Page last updated: 2024-09-28

Osteoid Osteoma

A benign osteoblastic tumor with central vascularized nidus surrounded by normal reactive bone. It occurs especially in second decade of life most commonly in the femoral neck but can occur in any bone and any site within a bone.

Synonyms(2)

Synonym
Osteoid Osteoma
Osteoma, Osteoid

Research Excerpts

Overview

ExcerptReference
"Osteoid osteoma is a benign osteoid-forming tumor of the bone characterized by pain which is relieved by nonsteroidal anti-inflammatory drugs."( Ciabattoni, G; Greco, F; Tamburrelli, F, 1991)
"Osteoid osteoma is infrequently localized to the hand."( Engkvist, O; Höglund, M; Juhlin, L; Muren, C, 1991)
"Osteoid osteoma is a tumour of bone characterised by pain which is relieved by aspirin and nonsteroidal anti-inflammatory drugs."( Ciabattoni, G; Greco, F; Tamburrelli, F, 1991)
"When osteoid osteoma is suspected in nondiaphyseal locations, CT is likely to aid in the diagnosis and localization of the lesion for biopsy."( Davidson, RS; Drummond, DS; Heyman, S; Mahboubi, S, 1989)
"Surgical excision of osteoid osteomas is curative, but intraoperative localization and pathologic identification in submitted fragments may be difficult."( Ghelman, B; Vigorita, VJ, 1983)
"A series of 42 osteoid osteomas is reviewed, and the scintigraphic appearances are described."( Gilday, DL; Smith, FW, 1980)
"Osteoid osteoma is a benign bone tumour characterized by pain which is relieved by non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin."( Hasegawa, T; Hirose, T; Hizawa, K; Ikata, T; Sakamoto, R; Seki, K, 1993)
"Osteoid osteoma is infrequently encountered in the carpal bones."( Lopez-Prats, F; Olmedo-Garcia, N, 2002)
"Osteoid osteoma is a benign bone tumor that can be removed by marginal excision."( Ho, PC; Hung, LK; Law, B; Tse, WL, 2003)
"Osteoid osteoma is infrequently localized to the hand."( Garg, V; Kapoor, SK, 2003)
"Osteoid osteoma is a painful benign bone tumour and very rare in the hand and wrist."( Kalb, K; Lanz, U; Meier, M; Schlör, U; Schmitt, R, 2004)
"Osteoid osteoma is one of the unusual causes of musculosceletal pain."( Aydemir, K; Dinçer, K; Duman, I; Kalyon, TA; Tan, AK, 2007)
"Osteoid osteoma is a benign tumor of bone characterized by pain, usually occurring at night, that shows a dramatic response to aspirin."( Mintz, S; Velez, I, 2007)
"Osteoid osteoma is a common skeletal neoplasm with distinctive histologic abnormalities that consist of a central core of vascular osteoid tissue and a peripheral sclerotic zone."( Chung, SK; Lee, SY; Lim, CH; Park, YH, 2007)
"Osteoid osteoma is one of the unusual causes of musculoskeletal pain."( Ajlani, H; Ben Hadj Yahia, C; Chaabouni, L; Cheikhrouhou Abdelmoula, L; El Manaa, K; Lebib, H; Zouari, R, 2009)
"Osteoid osteoma is a benign skeletal neoplasm composed of osteoid and woven bone."( Altinörs, N; Cansever, T; Demiralay, E; Kabataş, S; Sükan, A; Yilmaz, C, 2009)
"Osteoid osteoma is a benign tumor commonly found in young patients."( Ahmadzadeh-Chabock, H; Ebrahimzadeh, AR; Ebrahimzadeh, MH, 2009)
"Intra-articular osteoid osteoma is rare and difficult to diagnose."( Kuntz, JL; Moser, T; Sibilia, J; Sordet, C; Sparsa, L, 2010)
"Osteoid osteomas are benign osseous lesions."( Borys, D; Strong, EB; Tate, JR, 2012)
"Osteoid osteoma is a benign bone tumor."( Bodart, E; Charlier, H; de Wispelaere, JF; Gilliaux, O, 2012)
"Osteoid osteoma is a benign bone tumour which is usually seen in long bones."( Karayalcin, B; Koç, ZP, 2012)
"Osteoid osteoma is a painful benign tumour, which is commonly treated by radiofrequency ablation (RFA)."( Bruners, P; Delbrück, H; Günther, RW; Mahnken, AH; Plumhans, C, 2012)
"Osteoid osteoma is a primary benign bone lesion, which constitutes about 10% of all primary benign bone tumors and 3% of all primary bone tumors."( Liu, Z; Qian, B; Qiao, J; Qiu, Y; Zhu, F; Zhu, Z, 2014)
"A minority of osteoid osteomas are found to be juxta-articular and within the small bones of the wrist."( Cheah, JTL; Fields, TR, 2018)
