receptor subunit alpha-66006
Carbonic anhydrase 5A, mitochondrial0202
Prostaglandin G/H synthase 206210
Carbonic anhydrase 70202
Nuclear receptor ROR-gamma3003
Cytochrome P450 2J20303
Gamma-aminobutyric acid receptor subunit alpha-16107
Gamma-aminobutyric acid receptor subunit beta-36006
Gamma-aminobutyric acid receptor subunit beta-26006
Carbonic anhydrase 90303
GABA theta subunit6006
Canalicular multispecific organic anion transporter 10909
Carbonic anhydrase 150303
Carbonic anhydrase 130101
Gamma-aminobutyric acid receptor subunit epsilon6006
Carbonic anhydrase 140202
Carbonic anhydrase 5B, mitochondrial0202
toxin B0001
pregnane X receptor3003
GLI family zinc finger 36006
AR protein110011
cytochrome P450 family 3 subfamily A polypeptide 46006
glucocorticoid receptor [Homo sapiens]100010
farnesoid X nuclear receptor3003
pregnane X nuclear receptor7007
vitamin D (1,25- dihydroxyvitamin D3) receptor8008
IDH16006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a7007
nuclear receptor subfamily 1, group I, member 25005
thyroid hormone receptor beta isoform a4004
nuclear factor erythroid 2-related factor 2 isoform 27007
galanin receptor type 30101
nuclear factor erythroid 2-related factor 2 isoform 15005
Glucocorticoid receptor010010
Glycine receptor subunit alpha-1010010
Glycine receptor subunit beta010010
Glycine receptor subunit alpha-2010010
Glycine receptor subunit alpha-3010010
ORF730011
Potassium channel subfamily K member 30303
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20112
Potassium channel subfamily K member 90101
Chain A, Carbonic anhydrase II0101
Chain A, Cruzipain2002
Carbonic anhydrase 0001
Carbonic anhydrase 0101
GTP-binding protein (rab7)0011
ras protein, partial0011
glp-1 receptor, partial2002
hypoxia-inducible factor 1 alpha subunit4004
SMAD family member 26006
USP1 protein, partial3003
PPM1D protein3003
SMAD family member 36006
TDP1 protein7007
caspase 7, apoptosis-related cysteine protease1001
estrogen receptor 2 (ER beta)2002
G4004
cytochrome P450 2D62002
Carbonic anhydrase 0101
Carbonic anhydrase 0101
67.9K protein3003
peroxisome proliferator-activated receptor delta5005
Carbonic anhydrase0101
Rac1 protein0011
caspase-31001
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
thyroid stimulating hormone receptor1001
activating transcription factor 62002
thyrotropin-releasing hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
v-jun sarcoma virus 17 oncogene homolog (avian)2002
Histone H2A.x1001
Caspase-71001
interferon gamma precursor0001
prostaglandin E2 receptor EP2 subtype0001
potassium voltage-gated channel subfamily H member 2 isoform d1001
caspase-31001
heat shock protein beta-15005
geminin9009
lamin isoform A-delta107007
Prostaglandin E synthase0202
Histone deacetylase 30101
3-phosphoinositide-dependent protein kinase 10101
Prostaglandin G/H synthase 1 0304
Prostaglandin G/H synthase 2 0203
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Cytochrome c oxidase subunit 10101
Cytochrome c oxidase subunit 20101
Catechol O-methyltransferase0101
Cytochrome c oxidase subunit 20202
Interferon beta5005
HLA class I histocompatibility antigen, B alpha chain 4004
Cellular tumor antigen p533003
Procathepsin L0202
Aldo-keto reductase family 1 member B10202
Seed linoleate 13S-lipoxygenase-10101
Neuronal acetylcholine receptor subunit alpha-40202
Polyunsaturated fatty acid 5-lipoxygenase0101
Quinolone resistance protein NorA0101
Adenosine receptor A30202
Neuronal acetylcholine receptor subunit beta-20202
Beta-3 adrenergic receptor0202
Alpha-1B adrenergic receptor0202
Calpain-2 catalytic subunit0101
Alpha-2B adrenergic receptor0202
5-hydroxytryptamine receptor 1A0101
D(1A) dopamine receptor0202
Prostaglandin G/H synthase 10202
Sodium-dependent noradrenaline transporter 0202
Adenosine receptor A10303
Cruzipain0101
Sodium/hydrogen exchanger 10101
Indoleamine 2,3-dioxygenase 10202
Sodium-dependent serotonin transporter0202
Sodium-dependent serotonin transporter0011
Delta-type opioid receptor0101
