1,3,5-triaza-7-phosphaadamantane profile

1,3,5-triaza-7-phosphaadamantane, also known as **PTA**, is a cage-like organic compound with a unique structure consisting of a phosphorus atom and three nitrogen atoms arranged in a rigid adamantane-like framework. It's an important molecule in research due to its fascinating properties and diverse applications.

**Key Properties:**

* **High Stability:** The rigid structure of PTA makes it very stable, resistant to decomposition and oxidation.
* **Strong Donor:** The lone pair of electrons on the phosphorus atom makes PTA a strong donor ligand.
* **Versatile Coordination Chemistry:** PTA can form stable complexes with various metal ions, including both transition and main group metals.
* **Biocompatibility:** PTA exhibits low toxicity and good biocompatibility, making it suitable for biological applications.

**Importance in Research:**

**1. Catalysis:**
* PTA is a highly effective ligand for various catalytic reactions, including:
* **Homogeneous Catalysis:** In transition metal-catalyzed reactions like C-H activation, hydrogenation, and cross-coupling reactions.
* **Heterogeneous Catalysis:** As a component in catalyst supports, enhancing stability and activity.
* The strong donor ability and stability of PTA contribute to efficient catalyst design and performance.

**2. Material Science:**
* PTA-based materials exhibit interesting properties:
* **Luminescence:** PTA complexes can exhibit fluorescence and phosphorescence, making them potential candidates for optoelectronic applications.
* **Conducting Polymers:** PTA can be incorporated into conducting polymers to enhance their properties.
* **Nanomaterials:** PTA can be used in the synthesis and functionalization of nanoparticles, contributing to their stability and reactivity.

**3. Biological Applications:**
* PTA's biocompatibility makes it a promising molecule for:
* **Drug Delivery:** As a carrier for drug delivery, PTA can target specific cells and tissues.
* **Medical Imaging:** PTA complexes can act as contrast agents for magnetic resonance imaging (MRI).
* **Biomolecule Labeling:** PTA can be used to label proteins and other biomolecules for various studies.

**4. Theoretical Studies:**
* The unique structure and properties of PTA have also attracted attention from theoretical chemists for studying:
* **Electron Density Distribution:** Understanding the electronic structure and bonding within PTA.
* **Reactivity Predictions:** Modeling the reactivity of PTA and its complexes.

**In summary, 1,3,5-triaza-7-phosphaadamantane (PTA) is a versatile and important molecule in research due to its high stability, strong donor ability, versatile coordination chemistry, and biocompatibility. Its applications span diverse fields, including catalysis, material science, biology, and theoretical chemistry.**

1,3,5-triaza-7-phosphaadamantane: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	143061
SCHEMBL ID	270566
SCHEMBL ID	22993970
MeSH ID	M0486589

Synonym
1,3,5-triaza-7-phosphaadamantane
1,3,5-triaza-7-phosphatricyclo(3.3.1.13,7)decane
nsc266642
nsc-266642
1,5-triaza-7-phosphatricyclo[3.3.1.13,7]decane
53597-69-6
1,5-triaza-9-phospha-adamantane
unii-6w8jqp73m4
6w8jqp73m4 ,
nsc 266642
PTW ,
1,3,5-triaza-7-phosphatricyclo[3.3.1.1~3,7~]decane
1,3,5-triaza-7-phosphatricyclo[3.3.1.13,7]decane
SCHEMBL270566
mfcd00154905
1,3,5-triaza-7-phosphatricyclo[3.3.1.1(3,7)]decane
AKOS025214125
DTXSID40201812
1,3,5-triaza-7-phosphaadamantane, 97%
1,3,5-triaza-7-phosphatricyclo[3.3.1.1(3),?]decane
AS-61189
SCHEMBL22993970
A870679
Q27464577
1,3,5-triaza-7-phosphatricyclo[3.3.1.1^{3,7]decane
1,3,5-triaza-7-phospha-adamantane
D94687
1,3,5-triaza-7-phosphatricyclo(3.3.1.1 3,7)decane
CS-0107716
c6h12n3p
1,3,5-triaza-7-phosphatricyclo[3.3.1.1,3,7]decane
EN300-7645225
SY068374