"OO (osteoid osteoma) is a common, osteoblastic, benign bone tumor but rarely seen in the hand region."( Erdogan, O; Gurkan, V, 2019)
"Osteoid osteoma is usually seen below 25 years, and rarely found over 40 years of age."( Erdogan, O; Gurkan, V, 2019)
"Osteoid osteoma is a benign osteogenic tumour traditionally treated by surgical excision or percutaneous CT-guided procedures."( Jacquier, C; Lafforgue, P; Laredo, JD; Larid, G; Pham, T; Valayer, S, 2023)

Treatment

ExcerptReference
"Surgical localization of osteoid osteomas is a major problem in the diagnosis and therapy of this lesion."( Hall, JE; O'Brien, T; Shea, N; Taylor, GA; Treves, ST, 1986)
"To evaluate treatment of osteoid osteoma with computed tomography (CT)-guided percutaneous excision and immediate follow-up scintigraphy."( Bellin, MF; Grenier, P; Roger, B; Wioland, M, 1996)
"Eighteen cases of osteoid osteoma of the hand and wrist were treated between 1985 and 1999."( Acciaro, AL; Landi, A; Marcuzzi, A, 2002)
"Fifteen patients with an osteoid osteoma (10 males, 5 females) were treated in the Oncology Unit, Orthopaedic Department, Mansoura University Hospital."( el-Mowafi, H; Kotb, S; Refaat, H, 2003)
"To assess the efficacy of percutaneous osteoid osteoma treatment using a combination of radiofrequency ablation (RFA) and alcohol ablation with regard to technical and long-term clinical success."( Akhlaghpoor, S; Alinaghizadeh, MR; Arjmand Shabestari, A; Ebrahimi, M; Tomasian, A, 2007)
"Percutaneous osteoid osteoma treatment with combination of radiofrequency and alcohol ablation is safe, effective and minimally invasive with high primary and secondary success rates."( Akhlaghpoor, S; Alinaghizadeh, MR; Arjmand Shabestari, A; Ebrahimi, M; Tomasian, A, 2007)
"After identifying the osteoid osteoma close to the cartilage with MRI and CT investigations, we decided that in this case, arthroscopic removal was the best treatment."( Barnhard, R; Raven, EE, 2011)
"To define specific characteristics of osteoid osteomas treated with radiofrequency ablation, that may benefit from special technical recommendations."( Bueno Horcajadas, A; Esteban Cuesta, H; Kassarjian, A; Martel Villagran, J; Rodriguez Caravaca, G, 2018)
"We describe three cases of osteoid osteomas of which the locations were difficult to access, or for which the procedure was potentially unsafe, involving treatment with zoledronic acid infusions."( Jacquier, C; Lafforgue, P; Laredo, JD; Larid, G; Pham, T; Valayer, S, 2023)

Research

Studies (303)

TimeframeStudies, This Condition (%)All Conditions %
pre-1990156 (51.49)23.3326
1990's53 (17.49)12.5806
2000's50 (16.50)18.1394
2010's37 (12.21)28.8240
2020's7 (2.31)9.53
DrugIndicatedRelationship StrengthStudiesTrials
aspirin0medium141
bupivacaine0low10
celecoxib0low30
pentetic acid0low20
etidronate0low20
gentamicin0low10
ibuprofen0low10
khellin0low10
oxyphenbutazone0low10
rofecoxib0medium21
sodium iodide0low10
thymidine0low10
prednisone0low10
9,10-dimethyl-1,2-benzanthracene0low10
edetic acid0low20
cloxacillin0low10
methylene blue0low20
oxacillin0low10
ampicillin0low10
technetium0low470
cadmium0low10
gadolinium0low70
barium sulfate0low10
tricalcium phosphate0low10
fluorine0low40
chlorine0low10
trolamine salicylate0low290
fluorides0low10
tramadol0low10
1-carboxyglutamic acid0low10
propiconazole0low70
fluorodeoxyglucose f180low30
zoledronic acid0low10
6-amino-1-hydroxyhexane-1,1-diphosphonate0low10
nicotine0low10
cadmium telluride0low10
pyridinoline0low10
technetium tc 99m hydroxymethylene diphosphonate0low70
technetium tc 99m etidronate0low10
methotrexate0low20
proline0low10
naproxen0low40
indium trichloride0low10
cortisone0low10
glycogen0low20
ouabain0low10
melphalan0low10
pyrophosphate0low20
dinoprostone0low50
calcitriol0low10
6-ketoprostaglandin f1 alpha0low30
2,3-dinor-6-ketoprostaglandin f1alpha0low30
phenylephrine hydrochloride0low20
rubidium0low10
indium0low10
phosphorus0low40
strontium radioisotopes0low80
tellurium0low10
radium0low10
technetium tc 99m pyrophosphate0low10
