naproxen has been researched along with indomethacin in 421 studies
| Studies (naproxen) | Trials (naproxen) | Recent Studies (post-2010) (naproxen) | Studies (indomethacin) | Trials (indomethacin) | Recent Studies (post-2010) (indomethacin) |
|---|---|---|---|---|---|
| 4,551 | 1,057 | 1,429 | 29,527 | 1,838 | 3,396 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 195 (46.32) | 18.7374 |
| 1990's | 84 (19.95) | 18.2507 |
| 2000's | 57 (13.54) | 29.6817 |
| 2010's | 72 (17.10) | 24.3611 |
| 2020's | 13 (3.09) | 2.80 |
| Authors | Studies |
|---|---|
| Heikes, JE; Sprague, PW | 1 |
| Ackrell, J; Antonio, Y; Franco, F; Landeros, R; Leon, A; Maddox, ML; Muchowski, JM; Nelson, PH; Rooks, WH; Roszkowski, AP; Wallach, MB | 1 |
| Asselin, AA; Dobson, TA; Humber, LG; Komlossy, J | 1 |
| Bruins, AP; de Zeeuw, D; Franssen, EJ; Kellogg, RM; Koiter, J; Kruizinga, WH; Kuipers, CA; Meijer, DK; Moolenaar, F | 1 |
| Bell, MR; D'Ambra, TE; Daum, SJ; Eissenstat, MA; Herrmann, JL; Hlasta, DJ; Kumar, V; Philion, RE; Rosi, D; Wetzel, JR | 1 |
| Carty, TJ; Moore, PF; Mylari, BL; Zembrowski, WJ | 1 |
| Ackerman, N; Ballaron, SA; Galeazzi, E; Greenhouse, R; Guzmán, A; Muchowski, JM; Peréz, V; Rovito, JR; Tomolonis, AJ; Young, JM | 1 |
| Blythin, DJ; Bober, LA; Chiu, PJ; Conn, DJ; Domalski, MS; Kaminski, JJ; Solomon, DM; Spitler, J; Verbiar, LL; Wong, SC | 1 |
| Ackrell, J; Cooper, GF; Halpern, O; Kluge, AF; Koehler, R; Muchowski, JM; Simon, RL; Unger, SH; Van Horn, AR; Wren, DL | 1 |
| Bundgaard, H; Nielsen, NM | 1 |
| Millonig, RC; Rovnyak, GC; Schwartz, J; Shu, V | 1 |
| Boettcher, I; Elger, W; Kirsch, G; Siegmund, F; Wachtel, H | 1 |
| Ariyan, ZS; Fogt, SW; Heilman, RD; Matthews, RJ; Powers, LJ; Rippin, DJ | 1 |
| Copeland, RA; Covington, M; Trzaskos, JM; Wilkerson, WW | 1 |
| Abelman, MM; Batt, DG; Bostrom, LL; Corbett, RL; Decicco, CP; Di Meo, SV; Freimark, B; Giannaras, JV; Petraitis, JJ; Wright, SW | 1 |
| Bell, RL; Bouska, J; Brooks, CD; Carter, GW; Dellaria, JF; Hulkower, KI; Kolasa, T; Rodriques, KE; Summers, JB | 1 |
| Bertenshaw, SR; Burton, EG; Carter, JS; Cogburn, JN; Collins, PW; Docter, S; Graneto, MJ; Gregory, SA; Isakson, PC; Koboldt, CM; Lee, LF; Malecha, JW; Miyashiro, JM; Penning, TD; Perkins, WE; Rogers, RS; Rogier, DJ; Seibert, K; Talley, JJ; Veenhuizen, AW; Yu, SS; Zhang, YY | 1 |
| Casler, JJ; Collins, PW; Gregory, SA; Isakson, PC; Khanna, IK; Koboldt, CM; Koszyk, FJ; Masferrer, JL; Perkins, WE; Seibert, K; Veenhuizen, AW; Weier, RM; Xu, XD; Yu, Y; Zhang, YY | 1 |
| Bohlin, L; Danielson, H; Noreen, Y; Perera, P; Ringbom, T | 1 |
| Bohlin, L; Noreen, Y; Perera, P; Ringbom, T; Segura, L | 1 |
| Apiwattanakul, N; Chairoungdua, A; Endou, H; Kanai, Y; Nakajima, N; Sekine, T; Sophasan, S | 1 |
| Beleta, J; Cardelús, I; Crespo, MI; Feixas, J; Godessart, N; Heredia, A; Huerta, JM; Ibarzo, J; Jiménez, JM; López, M; Miralpeix, M; Palacios, JM; Puig, C; Puig, J; Ryder, H; Segarra, V; Soca, L | 1 |
| Strassburg, CP; Tukey, RH | 1 |
| Duffy, EM; Jorgensen, WL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Cogburn, JN; Collins, PW; Huff, RM; Isakson, PC; Khanna, IK; Koboldt, CM; Koszyk, FJ; Masferrer, JL; Perkins, WE; Seibert, K; Veenhuizen, AW; Weier, RM; Xu, X; Yang, DC; Yu, Y; Yuan, J; Zhang, YY | 1 |
| Cihlar, T; Ho, ES; Mulato, AS | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Abe, T; Itoh, T; Kato, Y; Kusuhara, H; Meier, PJ; Shitara, Y; Sugiyama, D; Sugiyama, Y | 1 |
| Charitos, C; Doulgkeris, C; Galanakis, D; Gavalas, A; Kourounakis, AP; Kourounakis, PN; Kravaritou, C; Rekka, EA; Tsiakitzis, KC | 1 |
| Caron, G; Ermondi, G; Lorenti, M | 1 |
| Beroza, P; Cai, D; Damodaran, K; Gomez, RF; Hsu, N; Keck, JG; Laborde, E; Lum, RT; Macke, TJ; Martin, G; Schow, SR; Simon, RJ; Villar, HO; Wick, MM | 1 |
| Chang, TK; Ensom, MH; Kiang, TK | 1 |
| Caron, G; Ermondi, G | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Doulgkeris, CM; Eleftheriou, PT; Galanakis, D; Gavalas, AM; Kourounakis, AP; Kourounakis, PN; Rekka, EA; Tsiakitzis, KC; Victoratos, P | 1 |
| Bain, G; Beher, D; Chen, W; Jiang, X; Munoz, B; Peachey, J; Prasit, P; Shearman, MS; St-Jacques, R; Stock, N; Williamson, TL; Wrigley, JD | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Carrupt, PA; Martel, S; Ottaviani, G | 2 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Girish, V; Khanum, NF; Khanum, SA; Suparshwa, SS | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Avdeef, A; Tam, KY | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Buttar, D; Colclough, N; Gerhardt, S; MacFaul, PA; Maskos, K; Phillips, SD; Plowright, A; Steinbacher, S; Steuber, H; Tam, K; Whittamore, P | 1 |
| Fujiwara, R; Koga, T; Nakajima, M; Yokoi, T | 1 |
| Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A | 1 |
| Abdellatif, KR; Chowdhury, MA; DuMond, JF; Huang, Z; King, SB; Knaus, EE; Reisz, JA; Velázquez, CA | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Chaudhaery, SS; Eleftheriou, P; Filimonov, D; Filz, O; Geronikaki, A; Hadjipavlou-Litina, D; Poroikov, V; Roy, KK; Saxena, AK; Vicini, P | 1 |
| Kumar, M; Sinha, VR; Thareja, S | 1 |
| Atwell, GJ; Brooke, DG; Denny, WA; Flanagan, JU; Hamilton, EJ; Heinrich, D; Jamieson, SM; Owen, PJ; Raynham, T; Rigoreau, LJ; Samlal, SS; Schroeder, E; Silva, S; Soudy, C; Trivier, E; Turnbull, AP | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Ambrosi, G; Bauer, J; Elkady, M; Laufer, SA; Luderer, S; Nieß, R; Schaible, AM; Werz, O | 1 |
| Apostolidis, I; Ćirić, A; Gavalas, A; Geronikaki, A; Glamočlija, J; Hadjipavlou-Litina, D; Liaras, K; Soković, M | 1 |
| Capim, SL; Dos Santos, GC; Gonçalves, GM; Marinho, BG; Vasconcellos, ML | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Kourounakis, AP; Matralis, AN | 1 |
| Brewster, C; Deering-Rice, CE; Reilly, CA; Rose, TM | 1 |
| Alcaraz, B; Bratoeff, E; Cabeza, M; Camacho-Arroyo, I; Garrido, M; González-Arenas, A | 1 |
| Alonso-Castro, AJ; Campos-Xolalpa, N; Hernández-Munive, A; Pérez-González, C; Pérez-Gutiérrez, S; Zapata-Morales, JR | 1 |
| Ertan, M; Kazkayasi, I; Okay, G; Ozadali-Sari, K; Sarigol, D; Somuncuoglu, EI; Tel, BC; Tozkoparan, B; Unsal-Tan, O; Uzgoren-Baran, A | 1 |
| Kourounakis, PN; Kourti, M; Rekka, EA; Theodosis-Nobelos, P; Tziona, P | 1 |
| Gavalas, A; Kourti, M; Rekka, EA; Theodosis-Nobelos, P | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Boixareu, N; Campanera, JM; Navarro, L; Pors, K; Pouplana, R; Pujol, MD; Rosell, G; Sánchez, S | 1 |
| Daniel Pedro-Hernández, L; Hernández-Montalbán, C; Martínez-García, M; Martínez-Klimova, E; Ramírez-Ápan, T | 1 |
| Chen, R; Guo, Z; Han, X; Wang, S; Xu, Y; Yang, Y; Zhu, Q | 1 |
| Gou, S; Liu, Z; Wang, C; Zhou, W | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Boyle, E; Freeman, PC; Goudie, AC; Mangan, FR; Thomson, M | 1 |
| Huskisson, EC | 2 |
| Lubbe, S; Potgieter, A; Van Zyl, A; Van Zyl, J | 1 |
| Lundström, V | 1 |
| Gréen, K; Lundström, V; Svanborg, K | 1 |
| Cavalli-Björkman, K; Jacobson, J; Lundström, V; Nilsson, B; Norbeck, M | 1 |
| Akbar, M; Burke, G; Park, S; Richman, R; Yu, S | 1 |
| Lubbe, S; Theron, CN; Van Zyl, A | 1 |
| Chappel, R; De Cuyer, H; Mortier, G | 1 |
| Roe, RL | 1 |
| Reinicke, C | 1 |
| Bolzan, JA; Caldwell, JR; Castles, JJ; Ehrlich, GE; Kaye, R; Lee, M; Lidsky, MD; Moore, TL; Sharp, JT; Vaughan, JH | 1 |
| Aromaa, U; Asp, K | 1 |
| Emmerson, BT | 1 |
| Desai, MM; Shetty, RN | 1 |
| Anderson, JA; Caughey, DE; Lee, P; Rose, BS | 1 |
| Cohen, GN; Fisherman, EW | 1 |
| Berry, H; Hamilton, EB; Jones, J; Swinson, D | 1 |
| Burdeĭnyĭ, AP | 1 |
| Henzl, MR; Izu, A | 1 |
| Kajanoja, P; Vesanto, T | 1 |
| Boeynaems, JM; Dumont, JE; Waelbroeck, M | 1 |
| Bouchier-Hayes, TA; Jones, CW | 1 |
| Chaudri, HA; Ciccolunghi, SN; Schubiger, BI | 1 |
| Nesheim, B | 1 |
| Spisani, S; Traniello, S; Vanzini, G | 1 |
| Błaszkiewicz, Z; Małofiejew, M | 1 |
| Spätling, R; Stähler, E | 1 |
| Louw, A; Van Zyl, A | 1 |
| Chen, TT; Lanza, FL; Nelson, RS; Rack, MF; Royer, GL; Seckman, CE | 2 |
| Ciccolunghi, SN; Reddrop, R; Schubiger, BI | 1 |
| Mörsdorf, K; Wolf, G | 1 |
| Anggärd, E; Lundén, I; Oliw, E | 1 |
| Engler, C; Williams, JG | 1 |
| Datko, LJ; Jones, RC | 1 |
| Ahlberg, KF | 1 |
| Dinarello, CA; Gallin, JI; Klempner, MS | 1 |
| Willkens, RF | 1 |
| Brooks, PM | 1 |
| Abdel-Halim, MS; Anggård, E; Sjöquist, B | 1 |
| Kaye, RL; Pemberton, RE | 1 |
| Jaffé, G | 1 |
| Katona, G | 1 |
| Gutmann, W; Scheiffarth, F; Warnatz, H | 1 |
| Bacon, PA; Chan, R; Collins, AJ; Crook, D | 1 |
| Mann, NS; Sachdev, AJ | 1 |
| Smith, RJ | 1 |
| Alvsaker, JO | 1 |
| Turner, R | 1 |
| Moen, F | 1 |
| Kitchen, EA; Meacock, SC | 1 |
| Docken, W; Kantrowitz, FG | 1 |
| Castracane, VD; Jordan, VC | 1 |
| Guyonnet, JC; Julou, L | 1 |
| Barnes, CG; Clarke, AK; Cochrane, GM; Eade, AW; Goodman, HV; Misra, HN; Stoppard, M | 1 |
| Clarke, AK | 1 |
| Binzus, G | 1 |
| Aeidler, H | 1 |
| Peter, E | 1 |
| Buchanan, WW; Grennan, DM; Hernandez, LA; MacLeod, M; Palmer, DG | 1 |
| Dorfman, RI | 1 |
| Mathies, H | 1 |
| Adamska-Dyniewska, H; Bala, T; Chojnacki, J; Chojnowska-Jezierska, J; Goch, JH; Tkaczewski, W | 1 |
| Gale, D; Keenan, CM; Shoupe, TS; Wallace, JL | 1 |
| Beró, T; Jávor, T; Nagy, L; Vincze, A | 1 |
| Ardizzone, S; Bianchi Porro, G; Caruso, I; Montone, F; Petrillo, M | 1 |
| Gerges, F; Khalil, H; Kholeif, A; Marzouk, S; Toppozada, M | 1 |
| Aranda, JV; Chemtob, S; Malcolm, D; Parys-Van Ginderdeuren, R; Varma, DR | 1 |
| Bakken, IJ; Cappelen, J; Sjaastad, O; Skaanes, KO; Vincent, MB; White, LR | 1 |
| Cheung, D; Filonzi, EL; Gallichio, M; Hamilton, JA; Last, K; McGrath, K; Piccoli, DS; Wojta, J | 1 |
| Croxtall, JD; Flower, RJ | 1 |
| Ferrell, JB; Fleisher, LN; McGahan, MC; Smith, MG | 1 |
| Granley, K; Jang, Y; Mishra, U; Singh, AK | 1 |
| Carrasco, E; Felipe, A; Grau, M; Guasch, J; Juliá, S; Montero, JL | 2 |
| Besser, GM; Faria, MS; Grossman, AB; Navarra, P; Rees, LH; Tsagarakis, S | 1 |
| Blackburn, WD; Chatham, WW; Heck, LW; Loose, LD | 1 |
| Haerslev, T; Hansen, TM; Jespersen, SM; Mathiesen, FK; Wester, JU | 1 |
| King, RL; Levine, RA; Nandi, J | 1 |
| Aranda, JV; Barna, T; Beharry, K; Chemtob, S; Varma, DR | 1 |
| Barthwal, M; Srivastava, K | 1 |
| Gribnau, F; van 't Hof, M; van de Putte, L; van Riel, P; Wijnands, M | 1 |
| Dandona, P; Jeremy, JY | 1 |
| Barradas, MA; Dandona, P; Jeremy, JY; Kirk, RM; Mikhailidis, DP | 2 |
| Kazemifard, AG; Moore, DE | 1 |
| Casady, RL; Itoh, T; Magavi, R; Nishihata, T; Rytting, JH | 1 |
| McKnight, GW; Wallace, JL | 1 |
| Cox, PG; Moons, MM; Russel, FG; van Ginneken, CA | 1 |
| Bacojanis, C; Beldecos, D; Karabelis, A; Karvounis, N; Kosmidis, P; Milonacis, N; Tsavaris, N; Zinelis, A | 1 |
| Dandona, P; Jeremy, JY; Mikhailidis, DP; Thompson, CS | 1 |
| Montenegro, MA; Palomino, H | 1 |
| Boyle, EA; Crummey, A; Harper, GP; Mangan, FR | 1 |
| Bálint, G; Bartha, J; Bräunlich, H; Hably, C; Herceg, R | 1 |
| Dasgupta, PK; Murthy, PS; Srivastava, AK; Srivastava, K | 1 |
| Burghardt, B; Cardell, M; Janero, DR; Lopez, R | 1 |
| Collet, P; Gravagna, B; Later, D; Lejeune, E; Llorca, G | 1 |
| Grönneberg, R; Zetterström, O | 1 |
| Ramanathan, M | 1 |
| Cook, L; Ternai, B | 1 |
| Bodor, N; Phelan, MJ | 1 |
| Bennett, A; Capasso, F; Tavares, IA; Vine, ND | 1 |
| Faulkner, G; Langman, M; Somerville, K | 1 |
| Paulus, HE; Schlegel, SI | 1 |
| Fujimura, H; Hidaka, T; Hiramatsu, Y; Hosoe, K; Watanabe, K; Yamashita, T | 1 |
| Breckwoldt, M; Zahradnik, HP | 1 |
| Ceuppens, JL; Deckmyn, H; Dequeker, J; Robaeys, G; Verdickt, W; Vertessen, S | 1 |
| Lanza, F; Lynn, M; Rack, MF; Sanda, M; Wolf, J | 1 |
| Condorelli, M; Cuocolo, A; de Luca, N; Patrignani, P; Ricciardelli, B; Trimarco, B; Volpe, M | 1 |
| Sallmann, AR | 1 |
| Foidart, JB; Mahieu, P | 1 |
| Chaudhuri, G; Hayden, B; Soderberg, R; Zarem, H | 1 |
| Gustafson, GT; Lerner, UH | 1 |
| Condorelli, M; Cuocolo, A; De Simone, A; Patrono, C; Ricciardelli, B; Trimarco, B; Volpe, M | 1 |
| Greenwood, A; Huskisson, EC | 1 |
| Hollenberg, MD; Itoh, H; Lederis, K; Muramatsu, I; Patel, P | 1 |
| Heere, LP | 2 |
| Cerlek, S; Dominis, M; Greb, WH; Hauptmann, E; von Schrader, HW; Zenić, N | 1 |
| Aarbakke, J; Jaeger, R; Sager, G; Slørdal, L | 1 |
| Chappuis, PP; Moore, DE | 1 |
| Carney, SL; Hall, LG; Muir, H | 1 |
| Khanna, R; Mactier, RA | 1 |
| Alvarez, J; Blanco, A; Crespo, M; Herrero Beaumont, G; López-Linares, M; Rodríguez, A; Sánchez Villares, E; Solís, P; Taracena del Piñal, B | 1 |
| Blazaki, D; Löscher, W | 1 |
| Laufer, I; Levine, MS; Verstandig, A | 1 |
| Giercksky, KE | 1 |
| Gyires, K; Hermecz, I; Knoll, J | 1 |
| Zuckner, J | 1 |
| Altman, R | 1 |
| Bakke, O; Haneberg, B; Solberg, CO; Sørnes, S | 1 |
| Isomäki, H; Laitinen, O; Nissilä, M; Nuotio, P; Nykänen, E; Seppälä, E; Vapaatalo, H | 1 |
| McGill, PE | 1 |
| Brogden, RN; Sorkin, EM | 1 |
| Gordin, A; Nuutila, J; Sotka, S | 1 |
| de Jong, PE; de Zeeuw, D; Donker, AJ; van der Hem, GK; Vriesendorp, R | 1 |
| Bassi, GP; Borghi, C; Camarri, E; Cocco, F; Francucci, BM; Giannini, R; Giordano, N; Marcolongo, R; Mordini, M; Neri, D | 1 |
| Delbridge, L; Handelsman, DJ; McLennan, S; Reeve, T; Turtle, JR; Yue, DK | 1 |
| Condorelli, M; Cuocolo, A; De Simone, A; Ricciardelli, B; Trimarco, B; Van Dorne, D; Volpe, M | 1 |
| Kimble, EF; Kothari, HV; Ku, EC; Lee, W; Liauw, L; Tjan, J | 1 |
| Gasparich, JP; Mayo, ME | 1 |
| Buchanan, WW; Kassam, YB | 1 |
| Gilfillan, AM; Rooney, SA | 1 |
| Foley, RJ; Reeves, WB; Weinman, EJ | 1 |
| Hudyma, EO; Kollenberg, LO; Robbins, JM | 1 |
| Clark, JS; Jubb, SN; Maloney, PJ; Young, JM | 1 |
| Macauley, D | 1 |
| Machtey, I | 1 |
| Boyle, EA; Freeman, PC; Mangan, FR; Thomson, MJ | 1 |
| Edelman, J; O'Leary, PC; Riley, WJ | 1 |
| Eriksson, S; Hagenfeldt, L; Law, D; Patrono, C; Pinca, E; Wennmalm, A | 3 |
| Attie, MF; Aurbach, GD; Brown, EM; Gardner, DG | 1 |
| Hurst, PR; Peplow, PV | 1 |
| Burch, RM; Halushka, PV; Wise, WC | 1 |
| Colombo, G; Glässer, A; Luzzani, F; Schiatti, P; Selva, D | 1 |
| Chan, WY | 1 |
| Capell, HA; MacGregor, J; Steven, MM; Sturrock, RD | 1 |
| Clarke, TK; Mungavin, JM | 1 |
| Bune, AJ; Chalmers, JP; Graham, JR; West, MJ; Wing, LM | 1 |
| Altman, RD | 1 |