Delta-type opioid receptor0202
Mu-type opioid receptor0202
Bifunctional epoxide hydrolase 20202
Prostaglandin G/H synthase 2 0304
Carbonic anhydrase0202
Alpha-1A adrenergic receptor0202
Urotensin-2 receptor0101
Carbonic anhydrase0101
Histone deacetylase 40101
Ras-related protein Rab-2A0011
D(2) dopamine receptor0101
Prostaglandin G/H synthase 20505
Carbonic anhydrase 0101
Mu-type opioid receptor0202
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Sodium-dependent dopamine transporter 0202
Prostaglandin G/H synthase 20203
Histone deacetylase 10101
Mitogen-activated protein kinase 140101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase0101
Carbonic anhydrase 0101
Sigma intracellular receptor 20202
Delta carbonic anhydrase0101
Prostaglandin G/H synthase 1 0304
Carbonic anhydrase 0101
Prostaglandin G/H synthase 10101
Carbonic anhydrase 130101
Cyclooxygenase-2 0101
Histone deacetylase 70101
Rap guanine nucleotide exchange factor 41001
Inositol hexakisphosphate kinase 14004
Histone deacetylase 20101
Carbonic anhydrase 40202
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
ATPase family AAA domain-containing protein 55005
Ataxin-26006
Histone deacetylase 80101
P2Y purinoceptor 120202
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
cytochrome P450 2C9, partial4004
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
endonuclease IV1001
dopamine D1 receptor1001
thioredoxin reductase5005
regulator of G-protein signaling 42002
euchromatic histone-lysine N-methyltransferase 27007
peripheral myelin protein 22 isoform 13003
atrial natriuretic peptide receptor 1 precursor1001
flap endonuclease 13003
survival motor neuron protein isoform d2002
M-phase phosphoprotein 82002
muscarinic acetylcholine receptor M12002
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0101
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 432002
Multidrug and toxin extrusion protein 10303
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Glutamine synthetase 0101
Cytochrome P450 71B10102
Glutamine synthetase 0101
2-dehydro-3-deoxyphosphooctonate aldolase0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain E, Fibrin beta chain0101
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, 2-oxoglutarate Oxygenase2002
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, RNA-directed RNA polymerase NS50101
Luciferase3003
15-lipoxygenase, partial1001
WRN1001
Mcl-10101
phosphopantetheinyl transferase2002
MPI protein0101
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)0001
alkaline phosphatase, intestinal0011
thioredoxin glutathione reductase2002
apical membrane antigen 1, AMA11001
hypothetical protein, conserved1001
glucocerebrosidase2002
luciferase1001
bromodomain adjacent to zinc finger domain 2B3003
pyruvate kinase1001
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
CDK50001
serine-protein kinase ATM isoform a1001
lysosomal alpha-glucosidase preproprotein1001
major prion protein preproprotein Prp precursor0101
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0011
cellular tumor antigen p53 isoform a1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
vitamin D3 receptor isoform VDRA3003
glucose-6-phosphate 1-dehydrogenase isoform b0101
intestinal alkaline phosphatase precursor0011
DNA polymerase beta1001
mitogen-activated protein kinase 12002
serine/threonine-protein kinase PLK11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)2002
nuclear receptor ROR-gamma isoform 13003
lethal(3)malignant brain tumor-like protein 1 isoform I1001
DNA polymerase kappa isoform 13003
Vif0101
Tat0101
histone acetyltransferase KAT2A isoform 11001
DNA dC->dU-editing enzyme APOBEC-3G isoform 10101
alkaline phosphatase, germ cell type preproprotein0011
endoribonuclease toxin MazF0011
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Rap guanine nucleotide exchange factor 31001
Integrin beta-31001
Integrin alpha-IIb1001
Pyruvate kinase PKM0101
Endothelin receptor type B1001
Endothelin-1 receptor1001
Histamine H2 receptor2002