gadolinium dtpa0low50
technetium tc 99m diphosphonate0low10
acid phosphatase0low30
jaw0low20
ro13-99040low10
tetracycline0low60
salicylates0low50
agar0low10
hyaluronoglucosaminidase0low10
technetium tc 99m medronate0low540
exudates0low10
levoleucovorin0low10
folic acid0low10

Protein Targets (766)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Geranylgeranyl pyrophosphate synthase0304
Farnesyl pyrophosphate synthase0404
Solute carrier organic anion transporter family member 2A10002
Chain A, Beta-lactamase7007
Chain A, HADH2 protein6006
Chain B, HADH2 protein6006
Chain A, JmjC domain-containing histone demethylation protein 3A4004
Chain A, Cruzipain5005
Luciferase5005
acid sphingomyelinase5005
pregnane X receptor5005
hypoxia-inducible factor 1 alpha subunit5005
RAR-related orphan receptor gamma120012
SMAD family member 28008
ATAD5 protein, partial6006
SMAD family member 38008
TDP1 protein160016
GLI family zinc finger 3160016
AR protein210021
apical membrane antigen 1, AMA13003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
thyroid stimulating hormone receptor7007
estrogen receptor 2 (ER beta)100010
nuclear receptor subfamily 1, group I, member 3100010
progesterone receptor110011
glucocorticoid receptor [Homo sapiens]130013
retinoic acid nuclear receptor alpha variant 1130013
retinoid X nuclear receptor alpha130013
estrogen-related nuclear receptor alpha160016
farnesoid X nuclear receptor110011
pregnane X nuclear receptor100010
estrogen nuclear receptor alpha200020
glucocerebrosidase4004
bromodomain adjacent to zinc finger domain 2B3003
P531001
peroxisome proliferator-activated receptor delta110011
peroxisome proliferator activated receptor gamma120012
vitamin D (1,25- dihydroxyvitamin D3) receptor110011
IDH1100010
euchromatic histone-lysine N-methyltransferase 2160016
aryl hydrocarbon receptor8008
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a7007
thyroid stimulating hormone receptor6006
activating transcription factor 66006
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a5005
v-jun sarcoma virus 17 oncogene homolog (avian)8008
Caspase-74004
serine-protein kinase ATM isoform a2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 18008
chromobox protein homolog 1100010
thyroid hormone receptor beta isoform a4004
parathyroid hormone/parathyroid hormone-related peptide receptor precursor3003
caspase-34004
thyroid hormone receptor beta isoform 2140014
heat shock protein beta-15005
mitogen-activated protein kinase 15005
nuclear factor NF-kappa-B p105 subunit isoform 11001
ras-related protein Rab-9A3003
nuclear factor erythroid 2-related factor 2 isoform 1160016
urokinase-type plasminogen activator precursor5005
plasminogen precursor5005
urokinase plasminogen activator surface receptor precursor5005
nuclear receptor ROR-gamma isoform 15005
lethal(3)malignant brain tumor-like protein 1 isoform I1001
geminin150015
cytochrome P450 3A4 isoform 16006
caspase-1 isoform alpha precursor2002
Gamma-aminobutyric acid receptor subunit pi6006
Voltage-dependent calcium channel gamma-2 subunit9009
Cellular tumor antigen p53160016
Gamma-aminobutyric acid receptor subunit beta-16006
Gamma-aminobutyric acid receptor subunit delta6006
Gamma-aminobutyric acid receptor subunit gamma-26006
Glutamate receptor 29009
Gamma-aminobutyric acid receptor subunit alpha-56006
Gamma-aminobutyric acid receptor subunit alpha-36006
Gamma-aminobutyric acid receptor subunit gamma-16006
Gamma-aminobutyric acid receptor subunit alpha-26006
Gamma-aminobutyric acid receptor subunit alpha-46006
Gamma-aminobutyric acid receptor subunit gamma-36006
Gamma-aminobutyric acid receptor subunit alpha-66006
Nuclear receptor ROR-gamma6006
Caspase-72002
Gamma-aminobutyric acid receptor subunit alpha-16309
Gamma-aminobutyric acid receptor subunit beta-36006
Gamma-aminobutyric acid receptor subunit beta-26006
GABA theta subunit6006
ATPase family AAA domain-containing protein 58008
Ataxin-28008
Gamma-aminobutyric acid receptor subunit epsilon6006