| Ward, JR | 1 |
| Johnson, EA; Schwender, CF; Sircar, JC | 1 |
| Carlsson, I; Wennmalm, A | 1 |
| Owen, PR | 1 |
| de Medicis, R; Lussier, A | 1 |
| Banki, K; Bartha, J; Bräunlich, H; Hably, C | 1 |
| Bjelle, A; Mjörndal, T | 1 |
| Gribnau, FW; Koopmans, PP; Thien, T | 1 |
| Lanza, FL | 1 |
| Bhalla, AK; Simon, LS | 1 |
| Cronberg, S; Söderberg, I; Wallmark, E | 1 |
| Levin, DL; Turner, GR | 1 |
| Court, H; Volans, GN | 1 |
| Benoit, P; Commissionat, Y | 1 |
| Akerlund, M; Kostrzewska, A; Laudański, T | 1 |
| Greenberg, BP; Lanza, FL; Nelson, RS | 1 |
| Porter, RS | 1 |
| Isomäki, H; Kaarela, K; Kajander, A; Koota, K; Lehtinen, K; Luukkainen, R; Martio, J; Martio, T; Nissilä, M; Nuotio, P | 1 |
| Babayan, RK; Krane, RJ; Kraus, SE; Siroky, MB | 1 |
| Obel, AO | 1 |
| Kaihola, HL; Kangas, L; Nieminen, L; Pulkkinen, M; Túri, S | 1 |
| Ciofalo, VB; Diamantis, W; Melton, J; Sofia, RD | 1 |
| Fraser, IS | 1 |
| Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM | 1 |
| Falotico, R; Zimmerman, BG | 1 |
| Whittle, BJ | 1 |
| Dunham, EW; Sakr, HM | 1 |
| Alvin, PE; Litt, IF | 1 |
| Bennedsen, J; Nielsen, H | 1 |
| Bailey, RR; Lynn, KL; Munn, E | 1 |
| Zizic, TM | 1 |
| Felder, M | 1 |
| Crabtree, RE; Johnson, DW; Ridolfo, AS; Rockhold, FW | 1 |
| Segre, EJ | 1 |
| Sigidin, IaA; Tsvetkova, ES | 1 |
| Duke, O; Grahame, R; Zecler, E | 1 |
| Dingfelder, JR | 1 |
| Bird, HA; Downie, WW; Engler, C; Rhind, V; Wright, V | 1 |
| Drozdz, M; Kucharz, E; Stawiarska, B | 1 |
| Baylis, EM; English, J; Rae, SA; Williams, IA | 1 |
| Arumugham, R; Bose, SM | 2 |
| Doménech, J; Lauroba, J; Moreno, J; Plá-Delfina, JM | 1 |
| Kobylec, E; Laudański, T; Małofiejew, M | 1 |
| Hurst, PR; MacFarlane, DW | 1 |
| Fung, WP; Matz, L; Papadimitriou, JM | 1 |
| Hierton, C | 1 |
| Anggård, E; Davila, D; Davila, T; Oliw, E | 1 |
| Backhouse, CI; Engler, C; English, JR | 1 |
| Engler, C; Seifert, MH | 1 |
| Batt, DG; Corbett, RL; Di Meo, SV; Freimark, B; Giannaras, JV; Orwat, MJ; Petraitis, JJ; Pinto, DJ; Pratta, MA; Wright, SW | 1 |
| Friedman, DI; Schwarz, JS; Weisspapir, M | 1 |
| Chemtob, S; Hanna, N; Lachapelle, P; Orquin, J; Roy, MS; Varma, DR | 1 |
| Dainaka, J; Hashii, H; Inoue, K; Kimura, K; Motonaga, A; Nishimura, T; Ueda, F; Yamate, K | 1 |
| Barbacane, RC; Bartle, L; Conti, P; Reale, M; Sipe, JD | 1 |
| DiBattista, JA; Martel-Pelletier, J; Pelletier, JP; Ranger, P | 1 |
| Fraser, L; Larkin, SW; Showell, HJ; Warren, JB; Williams, TJ | 1 |
| Bell, CJ; McKnight, GW; Wallace, JL | 1 |
| Phillips, TE; Stanley, CM | 1 |
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| Cloutier, JM; DiBattista, J; Loose, LD; Martel-Pelletier, J; McCollum, R; Pelletier, JP | 1 |
| Hill, RE; Hunt, RH; James, C; Johnson, DM; Rainsford, KD; Salena, BJ; Stetsko, PI | 1 |
| Colombo, C; DiPasquale, G; Fryer, LR; Greenspan, PD; Haston, W; Healy, C; Kotyuk, B; Pastor, G; Pellas, TC; Raychaudhuri, A | 1 |
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| Cahill, RJ; Gilvarry, J; O'Morain, CA; Sant, SM | 1 |
| Carrabba, M; Galante, A; Manfredi, B; Panerai, AE; Pisati, R; Sacerdote, P | 1 |
| Mue, S; Ohuchi, K; Watanabe, M; Yamada, M | 1 |
| Coltau, M; Pasca, R; Puscas, I | 1 |
| Aabakken, L; Meling, TR; Osnes, M; Røseth, A | 1 |
| Rioux, KP; Wallace, JL | 1 |
| Appleyard, CB; McCafferty, DM; Swain, MG; Tigley, AW; Wallace, JL | 1 |
| Barrios-Rodiles, M; Belley, A; Chadee, K; Keller, K | 1 |
| Carson, JL; Manoukian, AV | 1 |
| Akatsu, T; Consolaro, A; Guimarães, SA; Tago, EM | 1 |
| Pedibhotla, VK; Sauer, JR; Stanley-Samuelson, DW | 1 |
| Fox, SM; Johnston, SA | 1 |
| Agut, J; Conejo, L; Márquez, M; Ortiz, JA; Palop, D; Sacristán, A | 1 |
| Chouini-Lalanne, N; Defais, M; Paillous, N | 1 |
| Alagiakrishnan, K; Botti, AC; Kodali, P | 1 |
| Bommelaer, G; Giraud, MN; Lichtenberger, LM; Motta, C; Romero, JJ | 1 |
| Gierse, JK; Isakson, PC; Koboldt, CM; Seibert, K; Walker, MC | 1 |
| Ikeda, M; Koshika, A; Miyajima, M; Okada, J | 1 |
| Arslan, S; Hasçelik, Z; Inanici, F; Orhan, H; Sahin, G | 1 |
| Archer, D; Breen, TW; Fick, G; Yang, T | 1 |
| Hulet, C; Joubert, JM; Vielpeau, C | 1 |
| Wallace, JL | 1 |
| Jurenka, RA; Stanley, DW; Tunaz, H | 1 |
| Asanuma, M; Kohno, M; Miyazaki, I; Nishibayashi-Asanuma, S; Ogawa, N | 1 |
| Iwabe, K; Kobayashi, S; Masuda, M; Mizoguchi, H; Motoji, T; Teramura, M; Yoshinaga, K | 1 |
| Mateo, I; Pascual, J | 1 |
| Skelton, HG; Smith, KJ | 1 |
| Clements, S; Cox, M; Harrall, RL; Hazleman, BL; Riley, GP | 1 |
| Sadowski, T; Steinmeyer, J | 2 |
| Bellini, MS; Deyl, Z; Kohlícková, M; Manetto, G | 1 |
| Bai, JC; Mauriño, E; Meddings, J; Niveloni, S; Pedreira, S; Smecuol, E; Sugai, E; Vazquez, H | 1 |
| Browning, RA; Burgess, FW | 1 |
| Feller, DR; Jaradat, MS; Noonan, DJ; Phornchirasilp, S; Rangwala, SM; Romstedt, KJ; Shams, G; Sutton, M; Wongsud, B | 1 |
| Putnam, SM; Stanley, DW; Tunaz, H | 1 |
| Lozano, JJ; Pouplana, R; Ruiz, J | 1 |
| Büyükgüzel, K; Putnam, SM; Stanley, D; Tunaz, H | 1 |
| Downing, SJ; Leese, HJ; Maguiness, SD; Tay, JI; Watson, A | 1 |
| Kato, S; Kunikata, T; Miyazawa, T; Takeuchi, K; Tanaka, A | 1 |
| Backhouse, N; Bórquez, J; Delporte, C; Loyola, A; Salinas, P; San-Martín, A | 1 |
| Boulet, J; Gottshall, S; Harrison, J; Mark, L; Pearson, M; Walker, K; Whiteside, GT | 1 |
| Bhatia, SR; Sharma, PK | 1 |
| Dial, EJ; Dohrman, AJ; Lichtenberger, LM; Romero, JJ | 1 |
| Breese, E; Del Soldato, P; Mitchell, J; Warner, T; Wood, E; Zacharowski, P | 1 |
| Lucas, R; Mitchell, JA; Vojnovic, I; Warner, TD | 1 |
| Bishop-Bailey, D; Mitchell, JA; Vojnovic, I; Warner, TD | 1 |
| Bjarnason, I; Bjornsson, E; Maiden, L; Premchand, P; Sherwood, R; Smale, S; Takeuchi, K; Thjodleifsson, B | 1 |
| Baraliakos, X; Bohl-Bühler, MH; Braun, J; Feldtkeller, E; Zochling, J | 1 |
| Joseph-Ridge, N; Khosravan, R; Vernillet, L; Wu, JT | 1 |
| Khan, NK; Radi, ZA | 1 |
| Takahira, Y; Takeuchi, K; Tanaka, A; Yokota, A | 1 |
| El Masry, MA; Gamie, Z; Macfarlane, RJ; Ng, BH; Schizas, C; Tsiridis, E; Velonis, S | 1 |
| Buyse, M; Farinotti, R; Zrieki, A | 1 |
| Cárdenas, S; Cruz-Vera, M; Lucena, R; Valcárcel, M | 1 |
| Asami, M; Fujiwara, J; Kunikane, S; Manabe, S; Matsuda, M; Simazaki, D | 1 |
| Desikan, S; Haddadin, R; Hussain, M; Qian, F; Smith, RL | 1 |
| Chasovskikh, E; Imran ul-haq, M; Signorell, R | 1 |
| Gordon, KC; Grohganz, H; Laitinen, R; Löbmann, K; Rades, T; Strachan, C | 2 |
| Cheng, KW; Constantinides, PP; Rigas, B; Wong, CC; Xie, G; Zhou, D; Zhu, CH | 1 |
| Unlü, B; van Leeuwen, JS; Vermeulen, NP; Vos, JC | 1 |
| Alcudia-León, MC; Cárdenas, S; Lucena, R; Riaño, S; Valcárcel, M | 1 |
| Chai, MZ; Flanagan, JU; Squire, CJ; Teague, RM; Turnbull, AP; Yosaatmadja, Y | 1 |
| Chandra, C; Chandy, SJ; Danda, D; Iliyas, MM; Mathew, AJ | 1 |
| Shi, NQ; Wang, XL; Yao, J | 1 |
| Dong, L; Jurban, BJ; Sharma, NP; Smith, WL | 1 |
| Lee, PI; Sun, DD | 1 |
| Emery, JD; Holman, CD; Price, SD; Sanfilippo, FM | 1 |
| de Graaf, IA; Groothuis, GM; Niu, X; van der Bij, HA | 1 |
| Nalamachu, S; Wortmann, R | 1 |
| Aguilar, MI; Benítez, WV; Bye, R; Calzada, F; Colín, A; Ríos-Gómez, R | 1 |
| Ji, Y; Lübbert, C; Paus, R; Prudic, A; Sadowski, G | 1 |
| Ji, Y; Paus, R; Prudic, A | 1 |
| Daniel, S; Koren, G; Levy, A; Lunenfeld, E | 1 |
| Löbmann, K; Rades, T; Sibik, J; Zeitler, JA | 1 |
| Ji, Y; Luebbert, C; Prudic, A; Sadowski, G | 1 |
| Buchbinder, R; Falzon, L; Kroon, FP; Landewé, RB; Ramiro, S; van der Burg, LR; van der Heijde, D | 1 |
| Beyer, A; Grohganz, H; Leopold, CS; Löbmann, K; Rades, T | 3 |
| Chieng, N; Grohganz, H; Lim, AW; Löbmann, K; Rades, T | 1 |
| Matteson, EL; Thongprayoon, C; Ungprasert, P | 1 |
| Ainslie, PN; Bain, AR; Hoiland, RL; Monteleone, B; Tymko, MM; Wildfong, KW | 1 |
| Jang, IS; Nakamura, M | 1 |
| Beyer, A; Grohganz, H; Leopold, CS; Löbmann, K; Rades, T; Radi, L | 1 |
| Hamaguchi, T; Inagaki, Y; Inoue, S; Iwakawa, S; Okada, M; Tatsumi, A | 1 |
| Abbasinazari, M; Abdi, S; Ahmadpour, F; Dabir, S; Fatehi, S; Hatami, B; Mohammad Alizadeh, AH; Nematollahi, A; Pourhoseingholi, MA | 1 |
| Kramulová, B; Marsik, P; Rezek, J; Tauchen, J; Vaněk, T; Židková, M | 1 |
| Han, YR; Lee, PI | 1 |
| Bucci, G; Gillen, M; Kerr, B; Lee, C; Shen, Z; Tieu, K; Wilson, D | 1 |
| Cinghia, G; Dereymaker, A; Van den Mooter, G | 1 |
| Hamaguchi, T; Inoue, S; Iwakawa, S; Tatsumi, A | 1 |
| Fujita, T; Kumamoto, E; Mizuta, K; Suzuki, R | 1 |
| Grohganz, H; Leopold, CS; Löbmann, K; Petry, I; Rades, T | 1 |
| Aldous, L; Eskandari, A; Laws, K; Lu, C; Suntharalingam, K; Zheng, P | 1 |
| Kadota, K; Tanida, S; Tozuka, Y; Uchiyama, H; Yoshida, M; Yoshimoto, A | 1 |
| Bergonzi, A; Clasen, C; Koekoekx, R; Michiels, E; Pas, T; Rousseau, F; Schymkowitz, J; Van den Mooter, G; Vergauwen, B | 1 |
| Chan, C; Ferrar, JA; Leung, DH; Sellers, BD | 1 |
| Ji, Y; Sadowski, G; Schneider, R; Taspinar, L | 1 |
| Brinkmann, J; Luebbert, C; Rest, F; Sadowski, G | 1 |
| Andrews, GP; Jacobs, E; Jones, DS; McCoy, CP; Tian, Y; Wu, H | 1 |
| Akerman, S; Andreou, AP; Goadsby, PJ; Hoffmann, J; Holland, PR; Summ, O | 1 |
| Dahl, TA; Iversen, JM; Kiani, P; McMann, L; Scholey, A; Verster, JC | 1 |
| Niamlang, S; Paradee, N; Ruangmak, K; Sakunpongpitiporn, P; Sirivat, A | 1 |
| Encío, I; Plano, D; Ramos-Inza, S; Raza, A; Sanmartín, C; Sharma, AK | 1 |
29 review(s) available for naproxen and indomethacin
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
UDP-glucuronosyltransferases and clinical drug-drug interactions.
Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Antiinflammatory drugs.
Topics: Adult; Anti-Inflammatory Agents; Apazone; Arthritis, Rheumatoid; Aspirin; Benzylidene Compounds; Child; Drug Evaluation; Female; Humans; Ibuprofen; Indenes; Indomethacin; Ketoprofen; Mefenamic Acid; Naproxen; Phenylacetates; Phenylbutazone; Pregnancy; Pregnancy Complications; Propionates; Tolmetin | 1977 |
Drug therapy in rheumatic diseases.
Topics: Acetaminophen; Adrenal Cortex Hormones; Antimalarials; Aspirin; Colchicine; Fenoprofen; Gold; Humans; Ibuprofen; Indomethacin; Levamisole; Naproxen; Penicillamine; Phenylbutazone; Rheumatic Diseases; Tolmetin | 1977 |
[Nonsteroid antirheumatic agents].
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Fenoprofen; Flufenamic Acid; Humans; Indomethacin; Ketoprofen; Mefenamic Acid; Naproxen; Phenylbutazone; Propionates; Salicylates | 1977 |
Drug control of gout and hyperuricaemia.
Topics: Allopurinol; Arthritis; Chronic Disease; Colchicine; Gout; Humans; Indomethacin; Naproxen; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1978 |
[Drug therapy of ankylosing spondyloarthritis (Bechterew's disease)].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Apazone; Butadienes; Cyclophosphamide; Diclofenac; Drug Combinations; Drug Evaluation; Glycolates; Gold; Humans; Ibuprofen; Indomethacin; Ketoprofen; Levamisole; Naproxen; Oxyphenbutazone; Phenylbutazone; Salicylates; Spondylitis, Ankylosing; Sulindac | 1978 |
Treatment of rheumatoid arthritis: a review including newer and experimental anti-inflammatory agents.
Topics: Activities of Daily Living; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Arthritis, Rheumatoid; Aspirin; Aurothioglucose; Fenoprofen; Humans; Ibuprofen; Immunosuppressive Agents; Indomethacin; Naproxen; Oxyphenbutazone; Penicillamine; Phenylbutazone; Physical Therapy Modalities; Tolmetin | 1976 |
Gastroscopic evaluation of the effects of nabumetone on the gastrointestinal mucosa of rheumatic patients.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Butanones; Controlled Clinical Trials as Topic; Digestive System; Gastroscopy; Humans; Indomethacin; Nabumetone; Naproxen; Prospective Studies; Randomized Controlled Trials as Topic; Rheumatic Diseases | 1991 |
Non-steroidal and analgesic therapy in the elderly.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents; Apazone; Aspirin; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Diclofenac; Drug Hypersensitivity; Gastrointestinal Diseases; Hematologic Diseases; Humans; Ibuprofen; Indomethacin; Ketoprofen; Kidney Diseases; Kinetics; Naproxen; Phenylbutazone; Piroxicam; Salicylates; Thiazines | 1986 |
Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Blood Platelets; Drug Evaluation; Drug Interactions; Humans; Indomethacin; Intestinal Absorption; Intestinal Mucosa; Kinetics; Naproxen; Osteoarthritis; Pain; Propionates; Prostaglandins; Rheumatic Diseases; Tissue Distribution | 1985 |
Prostaglandins and nonsteroidal antiinflammatory drugs in dysmenorrhea.
Topics: Anti-Inflammatory Agents; Aspirin; Contraceptives, Oral; Dysmenorrhea; Female; Humans; Ibuprofen; Indomethacin; Naproxen; ortho-Aminobenzoates; Phenylpropionates; Prostaglandins | 1983 |
Review of ibuprofen for osteoarthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Diflunisal; Drug Tolerance; Fenoprofen; Humans; Ibuprofen; Indomethacin; Meclofenamic Acid; Naproxen; Osteoarthritis; Phenylbutazone; Sulindac; Tolmetin | 1984 |
Update on ibuprofen for rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Tolerance; Fenoprofen; Humans; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Piroxicam; Sulindac; Thiazines; Tolmetin | 1984 |
Practical therapeutics: the newer nonsteroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents; Arthritis; Aspirin; Diclofenac; Humans; Ibuprofen; Indomethacin; Naproxen; Phenylbutazone; Phenylbutyrates; Piroxicam; Propionates; Sulindac; Thiazines | 1982 |
Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin.
Topics: Adult; Animals; Arthritis, Rheumatoid; Aspirin; Cyclooxygenase Inhibitors; Diclofenac; Drug Interactions; Female; Gastric Mucosa; Gout; Humans; Ibuprofen; Indomethacin; Male; Middle Aged; Naproxen; Osteoarthritis; Pain; Phenylacetates; Platelet Aggregation; Rheumatic Diseases; Spondylitis, Ankylosing; Ulcer | 1980 |
Current status of the etiology and management of dysmenorrhea in adolescence.
Topics: Adolescent; Aspirin; Contraceptives, Oral; Cyclooxygenase Inhibitors; Dysmenorrhea; Female; Humans; Ibuprofen; Indomethacin; Naproxen; ortho-Aminobenzoates; Ovulation; Prostaglandin Antagonists; Prostaglandins; Uterine Contraction | 1982 |
Naproxen sodium (Anaprox): pharmacology, pharmacokinetics and drug interactions.
