Compounds > croneton
Page last updated: 2024-12-06

croneton

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

croneton: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID34766
CHEMBL ID493480
CHEBI ID38483
SCHEMBL ID74938
MeSH IDM0058261

Synonyms (73)

Synonym
caswell no. 263aa
carbamic acid, methyl-, alpha-(ethylthio)-o-tolyl ester
einecs 249-981-9
arylmate
ethiophencarbe [iso-french]
2-ethylthiomethylphenyl n-methylcarbamate
(2-ethylthiomethyl-phenyl)-n-methylcarbamate
ethiofencarb [bsi:iso]
croneton 500
ai3-29007
phenol, 2-((ethylthio)methyl)-, methylcarbamate
2-ethyl-mercaptomethyl-phenyl-n-methylcarbamate
alpha-(ethylthio)-o-tolyl methylcarbamate [iso:bsi]
brn 2973224
chox 1901
bay-hox-1901
kronetone
hox 1901
epa pesticide chemical code 112101
carbamic acid, methyl-, 2-(ethylthiomethyl)phenyl ester
hsdb 7140
alpha-(ethylthio)-o-tolyl methylcarbamate
29973-13-5
2-((ethylthio)methyl)phenyl methylcarbamate
croneton
ethiofencarb
CHEBI:38483 ,
2-[(ethylsulfanyl)methyl]phenyl methylcarbamate
2-((ethylthio)methyl)phenol methylcarbamate
alpha-ethylthio-o-tolyl methylcarbamate
NCGC00163882-01
bdbm50253090
[2-(ethylsulfanylmethyl)phenyl] n-methylcarbamate
CHEMBL493480 ,
inchi=1/c11h15no2s/c1-3-15-8-9-6-4-5-7-10(9)14-11(13)12-2/h4-7h,3,8h2,1-2h3,(h,12,13)
heznviyqeuhlni-uhfffaoysa-
C18649
tox21_301356
NCGC00255441-01
dtxsid3037545 ,
cas-29973-13-5
dtxcid1017545
fy0yb813xv ,
ethiophencarbe
unii-fy0yb813xv
carbamic acid, methyl-,2-(ethylthiomethyl)phenyl ester
AKOS015888329
phenol, 2-((ethylthio)methyl)-, 1-(n-methylcarbamate
.alpha.-(ethylthio)-o-tolyl methylcarbamate
croneton-500
ethiofencarb [hsdb]
bay-hox 1901
carbamic acid, methyl-, .alpha.-(ethylthio)-o-tolyl ester
chox-1901
ethiofencarb [iso]
2-((ethylthio)methyl)phenyl n-methylcarbamate
hox-1901
o-cresol, .alpha.-(ethylthio)-, methylcarbamate
.alpha.-ethylthio-o-tolyl methylcarbamate
SCHEMBL74938
phenol, 2-[(ethylthio)methyl]-, methylcarbamate
2-[(ethylsulfanyl)methyl]phenyl n-methylcarbamate
ethiofencarb, pestanal(r), analytical standard
mfcd00055463
2-[(ethylthio)methyl]phenyl n-methylcarbamate
ethiofencarb 100 microg/ml in cyclohexane
2-(ethylthiomethyl)phenyl methylcarbamate, 9ci
phenol, 2-((ethylthio)methyl)-, methylcarbamate (9ci)
n-methyl-o-(2-ethylthiomethyl) phenylcarbamate
J-017713
alpha-ethylthio-o-tolylmethyl carbamate
2-(ethylthiomethyl)phenyl methylcarbamate
Q3591963
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
carbamate insecticideDerivatives of carbamic acid with insecticidal properties of general formula ROC(=O)NR(1)R(2), where ROH is an alcohol, oxime, or phenol and R(1) is hydrogen or methyl. Like organophosphate insecticides, they are cholinesterase inhibitors, but carbamate insecticides differ in action from the organophosphates in that the inhibitory effect on cholinesterase is generally brief.
EC 3.1.1.7 (acetylcholinesterase) inhibitorAn EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid.
agrochemicalAn agrochemical is a substance that is used in agriculture or horticulture.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
carbamate esterAny ester of carbamic acid or its N-substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (6)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
acetylcholinesteraseHomo sapiens (human)Potency17.49230.002541.796015,848.9004AID1347395; AID1347397; AID1347398
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency15.31110.001022.650876.6163AID1224838; AID1224839; AID1224893
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency0.19490.000214.376460.0339AID720691
pregnane X nuclear receptorHomo sapiens (human)Potency70.79460.005428.02631,258.9301AID720659
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency34.37620.000627.21521,122.0200AID651741
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Hormone-sensitive lipaseRattus norvegicus (Norway rat)IC50 (µMol)0.37000.37001.27003.2500AID390722
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (2)

Processvia Protein(s)Taxonomy
lipid dropletHormone-sensitive lipaseRattus norvegicus (Norway rat)
cytosolHormone-sensitive lipaseRattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID390724Inhibition of HSL in Wistar rat isolated fat cells at 10 uM by spectrophotometric assay2008Journal of medicinal chemistry, Oct-23, Volume: 51, Issue:20
Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of new potent hormone sensitive lipase inhibitors.
AID390722Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay2008Journal of medicinal chemistry, Oct-23, Volume: 51, Issue:20
Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of new potent hormone sensitive lipase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (36.36)18.7374
1990's4 (36.36)18.2507
2000's2 (18.18)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index19.47 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.27 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index3.00 (0.95)