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE100010
Chain A, Mutant Al2 6e7p9g0011
Chain A, 2-oxoglutarate Oxygenase7007
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Beta-lactamase 0001
GLS protein5005
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
DNA polymerase beta4004
DNA polymerase eta isoform 13003
DNA polymerase iota isoform a (long)7007
DNA polymerase kappa isoform 14004
Carbonic anhydrase 1011011
Carbonic anhydrase 2011112
60 kDa heat shock protein, mitochondrial0101
Beta-lactamase OXA-70003
Solute carrier family 15 member 10404
Solute carrier family 15 member 10101
Spike glycoprotein9009
10 kDa heat shock protein, mitochondrial0101
Angiopoietin-1 receptor0011
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 15 member 20303
Thiosulfate sulfurtransferase0101
Metallo-beta-lactamase VIM-130102
Efflux transporter 0102
Beta-lactamase 0001
Beta-lactamase Toho-10001
Beta-lactamase 0102
Class D beta-lactamase0002
60 kDa chaperonin 0101
Metallo-beta-lactamase0001
Solute carrier family 15 member 20303
Beta-lactamase 0001
Beta-lactamase 0001
10 kDa chaperonin 0101
Metallo-b-lactamase 0002
Carbapenem-hydrolyzing beta-lactamase KPC0001
Histamine H3 receptor0001
Beta-lactamase class B VIM-2 0002
Beta-lactamase VIM-1 0102
ATP-dependent phosphofructokinase5005
Chain A, TYROSYL-DNA PHOSPHODIESTERASE8008
Chain A, Phospholipase A2 isoform 30011
GTP-binding protein (rab7)0022
ras protein, partial0022
interleukin 82002
thioredoxin reductase8008
aldehyde dehydrogenase 1 family, member A1100010
hypothetical protein, conserved3003
cytochrome P450 family 3 subfamily A polypeptide 47007
EWS/FLI fusion protein7007
cytochrome P450 2D66006
Rac1 protein0022
cell division cycle 42 (GTP binding protein, 25kDa), partial0022
Bloom syndrome protein isoform 15005
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)2002
Prostaglandin-H2 D-isomerase0101
ATP-binding cassette sub-family C member 3010010
Multidrug resistance-associated protein 4010013
Solute carrier family 22 member 60404
Prostaglandin G/H synthase 1 0505
Prostaglandin G/H synthase 2 0404
Bile salt export pump019019
Epidermal growth factor receptor0202
Fatty acid-binding protein, liver0303
Integrin beta-31102
Myeloperoxidase0101
Prostaglandin G/H synthase 10707
Seed linoleate 13S-lipoxygenase-10303
Integrin alpha-IIb1102
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10708
Adenosine receptor A10404
Adenosine receptor A2a0303
Substance-P receptor0202
Prostaglandin G/H synthase 208110
Urotensin-2 receptor0202
4-aminobutyrate aminotransferase, mitochondrial0202
Ras-related protein Rab-2A0022
Prostaglandin G/H synthase 20808
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0202
Solute carrier family 22 member 200404
Solute carrier family 22 member 60404
Canalicular multispecific organic anion transporter 1010010
Sigma non-opioid intracellular receptor 10011
Sigma non-opioid intracellular receptor 10011
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20011
Potassium channel subfamily K member 90101
Chain A, Vitamin D Nuclear Receptor0011
Chain A, Ferritin light chain5005
Vitamin D3 receptor0011
USP1 protein, partial9009
PPM1D protein4004
Microtubule-associated protein tau5005
thioredoxin glutathione reductase5005
peripheral myelin protein 22100010
Interferon beta7007
Vitamin D-binding protein0011
Cytochrome P450 1A20304
Cytochrome P450 3A40618
Androgen receptor0101
Cytochrome P450 2D60303
Vitamin D3 receptor0124
Cytochrome P450 2C9 0709
Vitamin D3 receptor0113
Retinoic acid receptor RXR-alpha0011
Cytochrome P450 2C190202
Kappa-type opioid receptor0011
Vitamin D3 receptor0011
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0011
Vitamin D3 receptor0112
Transporter0101
Vitamin D3 receptor A0022
Chain A, Carbonic anhydrase II0101
Carbonic anhydrase 0001
Carbonic anhydrase 0303
glp-1 receptor, partial9009
Smad35005
caspase 7, apoptosis-related cysteine protease3003
G5005
Carbonic anhydrase 0101
Carbonic anhydrase 0101
67.9K protein3003
Carbonic anhydrase0101
caspase-33003