Topics: Acid-Base Equilibrium; Animals; Chemical Phenomena; Chemistry; Depression, Chemical; Drug Interactions; Female; Humans; Indomethacin; Kinetics; Male; Naproxen; Pregnancy; Prostaglandins | 1980 |
Primary dysmenorrhea treatment with prostaglandin inhibitors: a review.
Topics: Adolescent; Adult; Dysmenorrhea; Female; Humans; Ibuprofen; Indomethacin; Middle Aged; Naproxen; ortho-Aminobenzoates; Phenylbutazone; Prostaglandin Antagonists | 1981 |
Nonsteroidal anti-inflammatory drug-induced hepatic disorders. Incidence and prevention.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Chemical and Drug Induced Liver Injury; Cohort Studies; Diclofenac; Humans; Incidence; Indomethacin; Liver; Liver Diseases; Naproxen; Oxaprozin; Phenylbutazone; Propionates; Risk Factors; Sulindac | 1996 |
Use of carprofen for the treatment of pain and inflammation in dogs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carbazoles; Clonixin; Cyclooxygenase Inhibitors; Dog Diseases; Dogs; Ibuprofen; Indomethacin; Ketoprofen; Meclofenamic Acid; Meloxicam; Naproxen; Osteoarthritis; Pain; Phenylbutazone; Piroxicam; Thiazines; Thiazoles | 1997 |
Distribution and expression of cyclooxygenase (COX) isoenzymes, their physiological roles, and the categorization of nonsteroidal anti-inflammatory drugs (NSAIDs).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Controlled Clinical Trials as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Etodolac; Gene Expression; Humans; Ibuprofen; Indomethacin; Isoenzymes; Meloxicam; Membrane Proteins; Naproxen; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thiazines; Thiazoles | 1999 |
Effects of cyclooxygenase inhibition on the gastrointestinal tract.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clonixin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Etodolac; Gastrointestinal Tract; Humans; Indomethacin; Naproxen; Species Specificity | 2006 |
Pharmacological treatment of heterotopic ossification following hip and acetabular surgery.
Topics: Acetabulum; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Celecoxib; Diclofenac; Humans; Indomethacin; Naproxen; Ossification, Heterotopic; Postoperative Complications; Pyrazoles; Sulfonamides | 2008 |
[The development of co-amorphous drug systems].
Topics: Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Cimetidine; Drug Combinations; Drug Compounding; Drug Stability; Glipizide; Indomethacin; Naproxen; Ranitidine; Simvastatin; Solubility; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Technology, Pharmaceutical; Temperature; X-Ray Diffraction | 2013 |
Role of indomethacin in acute pain and inflammation management: a review of the literature.
Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Humans; Indomethacin; Inflammation; Ketorolac; Naproxen; Oxycodone; Piroxicam; Tramadol; Treatment Outcome | 2014 |
Non-steroidal anti-inflammatory drugs (NSAIDs) for axial spondyloarthritis (ankylosing spondylitis and non-radiographic axial spondyloarthritis).
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Cyclooxygenase 2 Inhibitors; Humans; Indomethacin; Naproxen; Pain; Pain Measurement; Randomized Controlled Trials as Topic; Spondylarthritis; Spondylitis, Ankylosing | 2015 |
Nonaspirin Nonsteroidal Anti-Inflammatory Drugs and Risk of Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of Observational Studies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cerebral Hemorrhage; Diclofenac; Humans; Ibuprofen; Incidence; Indomethacin; Lactones; Meloxicam; Naproxen; Observational Studies as Topic; Odds Ratio; Piroxicam; Proportional Hazards Models; Stroke; Sulfones; Thiazines; Thiazoles | 2016 |
68 trial(s) available for naproxen and indomethacin
| Article | Year |
|---|---|
Treatment of primary dysmenorrhea with prostaglandin synthetase inhibitors--a promising therapeutic alternative.
Topics: Administration, Oral; Adolescent; Adult; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Evaluation; Dysmenorrhea; Female; Humans; Indomethacin; Menstruation; Middle Aged; Naproxen; Placebos; Uterine Contraction | 1978 |
Prostaglandin synthetase inhibitors and dysmenorrhea. A survey and personal clinical experience.
Topics: Adolescent; Adult; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Evaluation; Dysmenorrhea; Female; Flufenamic Acid; Humans; Ibuprofen; Indomethacin; Mefenamic Acid; Naproxen; ortho-Aminobenzoates; Placebos; Prostaglandin Antagonists | 1979 |
Multicenter comparison of naproxen and indomethacin in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Central Nervous System; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Humans; Indomethacin; Middle Aged; Naproxen | 1978 |
A comparison of naproxen, indomethacin and acetylsalicylic acid in pain after varicose vein surgery.
Topics: Adolescent; Adult; Aged; Aspirin; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Female; Humans; Indomethacin; Middle Aged; Naproxen; Pain, Postoperative; Varicose Veins | 1978 |
Double-blind crossover comparison of naproxen and indomethacin in rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomethacin; Male; Middle Aged; Naproxen | 1977 |
Naproxen in the treatment of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Indomethacin; Naproxen; Patient Dropouts; Placebos | 1978 |
Hypersensitivity to five non-steroidal anti-inflammatory agents: ibuprofen, fenoprofen, indomethacin, naproxen and tolmetin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Drug Hypersensitivity; Fenoprofen; Humans; Ibuprofen; Indomethacin; Iodides; Naproxen; Tolmetin | 1978 |
Indomethacin and naproxen suppositories in the treatment of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomethacin; Male; Naproxen; Suppositories | 1978 |
Naproxen and naproxen sodium in dysmenorrhea: development from in vitro inhibition of prostaglandin synthesis to suppression of uterine contractions in women and demonstration of clinical efficacy.
Topics: Animals; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Dysmenorrhea; Female; Humans; Indomethacin; Naproxen; Placebos; Prostaglandins; Rats; Uterine Contraction | 1979 |
Naproxen and indomethacin in the treatment of primary dysmenorrhea.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Dysmenorrhea; Female; Gastrointestinal Diseases; Humans; Indomethacin; Naproxen | 1979 |
The treatment of sports injuries: a comparison between naproxen and indomethacin. A Royal Army Medical Corps multicentre study.
Topics: Athletic Injuries; Clinical Trials as Topic; Double-Blind Method; Humans; Indomethacin; Male; Naproxen | 1979 |
The value and results of long-term studies with diclofenac sodium (Voltarol).
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Tolerance; Hematologic Tests; Humans; Indomethacin; Liver Function Tests; Naproxen; Phenylacetates; Time Factors | 1979 |
The effects of ibuprofen, indomethacin, aspirin, naproxen, and placebo on the gastric mucosa of normal volunteers: a gastroscopic and photographic study.
Topics: Adult; Aspirin; Gastric Mucosa; Gastroscopy; Humans; Ibuprofen; Indomethacin; Middle Aged; Naproxen; Placebos | 1979 |
A double-glind comparative trial of naproxen and indomethacin in sports injuries.
Topics: Adolescent; Adult; Athletic Injuries; Double-Blind Method; Female; Humans; Indomethacin; Male; Naproxen | 1977 |
A double-blind, multi-centre comparison of naproxen and indomethacin in acute musculo-skeletal disorders.
Topics: Clinical Trials as Topic; Female; Humans; Indomethacin; Male; Muscular Diseases; Naphthaleneacetic Acids; Naproxen; Spinal Diseases | 1976 |
Clinical and objective assessments of naproxen through 5 years of clinical experience.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Arthritis, Rheumatoid; Aspirin; Chronic Disease; Clinical Trials as Topic; Female; Follow-Up Studies; Gout; Humans; Indomethacin; Long-Term Care; Male; Middle Aged; Naphthaleneacetic Acids; Naproxen; Osteoarthritis; Placebos; Polymyalgia Rheumatica | 1975 |
[Long term treatment of rheumatoid arthritis. Experiences with D-penicillamine in comparison with gold and immunosuppressive drugs (author's transl)].
Topics: Adolescent; Adult; Arthritis, Rheumatoid; Blood Sedimentation; Clinical Trials as Topic; Female; Gold; Humans; Immunosuppressive Agents; Indomethacin; Long-Term Care; Male; Middle Aged; Naproxen; Penicillamine; Prednisolone; Rheumatoid Factor | 1975 |
A double-blind comparison of naproxen with indomethacin in osteoarthrosis.
Topics: Anti-Inflammatory Agents; Clinical Trials as Topic; Humans; Indomethacin; Naphthaleneacetic Acids; Naproxen; Osteoarthritis | 1975 |
A Double-blind comparison of naproxen against indometacin in osteoarthrosis.
Topics: Clinical Trials as Topic; Hip Joint; Humans; Indomethacin; Knee Joint; Naphthaleneacetic Acids; Naproxen; Osteoarthritis | 1975 |
[Methods and statistics of multicentral double-blind "cross-over" examination of naproxen compared to indomethacin].
Topics: Aged; Arthritis, Rheumatoid; Chronic Disease; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Indomethacin; Male; Medical Records; Methods; Naphthaleneacetic Acids; Naproxen; Osteoarthritis; Pain; Spondylitis, Ankylosing; Statistics as Topic | 1975 |
[Clinical results of a multicentral double-blind examination of naproxen compared to indomethacin in chronic rheumatoid arthritis, ankylosing spondylitis, and osteoarthrosis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Chronic Disease; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Indomethacin; Male; Middle Aged; Naphthaleneacetic Acids; Naproxen; Nausea; Osteoarthritis; Spondylitis, Ankylosing; Tinnitus; Vertigo | 1975 |
[A double blind comparison of naproxen and indomethacin on the after-midnight-pain of patients with morbus bechterew].
Topics: Adult; Clinical Trials as Topic; Female; Humans; Indomethacin; Male; Middle Aged; Naphthaleneacetic Acids; Naproxen; Pain; Spondylitis, Ankylosing; Suppositories; Time Factors | 1975 |
Clinical evaluation of two daily doses of naproxen and indomethacin: result of a double-blind crossover trail.
Topics: Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Indomethacin; Male; Middle Aged; Naphthaleneacetic Acids; Naproxen | 1975 |
Four commonly prescribed non-steroidal anti-inflammatory drugs for rheumatoid arthritis.
Topics: Administration, Oral; Arthritis, Rheumatoid; Cross-Over Studies; Delayed-Action Preparations; Diclofenac; Humans; Indomethacin; Naproxen; Pain; Piroxicam; Single-Blind Method; Surveys and Questionnaires | 1991 |
Effect of prostaglandin E2 or prostaglandin synthesis inhibitors on human gonadotrophins and prolactin.
Topics: Adult; Dinoprostone; Female; Follicle Stimulating Hormone; Humans; Indomethacin; Luteinizing Hormone; Male; Naproxen; Prolactin; Prostaglandins | 1992 |
[Naproxen versus indomethacin as night-time medication for patients with rheumatoid arthritis].
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Circadian Rhythm; Double-Blind Method; Female; Humans; Indomethacin; Male; Middle Aged; Naproxen | 1991 |
Longterm treatment with nonsteroidal antiinflammatory drugs in rheumatoid arthritis: a prospective drug survival study.
Topics: Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diclofenac; Dose-Response Relationship, Drug; Female; Humans; Indomethacin; Male; Middle Aged; Naproxen; Prospective Studies; Sex Factors; Time Factors | 1991 |
A randomized trial of the effect of three non-steroid anti-inflammatory agents in ameliorating cancer-induced fever.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Fever; Humans; Indomethacin; Male; Naproxen; Neoplasms; Paraneoplastic Syndromes | 1990 |
Inhibition of the late phase response to anti-IgE in humans by indomethacin.
Topics: Adult; Animals; Anti-Inflammatory Agents; Antibodies, Anti-Idiotypic; Arachidonic Acids; Cyclooxygenase Inhibitors; Female; Histamine Release; Humans; Hypersensitivity, Delayed; Immunoglobulin E; Indomethacin; Intradermal Tests; Middle Aged; Naproxen; Prostaglandins; Rabbits | 1985 |
An endoscopic comparison of the effects of etodolac, indomethacin, ibuprofen, naproxen, and placebo on the gastrointestinal mucosa.
Topics: Acetates; Adolescent; Adult; Endoscopy; Etodolac; Gastric Mucosa; Humans; Ibuprofen; Indomethacin; Intestinal Mucosa; Middle Aged; Naproxen; Placebos | 1987 |
Four popular anti-inflammatories. Which?
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Evaluation; Female; Humans; Ibuprofen; Indomethacin; Male; Middle Aged; Naproxen; Piroxicam; Random Allocation | 1988 |
Piroxicam in acute musculoskeletal disorders and sports injuries.
Topics: Activities of Daily Living; Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Athletic Injuries; Bone Diseases; Child; Clinical Trials as Topic; Humans; Indomethacin; Middle Aged; Muscular Diseases; Naproxen; Pain; Piroxicam | 1988 |
Piroxicam in acute musculoskeletal disorders and sport injuries.
Topics: Acute Disease; Adult; Athletic Injuries; Central Nervous System Diseases; Clinical Trials as Topic; Female; Gastrointestinal Diseases; Humans; Indomethacin; Male; Muscular Diseases; Naproxen; Piroxicam | 1987 |
Endoscopic studies of nabumetone in patients with rheumatoid arthritis. A comparative endoscopic and histologic evaluation.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biopsy; Butanones; Clinical Trials as Topic; Drug Administration Schedule; Female; Gastric Mucosa; Gastroscopy; Humans; Indomethacin; Male; Middle Aged; Nabumetone; Naproxen; Random Allocation | 1987 |
International experience with diclofenac in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Humans; Ibuprofen; Indomethacin; Naproxen; Phenylbutazone | 1986 |
International experiences with diclofenac in osteoarthritis.
Topics: Aspirin; Clinical Trials as Topic; Diclofenac; Diflunisal; Double-Blind Method; Gastrointestinal Diseases; Humans; Ibuprofen; Indomethacin; Naproxen; Osteoarthritis; Random Allocation; Sulindac | 1986 |
Comparison of a slow-release indomethacin tablet and naproxen in osteoarthrosis.
Topics: Adult; Aged; Central Nervous System Diseases; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Female; Gastrointestinal Diseases; Hip Joint; Humans; Indomethacin; Knee Joint; Male; Middle Aged; Movement; Naproxen; Osteoarthritis; Pain; Random Allocation; Tablets | 1985 |
Antiproteinuric effect of naproxen and indomethacin. A double-blind crossover study.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; Indomethacin; Male; Middle Aged; Naproxen; Nephrotic Syndrome; Proteinuria; Renal Circulation; Renin | 1985 |
Double-blind preference and compliance multicentre study in osteoarthritis: once-a-day treatment.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Administration Schedule; Humans; Indomethacin; Indoprofen; Ketoprofen; Middle Aged; Naproxen; Osteoarthritis; Pain; Patient Compliance; Piroxicam; Thiazines | 1985 |
The physiological cost of gait (PCG): a new technique for evaluating nonsteroidal anti-inflammatory drugs in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Biomechanical Phenomena; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Female; Gait; Heart Rate; Humans; Indomethacin; Male; Methods; Middle Aged; Naproxen; Random Allocation | 1983 |
A multi-centre study of tiaprofenic acid ('Surgam') and five comparative drugs in rheumatoid arthritis and osteoarthritis in general practice.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; Ibuprofen; Indomethacin; Male; Middle Aged; Naproxen; Osteoarthritis; Patient Compliance; Propionates; Sex Factors; Thiazines | 1983 |
Effects of indomethacin, sulindac, naproxen, aspirin, and paracetamol in treated hypertensive patients.
Topics: Acetaminophen; Aldosterone; Aspirin; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Heart Rate; Humans; Hypertension; Indenes; Indomethacin; Naproxen; Placebos; Random Allocation; Renin; Sodium; Sulindac; Time Factors | 1984 |
Review of ibuprofen for osteoarthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Diflunisal; Drug Tolerance; Fenoprofen; Humans; Ibuprofen; Indomethacin; Meclofenamic Acid; Naproxen; Osteoarthritis; Phenylbutazone; Sulindac; Tolmetin | 1984 |
Update on ibuprofen for rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Tolerance; Fenoprofen; Humans; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Piroxicam; Sulindac; Thiazines; Tolmetin | 1984 |
Effect of different prostaglandin synthesis inhibitors on post-occlusive blood flow in human forearm.
Topics: Adolescent; Adult; Aspirin; Cyclooxygenase Inhibitors; Diclofenac; Female; Forearm; Humans; Hyperemia; Ibuprofen; Indomethacin; Male; Middle Aged; Naproxen; Piroxicam; Regional Blood Flow; Thiazines | 1983 |
Prostaglandin synthetase inhibitors in the treatment of primary dysmenorrhea. Outcome trials reviewed.
Topics: Clinical Trials as Topic; Cyclooxygenase Inhibitors; Dysmenorrhea; Female; Flufenamic Acid; Humans; Ibuprofen; Indomethacin; Mefenamic Acid; Naproxen | 1984 |
Influence of non-steroidal anti-inflammatory drugs on diuretic treatment of mild to moderate essential hypertension.
Topics: Adult; Aged; Anti-Inflammatory Agents; Blood Pressure; Drug Interactions; Female; Humans; Hydrochlorothiazide; Hypertension; Indomethacin; Male; Middle Aged; Naproxen; Prospective Studies; Sulindac | 1984 |
Endoscopic studies of gastric and duodenal injury after the use of ibuprofen, aspirin, and other nonsteroidal anti-inflammatory agents.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Aspirin; Buffers; Duodenum; Endoscopy; Female; Gastric Mucosa; Humans; Ibuprofen; Indomethacin; Intestinal Mucosa; Male; Middle Aged; Naproxen; Time Factors; Tolmetin | 1984 |
Effects of fenbufen, indomethacin, naproxen, and placebo on gastric mucosa of normal volunteers. A comparative endoscopic and photographic evaluation.
Topics: Adult; Anti-Inflammatory Agents; Capsules; Drug Evaluation; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Indomethacin; Male; Naproxen; Phenylbutyrates; Placebos; Propionates; Stomach Ulcer; Tablets | 1983 |
Comparison of the analgesic effect of ten nonsteroidal anti-inflammatory drugs.
Topics: Adult; Aged; Analgesics; Anti-Inflammatory Agents; Apazone; Arthritis, Rheumatoid; Aspirin; Carbazoles; Diclofenac; Female; Humans; Ibuprofen; Indomethacin; Ketoprofen; Male; Middle Aged; Naproxen; ortho-Aminobenzoates; Quinazolines | 1984 |
Gastrointestinal microbleeding: comparisons between benoxaprofen and other nonsteroidal antiinflammatory agents.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Benzoxazoles; Clinical Trials as Topic; Double-Blind Method; Gastrointestinal Hemorrhage; Humans; Indomethacin; Melena; Naproxen; Propionates; Prostaglandins; Sulindac; Time Factors | 1980 |
[Comparative effectiveness of new antirheumatic drugs].
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Flufenamic Acid; Humans; Indomethacin; Naproxen | 1980 |
Anti-inflammatory drugs in periarthritis of the shoulder: a double-blind, between-patient study of naproxen versus indomethacin.
Topics: Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomethacin; Male; Naproxen; Periarthritis; Shoulder Joint | 1981 |
Naproxen and indomethacin in periarthritis of the shoulder.
Topics: Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomethacin; Male; Middle Aged; Naproxen; Pain; Periarthritis; Shoulder Joint | 1982 |
A comparative endoscopic evaluation of the damaging effects of nonsteroidal anti-inflammatory agents on the gastric and duodenal mucosa.
Topics: Adult; Anti-Inflammatory Agents; Duodenum; Endoscopy; Gastric Mucosa; Humans; Ibuprofen; Indomethacin; Intestinal Mucosa; Middle Aged; Naproxen; Tolmetin | 1981 |
Naproxen suppositories in combination with oral naproxen, indomethacin and ibuprofen in the treatment of rheumatoid arthritis.
Topics: Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Ibuprofen; Indomethacin; Male; Middle Aged; Naproxen; Suppositories | 1980 |
Prolonged microvascular vasodilation induced by leukotriene B4 in human skin is cyclooxygenase independent.
Topics: Administration, Oral; Administration, Topical; Adult; Arachidonic Acid; Dose-Response Relationship, Drug; Erythema; Humans; Indoles; Indomethacin; Leukotriene B4; Male; Microcirculation; Naproxen; Oxindoles; Regional Blood Flow; Skin; Vasodilation | 1995 |
Worldwide experience with etodolac (Lodine) 300 mg b.i.d. in the treatment of osteoarthritis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Delayed-Action Preparations; Diclofenac; Double-Blind Method; Etodolac; Global Health; Hip Joint; Humans; Indomethacin; Knee Joint; Middle Aged; Naproxen; Osteoarthritis; Pain; Piroxicam; Time Factors | 1993 |
Effects of chronic NSAIDs on gastric mucosal injury related to mucosal prostanoids, and plasma drug concentrations in human volunteers.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Anti-Inflammatory Agents, Non-Steroidal; Apazone; Dinoprostone; Gastric Fundus; Gastric Mucosa; Humans; Indomethacin; Male; Naproxen; Piroxicam; Pyloric Antrum; Thromboxane B2 | 1993 |
The effects of indomethacin and naproxen on zidovudine pharmacokinetics.