Inositol monophosphatase 11001
phosphoglycerate kinase1001
hypothetical protein CAALFM_CR05890CA0001
H3 histone acetyltransferase0001
ATP-dependent phosphofructokinase2002
large T antigen0101
Chain A, membrane-associated prostaglandin E synthase-20101
interleukin 81001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
Parkin1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
cytochrome P450 2D6 isoform 11001
cytochrome P450 2C9 precursor1001
ras-related protein Rab-9A2002
serine/threonine-protein kinase mTOR isoform 11001
neuropeptide S receptor isoform A1001
Prostaglandin-H2 D-isomerase0101
3',5'-cyclic-AMP phosphodiesterase 0101
Solute carrier organic anion transporter family member 2B1 0202
Epidermal growth factor receptor0101
Phospholipase A2, major isoenzyme0101
Albumin0213
ATP-dependent translocase ABCB10101
Interleukin-80101
Androgen receptor0011
Polyunsaturated fatty acid 5-lipoxygenase0205
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member C40202
Sodium-dependent dopamine transporter0101
Sodium- and chloride-dependent GABA transporter 10101
Thromboxane-A synthase 0101
Serum paraoxonase/arylesterase 10101
Caspase-10203
Nitric oxide synthase, inducible0101
Adenosine receptor A2a0202
Substance-P receptor0101
Prostaglandin E2 receptor EP3 subtype0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Prostaglandin E2 receptor EP4 subtype0101
Multidrug resistance-associated protein 1 0101
Prostaglandin E2 receptor EP1 subtype0101
Peroxisome proliferator-activated receptor gamma0011
Aldo-keto reductase family 1 member C30303
Sodium- and chloride-dependent betaine transporter0101
C-X-C chemokine receptor type 30101
Aldo-keto reductase family 1 member C2 0202
Spike glycoprotein3003
Guanine nucleotide-binding protein G1001
Prostaglandin D2 receptor 0202
Solute carrier organic anion transporter family member 1A30101
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10202
Potassium voltage-gated channel subfamily H member 20303
Uracil nucleotide/cysteinyl leukotriene receptor0101
Solute carrier family 22 member 60202
Solute carrier family 22 member 70001
Prostaglandin E2 receptor EP2 subtype0101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 80101
Dehydrogenase/reductase SDR family member 90101
Solute carrier organic anion transporter family member 1B30202
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Solute carrier organic anion transporter family member 1B10202
NPC intracellular cholesterol transporter 1 precursor1001
Fatty acid-binding protein, liver0101
Fatty acid-binding protein, intestinal0112
Caspase-30202
Caspase-40202
Caspase-50202
Caspase-90202
Cell division control protein 42 homolog0101
Ras-related C3 botulinum toxin substrate 10101
Serine/threonine-protein kinase PAK 10101
Chain A, Beta-lactamase2002
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Potassium voltage-gated channel subfamily A member 50101
Sodium channel protein type 4 subunit alpha0101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Sodium channel protein type 3 subunit alpha0101
acetylcholinesterase1001
nonstructural protein 11001
muscleblind-like protein 1 isoform 12002
Nuclear receptor subfamily 1 group I member 20011
Androgen receptor0202
Nuclear receptor subfamily 1 group I member 20011
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Glucose-6-phosphate 1-dehydrogenase0101
Dihydrofolate reductase0101
Hormone-sensitive lipase0101
Solute carrier family 22 member 1 0101
Acetylcholinesterase0101
Kappa-type opioid receptor0011
Kappa-type opioid receptor0101
Mu-type opioid receptor0112
Delta-type opioid receptor0011
Kappa-type opioid receptor0101
Kappa-type opioid receptor0011
Mu-type opioid receptor0011
Sigma non-opioid intracellular receptor 10101
Chain A, PLASMINOGEN0011
Chain A, PLASMINOGEN0011
Plasminogen0213
Urokinase-type plasminogen activator0101
NFKB1 protein, partial1001
arylsulfatase A1001
Bloom syndrome protein isoform 11001
procathepsin L isoform 1 preproprotein0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]