thyrotropin-releasing hormone receptor1001
Histone H2A.x6006
interferon gamma precursor0001
prostaglandin E2 receptor EP2 subtype1002
nuclear factor erythroid 2-related factor 2 isoform 26006
potassium voltage-gated channel subfamily H member 2 isoform d3003
lamin isoform A-delta109009
Prostaglandin E synthase0101
Histone deacetylase 30101
3-phosphoinositide-dependent protein kinase 10101
Carbonic anhydrase 120202
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Cytochrome c oxidase subunit 10101
Cytochrome c oxidase subunit 20101
Catechol O-methyltransferase0101
Cytochrome c oxidase subunit 20303
HLA class I histocompatibility antigen, B alpha chain 5005
Carbonic anhydrase 30101
Procathepsin L0101
Aldo-keto reductase family 1 member B10202
Neuronal acetylcholine receptor subunit alpha-41327
Polyunsaturated fatty acid 5-lipoxygenase0303
Quinolone resistance protein NorA0101
Adenosine receptor A30202
Neuronal acetylcholine receptor subunit beta-21327
Beta-3 adrenergic receptor0202
Alpha-1B adrenergic receptor0404
Calpain-2 catalytic subunit0202
Alpha-2B adrenergic receptor0202
5-hydroxytryptamine receptor 1A0101
D(1A) dopamine receptor0202
Prostaglandin G/H synthase 10303
Carbonic anhydrase 40202
Carbonic anhydrase 60101
Sodium-dependent noradrenaline transporter 0213
Cruzipain0202
Sodium/hydrogen exchanger 10101
Indoleamine 2,3-dioxygenase 10101
Sodium-dependent serotonin transporter0202
Sodium-dependent serotonin transporter0011
Delta-type opioid receptor0202
Delta-type opioid receptor0303
Mu-type opioid receptor0505
Bifunctional epoxide hydrolase 20202
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 2 0507
Carbonic anhydrase0505
Alpha-1A adrenergic receptor0404
Carbonic anhydrase 70101
Carbonic anhydrase0101
Histone deacetylase 40101
D(2) dopamine receptor0101
Carbonic anhydrase 0101
Mu-type opioid receptor0505
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Sodium-dependent dopamine transporter 0202
Prostaglandin G/H synthase 20404
Histone deacetylase 10101
Mitogen-activated protein kinase 140101
Carbonic anhydrase 90404
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase0101
Carbonic anhydrase 0101
Sigma intracellular receptor 20101
Delta carbonic anhydrase0101
Prostaglandin G/H synthase 1 0507
Carbonic anhydrase 0101
Prostaglandin G/H synthase 10101
Carbonic anhydrase 130101
Cyclooxygenase-2 0101
Histone deacetylase 70101
Rap guanine nucleotide exchange factor 41001
Inositol hexakisphosphate kinase 15005
Histone deacetylase 20101
Carbonic anhydrase 40303
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Carbonic anhydrase 150202
Histone deacetylase 80101
P2Y purinoceptor 120202
Histone deacetylase 60101
Histone deacetylase 90101
Carbonic anhydrase 140202
Histone deacetylase 50101
Carbonic anhydrase 5B, mitochondrial0101
cytochrome P450 2C9, partial5005
Beta-lactamase 0101
Bile salt export pump0303
Solute carrier family 22 member 80202
Beta-lactamase TEM0101
endonuclease IV2002
dopamine D1 receptor2002
regulator of G-protein signaling 43003
peripheral myelin protein 22 isoform 13003
atrial natriuretic peptide receptor 1 precursor1001
flap endonuclease 14004
survival motor neuron protein isoform d6006
M-phase phosphoprotein 83003
Glucocorticoid receptor0415
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10404
Corticosteroid-binding globulin0101
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 438008
Multidrug and toxin extrusion protein 10202
Aldo-keto reductase family 1 member B100101
UDP-glucuronosyltransferase 1A90102
Transient receptor potential cation channel subfamily A member 10022
Dihydrofolate reductase0506
Transthyretin0013
Albumin0224
Interleukin-80101
Calcium/calmodulin-dependent protein kinase type II subunit alpha0101
Fatty acid-binding protein, intestinal0202
Aldo-keto reductase family 1 member B10202
UDP-glucuronosyltransferase 2B70103
UDP-glucuronosyltransferase 1-60202
UDP-glucuronosyltransferase 1A1 0202
UDP-glucuronosyltransferase 1A40101
Sodium- and chloride-dependent GABA transporter 10101