Topics: Acquired Immunodeficiency Syndrome; Adult; Female; Glucuronates; HIV Infections; Humans; Indomethacin; Male; Middle Aged; Naproxen; Zidovudine | 1993 |
Nonsteroidal anti-inflammatory drug use in relation to major upper gastrointestinal bleeding.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Diclofenac; Female; Gastrointestinal Hemorrhage; Humans; Hungary; Ibuprofen; Indomethacin; Male; Middle Aged; Naproxen; Piroxicam; Risk Factors; Sweden; United States | 1993 |
Plasma and synovial fluid interleukin-1, interleukin-6 and substance P concentrations in rheumatoid arthritis patients: effect of the nonsteroidal anti inflammatory drugs indomethacin, diclofenac and naproxen.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diclofenac; Female; Humans; Indomethacin; Interleukin-1; Interleukin-6; Male; Middle Aged; Naproxen; Substance P; Synovial Fluid | 1995 |
Faecal calprotectin shedding after short-term treatment with non-steroidal anti-inflammatory drugs.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Feces; Gastric Mucosa; Humans; Indomethacin; Inflammation; Intestinal Mucosa; Leukocyte L1 Antigen Complex; Male; Naproxen; Neural Cell Adhesion Molecules; Piroxicam; Reproducibility of Results | 1996 |
Comparison of 0.25 mg and 0.1 mg intrathecal morphine for analgesia after Cesarean section.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cesarean Section; Female; Humans; Indomethacin; Injections, Spinal; Morphine; Naproxen; Pain Measurement; Pain, Postoperative | 1999 |
Naproxen in the prevention of heterotopic ossification after total hip replacement.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Chi-Square Distribution; Double-Blind Method; Humans; Indomethacin; Logistic Models; Male; Middle Aged; Naproxen; Ossification, Heterotopic; Postoperative Complications; Prospective Studies; Radiography; Statistics, Nonparametric; Time Factors | 1999 |
Pharmacokinetic interactions of concomitant administration of febuxostat and NSAIDs.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Cross-Over Studies; Drug Interactions; Febuxostat; Female; Gout Suppressants; Humans; Indomethacin; Male; Metabolic Clearance Rate; Middle Aged; Naproxen; Reference Values; Thiazoles | 2006 |
Carbon dioxide-mediated vasomotion of extra-cranial cerebral arteries in humans: a role for prostaglandins?
Topics: Adolescent; Adult; Carbon Dioxide; Carotid Artery, Internal; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Humans; Hypercapnia; Hypocapnia; Indomethacin; Ketorolac; Male; Middle Cerebral Artery; Naproxen; Prostaglandins; Single-Blind Method; Ultrasonography, Doppler, Duplex; Vasoconstriction; Vasodilation; Young Adult | 2016 |
Comparison of rectal indomethacin, diclofenac, and naproxen for the prevention of post endoscopic retrograde cholangiopancreatography pancreatitis.
Topics: Administration, Rectal; Adult; Aged; Amylases; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cholangiopancreatography, Endoscopic Retrograde; Diclofenac; Double-Blind Method; Eicosapentaenoic Acid; Female; Humans; Incidence; Indomethacin; Iran; Lipase; Lipoxins; Male; Middle Aged; Naproxen; Pancreatitis; Risk Factors; Time Factors; Treatment Outcome | 2017 |
326 other study(ies) available for naproxen and indomethacin
| Article | Year |
|---|---|
Synthesis and antiinflammatory activity of cis-4,5,6,7,8,8a,9-hexahydro-alpha-methyl-5H-fluorene-2-acetic acid.
Topics: Animals; Anti-Inflammatory Agents; Arthus Reaction; Edema; Fluorenes; Magnetic Resonance Spectroscopy; Molecular Conformation; Rabbits; Rats; Stereoisomerism | 1977 |
Synthesis and antiinflammatory activity of 6,11-dihydro-11-oxodibenzo[b,e]thiepinalkanoic acids and related compounds.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Chemical Phenomena; Chemistry; Dibenzothiepins; Dogs; Edema; Female; Gossypium; Granuloma; Male; Mice; Quinones; Rats; Stomach Ulcer; Structure-Activity Relationship | 1978 |
Cycloalkanoindoles. 1. Syntheses and antiinflammatory actions of some acidic tetrahydrocarbazoles, cyclopentindoles, and cycloheptindoles.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carbazoles; Cycloheptanes; Cyclopentanes; Edema; Indoles; Rats; Stomach Ulcer; Structure-Activity Relationship | 1976 |
Low molecular weight proteins as carriers for renal drug targeting. Preparation of drug-protein conjugates and drug-spacer derivatives and their catabolism in renal cortex homogenates and lysosomal lysates.
Topics: Amino Acids; Animals; Chromatography, High Pressure Liquid; Drug Carriers; Endopeptidases; Hydrogen-Ion Concentration; Kidney Cortex; Lactates; Lactic Acid; Leucine; Lysosomes; Male; Molecular Weight; Muramidase; Naproxen; Oligopeptides; Proteins; Rats; Rats, Inbred Strains; Serum Albumin, Bovine; Succinimides | 1992 |
Antinociceptive (aminoalkyl)indoles.
Topics: Analgesia; Analgesics; Animals; Chemical Phenomena; Chemistry; Cyclooxygenase Inhibitors; Indoles; Magnetic Resonance Spectroscopy; Male; Methylation; Mice; Molecular Conformation; Molecular Structure; Muscle Contraction; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Vas Deferens | 1991 |
1,2-Dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with antiinflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Cell Line; Cyclooxygenase Inhibitors; Edema; Indicators and Reagents; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Models, Molecular; Molecular Structure; Prostaglandin Antagonists; Pyrroles; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thiazines | 1990 |
Synthesis and antiinflammatory and analgesic activity of 5-aroyl-6-(methylthio)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-ca rboxyl ic acids and 1-methyl-4-(methylthio)-5-aroylpyrrole-2-acetic acids.
Topics: Acetates; Analgesia; Animals; Aspirin; Benzoquinones; Carboxylic Acids; Carrageenan; Chemical Phenomena; Chemistry; Edema; Inflammation; Mice; Molecular Structure; Pain Measurement; Phenylbutazone; Pyrroles; Quinones; Rats | 1989 |
Antiinflammatory activity of substituted 6-hydroxypyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-triones. Atypical nonsteroidal antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Biological Availability; Cyclooxygenase Inhibitors; Gastrointestinal Diseases; Male; Purines; Pyrimidines; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Ulcer | 1986 |
Synthesis and antiinflammatory and analgesic activity of 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids. The 6-substituted compounds.
Topics: Analgesia; Animals; Carboxylic Acids; Chemical Phenomena; Chemistry; Inflammation; Magnetic Resonance Spectroscopy; Mice; Pyrroles; Rats; Structure-Activity Relationship | 1987 |
Esters of N,N-disubstituted 2-hydroxyacetamides as a novel highly biolabile prodrug type for carboxylic acid agents.
Topics: Acetamides; Biotransformation; Carboxylic Acids; Half-Life; Humans; Indicators and Reagents; Kinetics; Structure-Activity Relationship | 1987 |
Synthesis and antiinflammatory activity of hexahydrothiopyrano[4,3-c]pyrazoles and related analogues.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthus Reaction; Chemical Phenomena; Chemistry; Edema; Guinea Pigs; Hypersensitivity, Delayed; Male; Mice; Pyrazoles; Rats; Rats, Inbred Lew; Rats, Inbred Strains | 1982 |
Nonsteroidal antiinflammatory agents. 14. Synthesis and pharmacological profile of 6-chloro-5-(cyclopentylmethyl)indan-1-carboxylic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Edema; Indans; Indenes; Male; Rats; Rats, Inbred Strains | 1984 |
Effect of structural change on acute toxicity and antiinflammatory activity in a series of imidazothiazoles and thiazolobenzimidazoles.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chemical Phenomena; Chemistry; Imidazoles; Lethal Dose 50; Locomotion; Male; Mice; Muscle Tonus; Nervous System; Orientation; Rats; Structure-Activity Relationship; Thiazoles | 1981 |
Antiinflammatory 4,5-diarylpyrroles. 2. Activity as a function of cyclooxygenase-2 inhibition.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Pyrroles; Rats; Structure-Activity Relationship | 1995 |
Heteroaryl-fused 2-phenylisothiazolone inhibitors of cartilage breakdown.
Topics: Animals; Cartilage; Cattle; Dose-Response Relationship, Drug; Humans; Interleukin-1; Isomerism; Male; Metalloendopeptidases; Models, Biological; Proteoglycans; Pyridines; Pyrimidines; Rats; Structure-Activity Relationship; Thiazoles | 1994 |
Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors.
Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Drug Design; Humans; Hydroxyurea; Ibuprofen; Indomethacin; Leukocytes; Leukotriene E4; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Male; Naproxen; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Tumor Cells, Cultured | 1997 |
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Carrageenan; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Hyperalgesia; Isoenzymes; Magnetic Resonance Spectroscopy; Male; Membrane Proteins; Molecular Structure; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfonamides | 1997 |
1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Edema; Gastrointestinal Diseases; Humans; Imidazoles; Isoenzymes; Membrane Proteins; Mice; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Rats; Structure-Activity Relationship; Sulfonamides; Sulfones | 1997 |
Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis.
Topics: Animals; Biological Assay; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Isoenzymes; Kinetics; Placenta; Prostaglandin Antagonists; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sheep | 1998 |
Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis.
Topics: Animals; Cattle; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; In Vitro Techniques; Isoenzymes; Plantago; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sheep; Triterpenes; Ursolic Acid | 1998 |
Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes.
Topics: Animals; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Carrier Proteins; Oocytes; Xenopus laevis | 1999 |
Synthesis and biological evaluation of 3,4-diaryloxazolones: A new class of orally active cyclooxygenase-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase Inhibitors; Fever; Humans; Magnetic Resonance Spectroscopy; Male; Oxazoles; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Structure-Activity Relationship | 2000 |
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Selective cyclooxygenase-2 inhibitors: heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dogs; Edema; Gastrointestinal Hemorrhage; Humans; Hyperalgesia; Imidazoles; Intestines; Isoenzymes; Membrane Proteins; Mice; Nitriles; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Stomach; Structure-Activity Relationship; Sulfonamides | 2000 |
Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1.
Topics: Adenine; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Biological Transport; Carrier Proteins; Humans; Kidney; Organophosphonates; Structure-Activity Relationship | 2000 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport.
Topics: Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibiotics, Antitubercular; Antimalarials; Biological Transport, Active; Digoxin; Enzyme Inhibitors; Estradiol; Ibuprofen; LLC-PK1 Cells; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Quinidine; Quinine; Rats; Rifampin; Swine | 2002 |
Synthesis and pharmacological evaluation of amide conjugates of NSAIDs with L-cysteine ethyl ester, combining potent antiinflammatory and antioxidant properties with significantly reduced gastrointestinal toxicity.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cholesterol; Cysteine; Drug Evaluation; Gastrointestinal Diseases; Lipoproteins, LDL; Mice; Rats; Triglycerides | 2004 |
Contribution of ionization and lipophilicity to drug binding to albumin: a preliminary step toward biodistribution prediction.
Topics: Chromatography, Affinity; Hydrogen-Ion Concentration; Ions; Models, Molecular; Molecular Conformation; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Serum Albumin, Bovine; Ultracentrifugation | 2004 |
Novel cyclooxygenase-1 inhibitors discovered using affinity fingerprints.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Combinatorial Chemistry Techniques; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Design; Drug Evaluation, Preclinical; Ibuprofen; Inhibitory Concentration 50; Isoenzymes; Models, Molecular; Models, Theoretical; Molecular Structure; Prospective Studies; Prostaglandin-Endoperoxide Synthases; Quantitative Structure-Activity Relationship | 2004 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Synthesis and pharmacochemical study of novel polyfunctional molecules combining anti-inflammatory, antioxidant, and hypocholesterolemic properties.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Antioxidants; Arthritis; Cholesterol; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Female; Inflammation; Pipecolic Acids; Proline; Rats; Rats, Inbred F344; Structure-Activity Relationship; Triglycerides | 2006 |
The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclooxygenase Inhibitors; Disease Models, Animal; Flurbiprofen; Mice; Peptide Fragments | 2006 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability.
Topics: 1-Octanol; Diffusion; Dimethylpolysiloxanes; Humans; In Vitro Techniques; Membranes, Artificial; Myristates; Permeability; Skin; Skin Absorption; Water | 2006 |
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water | 2007 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Benzophenone-N-ethyl piperidine ether analogues--synthesis and efficacy as anti-inflammatory agent.
Topics: Animals; Anti-Inflammatory Agents; Benzophenones; Carrageenan; Edema; Mice; Piperidines; Prostaglandins | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.
Topics: Binding Sites; Crystallography, X-Ray; Drug Interactions; Humans; Pharmaceutical Preparations; Protein Binding; Protein Structure, Tertiary; Serum Albumin; Spectrometry, Fluorescence | 2010 |
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Comet Assay; DNA Damage; Glucuronides; Glucuronosyltransferase; HEK293 Cells; Hepatocytes; Humans; Kidney | 2011 |
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics | 2011 |
Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase Inhibitors; Edema; Esters; Gastric Mucosa; Humans; Hydroxamic Acids; Ibuprofen; Indomethacin; Male; Naproxen; Nitric Oxide Donors; Nitrogen Oxides; Prodrugs; Rats; Rats, Sprague-Dawley; Stereoisomerism; Stomach Ulcer; Structure-Activity Relationship | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Fragment-based design, docking, synthesis, biological evaluation and structure-activity relationships of 2-benzo/benzisothiazolimino-5-aryliden-4-thiazolidinones as cycloxygenase/lipoxygenase inhibitors.
Topics: Animals; Anti-Inflammatory Agents; Catalytic Domain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Design; Edema; Female; Lipoxygenase; Lipoxygenase Inhibitors; Male; Mice; Models, Molecular; Structure-Activity Relationship; Thiazolidines | 2012 |
Self-organizing molecular field analysis of NSAIDs: assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Computational Biology; Least-Squares Analysis; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship | 2012 |
3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic Acids: highly potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3.
Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Benzoates; Enzyme Inhibitors; Humans; Hydroxyprostaglandin Dehydrogenases; Models, Molecular; Structure-Activity Relationship | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Cell Line; Humans; Indomethacin; Intramolecular Oxidoreductases; Lipoxygenase Inhibitors; Microsomes; Prostaglandin-E Synthases; Pyrazoles; Structure-Activity Relationship; Sulfonamides | 2012 |
Synthesis and biological evaluation of some 5-arylidene-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-ones as dual anti-inflammatory/antimicrobial agents.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Edema; Gram-Negative Bacteria; Gram-Positive Bacteria; Mice; Microbial Sensitivity Tests; Thiazoles | 2013 |
High analgesic and anti-inflammatory in vivo activities of six new hybrids NSAIAs tetrahydropyran derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Mice; Molecular Structure; Motor Activity; Pyrans | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Design of novel potent antihyperlipidemic agents with antioxidant/anti-inflammatory properties: exploiting phenothiazine's strong antioxidant activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Atherosclerosis; Biphenyl Compounds; Carrageenan; Cholesterol, Dietary; Cyclooxygenase Inhibitors; Diet, High-Fat; Drug Design; Edema; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Hypolipidemic Agents; In Vitro Techniques; Indicators and Reagents; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Male; Mice; Microsomes; Phenothiazines; Picrates; Rats | 2014 |
Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates.
Topics: Amidohydrolases; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Flurbiprofen; Humans; Serotonin; TRPV Cation Channels | 2014 |
Effect of new hybrids based on 5,16-pregnadiene scaffold linked to an anti-inflammatory drug on the growth of a human astrocytoma cell line (U373).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Humans; Molecular Structure; Pregnadienes; Sulindac; Time Factors | 2015 |
Synthesis, antinociceptive and anti-inflammatory effects of porphyrins.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Disease Models, Animal; Edema; Erythrocytes; Hemolysis; Indomethacin; Male; Mice; Naproxen; Nociception; Pain; Pain Measurement; Porphyrins; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 2015 |
Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Drug Design; Edema; Humans; Inflammation; Mice; Molecular Docking Simulation; Molecular Dynamics Simulation; Naproxen; Nociception; Pain; Pain Measurement; Structure-Activity Relationship; Thiazoles; Thiones; Triazoles | 2015 |
Esters of some non-steroidal anti-inflammatory drugs with cinnamyl alcohol are potent lipoxygenase inhibitors with enhanced anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cinnamates; Edema; Esters; Glycine max; Hyperlipidemias; Indoleacetic Acids; Lipoxygenase Inhibitors; Polyethylene Glycols; Propanols; Propionates; Rats; Thioctic Acid | 2015 |
Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory activity.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholesterol; Cholesterol, LDL; Edema; Hyperlipidemias; Hypolipidemic Agents; Morpholines; Rats; Triglycerides | 2016 |
Synthesis and biological properties of aryl methyl sulfones.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Edema; Humans; Male; Mice; Models, Molecular; Molecular Structure; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Structure-Activity Relationship; Sulfones; Thermodynamics | 2018 |
Synthesis and anticancer activity of open-resorcinarene conjugates.
Topics: Animals; Antineoplastic Agents; Calixarenes; Cell Line, Tumor; Cell Proliferation; Chlorocebus aethiops; COS Cells; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Phenylalanine; Structure-Activity Relationship | 2020 |
A practical synthesis of amino limonin/deoxylimonin derivatives as effective mitigators against inflammation and nociception.
Topics: | 2020 |
Hypoxia-Activated Prodrugs with Dual COX-2/CA Inhibitory Effects on Attenuating Cardiac Inflammation under Hypoxia.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Hypoxia; Inflammation; Nitroreductases; Prodrugs | 2022 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
The role of copper in preventing gastrointestinal damage by acidic anti-inflammatory drugs.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chelating Agents; Copper; Edema; Female; In Vitro Techniques; Indomethacin; Ketoprofen; Male; Naproxen; Niflumic Acid; Peptic Ulcer; Prostaglandins E; Pyrroles; Rats | 1976 |
The influence of non-steroidal anti-inflammatory and antithyroid agents on myeloperoxidase-catalysed activities of human leucocytes.
Topics: Antithyroid Agents; Diiodotyrosine; Flufenamic Acid; Humans; Imidazoles; Indomethacin; Iodine Radioisotopes; Leukocytes; Models, Biological; Naproxen; Peroxidase; Peroxidases; Phagocytosis; Serum Albumin, Bovine; Sonication; Thyroid Gland; Thyroxine | 1979 |
Endogenous prostaglandins in dysmenorrhea and the effect of prostaglandin synthetase inhibitors (PGSI) on uterine contractility.
Topics: Cyclooxygenase Inhibitors; Dysmenorrhea; Endometrium; Female; Humans; Indomethacin; Menstruation; Muscle Tonus; Naproxen; Placebos; Prostaglandins F; Uterine Contraction | 1979 |
Regulation of thyroid ornithine ornithine decarboxylase (ODC) by thyrotropin. I. The rat.
Topics: Animals; Arachidonic Acids; Aspirin; Bucladesine; Carboxy-Lyases; Colchicine; Cyclic AMP; Indomethacin; Kinetics; Male; Naproxen; Organ Size; Ornithine Decarboxylase; Phenylbutazone; Prostaglandins E; Putrescine; Rats; Thyroid Gland; Thyrotropin; Time Factors; Triiodothyronine; Vinblastine | 1975 |
Inhibitory effects of non-steroidal anti-inflammatory drugs on human myeloperoxidase.
Topics: Flufenamic Acid; Guaiacol; Humans; Indomethacin; Iodine; Leukocytes; Naproxen; Peroxidase; Peroxidases; Serum Albumin, Bovine | 1979 |
[Clinical study of naproxen suppositories in polyclinic practice (author's transl)].
Topics: Arthritis, Rheumatoid; Humans; Indomethacin; Naproxen; Rheumatic Diseases; Spondylitis, Ankylosing; Suppositories | 1979 |
Cholinergic and alpha-adrenergic stimulation of prostaglandin release by dog thyroid in vitro.
Topics: Animals; Atropine; Calcimycin; Carbachol; Dogs; Dose-Response Relationship, Drug; Epinephrine; In Vitro Techniques; Indomethacin; Naproxen; Prostaglandins; Prostaglandins F; Radioimmunoassay; Thyroid Gland | 1979 |
[Antagonist of prostaglandin synthesis in the treatment of dysmenorrhea].
