Compounds > naproxen
Page last updated: 2024-09-04

naproxen and orphenadrine

naproxen has been researched along with orphenadrine in 5 studies

Compound Research Comparison

Studies
(naproxen)		Trials
(naproxen)		Recent Studies (post-2010)
(naproxen)		Studies
(orphenadrine)		Trials
(orphenadrine)		Recent Studies (post-2010) (orphenadrine)
4,5511,0571,4295416159

Protein Interaction Comparison

ProteinTaxonomynaproxen (IC50)orphenadrine (IC50)
Solute carrier family 22 member 2Homo sapiens (human)2.5
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.534
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)2.666
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.376
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.125
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.028
Alpha-2A adrenergic receptorHomo sapiens (human)2.156
Cytochrome P450 2D6Homo sapiens (human)0.4
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.148
Alpha-2B adrenergic receptorHomo sapiens (human)1.895
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.175
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.666
Histamine H2 receptorHomo sapiens (human)6.961
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.436
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.534
Sodium-dependent serotonin transporterHomo sapiens (human)0.458
Histamine H1 receptorHomo sapiens (human)1.241
5-hydroxytryptamine receptor 2BHomo sapiens (human)3.391
5-hydroxytryptamine receptor 6Homo sapiens (human)1.121
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.8511

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Cisewski, D; Davitt, M; Friedman, BW; Gallagher, EJ; Irizarry, E; Nassery, A; Pearlman, S; Solorzano, C; White, D1

Reviews

1 review(s) available for naproxen and orphenadrine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for naproxen and orphenadrine

ArticleYear
A Randomized, Double-Blind, Placebo-Controlled Trial of Naproxen With or Without Orphenadrine or Methocarbamol for Acute Low Back Pain.
    Annals of emergency medicine, 2018, Volume: 71, Issue:3

    Topics: Acute Pain; Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Emergency Service, Hospital; Female; Follow-Up Studies; Humans; Low Back Pain; Male; Methocarbamol; Muscle Relaxants, Central; Naproxen; Orphenadrine; Pain Measurement; Time Factors; Treatment Outcome

2018

Other Studies

3 other study(ies) available for naproxen and orphenadrine

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012