C-X-C chemokine receptor type 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
UDP-glucuronosyltransferase 1A30002
UDP-glucuronosyltransferase 2B10 0101
Sodium- and chloride-dependent betaine transporter0101
Cytochrome P450 2J20303
Solute carrier family 22 member 60305
UDP-glucuronosyltransferase 1A70101
UDP-glucuronosyltransferase 1A100101
vitamin D3 receptor isoform VDRA5005
Solute carrier family 22 member 20001
Solute carrier family 22 member 1 0103
Solute carrier organic anion transporter family member 1A50002
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0101
Prostaglandin E2 receptor EP1 subtype0213
Prostaglandin E2 receptor EP1 subtype0101
Prostaglandin E2 receptor EP4 subtype0213
Prostaglandin F2-alpha receptor0011
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP3 subtype0213
Prostaglandin E2 receptor EP2 subtype0213
Prostacyclin receptor0213
Solute carrier family 22 member 70001
Prostaglandin E2 receptor EP2 subtype0101
Prostaglandin E2 receptor EP2 subtype0112
Solute carrier family 22 member 80104
Solute carrier family 22 member 70001
Solute carrier organic anion transporter family member 2A10001
Solute carrier family 22 member 110003
Solute carrier organic anion transporter family member 1B20001
Solute carrier family 22 member 70002
Eyes absent homolog 20202
Polyunsaturated fatty acid lipoxygenase ALOX15B3003
Amyloid-beta precursor protein0202
Angiotensin-converting enzyme 0202
Histamine H2 receptor3003
Beta-lactamase 0101
Beta-lactamase 0101
Type IV secretion-like conjugative transfer relaxase protein TraI 0101
histone acetyltransferase KAT2A isoform 13003
Chain A, Dihydrofolate reductase0011
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
alpha-galactosidase2002
lysosomal alpha-glucosidase preproprotein2002
Thymidylate synthase0404
Thymidylate synthase0304
Dihydrofolate reductase0235
Alpha-synuclein2103
Folylpolyglutamate synthase, mitochondrial0104
Solute carrier organic anion transporter family member 1A30102
Folylpolyglutamate synthase, mitochondrial0104
Multidrug resistance associated protein0103
NFKB1 protein, partial1001
nonstructural protein 13003
arylsulfatase A3003
transcriptional regulator ERG isoform 32002
importin subunit beta-1 isoform 15005
snurportin-15005
muscleblind-like protein 1 isoform 13003
Acid-sensing ion channel 30101
Solute carrier organic anion transporter family member 1A40102
Albumin0102
Albumin0011
Cholinesterase0101
Polyunsaturated fatty acid 5-lipoxygenase0205
Acetylcholinesterase0101
Caspase-10202
Aldo-keto reductase family 1 member C30202
Caspase-30202
Solute carrier organic anion transporter family member 1A10102
Caspase-40202
Caspase-50202
Caspase-90202
Acid-sensing ion channel 10101
Fatty-acid amide hydrolase 10101
Dehydrogenase/reductase SDR family member 90101
Chymotrypsinogen A0101
GALC protein3003
cytochrome P450 2D6 isoform 11001
cytochrome P450 2C19 precursor2002
GTP-binding nuclear protein Ran isoform 12002
Cytochrome P450 1A10202
Cytochrome P450 1B10101
15-lipoxygenase, partial3003
phosphopantetheinyl transferase4004
Fumarate hydratase4004
polyprotein4004
Large neutral amino acids transporter small subunit 1 0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
ClpP1001
Thymidylate synthase 0101
Thymidylate synthase 0101
cellular tumor antigen p53 isoform a2002
polyunsaturated fatty acid lipoxygenase ALOX121001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Bifunctional dihydrofolate reductase-thymidylate synthase0101
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Glucose-6-phosphate 1-dehydrogenase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Kappa-type opioid receptor0101
Reduced folate transporter0202
6-phosphogluconate dehydrogenase, decarboxylating0101
Dihydrofolate reductase0101
Pteridine reductase 10101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Solute carrier organic anion transporter family member 1B30001
Protein-arginine deiminase type-40202
Broad substrate specificity ATP-binding cassette transporter ABCG20001