Topics: Aspirin; Dysmenorrhea; Female; Humans; Indomethacin; Naproxen; Prostaglandin Antagonists | 1979 |
Inhibition of human leucocytes locomotion by anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents; Aspirin; Cell Movement; Chemotaxis, Leukocyte; Depression, Chemical; Humans; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Neutrophils; Salicylates | 1979 |
[Effect of nonsteroid anti-inflammatory agents on the spontaneous contractility of rat myometrium].
Topics: Animals; Anti-Inflammatory Agents; Chemical Phenomena; Chemistry; Drug Evaluation; Female; Indomethacin; Mefenamic Acid; Naproxen; Rats; Sulfonamides; Uterine Contraction | 1979 |
Drugs for dysmenorrhea.
Topics: Acetaminophen; Aspirin; Dysmenorrhea; Female; Humans; Ibuprofen; Indomethacin; Mefenamic Acid; Nalbuphine; Naproxen; Time Factors | 1979 |
[Inhibition of spontaneous pressure changes in tissue and arterial vessels of in vitro perfused ovaries of man and cattle caused by prostaglandin synthesis inhibitors indomethacin and naproxen].
Topics: Animals; Blood Pressure; Cattle; Female; Humans; Indomethacin; Naproxen; Ovary; Pressure | 1979 |
Inhibition of peroxidase activity by some non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Diiodotyrosine; Flufenamic Acid; Horseradish Peroxidase; Indomethacin; Iodine Radioisotopes; Isotope Labeling; Kinetics; Naproxen; Peroxidases; Rats; Serum Albumin, Bovine; Thyroid Gland; Thyroxine | 1979 |
Comparisons of tolerability findings in international clinical trials.
Topics: Arthritis, Rheumatoid; Aspirin; Cardiovascular System; Clinical Trials as Topic; Diclofenac; Drug Tolerance; Follow-Up Studies; Gastrointestinal Diseases; Hematologic Tests; Humans; Ibuprofen; Indomethacin; International Cooperation; Naproxen; Phenylacetates; Time Factors | 1979 |
[On the efficiency of new antiinflammatory agents. A comparative study (author's transl)].
Topics: Animals; Anti-Inflammatory Agents; Benzylidene Compounds; Carrageenan; Diclofenac; Edema; Fenoprofen; In Vitro Techniques; Indenes; Indomethacin; Ketoprofen; Naproxen; Phenylbutazone; Protease Inhibitors; Rats | 1977 |
In vivo inhibition of prostaglandin synthesis in rabbit kidney by non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Diclofenac; Dose-Response Relationship, Drug; Indomethacin; Injections, Intravenous; Kidney; Kidney Medulla; Male; Naproxen; Prostaglandins E; Prostaglandins F; Rabbits; Time Factors | 1978 |
Administration of anti-inflammatory compounds in silastic capsules.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Capsules; Indomethacin; Injections, Subcutaneous; Male; Naproxen; Phenylbutazone; Rats; Silicone Elastomers | 1977 |
Dose-dependent inhibition of sensory nerve activity in the feline dental pulp by anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Cats; Dental Pulp; Diclofenac; Dose-Response Relationship, Drug; Hot Temperature; Indomethacin; Injections, Intravenous; Methysergide; Naproxen; Nerve Endings; Sensory Receptor Cells | 1978 |
Human leukocytic pyrogen induces release of specific granule contents from human neutrophils.
Topics: Cations, Divalent; Cytochalasin B; Humans; Indomethacin; Lactoferrin; Leukocytes; Lysosomes; Muramidase; Naproxen; Neutrophils; Phagocytosis; Pyrogens | 1978 |
The use of nonsteroidal anti-inflammatory agents.
Topics: Anti-Inflammatory Agents; Drug Interactions; Half-Life; Humans; Indomethacin; Naproxen; Prostaglandin Antagonists; Salicylates | 1978 |
Nonsteroidal anti-inflammatory drug treatment for arthritis.
Topics: Anti-Inflammatory Agents; Arthritis; Flufenamic Acid; Humans; Ibuprofen; Indomethacin; Mefenamic Acid; Naproxen; Oxyphenbutazone; Phenylbutazone; Salicylates | 1978 |
Inhibition of prostaglandin synthesis in rat brain.
Topics: Acetaminophen; Animals; Aspirin; Brain; Diclofenac; Dose-Response Relationship, Drug; Indomethacin; Male; Naproxen; Prostaglandin Antagonists; Prostaglandins E; Prostaglandins F; Rats; Time Factors | 1978 |
Prostaglandin synthetase activity from human rheumatoid synovial microsomes. Effect of 'aspirin-like' drug therapy.
Topics: Adult; Aged; Arachidonic Acids; Arthritis, Rheumatoid; Aspirin; Cyclooxygenase Inhibitors; Female; Humans; Ibuprofen; In Vitro Techniques; Indomethacin; Male; Microsomes; Middle Aged; Mixed Function Oxygenases; Naproxen; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Prostaglandins F; Synovial Membrane | 1976 |
Gastric effects of propoxyphene, acetaminophen, indomethacin, phenylbutazone, and naproxen.
Topics: Acetaminophen; Animals; Dextropropoxyphene; Gastritis; Indomethacin; Male; Naphthaleneacetic Acids; Naproxen; Phenylbutazone; Rats; Stomach | 1977 |
Modulation of phagocytosis by and lysosomal enzyme secretion from guinea-pig neutrophils: effect of nonsteroid anti-inflammatory agents and prostaglindins.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Chloroquine; Fenoprofen; Glucuronidase; Guinea Pigs; In Vitro Techniques; Indomethacin; Lysosomes; Naproxen; Neutrophils; Phagocytosis; Prostaglandins; Prostaglandins A; Prostaglandins E; Prostaglandins F | 1977 |
[Pharmacotherapy in uratic arthritis. I].
Topics: Acute Disease; Colchicine; Gout; Humans; Indomethacin; Naphthaleneacetic Acids; Naproxen; Phenylbutazone | 1977 |
Aspirin and newer anti-inflammatory agents in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Fenoprofen; Humans; Ibuprofen; Indomethacin; Naproxen; Peptic Ulcer; Phenylbutazone; Tolmetin | 1977 |
[Psoriatic arthropathy].
Topics: Arthritis; Humans; Indomethacin; Methotrexate; Naproxen; Phenylbutazone; Psoriasis | 1977 |
Some effects of non-steroidal anti-inflammatory drugs on leucocyte migration.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Cell Movement; Edema; Fenoprofen; Ibuprofen; Indomethacin; Ketoprofen; Leukocytes; Male; Methotrexate; Naproxen; Phenylbutazone; Pleurisy; Rats | 1976 |
Medical management of rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Arthritis, Rheumatoid; Aspirin; Chloroquine; Gold; Humans; Ibuprofen; Indomethacin; Naproxen; Occupational Therapy; Phenylbutazone; Physical Therapy Modalities | 1976 |
The effect of reported prostaglandin synthetase inhibitors on estradiol-stimulated uterine prostaglandin biosynthesis in vivo in the ovariectomized rat.
Topics: Animals; Aspirin; Dronabinol; Estradiol; Female; Indomethacin; Naproxen; Organ Size; Ovary; Prostaglandin Antagonists; Prostaglandins E; Prostaglandins F; Rats; Time Factors; Uterus | 1976 |
Relationship between the inhibitory activity on 'RCS' and prostaglandins synthesis and the anti-inflammatory activity of ketoprofen and several other non-steroidal anti-inflammatory agents.
Topics: Abscess; Animals; Anti-Inflammatory Agents; Aorta; Arachidonic Acids; Aspirin; Benzophenones; Colon; Guinea Pigs; Hydroxy Acids; Ibuprofen; In Vitro Techniques; Indomethacin; Ketoprofen; Lung; Muscle Contraction; Naproxen; Phenylbutazone; Prostaglandin Antagonists; Prostaglandins; Pyrans | 1976 |
Chemistry and pharmacology of naproxen.
Topics: Administration, Oral; Adrenalectomy; Animals; Aspirin; Carrageenan; Drug Evaluation, Preclinical; Edema; Female; Fever; Granuloma; Indomethacin; Male; Mice; Naphthaleneacetic Acids; Naproxen; Phenylbutazone; Pressure; Quinones; Rats; Yeast, Dried | 1975 |
[Steroid saving effect of naproxen].
Topics: Arthritis, Rheumatoid; Chronic Disease; Drug Therapy, Combination; Humans; Indomethacin; Naphthaleneacetic Acids; Naproxen; Prednisolone | 1975 |
[Methoxypropriocin in the treatment of degenerative bone disease (comparative studies)].
Topics: Aspirin; Benzydamine; Chronic Disease; Humans; Indomethacin; Naphthaleneacetic Acids; Naproxen; Osteoarthritis; Spondylitis, Ankylosing | 1976 |
Exacerbation of experimental colitis by nonsteroidal anti-inflammatory drugs is not related to elevated leukotriene B4 synthesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Dinoprostone; Drug Combinations; Indomethacin; Leukotriene B4; Male; Misoprostol; Naproxen; Peroxidase; Quinolines; Rats; Rats, Inbred Strains | 1992 |
Measurement of non-steroid antiinflammatory drugs induced gastric microbleeding.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Apazone; Diclofenac; Gastric Juice; Gastrointestinal Hemorrhage; Humans; Indomethacin; Middle Aged; Naproxen | 1992 |
Dissociation between prostaglandin levels and blood flow to the retina and choroid in the newborn pig after nonsteroidal antiinflammatory drugs.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Choroid; Ibuprofen; Indomethacin; Naproxen; Osmolar Concentration; Prostaglandins; Regional Blood Flow; Retina; Retinal Vessels; Swine | 1992 |
Low concentrations of lithium and cyclooxygenase inhibitors enhance endothelin-1 (ET-1)-induced contractions in human temporal artery, but not in porcine ophthalmic artery.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Endothelins; Humans; Indomethacin; Lithium; Naproxen; Ophthalmic Artery; Osmolar Concentration; Swine; Temporal Arteries; Vasoconstriction | 1992 |
Independent regulation of plasminogen activator inhibitor 2 and plasminogen activator inhibitor 1 in human synovial fibroblasts.
Topics: Blotting, Northern; Blotting, Western; Cells, Cultured; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Glucocorticoids; Humans; Indomethacin; Interleukin-1; Naproxen; Plasminogen Activator Inhibitor 1; Plasminogen Activator Inhibitor 2; RNA, Messenger; Synovial Membrane | 1992 |
Lipocortin 1 mediates dexamethasone-induced growth arrest of the A549 lung adenocarcinoma cell line.
Topics: Adenocarcinoma; Aldosterone; Annexins; Antibodies, Monoclonal; Calcium-Binding Proteins; Cell Division; Cell Membrane; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Humans; Hydrocortisone; Indomethacin; Kinetics; Lung Neoplasms; Mifepristone; Naproxen; Phospholipases; Progesterone; Recombinant Proteins | 1992 |
Lipid mediators of tumor necrosis factor-alpha-induced uveitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Eicosanoids; Eye Proteins; Indomethacin; Leukocyte Count; Leukotriene B4; Male; Naproxen; Platelet Activating Factor; Prostaglandins E; Quinolinium Compounds; Rabbits; Recombinant Proteins; Tumor Necrosis Factor-alpha; Uveitis, Anterior; Vitreous Body | 1991 |
Simultaneous analysis of flunixin, naproxen, ethacrynic acid, indomethacin, phenylbutazone, mefenamic acid and thiosalicylic acid in plasma and urine by high-performance liquid chromatography and gas chromatography-mass spectrometry.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Chromatography, High Pressure Liquid; Clonixin; Ethacrynic Acid; Gas Chromatography-Mass Spectrometry; Horses; Indomethacin; Mefenamic Acid; Naproxen; Phenylbutazone; Spectrophotometry, Ultraviolet; Sulfhydryl Compounds; Thimerosal | 1991 |
Pharmacology of the potent new non-steroidal anti-inflammatory agent aceclofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzoquinones; Capillary Permeability; Carrageenan; Diclofenac; Edema; Female; Granuloma; Indomethacin; Male; Mice; Naproxen; Pain; Phenylbutazone; Pleurisy; Rats; Rats, Inbred Strains; Silver Nitrate; Stomach Ulcer; Synovitis | 1991 |
Interleukins-1 and -6 stimulate the release of corticotropin-releasing hormone-41 from rat hypothalamus in vitro via the eicosanoid cyclooxygenase pathway.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adrenocorticotropic Hormone; Animals; Benzeneacetamides; Corticotropin-Releasing Hormone; Cytokines; Eicosanoids; Hydroxamic Acids; Hypothalamus; In Vitro Techniques; Indomethacin; Interleukin-1; Interleukin-6; Kinetics; Lipoxygenase Inhibitors; Male; Naproxen; Pituitary Gland; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Recombinant Proteins | 1991 |
Tenidap, in contrast to several available nonsteroidal antiinflammatory drugs, potently inhibits the release of activated neutrophil collagenase.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Hypochlorous Acid; Ibuprofen; In Vitro Techniques; Indoles; Indomethacin; Microbial Collagenase; Naproxen; Neutrophils; Oxindoles; Peroxidase; Piroxicam; Reference Values; Superoxides | 1991 |
Nonsalicylate nonsteroidal antiinflammatory drugs augment prestimulated acid secretion in rabbit parietal cells. Investigation of the mechanisms of action.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Carbazoles; Gastric Acid; Indomethacin; Naproxen; Parietal Cells, Gastric; Rabbits | 1991 |
Differences in the effects in the newborn piglet of various nonsteroidal antiinflammatory drugs on cerebral blood flow but not on cerebrovascular prostaglandins.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cerebrovascular Circulation; Ibuprofen; Indomethacin; Naproxen; Prostaglandins; Swine | 1991 |
Management of IUD-associated menorrhagia in female rhesus monkeys (Macaca mulatta).
Topics: Aminocaproic Acid; Animals; Anti-Inflammatory Agents; Antifibrinolytic Agents; Endometrium; Female; Ibuprofen; Indomethacin; Intrauterine Devices; Iron; Macaca mulatta; Menorrhagia; Menstrual Cycle; Menstruation; Naproxen; Plant Extracts; Tissue Plasminogen Activator; Tranexamic Acid | 1991 |
The pharmacological profile of aceclofenac, a new nonsteroidal antiinflammatory and analgesic drug.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dogs; Female; Indomethacin; Male; Mice; Naproxen; Phenylbutazone; Rats; Rats, Inbred Strains; Stomach Ulcer | 1991 |
Nonsteroidal anti-inflammatory drug therapy and gastric side effects. Does nabumetone provide a solution?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Gastric Mucosa; Humans; Indomethacin; Male; Nabumetone; Naproxen; Platelet Aggregation; Platelet Aggregation Inhibitors; Prodrugs; Prostaglandins; Rats; Rats, Inbred Strains; Thromboxane A2 | 1990 |
Effects of the prodrug nabumetone, and its active metabolite, 6-MNA, on human and rat gastric mucosal prostanoids and platelet function.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Butanones; Dinoprostone; Epoprostenol; Gastric Mucosa; Humans; Indomethacin; Male; Nabumetone; Naphthaleneacetic Acids; Naproxen; Platelet Aggregation; Platelet Aggregation Inhibitors; Prodrugs; Rats; Rats, Inbred Strains | 1990 |
Liquid chromatography with amperometric detection for the determination of non-steroidal anti-inflammatory drugs in plasma.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Diflunisal; Electric Conductivity; Humans; Indomethacin; Naproxen; Piroxicam; Sulindac | 1990 |
A method to predict the percutaneous permeability of various compounds: shed snake skin as a model membrane.
Topics: Animals; Cell Membrane Permeability; Hydrocortisone; Ibuprofen; Indomethacin; Ketoprofen; Models, Biological; Molecular Weight; Naproxen; Particle Size; Progesterone; Skin; Snakes | 1990 |
The effect of nabumetone and its principal active metabolite on in vitro human gastric mucosal prostanoid synthesis and platelet function.
Topics: 6-Ketoprostaglandin F1 alpha; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Butanones; Culture Techniques; Dinoprostone; Epoprostenol; Gastric Mucosa; Humans; Indomethacin; Nabumetone; Naphthaleneacetic Acids; Naproxen; Platelet Aggregation; Thromboxane A2; Thromboxane B2 | 1990 |
The mucoid cap over superficial gastric damage in the rat. A high-pH microenvironment dissipated by nonsteroidal antiinflammatory drugs and endothelin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Endothelins; Endothelium, Vascular; Fibrin; Gastric Mucosa; Hydrochloric Acid; Hydrogen-Ion Concentration; Indomethacin; Male; Mucus; Naproxen; Peptides; Rats; Rats, Inbred Strains; Regional Blood Flow; Time Factors | 1990 |
Naproxen and indomethacin: disposition and effects in the isolated perfused rat kidney.
Topics: Animals; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Kidney; Male; Naproxen; Perfusion; Rats; Rats, Inbred Strains | 1990 |
Effect of the antiinflammatory prodrug, nabumetone and its principal active metabolite on rat gastric mucosal, aortic and platelet eicosanoid synthesis, in vitro and ex vivo.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Blood Platelets; Butanones; Eicosanoids; Gastric Mucosa; In Vitro Techniques; Indomethacin; Male; Nabumetone; Naphthaleneacetic Acids; Naproxen; Prodrugs; Rats; Rats, Inbred Strains | 1990 |
Induction of cleft palate in mice by inhibitors of prostaglandin synthesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cleft Palate; Diclofenac; Female; Indomethacin; Injections, Intramuscular; Maternal-Fetal Exchange; Mice; Microscopy; Naproxen; Organ Culture Techniques; Palate; Pregnancy; Sulindac | 1990 |
Inhibition of arachidonic acid-induced ear oedema as a model for assessing topical anti-inflammatory compounds.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Edema; Free Radicals; Histamine Release; Indomethacin; Lipoxygenase Inhibitors; Mast Cells; Mathematics; Mice; Naproxen | 1987 |
Comparison of the effects on inhibition of cyclooxygenase and thromboxane synthetase on renal excretion and haemodynamics in rats of different ages.
Topics: Age Factors; Animals; Cyclooxygenase Inhibitors; Diuresis; Female; Hemodynamics; Imidazoles; Indomethacin; Kidney; Male; Naproxen; p-Aminohippuric Acid; Rats; Renal Circulation; Thromboxane-A Synthase | 1989 |
Role of plasminogen activators and leukocytes in IUD-induced inflammation: effect of some anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Endometritis; Epithelium; Female; Ibuprofen; Indomethacin; Intrauterine Devices; Leukocyte Count; Naproxen; Neutrophils; Organ Size; ortho-Aminobenzoates; Plasminogen Activators; Rats; Uterus | 1989 |
Influence of cardioprotective cyclooxygenase and lipoxygenase inhibitors on peroxidative injury to myocardial-membrane phospholipid.
Topics: Aspirin; Cyclooxygenase Inhibitors; Fatty Acids, Unsaturated; Humans; Indomethacin; Lipid Peroxidation; Lipid Peroxides; Lipoxygenase Inhibitors; Membrane Lipids; Myocardial Reperfusion Injury; Naproxen; Sulfinpyrazone; Superoxides; Time Factors; Xanthine Oxidase | 1989 |
[Evolution of enzymuria in the course of acute renal insufficiency caused by non-steroidal anti-inflammatory agents].
Topics: Acetylglucosaminidase; Acute Kidney Injury; Aged; Aged, 80 and over; Aminopeptidases; Anti-Inflammatory Agents, Non-Steroidal; CD13 Antigens; Diclofenac; Female; gamma-Glutamyltransferase; Hexosaminidases; Humans; Indomethacin; Middle Aged; Naproxen | 1989 |
Adult Still's disease: a missed diagnosis.
Topics: Adult; Arthritis, Gouty; Arthritis, Juvenile; Female; Fever; Humans; Indomethacin; Male; Naproxen | 1989 |
Effect of Cu2+ and Zn2+ on the inhibition of human leucocyte elastase by 6-alkyl-3-(omega-carboxyalkyl)-2-pyrone, oleic acid and sulindac sulfide.
Topics: Copper; Diflunisal; Humans; Indenes; Indomethacin; Leukocytes; Naproxen; Oleic Acid; Oleic Acids; Pancreatic Elastase; Pyrans; Pyrones; Structure-Activity Relationship; Sulindac; Zinc | 1989 |
Improved delivery through biological membranes. XXXVII. Synthesis and stability of novel redox derivatives of naproxen and indomethacin.