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	9 (20.45)	29.6817
2010's	30 (68.18)	24.3611
2020's	5 (11.36)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (2.27%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	43 (97.73%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
betaine glycine betaine : The amino acid betaine derived from glycine.	7.25	1	amino-acid betaine; glycine derivative	fundamental metabolite
bromide Bromides: Salts of hydrobromic acid, HBr, with the bromine atom in the 1- oxidation state. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	2.49	2	halide anion; monoatomic bromine
chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion.	2.13	1	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite
glutaric acid glutaric acid: RN given refers to parent cpd. glutaric acid : An alpha,omega-dicarboxylic acid that is a linear five-carbon dicarboxylic acid.	2.13	1	alpha,omega-dicarboxylic acid; dicarboxylic fatty acid	Daphnia magna metabolite; human metabolite
malonic acid malonic acid : An alpha,omega-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group.. dicarboxylic acid : Any carboxylic acid containing two carboxy groups.	2.13	1	alpha,omega-dicarboxylic acid	human metabolite
pyridine azine : An organonitrogen compound of general structure RCH=N-N=CHR or RR'C=N-N=CRR'.	7.08	1	azaarene; mancude organic heteromonocyclic parent; monocyclic heteroarene; pyridines	environmental contaminant; NMR chemical shift reference compound
1,10-phenanthroline 1,10-phenanthroline: RN given refers to parent cpd; inhibits Zn-dependent metalloproteinases	2.15	1	phenanthroline	EC 2.7.1.1 (hexokinase) inhibitor; EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor
2,2'-dipyridyl 2,2'-Dipyridyl: A reagent used for the determination of iron.. 2,2'-bipyridine : A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'.	2.66	2	bipyridine	chelator; ferroptosis inhibitor
pyrithione pyrithione: split from cephalosporin molecule; some metal complexes of this have fumarate reductase inhibitory activity and may be useful against trypanosomes; RN given refers to parent cpd; structure. pyrithione : A pyridinethione that is pyridine-2(1H)-thione in which the hydrogen attached to the nitrogen is replaced by a hydroxy group. It is a Zn(2+) ionophore; the zinc salt is used as an antifungal and antibacterial agent.	2.21	1	monohydroxypyridine; pyridinethione	ionophore
theophylline [no description available]	7.06	1	dimethylxanthine	adenosine receptor antagonist; anti-asthmatic drug; anti-inflammatory agent; bronchodilator agent; drug metabolite; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; fungal metabolite; human blood serum metabolite; immunomodulator; muscle relaxant; vasodilator agent
chloroquine Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.	2.21	1	aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug
ethylenediamine ethylenediamine: RN given refers to parent cpd; edamine is the recommended contraction for the ethylenediamine radical. ethylenediamine : An alkane-alpha,omega-diamine in which the alkane is ethane.	2.04	1	alkane-alpha,omega-diamine	GABA agonist
ibuprofen Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine	2.21	1	monocarboxylic acid	antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; environmental contaminant; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; radical scavenger; xenobiotic
stearic acid octadecanoic acid : A C18 straight-chain saturated fatty acid component of many animal and vegetable lipids. As well as in the diet, it is used in hardening soaps, softening plastics and in making cosmetics, candles and plastics.	2.15	1	long-chain fatty acid; saturated fatty acid; straight-chain saturated fatty acid	algal metabolite; Daphnia magna metabolite; human metabolite; plant metabolite
methanesulfonic acid [no description available]	2.48	2	alkanesulfonic acid; one-carbon compound	Escherichia coli metabolite
4-cymene 4-cymene: structure. p-cymene : A monoterpene that is toluene substituted by an isopropyl group at position 4.	2.13	1	monoterpene; toluenes	human urinary metabolite; plant metabolite; volatile oil component
indazoles Indazoles: A group of heterocyclic aromatic organic compounds consisting of the fusion of BENZENE and PYRAZOLES.	2.13	1	indazole
adamantane Adamantane: A tricyclo bridged hydrocarbon.	6.28	43	adamantanes; polycyclic alkane
tristearin tristearoylglycerol : A triglyceride that is glycerol in which all three hydroxy groups have been formally esterified with stearic acid.	2.07	1	triacylglycerol 54:0	Caenorhabditis elegans metabolite; plant metabolite
iridium Iridium: A metallic element with the atomic symbol Ir, atomic number 77, and atomic weight 192.22.	2.49	2	cobalt group element atom; platinum group metal atom
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	9.1	4	metal allergen; nickel group element atom; platinum group metal atom
platinum Platinum: A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as alutiae.	8.02	4	elemental platinum; nickel group element atom; platinum group metal atom