Chain E, Fibrin beta chain0101
T cell receptor, partial1001
acetylcholinesterase1001
luteinizing hormone receptor1001
integrase, partial0101
chaperonin-containing TCP-1 beta subunit homolog1001
lens epithelium-derived growth factor p750101
Caspase 6, apoptosis-related cysteine peptidase0001
TSHR protein1001
Apoptotic peptidase activating factor 10101
isocitrate dehydrogenase 1, partial1001
luciferase1001
neutrophil cytosol factor 10101
caspase-9 isoform alpha precursor0101
histone deacetylase 9 isoform 32002
huntingtin isoform 21001
pyruvate kinase PKM isoform a1001
caspase-3 isoform a preproprotein0101
protein AF-9 isoform a0001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
Vpr2002
replicative DNA helicase0001
recombinase A0011
POsterior Segregation0011
DNA repair protein RAD52 homolog isoform a0001
neuropeptide S receptor isoform A1001
Glutathione reductase0101
Glutathione reductase, mitochondrial0102
Glycoprotein hormones alpha chain1001
Dihydrolipoyl dehydrogenase, mitochondrial0102
Microtubule-associated protein tau0112
Amine oxidase [flavin-containing] A0101
Alpha-1D adrenergic receptor0202
Guanine nucleotide-binding protein G3003
Inositol monophosphatase 13003
Thioredoxin reductase 1, cytoplasmic0102
Dihydrolipoyl dehydrogenase 0102
Zinc finger protein mex-50011
phosphoglycerate kinase1001
Hormone-sensitive lipase0101
Aldo-keto reductase family 1 member C40101
Aldo-keto reductase family 1 member C2 0101
Aldo-keto reductase family 1 member C10101
5-hydroxytryptamine receptor 3E0101
D(1A) dopamine receptor1001
Neuronal acetylcholine receptor subunit alpha-40213
5-hydroxytryptamine receptor 3B0101
Acetylcholine receptor subunit alpha0213
Acetylcholine receptor subunit alpha0213
Acetylcholine receptor subunit beta0213
Acetylcholine receptor subunit gamma0213
Acetylcholine receptor subunit delta0213
Neuronal acetylcholine receptor subunit alpha-30225
Acetylcholine receptor subunit gamma0213
Muscarinic acetylcholine receptor M10202
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50101
Neuronal acetylcholine receptor subunit alpha-40101
Muscarinic acetylcholine receptor M20101
Acetylcholine receptor subunit beta0213
Cytochrome P450 2A60213
Neuronal acetylcholine receptor subunit alpha-20225
Neuronal acetylcholine receptor subunit beta-30225
Neuronal acetylcholine receptor subunit beta-40225
Translocator protein0101
Neuronal acetylcholine receptor subunit beta-20213
Neuronal acetylcholine receptor subunit alpha-50225
Cytochrome P450 2A50101
Acetylcholine receptor subunit beta-like 20202
Neuronal acetylcholine receptor subunit alpha-50011
Neuronal acetylcholine receptor subunit beta-40213
Muscarinic acetylcholine receptor M40101
Neuronal acetylcholine receptor subunit alpha-30213
Neuronal acetylcholine receptor subunit alpha-70224
Neuronal acetylcholine receptor subunit alpha-60225
Neuronal acetylcholine receptor subunit alpha-90225
Neuronal acetylcholine receptor subunit alpha-40213
5-hydroxytryptamine receptor 3A0101
Neuronal acetylcholine receptor subunit alpha-70202
Acetylcholine-binding protein0112
Acetylcholine receptor subunit epsilon0011
Neuronal acetylcholine receptor subunit beta-30112
Neuronal acetylcholine receptor subunit alpha-70225
Acetylcholine receptor subunit delta0213
Potassium voltage-gated channel subfamily H member 20202
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit alpha-60112
Cytochrome P450 2A130112
Neuronal acetylcholine receptor subunit alpha-50202
Liver carboxylesterase B-10101
Solute carrier family 22 member 10101
5-hydroxytryptamine receptor 3D0101
Transient receptor potential cation channel subfamily A member 10011
Neuronal acetylcholine receptor subunit beta-30202
Neuronal acetylcholine receptor subunit beta-40202
Neuronal acetylcholine receptor subunit alpha-30202
Soluble acetylcholine receptor0101
5-hydroxytryptamine receptor 3C0101
Neuronal acetylcholine receptor subunit alpha-20202
Neuronal acetylcholine receptor subunit beta-20213
Neuronal acetylcholine receptor subunit alpha-100225