Topics: Blood-Brain Barrier; Drug Carriers; Drug Stability; Indomethacin; Naproxen; Oxidation-Reduction | 1989 |
Effects of isoxicam and other non-steroidal anti-inflammatory drugs on arachidonic acid metabolism by rat peritoneal leucocytes.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Calcimycin; Hydroxyeicosatetraenoic Acids; Ibuprofen; In Vitro Techniques; Indomethacin; Leukocytes; Male; Naproxen; Piroxicam; Prostaglandins; Rats; Rats, Inbred Strains; Thiazines | 1985 |
Non-steroidal anti-inflammatory drugs and bleeding peptic ulcer.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Duodenal Ulcer; Female; Humans; Ibuprofen; Indomethacin; Male; Middle Aged; Naproxen; Osteoarthritis; Peptic Ulcer Hemorrhage; Piroxicam; Smoking; Stomach Ulcer; Surveys and Questionnaires; Thiazines | 1986 |
Analgesic and anti-inflammatory activities in rats of alpha-(3,5-di-t-butyl-4-hydroxybenzylidene)-gamma-butyrolactone (KME-4), and its intestinal damage.
Topics: 4-Butyrolactone; Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Capillary Permeability; Edema; Furans; Ibuprofen; Indomethacin; Intestinal Diseases; Lethal Dose 50; Male; Naproxen; Rats; Rats, Inbred Strains | 1986 |
[Drug therapy of dysmenorrhea].
Topics: Adrenergic beta-Agonists; Adult; Aspirin; Calcium Channel Blockers; Contraceptives, Oral; Dysmenorrhea; Female; Flufenamic Acid; Humans; Ibuprofen; Indomethacin; Magnesium; Mefenamic Acid; Models, Biological; Naproxen; Progestins | 1988 |
Immunomodulatory effects of treatment with naproxen in patients with rheumatic disease.
Topics: Arthritis, Rheumatoid; B-Lymphocytes; Cell Adhesion; Humans; Indomethacin; Lymphocyte Activation; Middle Aged; Naproxen; T-Lymphocytes; T-Lymphocytes, Regulatory | 1986 |
Effects of prostaglandin synthesis inhibition on sympathetic-and parasympathetic-mediated coronary hemodynamic responses.
Topics: Acetylcholine; Animals; Carotid Arteries; Coronary Vessels; Cyclooxygenase Inhibitors; Dogs; Epinephrine; Female; Hemodynamics; Indomethacin; Isoproterenol; Lactates; Lactic Acid; Male; Naproxen; Norepinephrine; Ouabain; Parasympathetic Nervous System; Prostaglandins; Sympathetic Nervous System; Vasodilation | 1986 |
The history of diclofenac.
Topics: Chemical Phenomena; Chemistry; Diclofenac; Humans; Hydrogen-Ion Concentration; Ibuprofen; Indenes; Indomethacin; Ketoprofen; Naproxen; Phenylbutazone; Piroxicam; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship; Thiazines | 1986 |
Glomerular mesangial cell contractility in vitro is controlled by an angiotensin-prostaglandin balance.
Topics: Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Dinoprostone; Fluorescent Antibody Technique; Glomerular Mesangium; Indomethacin; Lipoxygenase Inhibitors; Microscopy, Phase-Contrast; Naproxen; Prostaglandins; Prostaglandins E; Pyrazoles; Rats; Receptors, Angiotensin | 1986 |
Salvage of ischemic rabbit ear by BW-755C and steroids, but not by indomethacin.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Ear; Indomethacin; Ischemia; Methylprednisolone; Naproxen; Necrosis; Pyrazoles; Rabbits | 1987 |
Blood coagulation and bone metabolism: some characteristics of the bone resorptive effect of thrombin in mouse calvarial bones in vitro.
Topics: Adrenal Cortex Hormones; Animals; Arachidonic Acid; Arachidonic Acids; Bone and Bones; Bone Matrix; Bone Resorption; Calcitonin; Calcium; In Vitro Techniques; Indomethacin; Inflammation; Lactates; Lysosomes; Meclofenamic Acid; Mice; Naproxen; Phosphates; Rats; Thrombin | 1988 |
Indomethacin blunts the late phase of nitroglycerin-induced coronary vasodilatation in dogs.
Topics: Animals; Blood Pressure; Coronary Vessels; Cyclooxygenase Inhibitors; Dogs; Female; Heart Rate; Indomethacin; Injections, Intra-Arterial; Male; Naproxen; Nitroglycerin; Thromboxane B2; Vasodilation | 1985 |
Inhibition by anti-inflammatory agents of contraction induced by epidermal growth factor-urogastrone in isolated longitudinal smooth muscle strips from guinea-pig stomach.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Auranofin; Cycloheximide; Dexamethasone; Epidermal Growth Factor; Guinea Pigs; Ibuprofen; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Naproxen; Steroids; Stomach | 1988 |
Interactions with the protein binding of 7-hydroxy-methotrexate in human serum in vitro.
Topics: Adult; Humans; Indomethacin; Male; Methotrexate; Naproxen; Protein Binding; Serum Albumin | 1988 |
A comparative study of the photochemistry of the non-steroidal anti-inflammatory drugs, naproxen, benoxaprofen and indomethacin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Naproxen; Photochemistry; Propionates; Spectrum Analysis; Ultraviolet Rays | 1988 |
Effects of tiaprofenic acid and other NSAIDs on proteoglycan metabolism in articular cartilage explants.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cartilage, Articular; Culture Techniques; Dogs; Electrophoresis, Polyacrylamide Gel; Indomethacin; Naproxen; Propionates; Proteoglycans; Sulfur Radioisotopes | 1988 |
Hyperkalemia induced by indomethacin and naproxen and reversed by fludrocortisone.
Topics: Fludrocortisone; Humans; Hyperkalemia; Indomethacin; Kidney; Male; Middle Aged; Naproxen | 1988 |
[Chronic arthritis. Round table].
Topics: Adolescent; Adrenal Cortex Hormones; Arthritis, Juvenile; Aspirin; Autoantibodies; Child; Humans; Indomethacin; Naproxen; Penicillamine; Rheumatoid Factor; Tolmetin | 1987 |
Effect of non-steroidal anti-inflammatory drugs on fertility of male rats.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Dinoprostone; Fertility; Indomethacin; Kinetics; Male; Naproxen; Phenylbutazone; Prostaglandins E; Rats; Rats, Inbred Strains; Semen | 1986 |
Serpiginous gastric erosions caused by aspirin and other nonsteroidal antiinflammatory drugs.
Topics: Anti-Inflammatory Agents; Aspirin; Gastric Mucosa; Gastritis; Humans; Indomethacin; Naproxen; Radiography | 1986 |
Piroxicam and gastrointestinal bleeding.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Drug Utilization; Female; Gastrointestinal Hemorrhage; Hospitalization; Humans; Ibuprofen; Indomethacin; Male; Middle Aged; Naproxen; Norway; Piroxicam; Prospective Studies | 1986 |
1,6-Dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido(1,2-a)- pyrimidine-3-carboxamide (Ch-127) protects against the intestinal damage in rats caused by two weeks' daily administration of indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Indomethacin; Intestinal Diseases; Male; Naproxen; Pyrimidinones; Rats; Rats, Inbred Strains; Ulcer | 1987 |
Inhibition of in vitro lysozyme release from human granulocytes and monocytes by non-steroidal anti-inflammatory agents.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Granulocytes; Humans; In Vitro Techniques; Indomethacin; Monocytes; Muramidase; Naproxen | 1987 |
Comparison of the effects of different anti-inflammatory drugs on synovial fluid prostanoid concentrations in patients with rheumatoid arthritis.
Topics: 6-Ketoprostaglandin F1 alpha; Acetaminophen; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Carbazoles; Diclofenac; Dinoprostone; Guanidines; Humans; Indomethacin; Naproxen; ortho-Aminobenzoates; Prednisolone; Prostaglandins; Prostaglandins E; Quinazolines; Synovial Fluid; Thromboxane B2 | 1985 |
NSAID-plasma concentration monitoring--optimizing treatment of R.A.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Ibuprofen; Indomethacin; Kinetics; Metabolic Clearance Rate; Naproxen; Phenylacetates; Phenylbutazone | 1985 |
The effects of cyclooxygenase and lipoxygenase inhibitors on the collagen abnormalities of diabetic rats.
Topics: Acetaminophen; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Female; Indomethacin; Lipoxygenase Inhibitors; Naproxen; Rats; Rats, Inbred Strains | 1985 |
Late phase of nitroglycerin-induced coronary vasodilatation blunted by inhibition of prostaglandin synthesis.
Topics: Animals; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Female; Indomethacin; Male; Naproxen; Nitroglycerin; Prostaglandin Antagonists; Prostaglandins; Vasodilation | 1985 |
The effects of diclofenac sodium on arachidonic acid metabolism.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Chemotaxis, Leukocyte; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Hydroxyeicosatetraenoic Acids; Ibuprofen; Indomethacin; Leukocytes; Lipoxygenase; Naproxen; Phospholipases A; Phospholipases A2; Phospholipids; Piroxicam; Prostaglandins E; SRS-A; Thiazines; Triglycerides | 1985 |
Comparative effects of four prostaglandin synthesis inhibitors on the obstructed kidney in the dog.
Topics: Animals; Blood Pressure; Dogs; Female; Ibuprofen; Indomethacin; Ketorolac; Kidney Pelvis; Naproxen; Pressure; Prostaglandin Antagonists; Tolmetin; Ureteral Obstruction | 1986 |
European experience with flurbiprofen. A new analgesic/anti-inflammatory agent.
Topics: Aspirin; Drug Evaluation; Europe; Flurbiprofen; Humans; Ibuprofen; Indomethacin; Naproxen; Propionates | 1986 |
Arachidonic acid metabolites stimulate phosphatidylcholine secretion in primary cultures of type II pneumocytes.
Topics: Animals; Arachidonic Acids; Catechols; Cells, Cultured; Dose-Response Relationship, Drug; Flufenamic Acid; Ibuprofen; In Vitro Techniques; Indomethacin; Lung; Male; Masoprocol; Naproxen; Phosphatidylcholines; Rats; Rats, Inbred Strains | 1985 |
Nephrotoxicity from nonsteroidal anti-inflammatory drugs.
Topics: Acute Disease; Acute Kidney Injury; Aged; Anti-Inflammatory Agents; Aspirin; Female; Humans; Hyperkalemia; Ibuprofen; Indomethacin; Male; Middle Aged; Naproxen; Nephritis, Interstitial | 1985 |
Nonsteroidal anti-inflammatory agents. A review of the literature.
Topics: Absorption; Anti-Inflammatory Agents; Aspirin; Diflunisal; Drug Interactions; Female; Fenoprofen; Half-Life; Humans; Ibuprofen; Indomethacin; Kinetics; Meclofenamic Acid; Naproxen; Phenylbutazone; Piroxicam; Pregnancy; Thiazines; Tolmetin | 1985 |
Pharmacological investigation of the mechanisms of platelet-activating factor induced mortality in the mouse.
Topics: Anaphylaxis; Animals; Chloroquine; Chlortetracycline; Dexamethasone; Dose-Response Relationship, Drug; Female; Indomethacin; Injections, Intravenous; Male; Mice; Mice, Inbred DBA; Naproxen; Nicardipine; Nifedipine; Platelet Activating Factor; Pyrazoles; Quinacrine; Tetracycline; Verapamil | 1985 |
Worldwide experience with diclofenac in rheumatoid arthritis and osteoarthritis.
Topics: Arthritis, Rheumatoid; Aspirin; Diclofenac; Double-Blind Method; Humans; Indomethacin; Naproxen; Osteoarthritis; Sulindac; Tolmetin | 1985 |
Diclofenac in the treatment of painful joints and traumatic tendinitis (including strains and sprains): a brief review.
Topics: Diclofenac; Flufenamic Acid; Humans; Ibuprofen; Indomethacin; Joint Diseases; Ketoprofen; Naproxen; Pain; Sprains and Strains; Tendinopathy | 1985 |
Nabumetone (BRL 14777, 4-[6-methoxy-2-naphthyl]-butan-2-one): a new anti-inflammatory agent.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Female; Granuloma; Indomethacin; Nabumetone; Naproxen; Prostaglandins; Rats; Rats, Inbred Strains; Stomach Ulcer | 1982 |
Indomethacin therapy and the measurement of urinary 5-hydroxyindoleacetic acid.
Topics: Arthritis, Rheumatoid; False Positive Reactions; Humans; Hydroxyindoleacetic Acid; Indomethacin; Naproxen | 1982 |
Effect of prostaglandin synthesis inhibitors on basal and carbon dioxide-stimulated cerebral blood flow in man.
Topics: Adult; Arachidonic Acids; Aspirin; Carbon Dioxide; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Fatty Acids, Nonesterified; Female; Humans; Indomethacin; Male; Middle Aged; Naproxen; Platelet Aggregation | 1983 |
Prostaglandin-mediated stimulation of adenosine 3',5'-monophosphate accumulation and parathyroid hormone release in dispersed human parathyroid cells.
Topics: Animals; Cattle; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Hyperparathyroidism; Indomethacin; Naproxen; Parathyroid Glands; Parathyroid Hormone; Prostaglandins; Prostaglandins E; Prostaglandins F | 1980 |
Characteristic of indomethacin and naproxen release from silastic polymeric rods in vitro.
Topics: Albumins; Drug Implants; Hydrogen-Ion Concentration; Indomethacin; Naproxen; Polyvinyls; Silicon Dioxide; Silicone Elastomers | 1981 |
Prostaglandin-independent inhibition of calcium transport by nonsteroidal anti-inflammatory drugs: differential effects of carboxylic acids and piroxicam.
Topics: Animals; Anti-Inflammatory Agents; Biological Transport, Active; Calcium; Carboxylic Acids; Cell Membrane; Cricetinae; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Indomethacin; Ion Channels; Meclofenamic Acid; Microsomes, Liver; Mitochondria, Liver; Naproxen; Piroxicam; Prostaglandins; Rats; Thiazines; Thromboxanes | 1983 |
Inhibition of PG production by MDL 035, a new non-steroidal non-acidic anti-inflammatory compound, in rat gastric mucosa and inflammatory exudate.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dinoprostone; Dose-Response Relationship, Drug; Exudates and Transudates; Gastric Mucosa; Imidazoles; In Vitro Techniques; Indomethacin; Inflammation; Male; Naproxen; Prostaglandins; Prostaglandins E; Rats; Stomach Ulcer | 1984 |
Effect of prostaglandin synthesis inhibitors on basal and CO2-stimulated cerebral blood flow in man.
Topics: Arachidonic Acids; Aspirin; Carbon Dioxide; Cerebrovascular Circulation; Epoprostenol; Humans; In Vitro Techniques; Indomethacin; Naproxen; Platelet Aggregation; Prostaglandins | 1983 |
Soybean lipoxygenase inhibition by nonsteroidal antiinflammatory drugs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anti-Inflammatory Agents; Glycine max; Indomethacin; Kinetics; Lipoxygenase Inhibitors; Naproxen; Piroxicam; Plants; Pyrazoles; Structure-Activity Relationship; Thiazines | 1983 |
Effect of prostaglandin synthesis inhibitors on basal and carbon dioxide stimulated cerebral blood flow in man.
Topics: Adult; Arachidonic Acids; Aspirin; Carbon Dioxide; Cerebrovascular Circulation; Epoprostenol; Fatty Acids, Nonesterified; Female; Humans; Indomethacin; Male; Middle Aged; Naproxen; Oxygen; Oxygen Consumption; Platelet Aggregation; Prostaglandin Antagonists | 1983 |
Correlation between ossification and inflammation using a rat experimental model.
Topics: Animals; Arthritis; Arthritis, Experimental; Disease Models, Animal; Indomethacin; Naproxen; Ossification, Heterotopic; Phenylbutazone; Rats; Spine; Spondylitis, Ankylosing | 1983 |
Effects of indomethacin and naproxen on renal p-amino-hippurate (PAH) excretion in rats during postnatal development.
Topics: Aging; Aminohippuric Acids; Animals; Diuresis; Female; Glomerular Filtration Rate; Hematocrit; Indomethacin; Male; Naproxen; p-Aminohippuric Acid; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Sodium | 1984 |
Drug prescription patterns for rheumatic disorders in Sweden.
Topics: Administration, Oral; Anti-Inflammatory Agents; Chloroquine; Drug Prescriptions; Drug Utilization; Gold Sodium Thiomalate; Hospitals, University; Humans; Ibuprofen; Indomethacin; Naproxen; Penicillamine; Pharmacy Service, Hospital; Phenylbutazone; Rheumatic Diseases; Rheumatology; Suppositories; Sweden | 1984 |
A clinical evaluation of the antiarthritic agents.
Topics: Anti-Inflammatory Agents; Antimalarials; Arthritis; Aspirin; Diflunisal; Fenoprofen; Glucocorticoids; Gold; Humans; Ibuprofen; Immunosuppressive Agents; Indomethacin; Naproxen; ortho-Aminobenzoates; Penicillamine; Piroxicam; Prostaglandin Antagonists; Salicylates; Sulindac; Thiazines; Tolmetin | 1984 |
Effect on platelet aggregation of oral administration of 10 non-steroidal analgesics to humans.
Topics: Acetaminophen; Adult; Analgesics; Aspirin; Diclofenac; Diflunisal; Epinephrine; Female; Humans; Ibuprofen; Indomethacin; Male; Middle Aged; Naproxen; Oxyphenbutazone; Piroxicam; Platelet Aggregation; Thiazines; Time Factors | 1984 |
Prostaglandin synthesis inhibition in persistent pulmonary hypertension of the newborn.
Topics: Animals; Blood Pressure; Ductus Arteriosus, Patent; Female; Fetus; Humans; Hypertension, Pulmonary; Indomethacin; Infant, Newborn; Lung; Naproxen; Persistent Fetal Circulation Syndrome; Pregnancy; Prostaglandins; Pulmonary Circulation; Salicylates; Sheep; Vasoconstriction | 1984 |
Poisoning after overdose with non-steroidal anti-inflammatory drugs.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Child; Child, Preschool; Diflunisal; Female; Fenoprofen; Feprazone; Humans; Ibuprofen; Indomethacin; Ketoprofen; London; Male; Mefenamic Acid; Naproxen; Oxyphenbutazone; Phenylbutazone; Piroxicam; Thiazines; Tolmetin | 1984 |
[Comparative study of the anti-inflammatory and analgesic action of sodium Naproxen and Indomethacin in the post-operative period of tooth extraction].
Topics: Adult; Double-Blind Method; Female; Humans; Indomethacin; Male; Naproxen; Pain, Postoperative; Postoperative Complications; Tooth Extraction | 1983 |
Interaction of vasopressin and prostaglandins in the nonpregnant human uterus.
Topics: Arginine Vasopressin; Arteries; Dinoprost; Dinoprostone; Female; Humans; In Vitro Techniques; Indomethacin; Lypressin; Myometrium; Naproxen; Prostaglandins E; Prostaglandins F; Regional Blood Flow; Uterus | 1984 |
Factors determining efficacy of NSAIDs.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Indomethacin; Kinetics; Naproxen; Piroxicam; Prostaglandin Antagonists; Salicylates; Sulindac; Thiazines | 1984 |
Hematuria and the use of nonsteroidal anti-inflammatory drugs.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Female; Hematuria; Humans; Ibuprofen; Indomethacin; Male; Middle Aged; Naproxen | 1984 |
The effect of antidiuretic hormone, indomethacin and naproxen on prostaglandin synthesis of experimentally infected and healthy kidneys.
Topics: Animals; Arginine Vasopressin; Deamino Arginine Vasopressin; Dinoprost; Escherichia coli Infections; Female; Indomethacin; Kidney; Naproxen; Nephritis; Prostaglandins E; Prostaglandins F; Rats; Rats, Inbred Strains | 1982 |
Comparative gastric ulcerogenic effects of meseclazone, 5-chlorosalicylic acid and other nonsteroidal anti-inflammatory drugs following acute and repeated oral administration to rats.
Topics: Animals; Anti-Inflammatory Agents; Benzoxazines; Biotransformation; Fenoprofen; Ibuprofen; Indomethacin; Male; Naproxen; Oxazines; Peptic Ulcer Hemorrhage; Phenylbutazone; Rats; Salicylates; Stomach Ulcer; Time Factors; Tolmetin | 1980 |
Dysmenorrhoea: effective new approaches to a controversial problem.
Topics: Cyclooxygenase Inhibitors; Dysmenorrhea; Female; Flufenamic Acid; Humans; Ibuprofen; Indomethacin; Mefenamic Acid; Naproxen | 1980 |
Skeletal muscle vasoconstriction produced by prostaglandin synthesis inhibitors; dependence on pump perfusion.
Topics: Animals; Cyclooxygenase Inhibitors; Dogs; Female; Hindlimb; In Vitro Techniques; Indomethacin; Male; Meclofenamic Acid; Muscles; Naproxen; Perfusion; Regional Blood Flow; Vascular Resistance; Vasoconstriction | 1981 |
Arachidonic acid metabolites and the gastro-intestinal toxicity of anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Cyclooxygenase Inhibitors; Digestive System; Flurbiprofen; Gastric Mucosa; Indomethacin; Intestinal Mucosa; Ketoprofen; Naproxen; Prostaglandins; Rats | 1981 |
Enhanced renal vasoconstriction in rats fed essential fatty acid-deficient diet.