rhenium Rhenium: A metal, atomic number 75, atomic weight 186.207, symbol Re.	7.46	2	manganese group element atom
ruthenium Ruthenium: A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.	8.91	11	iron group element atom; platinum group metal atom
silver Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.	3.04	4	copper group element atom; elemental silver	Escherichia coli metabolite
gold Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.	2.77	3	copper group element atom; elemental gold
palladium chloride palladium chloride: RN given refers to parent cpd; structure. palladium(II) chloride : A palladium coordination entity consisting of palladium(II) bound to two chlorine atoms.	2.06	1	palladium coordination entity	catalyst
phosphine phosphane : The simplest phosphine, consisting of a single phosphorus atom with three hydrogens attached.. phosphine : Phosphane (PH3) and compounds derived from it by substituting one, two or three hydrogen atoms by hydrocarbyl groups: RPH2, R2PH, R3P (R =/= H) are called primary, secondary and tertiary phosphines, respectively. A specific phosphine is preferably named as a substituted phosphane.	2.78	3	mononuclear parent hydride; phosphanes; phosphine	carcinogenic agent; fumigant insecticide
deuterium Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.	2.13	1	dihydrogen
azides Azides: Organic or inorganic compounds that contain the -N3 group.. azide : Any nitrogen molecular entity containing the group -N3.	2.04	1	pseudohalide anion	mitochondrial respiratory-chain inhibitor
benzeneboronic acid [no description available]	2.06	1	boronic acids
1,7-phenanthroline [no description available]	2.15	1	phenanthroline
nalidixate sodium tris(hydroxymethyl)phosphine: coupling reagent for enzyme immobilization	2.04	1
1-(2-pyridinyl)piperazine 1-(2-pyridinyl)piperazine: metabolite of buspirone & gepirone	2.06	1
perrhenate perrhenate: RN given refers to cpd with MF of O4-Re	2.08	1	monovalent inorganic anion; rhenium oxoanion
naproxen Naproxen: An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.. naproxen : A methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes.	2.21	1	methoxynaphthalene; monocarboxylic acid	antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; environmental contaminant; gout suppressant; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic
bortezomib [no description available]	2.17	1	amino acid amide; L-phenylalanine derivative; pyrazines	antineoplastic agent; antiprotozoal drug; protease inhibitor; proteasome inhibitor
lithium Lithium: An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.	2.04	1	alkali metal atom
calixarenes Calixarenes: Phenolic metacyclophanes derived from condensation of PHENOLS and ALDEHYDES. The name derives from the vase-like molecular structures. A bracketed [n] indicates the number of aromatic rings.. calixarenes : Originally macrocyclic compounds capable of assuming a basket (or "calix") shaped conformation. They are formed from p-hydrocarbyl phenols and formaldehyde. The term now applies to a variety of derivatives by substitution of the hydrocarbon cyclo{oligo[(1,3-phenylene)methylene]}.. calixarene : A macrocycle composed of 1,3-phenylene groups linked by methylene groups. The number of 1,3-phenylene units in the macrocycle is denoted by the "n" in calix[n]arene name.	2.04	1
phosphorus Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.	2.53	2	monoatomic phosphorus; nonmetal atom; pnictogen	macronutrient
cytochrome c-t Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.	2.13	1
oligonucleotides [no description available]	2.13	1
guanine [no description available]	2.04	1	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite

Condition	Relationship Strength	Studies
Kahler Disease [description not available]	2.15	1
Multiple Myeloma A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.	2.15	1
Carcinoma, Anaplastic [description not available]	2.17	1
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	2.17	1
Acute Confusional Senile Dementia [description not available]	2.55	2
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	2.55	2
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.11	1
Angiogenesis, Pathologic [description not available]	2.11	1
Benign Neoplasms [description not available]	2.06	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.06	1
Bacterial Disease [description not available]	2.06	1
Candida Infection [description not available]	2.06	1
Malignant Melanoma [description not available]	2.06	1
Bacterial Infections Infections by bacteria, general or unspecified.	2.06	1
Candidiasis Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)	2.06	1
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	2.06	1
Cancer of Lung [description not available]	2.02	1
Experimental Mammary Neoplasms [description not available]	2.02	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.02	1

1,3,5-triaza-7-phosphaadamantane

Description

Cross-References

Synonyms (33)

Research

Studies (44)

Market Indicators

Research Demand Index: 24.42

Study Types