This Compound (19.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (8.33%)4.05%
Observational0 (0.00%)0.25%
Other11 (91.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbamates
[no description available]		3.69100amino-acid anion
bendiocarb
bendiocarb: FICAM 80W contains 80% of the above chemical cpd as the active ingredient		2.1110benzodioxoles;
carbamate ester		agrochemical;
carbamate insecticide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
benzyl benzoate
benzyl benzoate: structure; acarosan, a moist powder composed of wetted cellulose and benzyl benzoate, is used on carpets as an acaricide. benzyl benzoate : A benzoate ester obtained by the formal condensation of benzoic acid with benzyl alcohol. It has been isolated from the plant species of the genus Polyalthia.		2.0410benzoate ester;
benzyl ester		acaricide;
plant metabolite;
scabicide
fenvalerate
fenvalerate: synthetic pyrethroid; RN given refers to cpd without isomeric designation; structure. fenvalerate : A carboxylic ester obtained by formal condensation between 2-(4-chlorophenyl)-3-methylbutyric acid and cyano(3-phenoxyphenyl)methanol.		2.0410aromatic ether;
carboxylic ester;
monochlorobenzenes		pyrethroid ester acaricide;
pyrethroid ester insecticide
malathion
Malathion: A wide spectrum aliphatic organophosphate insecticide widely used for both domestic and commercial agricultural purposes.. malathion : A racemate comprising equimolar amounts of (R) and (S)-malathion. It is a broad spectrum organophosphate proinsecticide used to control a wide range of pests including Coleoptera, Diptera, fruit flies, mosquitos and spider mites.. diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate : A diester that is diethyl succinate in which position 2 is substituted by a (dimethoxyphosphorothioyl)thio group.		1.9910diester;
ethyl ester;
organic thiophosphate
oxybenzone
oxybenzone : A hydroxybenzophenone that is benzophenone which is substituted at the 2- and 4-positions of one of the benzene rings by hydroxy and methoxy groups respectively.		2.0410hydroxybenzophenone;
monomethoxybenzene		dermatologic drug;
environmental contaminant;
protective agent;
ultraviolet filter;
xenobiotic
ovex
ovex: structure		2.0410arenesulfonic acid
boric acid
[no description available]		1.9710boric acidsastringent
dibenzoylmethane
dibenzoylmethane : A beta-diketone that is acetylacetone (acac) in which both methyl groups have been replaced by phenyl groups. It is a minor constituent of the root extract of licorice (Glycyrrhiza glabra) and exhibits antimutagenic and anticancer effects.		2.0410aromatic ketone;
beta-diketone		antimutagen;
antineoplastic agent;
metabolite
3-hydroxyflavone
3-hydroxyflavone: structure given in first source. flavonol : A monohydroxyflavone that is the 3-hydroxy derivative of flavone.		2.0410flavonols;
monohydroxyflavone
bpmc
BPMC: structure. fenobucarb : A carbamate ester obtained by the formal condensation of 2-sec-butylphenol with methylcarbamic acid.		2.1110carbamate esteragrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
environmental contaminant;
herbicide;
insecticide
fenitrothion
Fenitrothion: An organothiophosphate cholinesterase inhibitor that is used as an insecticide.. fenitrothion : An organic thiophosphate that is O,O-dimethyl O-phenyl phosphorothioate substituted by a methyl group at position 3 and a nitro group at position 4.		1.9910C-nitro compound;
organic thiophosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
insecticide
pirimicarb
pirimicarb: structure. pirimicarb : An aminopyrimidine that is N,N,4,5-tetramethylpyrimidin-2-amine substituted by a (dimethylcarbamoyl)oxy group at position 4.		1.9910aminopyrimidine;
carbamate ester;
tertiary amino compound		agrochemical;
carbamate insecticide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
environmental contaminant;
insecticide;
xenobiotic
bifenox
[no description available]		2.0410nitrobenzoic acid
fenpropathrin, (+-)-isomer
fenpropathrin: RN given refers to cpd without isomeric designation. fenpropathrin : A cyclopropanecarboxylate ester obtained by formal condensation between 2,2,3,3-tetramethylcyclopropanecarboxylic acid and cyano(3-phenoxyphenyl)methanol.		2.0410aromatic ether;
cyclopropanecarboxylate ester		agrochemical;
pyrethroid ester acaricide;
pyrethroid ester insecticide
romucide
[no description available]		1.9710
naproxen
Naproxen: An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.. naproxen : A methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes.		2.0410methoxynaphthalene;
monocarboxylic acid		antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
gout suppressant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
capsaicin
ALGRX-4975: an injectable capsaicin (TRPV1 receptor agonist) formulation for longlasting pain relief. capsaicinoid : A family of aromatic fatty amides produced as secondary metabolites by chilli peppers.		2.0410capsaicinoidnon-narcotic analgesic;
TRPV1 agonist;
voltage-gated sodium channel blocker
2-Phenylethyl 3-phenyl-2-propenoate
[no description available]		2.0410cinnamate ester
pydrin, (s-(r*,r*))-isomer
[no description available]		2.0410fenvalerateagrochemical;
pyrethroid ester insecticide
ConditionIndicatedRelationship StrengthStudiesTrials
Edema, Pulmonary
[description not available]		02.0510
Pulmonary Edema
Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.		02.0510
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.6630
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.6630
Experimental Hepatoma
[description not available]		01.9910
Embryopathies
[description not available]		01.9710
Delayed Effects, Prenatal Exposure
[description not available]		01.9710