Topics: Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Fatty Acids, Essential; Indomethacin; Kidney; Male; Naproxen; Norepinephrine; Rats; Rats, Inbred Strains; Regional Blood Flow; Vascular Resistance; Vasoconstriction | 1982 |
Effect of nonsteroidal antiinflammatory drugs on human monocyte chemotaxis in vitro.
Topics: Anti-Inflammatory Agents; Cell Survival; Chemotaxis, Leukocyte; Humans; Ibuprofen; Indomethacin; Monocytes; Naproxen | 1983 |
Renal papillary necrosis following regular consumption of non-steroidal anti-inflammatory drugs.
Topics: Aged; Anti-Inflammatory Agents; Humans; Ibuprofen; Indomethacin; Ketoprofen; Kidney Papillary Necrosis; Male; Middle Aged; Naproxen; Osteoarthritis | 1982 |
Rheumatoid arthritis IV: non-steroidal anti-inflammatory agents use in treatment.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Fenoprofen; Humans; Ibuprofen; Indomethacin; Naproxen; Phenylbutazone; Tolmetin | 1982 |
[Non-steroidal antirheumatics: side-effects and interactions].
Topics: Anemia, Aplastic; Anti-Inflammatory Agents, Non-Steroidal; Coumarins; Drug Interactions; Gastrointestinal Diseases; Humans; Indomethacin; Naproxen; ortho-Aminobenzoates; Phenylbutazone; Prostaglandins; Rheumatic Diseases; Salicylates; Stomach Ulcer | 1982 |
Influence of anti-rheumatic drugs on the activity of collagenolytic cathepsin in hepatic culture.
Topics: Aminopyrine; Animals; Anti-Inflammatory Agents; Aspirin; Cathepsins; Culture Techniques; Indomethacin; L-Lactate Dehydrogenase; Liver; Naproxen; Phenylbutazone; Proteins; Rats; Rats, Inbred Strains | 1982 |
Alteration of plasma prednisolone levels by indomethacin and naproxen.
Topics: Aged; Female; Humans; Indomethacin; Male; Middle Aged; Naproxen; Prednisolone; Protein Binding | 1982 |
Effect of indomethacin and naproxen on the metabolism of glycosaminoglycans.
Topics: Acetylglucosaminidase; Animals; Cathepsin D; Cathepsins; Glucuronidase; Glycosaminoglycans; Indomethacin; Kidney; Liver; Male; Naproxen; Rats; Rats, Mutant Strains; Spleen; Sulfur Radioisotopes | 1982 |
A relationship between biological half-life and effective half-life according to pharmacological response in non-steroid antiinflammatory drugs.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Feprazone; Half-Life; Indomethacin; Injections, Intravenous; Kinetics; Male; Naproxen; Rats | 1981 |
[Effect of copper ions on the contractility of rabbit's myometrium in vitro].
Topics: Animals; Copper; Diestrus; Female; In Vitro Techniques; Indomethacin; Naproxen; Pregnancy; Rabbits; Uterine Contraction | 1981 |
Effect of indomethacin and naproxen on the metabolism of collagen in adjuvant-induced arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Collagen; Hydroxyproline; Indomethacin; Male; Naproxen; Rats | 1981 |
Further effects of nonsteroidal anti-inflammatory compounds on blastocyst hatching in vitro and implantation rates in the mouse.
Topics: Animals; Anti-Inflammatory Agents; Blastocyst; Culture Techniques; Dose-Response Relationship, Drug; Embryo Implantation; Female; Fetal Blood; Indomethacin; Male; Meclofenamic Acid; Mefenamic Acid; Mice; Naproxen | 1981 |
Effective of acetylsalicylic acid, indomethacin, phenylbutazone, paracetamol, ibuprofen and naproxen on canine gastric mucosa: a histological and ultrastructural study.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Aspirin; Dogs; Gastric Mucosa; Ibuprofen; Indomethacin; Naproxen; Phenylbutazone | 1981 |
Effects of indomethacin, naproxen and paracetamol on regional blood flow in rabbits: a microsphere study.
Topics: Acetaminophen; Animals; Female; Indomethacin; Male; Microspheres; Naproxen; Organ Specificity; Prostaglandin Antagonists; Rabbits; Regional Blood Flow | 1981 |
Renal prostaglandins and sodium balance in the rabbit: lack of effect of aspirin-like drugs.
Topics: Aldosterone; Animals; Anti-Inflammatory Agents; Aspirin; Diclofenac; Diet, Sodium-Restricted; Female; Indomethacin; Kidney; Mineralocorticoid Receptor Antagonists; Naproxen; Potassium; Prostaglandins E; Prostaglandins F; Rabbits; Sodium | 1980 |
Naproxen sodium and indomethacin in acute musculoskeletal disorders.
Topics: Acute Disease; Adult; Bone Diseases; Female; Humans; Indomethacin; Male; Middle Aged; Muscular Diseases; Naproxen | 1980 |
Metabolism resistant isothiazolone inhibitors of cartilage breakdown.
Topics: Animals; Cartilage; Cattle; Indomethacin; Interleukin-1; Matrix Metalloproteinase 3; Metalloendopeptidases; Microsomes; Naproxen; Nasal Septum; Organ Culture Techniques; Oxidation-Reduction; Proteoglycans; Pyrazoles; Pyridines; Structure-Activity Relationship; Thiazoles | 1995 |
Submicron emulsion vehicle for enhanced transdermal delivery of steroidal and nonsteroidal antiinflammatory drugs.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Indomethacin; Naproxen; Piroxicam; Rats; Rats, Sprague-Dawley; Skin; Steroids; Time Factors | 1995 |
Alterations in the electroretinogram of newborn piglets by propionic acid-derivative nonsteroidal antiinflammatory drugs but not by indomethacin and diclofenac.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Electroretinography; Flurbiprofen; Ibuprofen; Indomethacin; Naproxen; Photoreceptor Cells; Propionates; Prostaglandins; Retina; Swine | 1995 |
Effect of etodolac on prostaglandin E2 biosynthesis, active oxygen generation and bradykinin formation.
Topics: Animals; Aspirin; Bradykinin; Bromelains; Cartilage, Articular; Cell Line; Concanavalin A; Depression, Chemical; Diclofenac; Dinoprostone; Dogs; Etodolac; Gastric Mucosa; Guinea Pigs; Indomethacin; Interleukin-1; Ketoprofen; Kidney; Naproxen; Oxygen; Pain; Piroxicam; Rabbits; Rats | 1994 |
The down-regulation of IL-6-stimulated fibrinogen steady state mRNA and protein levels by human recombinant IL-1 is not PGE2-dependent: effects of IL-1 receptor antagonist (IL-1RA).
Topics: Arachidonic Acid; Carcinoma, Hepatocellular; Dinoprostone; Down-Regulation; Fibrinogen; Gene Expression; Humans; Indomethacin; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Interleukin-6; Naproxen; Phospholipases A; Recombinant Proteins; RNA, Messenger; Sialoglycoproteins; Tumor Cells, Cultured | 1995 |
The reduced expression of glucocorticoid receptors in synovial cells induced by nonsteroidal antiinflammatory drugs can be reversed by prostaglandin E1 analog.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Indomethacin; Misoprostol; Naproxen; Propionates; Receptors, Glucocorticoid; Synovial Membrane | 1994 |
Adaptation of rat gastric mucosa to aspirin requires mucosal contact.
Topics: Adaptation, Physiological; Animals; Aspirin; Dinoprostone; Gastric Mucosa; Gastritis; Gastrointestinal Hemorrhage; Indomethacin; Male; Naproxen; Ornithine Decarboxylase; Peroxidase; Rats; Rats, Wistar | 1995 |
Bradykinin modulates mucin secretion but not synthesis from an intestinal goblet cell line.
Topics: Adenocarcinoma; Bradykinin; Colonic Neoplasms; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Glucosamine; Humans; Indomethacin; Mucins; Naproxen; Tumor Cells, Cultured | 1994 |
Prostaglandin biosynthesis by fat body from the tobacco hornworm, Manduca sexta.
Topics: Animals; Arachidonic Acid; Fat Body; Hydroxyeicosatetraenoic Acids; Indomethacin; Larva; Microsomes; Moths; Naproxen; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Prostaglandins A; Temperature | 1994 |
Gastric mucosal damage induced by nonsalicylate nonsteroidal antiinflammatory drugs in rats is mediated systemically.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-Response Relationship, Drug; Gastric Mucosa; Indomethacin; Male; Naproxen; Rats; Rats, Wistar | 1993 |
Regulation of human normal and osteoarthritic chondrocyte interleukin-1 receptor by antirheumatic drugs.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Dexamethasone; Humans; Hydrocortisone; Indoles; Indomethacin; Metalloendopeptidases; Naproxen; Osteoarthritis; Oxindoles; Prostaglandins E; Protein Binding; Receptors, Interleukin-1 | 1993 |
LTB4-induced transient neutropenia in the rat: a model for evaluating efficacy and bioavailability of LTB4 receptor antagonists.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Dexamethasone; Hydroxyurea; Indomethacin; Leukocyte Count; Leukotriene B4; Male; Models, Biological; Naproxen; Neutropenia; Neutrophils; Rats; Rats, Sprague-Dawley; Receptors, Leukotriene B4 | 1993 |
Synthesis and evaluation of morpholinoalkyl ester prodrugs of indomethacin and naproxen.
Topics: Animals; Biological Availability; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Gastric Mucosa; Hydrolysis; Indomethacin; Male; Naproxen; Prodrugs; Rats; Rats, Sprague-Dawley; Solubility; Solutions; Stomach Ulcer | 1993 |
Neuronal M2 muscarinic receptor function in guinea-pig lungs is inhibited by indomethacin.
Topics: Acetylcholine; Animals; Bronchoconstriction; Depression, Chemical; Drug Interactions; Electric Stimulation; Gallamine Triethiodide; Guinea Pigs; Indomethacin; Lung; Naproxen; Neurons; Parasympathetic Nervous System; Pilocarpine; Receptors, Muscarinic; Stereoisomerism; Vagus Nerve | 1993 |
Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Colonic Neoplasms; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA, Neoplasm; HT29 Cells; Humans; Indomethacin; Naproxen; Piroxicam; Protein Serine-Threonine Kinases | 1996 |
Do non-steroidal anti-inflammatory drugs have an effect on gastric cell turnover?
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Bromodeoxyuridine; Cell Division; Diclofenac; Gastric Mucosa; Gastroscopy; Humans; Ibuprofen; Immunohistochemistry; Indomethacin; Mefenamic Acid; Naproxen; Pyloric Antrum | 1995 |
Enhancement by cyclo-oxygenase inhibitors of platelet-activating factor production in thapsigargin-stimulated macrophages.
Topics: Animals; Arachidonic Acid; Bucladesine; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Ibuprofen; Indomethacin; Macrophages, Peritoneal; Male; Naproxen; Platelet Activating Factor; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Terpenes; Thapsigargin | 1995 |
Nonsteroidal anti-inflammatory drugs activate carbonic anhydrase by a direct mechanism of action.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carbonic Anhydrases; Dose-Response Relationship, Drug; Humans; Indomethacin; Naproxen; Piroxicam | 1996 |
Mast cells do not contribute to nonsteroidal anti-inflammatory drug-induced gastric mucosal injury in rodents.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Degranulation; Dexamethasone; Disease Models, Animal; Gastric Mucosa; Indomethacin; Male; Mast Cells; Mice; Naproxen; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stomach Ulcer | 1996 |
Tumor necrosis factor mediation of NSAID-induced gastric damage: role of leukocyte adherence.
Topics: Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Cell Movement; Gastrointestinal Hemorrhage; Indomethacin; Leukocytes; Male; Naproxen; Rats; Rats, Wistar; Stomach; Stomach Diseases; Stomach Ulcer; Tumor Necrosis Factor-alpha | 1996 |
Nonsteroidal antiinflammatory drugs inhibit cyclooxygenase-2 enzyme activity but not mRNA expression in human macrophages.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gene Expression; Humans; Indomethacin; Isoenzymes; Lipopolysaccharides; Macrophages; Membrane Proteins; Naproxen; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides | 1996 |
Assessment of the antiexudative and antiproliferative activities of non-steroidal anti-inflammatory drugs in inflammatory models developed in rats by subcutaneous implantation of bacterial cell walls from the dental plaque.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Cell Division; Cell Wall; Child; Dental Plaque; DNA Replication; Duodenum; Edema; Exudates and Transudates; Granuloma; Growth Inhibitors; Humans; Ibuprofen; Indomethacin; Inflammation; Intestinal Mucosa; Naproxen; Rats; Sulindac | 1996 |
Prostaglandin biosynthesis by salivary glands isolated from the lone star tick, Amblyomma americanum.
Topics: Animals; Cyclooxygenase Inhibitors; Female; Freezing; Indomethacin; Naproxen; Prostaglandins; Proteins; Salivary Glands; Ticks | 1997 |
Histamine H2-receptor antagonist action of ebrotidine. Effects on gastric acid secretion, gastrin levels and NSAID-induced gastrotoxicity in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzenesulfonates; Diclofenac; Dose-Response Relationship, Drug; Female; Gastric Acid; Gastrins; Guinea Pigs; Heart Atria; Heart Rate; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Indomethacin; Ketoprofen; Male; Naproxen; Pentagastrin; Ranitidine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thiazoles | 1997 |
Nonsteroidal antiinflammatory drug-photosensitized formation of pyrimidine dimer in DNA.
Topics: Anti-Inflammatory Agents, Non-Steroidal; DNA; DNA Damage; DNA, Single-Stranded; Energy Transfer; In Vitro Techniques; Indomethacin; Ketoprofen; Naproxen; Photochemistry; Photosensitizing Agents; Propionates; Pyrimidine Dimers | 1998 |
Neoplastic fever: choice of antipyrogenic therapy makes a difference.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Squamous Cell; Fever; Humans; Indomethacin; Male; Naproxen; Patient Selection; Ureteral Neoplasms | 1998 |
Interaction of indomethacin and naproxen with gastric surface-active phospholipids: a possible mechanism for the gastric toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric Mucosa; Indomethacin; Liposomes; Male; Naproxen; Phospholipids; Rats; Rats, Sprague-Dawley; Solubility; Spectrometry, Fluorescence; Surface-Active Agents; Water | 1999 |
Kinetic basis for selective inhibition of cyclo-oxygenases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Ibuprofen; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Kinetics; Male; Membrane Proteins; Mice; Naproxen; Oxygen; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sheep; Structure-Activity Relationship; Sulfonamides; Tetramethylphenylenediamine; Thermodynamics | 1999 |
Mechanism of drug release from poly(L-lactic acid) matrix containing acidic or neutral drugs.
Topics: Biodegradation, Environmental; Crystallization; Delayed-Action Preparations; Diffusion; Griseofulvin; Hydrogen-Ion Concentration; Ibuprofen; Indomethacin; Lactic Acid; Naproxen; Polymers; Progesterone; Solubility; Testosterone | 1999 |
In vivo effects of non-steroidal antiinflammatory drugs on oxidative stress-related parameters of human erythrocytes.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Catalase; Erythrocytes; Female; Glutathione Peroxidase; Glutathione Transferase; Humans; Indomethacin; Kinetics; Lipid Peroxidation; Male; Malondialdehyde; Middle Aged; Naproxen; Oxidative Stress; Propionates | 1999 |
Prostaglandin biosynthesis by fat body from true armyworms, Pseudaletia unipuncta.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Fat Body; Gas Chromatography-Mass Spectrometry; Hydrogen-Ion Concentration; Indomethacin; Microsomes; Moths; Naproxen; Prostaglandin D2; Prostaglandins; Prostaglandins A; Temperature | 2001 |
Neuroprotective effects of non-steroidal anti-inflammatory drugs by direct scavenging of nitric oxide radicals.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoates; Cell Death; Cell Line; Cell Nucleus; Cell Survival; Dexamethasone; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Free Radicals; Humans; Hydrocortisone; Imidazoles; Indomethacin; Inflammation; Mefenamic Acid; Naproxen; Neuroblastoma; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Rats; Tumor Cells, Cultured | 2001 |
Anti-lymphoma effect of naproxen and indomethacin in a patient with relapsed diffuse large B-cell lymphoma.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Fever; Humans; Indomethacin; Lymph Nodes; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Male; Naproxen; Recurrence; Remission Induction | 2001 |
Coexistence of chronic paroxysmal hemicrania and benign cough headache.
Topics: Adult; Cough; Drug Therapy, Combination; Female; Headache; Humans; Indomethacin; Migraine Disorders; Naproxen; Ranitidine | 1999 |
Peroxisomal proliferator-activated ligand therapy for HIV lipodystrophy.
Topics: Anti-HIV Agents; Cyclooxygenase Inhibitors; Dehydroepiandrosterone; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Indomethacin; Lipodystrophy; Male; Middle Aged; Naproxen; Peroxisomal Disorders; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2001 |
Inhibition of tendon cell proliferation and matrix glycosaminoglycan synthesis by non-steroidal anti-inflammatory drugs in vitro.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Culture Techniques; Diclofenac; Female; Glycosaminoglycans; Humans; Indomethacin; Male; Middle Aged; Naproxen; Tendons; Wound Healing | 2001 |
Effects of non-steroidal antiinflammatory drugs and dexamethasone on the activity and expression of matrix metalloproteinase-1, matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 by bovine articular chondrocytes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Cattle; Cells, Cultured; Chondrocytes; Collagenases; Dexamethasone; Glucocorticoids; Indomethacin; Interleukin-1; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Matrix Metalloproteinases; Meloxicam; Metalloendopeptidases; Naproxen; Precipitin Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazines; Thiazoles; Tissue Inhibitor of Metalloproteinase-1 | 2001 |
Determination of apparent binding constants of drugs by capillary electrophoresis using beta-cyclodextrin as ligand and three different linear plotting methods.
Topics: Albuterol; beta-Cyclodextrins; Cyclodextrins; Electrophoresis, Capillary; Indomethacin; Ligands; Naproxen; Procaine | 2001 |
Acute gastrointestinal permeability responses to different non-steroidal anti-inflammatory drugs.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Chromatography, High Pressure Liquid; Confidence Intervals; Cyclooxygenase Inhibitors; Delayed-Action Preparations; Female; Gastric Mucosa; Humans; Indomethacin; Intestinal Mucosa; Lactulose; Male; Mannitol; Meloxicam; Middle Aged; Naproxen; Permeability; Pyrazoles; Statistics, Nonparametric; Sucrose; Sulfonamides; Thiazines; Thiazoles | 2001 |
Nonsteroidal anti-inflammatory drugs for perioperative pain control.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Butanones; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Etodolac; Humans; Ibuprofen; Indomethacin; Ketorolac; Lactones; Nabumetone; Naproxen; Pain, Postoperative; Piroxicam; Pyrazoles; Sulfonamides; Sulfones; Time Factors | 2001 |
Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H(2) synthases by ibuprofen, naproxen, and indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Ibuprofen; Indomethacin; Naproxen; Prostaglandin-Endoperoxide Synthases; Protein Isoforms; Rats; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Tumor Cells, Cultured | 2001 |
Prostaglandin biosynthesis by fat body from larvae of the beetle Zophobas atratus.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Coleoptera; Fat Body; Hydrogen-Ion Concentration; Indomethacin; Insect Proteins; Isotope Labeling; Larva; Naproxen; Prostaglandins; Subcellular Fractions; Substrate Specificity; Time Factors | 2002 |
Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Computer Graphics; Computer Simulation; Crystallography, X-Ray; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Energy Transfer; Flurbiprofen; Humans; Indomethacin; Isoenzymes; Ketoprofen; Meclofenamic Acid; Mefenamic Acid; Membrane Proteins; Models, Molecular; Naproxen; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides | 2002 |
Prostaglandin biosynthesis by midgut tissue isolated from the tobacco hornworm, Manduca sexta.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Culture Techniques; Cyclooxygenase Inhibitors; Digestive System; Dinoprost; Dinoprostone; Hydrogen-Ion Concentration; Indomethacin; Insect Proteins; Manduca; Molecular Structure; Moths; Naproxen; Prostaglandin D2; Prostaglandins; Prostaglandins A; Prostaglandins B; Subcellular Fractions; Temperature; Time Factors | 2002 |
Effect of inflammatory mediators on the physiology of the human Fallopian tube.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cells, Cultured; Diclofenac; Dose-Response Relationship, Drug; Electric Conductivity; Electrophysiology; Epithelial Cells; Fallopian Tubes; Female; Histamine; Humans; Ibuprofen; Indomethacin; Inflammation Mediators; Muscle Contraction; Muscle, Smooth; Naproxen; Pelvic Pain; Platelet Activating Factor | 2002 |
Differential effects of nonsteroidal antiinflammatory drugs on the IL-1 altered expression of plasminogen activators and plasminogen activator inhibitor-1 by articular chondrocytes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cattle; Cells, Cultured; Chondrocytes; Diclofenac; Dose-Response Relationship, Drug; Gene Expression Regulation; Indomethacin; Interleukin-1; Meloxicam; Naproxen; Plasminogen Activator Inhibitor 1; Plasminogen Activators; Propionates; RNA, Messenger; Thiazines; Thiazoles | 2002 |
Pathogenic importance of intestinal hypermotility in NSAID-induced small intestinal damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Flurbiprofen; Gastrointestinal Motility; Indomethacin; Intestinal Mucosa; Intestine, Small; Male; Naproxen; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Sprague-Dawley | 2002 |
Pharmaco-toxicological study of diterpenoids.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Apiaceae; Arachidonic Acid; Chile; Diterpenes; Dose-Response Relationship, Drug; Edema; Female; Indicators and Reagents; Indomethacin; Lipoxygenase Inhibitors; Male; Mice; Molecular Conformation; Naproxen; Pain Measurement; Plants, Medicinal; Structure-Activity Relationship; Sulfonamides; Tetradecanoylphorbol Acetate | 2003 |
Pharmacological characterisation of a rat model of incisional pain.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Evaluation, Preclinical; Etoricoxib; Foot; Gabapentin; gamma-Aminobutyric Acid; Hindlimb; Hyperalgesia; Indomethacin; Male; Morphine; Muscle, Skeletal; Naproxen; Nociceptors; Pain Threshold; Pain, Postoperative; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sulfonamides; Sulfones; Time Factors; Weight-Bearing | 2004 |
Effect of anti-inflammatories on Pluronic F127: micellar assembly, gelation and partitioning.