Solute carrier family 22 member 20101
Neuronal acetylcholine receptor subunit alpha-60202
Integrin beta0011
Glycoprotein IIb0011
Transporter0113
Chain H, Igg2b-kappa 40-50 Fab (heavy Chain)0101
Chain L, Igg2b-kappa 40-50 Fab (light Chain)0101
Chain A, Na, K-ATPase alpha subunit0011
STAT3, partial0101
Kruppel-like factor 50101
NPC intracellular cholesterol transporter 1 precursor1001
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
Sodium/potassium-transporting ATPase subunit alpha-1 0203
Sodium/potassium-transporting ATPase subunit beta-10203
Sodium/potassium-transporting ATPase subunit alpha-1 0101
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-3 0101
Sodium/potassium-transporting ATPase subunit beta-1 0101
Replicase polyprotein 1ab0101
Sodium/potassium-transporting ATPase subunit alpha-30102
Sodium/potassium-transporting ATPase subunit beta-20102
Solute carrier organic anion transporter family member 1A20001
Sodium/potassium-transporting ATPase subunit alpha-20203
Sodium/potassium-transporting ATPase subunit beta-30102
Sodium/potassium-transporting ATPase subunit gamma0102
Sodium/potassium-transporting ATPase subunit alpha-40102
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10001
MecA 0101
Nrf21001
Microphthalmia-associated transcription factor0001
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
caspase recruitment domain family, member 150101
glucose-6-phosphate 1-dehydrogenase isoform b0101
receptor-interacting serine/threonine-protein kinase 2 isoform 10101
serine/threonine-protein kinase PLK11001
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
Beta lactamase (plasmid)0101
beta-2 adrenergic receptor1001
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
Glutamate 5-kinase0001
Glutamate receptor ionotropic, NMDA 1 0101
Neutral amino acid transporter A0101
Neutral amino acid transporter B(0)0101
Proton-coupled amino acid transporter 10101
Amino acid transporter0101
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
heat shock protein HSP 90-alpha isoform 20102
heat shock protein 90, putative0001
Chain A, dATP pyrophosphohydrolase0101
Chain A, Adenylate cyclase type 50101
Chain B, Adenylate cyclase type 20101
inositol monophosphatase 11001
Prostaglandin G/H synthase 20101
Cytochrome c oxidase subunit 10101
C-X-C chemokine receptor type 30101
Transporter0101
Sodium-dependent serotonin transporter0101
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, 146aa long hypothetical transcriptional regulator0011
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain B, Anthranilate phosphoribosyltransferase0101
Chain C, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Anthranilate phosphoribosyltransferase0101
Carbonic anhydrase 0202
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Dihydroxyacetone phosphate acyltransferase0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Tetracycline resistance protein, class B0001
Muscarinic acetylcholine receptor M20101
72 kDa type IV collagenase0202
Stromelysin-10101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
Multidrug transporter MdfA0101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Neutrophil collagenase0202
Collagenase 30101
Cannabinoid receptor 10101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Integrase 0101
P2Y purinoceptor 120101
Thymidine kinase 0102
Thymidine kinase, cytosolic0204
Thymidine kinase0102
Thymidine phosphorylase0001
Thymidine phosphorylase0001
Thymidylate kinase0101
Thymidine kinase, cytosolic 0002
Thymidine kinase0001
Thymidylate kinase0101
Thymidine kinase 0102
Sterol O-acyltransferase 10101
Thymidine kinase0001
Thymidine kinase0001
Mu-type opioid receptor0112
Delta-type opioid receptor0101
Kappa-type opioid receptor0101
Butyrophilin subfamily 3 member A10012
Matrix metalloproteinase-90101
Farnesyl diphosphate synthase0101
Matrix metalloproteinase-140101
Farnesyl pyrophosphate synthase 0202
Geranylgeranyl pyrophosphate synthase0202
Farnesyl pyrophosphate synthase 0101
H0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]