Topics: Anti-Inflammatory Agents; Indomethacin; Micelles; Naproxen; Particle Size; Phase Transition; Poloxamer; Solubility | 2004 |
Recombinant human lactoferrin prevents NSAID-induced intestinal bleeding in rodents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Gastrointestinal Hemorrhage; Humans; Indomethacin; Lactoferrin; Male; Naproxen; Pain Measurement; Protein Binding; Rats; Rats, Sprague-Dawley; Recombinant Proteins | 2005 |
NSAIDs increase GM-CSF release by human synoviocytes: comparison with nitric oxide-donating derivatives.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Cells, Cultured; Cyclic AMP; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Flurbiprofen; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indomethacin; Membrane Proteins; Naproxen; Nitric Oxide Donors; Nitroprusside; Phosphodiesterase Inhibitors; Prostaglandin-Endoperoxide Synthases; Purinones; Synovial Membrane; Time Factors | 2005 |
Cellular mechanisms of acetaminophen: role of cyclo-oxygenase.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Cell Line; Cyclooxygenase Inhibitors; Diclofenac; Enzyme Activation; Humans; Ibuprofen; Indomethacin; Lactones; Lung; Naproxen; Oxidation-Reduction; Prostaglandin-Endoperoxide Synthases; Protein Biosynthesis; Sulfones; tert-Butylhydroperoxide; Transcription, Genetic | 2005 |
Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2.
Topics: Aspirin; Blood Platelets; Blood Proteins; Calcimycin; Calcium; Celecoxib; Cell Line; Cerebrospinal Fluid Proteins; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Indomethacin; Ionophores; Lactones; Meloxicam; Naproxen; Organ Specificity; Organic Chemicals; Protein Binding; Pyrazoles; Sodium Salicylate; Sulfonamides; Sulfones; Synovial Fluid; Thiazines; Thiazoles; Thromboxane A2 | 2006 |
Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease.
Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butanones; Colitis, Ulcerative; Crohn Disease; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Female; Humans; Indomethacin; Inflammatory Bowel Diseases; Male; Middle Aged; Nabumetone; Naproxen; Prevalence; Recurrence; Sulfonamides | 2006 |
Nonsteroidal anti-inflammatory drug use in ankylosing spondylitis--a population-based survey.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cohort Studies; Cross-Sectional Studies; Diclofenac; Female; Humans; Indomethacin; Male; Middle Aged; Naproxen; Pain; Pain Measurement; Patient Satisfaction; Pyrazoles; Retreatment; Spondylitis, Ankylosing; Sulfonamides; Surveys and Questionnaires; Treatment Outcome | 2006 |
Factors involved in upregulation of inducible nitric oxide synthase in rat small intestine following administration of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Disease Models, Animal; Enterobacteriaceae; Flurbiprofen; Gastrointestinal Motility; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Lactones; Male; Naproxen; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrazoles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfones; Time Factors; Up-Regulation | 2006 |
Cyclooxygenase inhibitors down regulate P-glycoprotein in human colorectal Caco-2 cell line.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Caco-2 Cells; Celecoxib; Colorectal Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Down-Regulation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Naproxen; Neoplasm Proteins; Pyrazoles; Reproducibility of Results; RNA, Messenger; Sulfonamides; Time Factors | 2008 |
Ionic liquid-based dynamic liquid-phase microextraction: application to the determination of anti-inflammatory drugs in urine samples.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Fractionation; Flurbiprofen; Humans; Hydrogen-Ion Concentration; Indomethacin; Ionic Liquids; Ketoprofen; Molecular Structure; Naproxen; Phenylbutyrates; Reproducibility of Results; Tolmetin | 2008 |
Removal of selected pharmaceuticals by chlorination, coagulation-sedimentation and powdered activated carbon treatment.
Topics: Antipyrine; Charcoal; Clofibric Acid; Diclofenac; Fenoprofen; Gemfibrozil; Halogenation; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Water Pollutants, Chemical; Water Purification; Water Supply | 2008 |
Estimation of drug solubility in polymers via differential scanning calorimetry and utilization of the fox equation.
Topics: Algorithms; Calorimetry, Differential Scanning; Chromatography, High Pressure Liquid; Complex Mixtures; Crystallization; Glass; Ibuprofen; Indomethacin; Molecular Structure; Naproxen; Pharmaceutical Preparations; Polyethylene Glycols; Polymers; Solubility; Thermography; Transition Temperature | 2009 |
Phase behavior of ketoprofen-poly(lactic acid) drug particles formed by rapid expansion of supercritical solutions.
Topics: Indomethacin; Ketoprofen; Kinetics; Lactic Acid; Microscopy, Electron, Scanning; Naproxen; Polyesters; Polymers; Solutions; Spectrophotometry, Infrared | 2010 |
Coamorphous drug systems: enhanced physical stability and dissolution rate of indomethacin and naproxen.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Drug Combinations; Drug Stability; Indomethacin; Models, Molecular; Molecular Conformation; Naproxen; Powder Diffraction; Solubility; Spectroscopy, Fourier Transform Infrared; Transition Temperature | 2011 |
Carboxylesterases 1 and 2 hydrolyze phospho-nonsteroidal anti-inflammatory drugs: relevance to their pharmacological activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carboxylesterase; Carboxylic Ester Hydrolases; Cell Line, Tumor; Cell Survival; Drug Interactions; Drug Therapy, Combination; Enzyme Inhibitors; Female; HEK293 Cells; Humans; Hydrolysis; Ibuprofen; Indomethacin; Inhibitory Concentration 50; Kinetics; Mice; Mice, Inbred BALB C; Mice, Nude; Naproxen; Nitrophenols; Organophosphates; Organophosphorus Compounds; Phenylglyoxal; Stomach Neoplasms; Sulindac; Transfection; Valproic Acid; Xenograft Model Antitumor Assays | 2012 |
Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; ATP-Binding Cassette Transporters; Biological Transport, Active; Cytochrome P-450 Enzyme System; Diclofenac; Electron Transport; Genes, MDR; Ibuprofen; Indomethacin; Ketoprofen; Ketorolac; Mitochondria; Naproxen; Reactive Oxygen Species; Sulindac; Tolmetin; Yeasts | 2012 |
Determination of non-steroidal anti-inflammatory drugs in urine by the combination of stir membrane liquid-liquid-liquid microextraction and liquid chromatography.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Flurbiprofen; Humans; Indomethacin; Ketoprofen; Limit of Detection; Liquid Phase Microextraction; Naproxen | 2012 |
A theoretical and spectroscopic study of co-amorphous naproxen and indomethacin.
Topics: Indomethacin; Molecular Conformation; Naproxen; Spectroscopy, Fourier Transform Infrared | 2013 |
Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3.
Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Anti-Inflammatory Agents, Non-Steroidal; Flufenamic Acid; Flurbiprofen; Hydroxyprostaglandin Dehydrogenases; Ibuprofen; Indomethacin; Meclofenamic Acid; Mefenamic Acid; Naproxen; Sulindac; Tolmetin | 2012 |
How safe is Celecoxib for Asian-Indian patients with rheumatic diseases?
Topics: Adult; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Drug Substitution; Female; Humans; Hypertension; India; Indomethacin; Male; Naproxen; Pyrazoles; Retrospective Studies; Rheumatic Diseases; Sulfonamides; Tertiary Care Centers | 2013 |
Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer.
Topics: Acetylation; Amino Acid Sequence; Amino Acid Substitution; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Flurbiprofen; Guanidine; Heme; Humans; Indomethacin; Kinetics; Models, Biological; Mutant Proteins; Mutation; Naproxen; Oxygen; Palmitic Acid; Peroxidase; Protein Multimerization; Pyrazoles; Substrate Specificity; Sulfonamides | 2013 |
Evolution of supersaturation of amorphous pharmaceuticals: the effect of rate of supersaturation generation.
Topics: Indomethacin; Kinetics; Naproxen; Piroxicam; Solubility | 2013 |
Impact of specific Beers Criteria medications on associations between drug exposure and unplanned hospitalisation in elderly patients taking high-risk drugs: a case-time-control study in Western Australia.
Topics: Adrenal Cortex Hormones; Aged; Amiodarone; Analgesics, Opioid; Anticoagulants; Antirheumatic Agents; Cardiovascular Agents; Case-Control Studies; Digoxin; Female; Hospitalization; Humans; Inappropriate Prescribing; Indomethacin; Male; Naproxen; Odds Ratio; Temazepam; Western Australia | 2014 |
Precision cut intestinal slices are an appropriate ex vivo model to study NSAID-induced intestinal toxicity in rats.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caspase 9; Cell Survival; Diclofenac; Diflunisal; Endoplasmic Reticulum Stress; Gene Expression; Glutathione; Heat-Shock Proteins; Heme Oxygenase (Decyclizing); Indomethacin; Jejunum; Male; Naproxen; Rats, Wistar; Tissue Culture Techniques | 2014 |
Evaluation of the diuretic activity in two Mexican medicinal species: Selaginella nothohybrida and Selaginella lepidophylla and its effects with ciclooxigenases inhibitors.
Topics: Animals; Aspirin; Celecoxib; Cyclooxygenase Inhibitors; Diuretics; Indomethacin; Male; Mexico; Mice; Naproxen; Plant Extracts; Plants, Medicinal; Potassium; Selaginellaceae; Sodium | 2015 |
A Novel Approach for Analyzing the Dissolution Mechanism of Solid Dispersions.
Topics: Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Desiccation; Excipients; Hydrogen-Ion Concentration; Indomethacin; Naproxen; Povidone; Solubility; Spectrophotometry, Ultraviolet; Surface Properties; Temperature; Thermodynamics; X-Ray Diffraction | 2015 |
Influence of excipients on solubility and dissolution of pharmaceuticals.
Topics: Chemistry, Pharmaceutical; Diffusion; Excipients; Indomethacin; Kinetics; Mannitol; Models, Chemical; Models, Statistical; Naproxen; Polyethylene Glycols; Povidone; Solubility; Technology, Pharmaceutical; Viscosity; Water | 2015 |
NSAIDs and spontaneous abortions - true effect or an indication bias?
Topics: Abortion, Spontaneous; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans; Ibuprofen; Indomethacin; Israel; Middle Aged; Naproxen; Pregnancy; Retrospective Studies; Time Factors; Young Adult | 2015 |
Predicting Crystallization of Amorphous Drugs with Terahertz Spectroscopy.
Topics: Acetaminophen; Calorimetry, Differential Scanning; Crystallization; Drug Stability; Flufenamic Acid; Indomethacin; Kinetics; Molecular Dynamics Simulation; Naproxen; Simvastatin; Temperature; Terahertz Spectroscopy; X-Ray Diffraction | 2015 |
Influence of humidity on the phase behavior of API/polymer formulations.
Topics: Absorption, Physicochemical; Chemistry, Pharmaceutical; Humidity; Indomethacin; Models, Chemical; Molecular Structure; Naproxen; Phase Transition; Povidone; Pyrrolidines; Vinyl Compounds; Water | 2015 |
Multivariate Quantification of the Solid State Phase Composition of Co-Amorphous Naproxen-Indomethacin.
Topics: Chemistry, Pharmaceutical; Indomethacin; Naproxen; Powder Diffraction; Regression Analysis; X-Ray Diffraction | 2015 |
Investigation of physical properties and stability of indomethacin-cimetidine and naproxen-cimetidine co-amorphous systems prepared by quench cooling, coprecipitation and ball milling.
Topics: Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Cimetidine; Crystallization; Drug Stability; Indomethacin; Naproxen; Powders; Solubility; Spectroscopy, Fourier Transform Infrared; Technology, Pharmaceutical; Temperature; Transition Temperature; X-Ray Diffraction | 2016 |
Indomethacin inhibits tetrodotoxin-resistant Na(+) channels at acidic pH in rat nociceptive neurons.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cells, Cultured; Female; Hydrogen-Ion Concentration; Ibuprofen; Indomethacin; Kinetics; Male; Membrane Potentials; Naproxen; Nociceptors; Patch-Clamp Techniques; Rats, Sprague-Dawley; Sodium Channels; Trigeminal Ganglion | 2016 |
Preparation and recrystallization behavior of spray-dried co-amorphous naproxen-indomethacin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Crystallization; Indomethacin; Naproxen; Powder Diffraction | 2016 |
Differences in Esterase Activity to Aspirin and p-Nitrophenyl Acetate among Human Serum Albumin Preparations.
Topics: Aspirin; Esterases; Humans; Hydrolysis; Indomethacin; Naproxen; Nitrophenols; Serum Albumin; Sulfhydryl Compounds; Warfarin | 2016 |
Influence of the cooling rate and the blend ratio on the physical stability of co-amorphous naproxen/indomethacin.
Topics: Crystallization; Drug Compounding; Drug Design; Drug Stability; Glass; Indomethacin; Naproxen; Polymers; Powder Diffraction; Principal Component Analysis; Solubility; Spectroscopy, Fourier Transform Infrared; Temperature; X-Ray Diffraction | 2016 |
Non-steroidal anti-inflammatory drugs in the watercourses of Elbe basin in Czech Republic.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Czech Republic; Diclofenac; Environmental Monitoring; Gas Chromatography-Mass Spectrometry; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Rivers; Water Pollutants, Chemical | 2017 |
Effect of Extent of Supersaturation on the Evolution of Kinetic Solubility Profiles.
Topics: Biological Availability; Chemistry, Pharmaceutical; Crystallization; Drug Liberation; Indomethacin; Kinetics; Naproxen; Polymers; Solubility | 2017 |
Evaluation of Pharmacokinetic Interactions Between Lesinurad, a New Selective Urate Reabsorption Inhibitor, and Commonly Used Drugs for Gout Treatment.
Topics: Adult; Aged; Aged, 80 and over; Colchicine; Drug Administration Schedule; Drug Interactions; Female; Gout Suppressants; Humans; Hyperuricemia; Indomethacin; Male; Middle Aged; Naproxen; Thioglycolates; Treatment Outcome; Triazoles; Uricosuric Agents; Young Adult | 2017 |
Eudragit® RL as a stabilizer for supersaturation and a substrate for nanocrystal formation.
Topics: Cinnarizine; Desiccation; Drug Carriers; Drug Compounding; Indomethacin; Nanoparticles; Naproxen; Polymers; Solubility; X-Ray Diffraction | 2017 |
Improvement of the physicochemical properties of Co-amorphous naproxen-indomethacin by naproxen-sodium.
Topics: Calorimetry, Differential Scanning; Drug Stability; Indomethacin; Naproxen; Solubility; Transition Temperature | 2017 |
The Effect of Ethanol on the Hydrolysis of Ester-Type Drugs by Human Serum Albumin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antihypertensive Agents; Aspirin; Binding Sites; Drug Stability; Ethanol; Excipients; Fatty Acids, Nonesterified; Humans; Hydrolysis; Indomethacin; Kinetics; Ligands; Naproxen; Nitrophenols; Olmesartan Medoxomil; Preservatives, Pharmaceutical; Serum Albumin, Human; Warfarin | 2018 |
Inhibition by non-steroidal anti-inflammatory drugs of compound action potentials in frog sciatic nerve fibers.
Topics: Action Potentials; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Female; Indomethacin; Male; Naproxen; Nerve Fibers; Ranidae; Sciatic Nerve | 2018 |
In situ co-amorphisation of arginine with indomethacin or furosemide during immersion in an acidic medium - A proof of concept study.
Topics: Arginine; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Citric Acid; Furosemide; Hydrolysis; Indomethacin; Methylmethacrylates; Naproxen; Proof of Concept Study; Solubility; Spectroscopy, Fourier Transform Infrared; Tablets; X-Ray Diffraction | 2018 |
Biophysical analysis of cancer stem cell-potent copper(ii) coordination complexes.
Topics: Antineoplastic Agents; Biophysical Phenomena; Breast Neoplasms; Cell Survival; Coordination Complexes; Copper; Female; Fluorescent Dyes; Humans; Indomethacin; Naproxen; Neoplastic Stem Cells; Optical Imaging; Oxidation-Reduction; Reactive Oxygen Species | 2019 |
Preparation of Amorphous Composite Particles of Drugs with Ursodeoxycholic Acid as Preclinical Formulations.
Topics: Calorimetry, Differential Scanning; Drug Compounding; Drug Evaluation, Preclinical; Drug Stability; Indomethacin; Naproxen; Nifedipine; Pharmaceutical Preparations; Solubility; Ursodeoxycholic Acid | 2019 |
Preparation of Amorphous Solid Dispersions by Cryomilling: Chemical and Physical Concerns Related to Active Pharmaceutical Ingredients and Carriers.
Topics: Cinnarizine; Crystallization; Drug Carriers; Drug Compounding; Drug Stability; Dynamic Light Scattering; Fenofibrate; Gelatin; Glass; Hypromellose Derivatives; Indomethacin; Molecular Structure; Molecular Weight; Naproxen; Povidone; Serum Albumin, Bovine; Solubility; Spectroscopy, Fourier Transform Infrared; Transition Temperature; Viscosity | 2020 |
Towards an improved understanding of drug excipient interactions to enable rapid optimization of nanosuspension formulations.
Topics: Chemistry, Pharmaceutical; Excipients; Hydrophobic and Hydrophilic Interactions; Indomethacin; Itraconazole; Models, Molecular; Nanoparticles; Naproxen; Particle Size; Suspensions | 2020 |
The influence of polymeric excipients on desupersaturation profiles of active pharmaceutical ingredients. 1: Polyethylene glycol.
Topics: Crystallization; Drug Compounding; Excipients; Indomethacin; Kinetics; Models, Chemical; Naproxen; Polyethylene Glycols; Proof of Concept Study; Solubility | 2020 |
Solubility of Pharmaceutical Ingredients in Natural Edible Oils.
Topics: Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Cinnarizine; Coconut Oil; Drug Compounding; Drug Delivery Systems; Excipients; Felodipine; Fenofibrate; Griseofulvin; Ibuprofen; Indomethacin; Models, Molecular; Naproxen; Plant Oils; Solubility; Soybean Oil; Spectrum Analysis, Raman; Thermodynamics; Transition Temperature; Triglycerides | 2020 |
The design and development of high drug loading amorphous solid dispersion for hot-melt extrusion platform.
Topics: Chemistry, Pharmaceutical; Drug Carriers; Drug Stability; Drug Storage; Excipients; Humidity; Ibuprofen; Indomethacin; Naproxen; Polymers; Polymethacrylic Acids; Solubility; Thermodynamics | 2020 |
Differential actions of indomethacin: clinical relevance in headache.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Headache; Humans; Ibuprofen; Indomethacin; Naproxen | 2021 |
In Vitro Assessment of the Antiviral Activity of Ketotifen, Indomethacin and Naproxen, Alone and in Combination, against SARS-CoV-2.
Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Cytopathogenic Effect, Viral; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Humans; Indomethacin; Ketotifen; Naproxen; SARS-CoV-2 | 2021 |
Electrically controlled transdermal delivery of naproxen and indomethacin from porous cis-1,4-polyisoprene matrix.
Topics: Administration, Cutaneous; Animals; Drug Delivery Systems; Hemiterpenes; Indomethacin; Latex; Naproxen; Porosity; Skin; Swine | 2022 |
Design, synthesis and anticancer evaluation of novel Se-NSAID hybrid molecules: Identification of a Se-indomethacin analog as a potential therapeutic for breast cancer.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Breast Neoplasms; Female; Humans; Indomethacin; Naproxen | 2022 |